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 Thursday, April 13, 2006     Volume 16   Number 15  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
Spotlight
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Images of population, and asian man E-Facts on Public Health Genomics
Adapted from a 45-minute presentation called Genomics for Public Health Practitioners, this e-fact sheet presents quick information about public health genomics.
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CDC Announcements
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New HuGE Review
The long QT syndrome family of cardiac ion channelopathies
Modell, Stephen M. MD, MS; Lehmann, Michael H. MD

 
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New HuGE Review
Association between the Transforming Growth Factor Alpha Gene and Nonsyndromic Oral Clefts

   
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From Public Health Emergency to Public Health Service: The Implications of Evolving Criteria for Newborn Screening Panels
Grosse S. et al. Pediatrics; March 2006
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Big hips, big belly? It's in your genes, Joslin-led study shows” This reference links to a non-governmental website
(April 10) EurekAlert! reports, “Do you have big hips or a "beer" belly? Are you "apple-shaped" or "pear-shaped"? It makes a difference, since we know that abdominal obesity is linked to diabetes and many other metabolic conditions, i.e., the metabolic syndrome.”

“Researchers find genetic "signature" that accurately identifies colon cancer”This reference links to a non-governmental website
(April 13) News-Medical.net reports, “Researchers at Jefferson Medical College in Philadelphia have uncovered a genetic "signature" that accurately identifies colon cancer--a key, they hope, to better understand how the cancer develops.”

“Seeking Ancestry in DNA Ties Uncovered by Tests”This reference links to a non-governmental website
(April 12) The New York Times reports, “Alan Moldawer's adopted twins, Matt and Andrew, had always thought of themselves as white.”

“Protein's Role In Hemoglobin Gene Silencing Identified”This reference links to a non-governmental website
(April 12) Science Daily reports, “Virginia Commonwealth University Massey Cancer Center researchers have identified the role of a protein in hemoglobin gene silencing that may one day be a potential target for the treatment of genetic blood disorders like sickle-cell anemia and beta-thalassemia on the molecular level.”

“Scientists Discover New Genetic Subtypes Of Common Blood Cancer”This reference links to a non-governmental website
(April 11) Science Daily reports, “Scientists at Dana-Farber Cancer Institute and collaborators have identified four distinct genetic subtypes of multiple myeloma, a deadly blood cancer, that have different prognoses and might be treated most effectively with drugs specifically targeted to those subtypes.”

“In the Genes: When the Littlest Family Member Snores, Too” This reference links to a non-governmental website
(April 11) The New York Times reports, “Snoring may be genetic. Children who snore are almost three times as likely as others to have parents who snore.”

“Genetic variants in estrogen-related genes linked to Parkinson's disease in women”This reference links to a non-governmental website
(April 11) News-Medical.Net reports, “Mayo Clinic researchers have discovered a possible connection between increased risk for Parkinson's disease and variants in three genes that control estrogen production and activity in the body.”

“Large Family Study Pinpoints Genetic Linkage In Drug Addiction” This reference links to a non-governmental website
(April 11) Medical News Today reports, “Based on data obtained from one of the largest family sets of its kind, Yale School of Medicine researchers have identified a genetic linkage for dependence on drugs such as heroin, morphine and oxycontin.”

“Omega-3 protects retina”This reference links to a non-governmental website
(April 10) myDNA reports, “A paper published in Trends in Neuroscience this week by Nicolas G. Bazan, M.D., Ph.D., Boyd Professor and director of the Neuroscience Center of Excellence at Louisiana State University Health Sciences Center (LSUHSC) in New Orleans, reports on the role that the omega-3 fatty acids in fish oil play in protecting cells in the retina from degenerative diseases like retinitis pigmentosa and age-related macular degeneration, the leading cause of loss of vision in those older than 65.”

“Pennsylvania researchers find liver transplants provide metabolic cure for rare genetic disease”This reference links to a non-governmental website
(April 10) EurekAlert! reports, “Liver transplants cured the metabolic symptoms of 11 patients with a rare but devastating genetic condition known as Maple Syrup Urine Disease (MSUD), according to a study by researchers from Children's Hospital of Pittsburgh and the Clinic for Special Children.”

“Altering genetic blueprint of receptors in brain could help stroke victims avoid brain damage”This reference links to a non-governmental website
(April 10) EurekAlert! reports, “A University of Central Florida researcher has demonstrated that altering AMPA receptors in animals improved their chances of surviving strokes and remaining healthier afterwards.”

“Curious consumers turn to own DNA for answers”This reference links to a non-governmental website
(April 10) elpasotimes.com reports, “For years, Art Thomas sifted through the stories and rumors traded among relatives and he wondered: Exactly where did I come from?”

“How A Faulty Gene Leads To Kidney Cancer May Pave Way For New Treatments To Block Kidney Cancer Growth”This reference links to a non-governmental website
(April 10) Medical  News Today reports, “An important discovery about how a faulty gene leads to kidney cancer could pave the way for new treatments to block kidney cancer growth, a study published in Cancer Research.* (Monday 4 April 2006) reveals.”

“Lung Cancer Risk Calculated Based On Medical History And Genetics”This reference links to a non-governmental website
(April 9) Medical  News Today reports, “Physicians have little to help them predict development of lung cancer in their patients - even a history of heavy smoking doesn't really help, since only a small fraction of lifetime smokers develops the cancer.”

“Markers Of Gene, Protein, Or Micro-RNA Activity Predict Outcome In Prostate And Colorectal Cancers”This reference links to a non-governmental website
(April 8) Science Daily reports, “Cancer researchers are working toward a future in which each patient's tumor will act like a crystal ball, revealing how oncologists should treat the cancer to obtain the best outcome.”

“Enzyme Crystal Structure Reveals 'Unexpected' Genome Repair Functions”This reference links to a non-governmental website
(April 7) Science Daily reports, “The research looked at XPB helicase from an archaea, a single cell organism similar to bacteria.”

“Enzyme could help prevent Alzheimer's?”This reference links to a non-governmental website
(April 7) myDNA reports, “An enzyme previously associated with preventing the dementia of Alzheimer's disease now appears to play an even bigger role in safeguarding against the disease, bringing the promise of new targets for drug therapies.”

“Half of cancer deaths preventable”This reference links to a non-governmental website
(April 7) myDNA reports, “A new report from the American Cancer Society says that far from being an unavoidable fate that is hard-wired into the genetic code, death from cancer is largely preventable.”

“Focus on common genetic disorders in Arab world”This reference links to a non-governmental website (last accessed 2/2008)
(April 7) Khaleej Times Online reports, “The last session of the first Pan Arab Human Genetics Conference that was held yesterday featured lectures on consanguinity — blood relative — marriages in the Arab world as well as on the Islamic perspective towards human cloning, stem cell research and pre-implantation genetic diagnosis.”

“Cancer spreads by waves?”This reference links to a non-governmental website
(April 6) myDNA reports, “Mayo Clinic researchers have uncovered a new cellular secret that may explain how certain cancers move and spread - a feature of cancers that makes treatment especially difficult.”

“Decoding the Genetics of Common Disease”This reference links to a non-governmental website
(April 6) Bio IT World.com reports, “Ten years after he returned to his native Iceland to build a biopharma company, Kari Stefansson says deCODE Genetics’ intense search for genes underlying common diseases is not only pushing promising new drug candidates into the clinic but is also revealing new insights into the very basis of common disease.”

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Genomics in Scientific Literature
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Cancer genetics: colorectal cancer as a model
Bodmer WF
J Hum Genet 2006 Apr

The genetic studies of dementias in Taiwan
Chen HH & Hu CJ
Acta Neurol Taiwan 2006 Mar;15(1):60-3

Selection of SNP subsets for association studies in candidate genes: comparison of the power of different strategies to detect single disease susceptibility locus effects
Cousin E, et al.
BMC Genet 2006 Apr;7(1):20

Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMP1 (SLC11A1) on host-pathogen interactions in tuberculosis and HIV
McDermid JM & Prentice AM
Clin Sci (Lond) 2006 May;110(5):503-24

Defining high-risk individuals in a population-based molecular-epidemiological study of lung cancer
Cassidy A, et al.
Int J Oncol 2006 May;28(5):1295-301

Multifactor dimensionality reduction: An analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies
Motsinger AA & Ritchie MD
Hum Genomics 2006 Mar;2(5):318-28

GAIA: An easy-to-use web-based application for interaction analysis of case-control data
Macgregor S & Khan IA
BMC Med Genet 2006 Apr;7(1):34

Testing for genetic heterogeneity in the genome search meta-analysis method
Lewis CM & Levinson DF
Genet Epidemiol 2006 Apr

Genetic determinants of the metabolic syndrome
Sale MM, et al.
Curr Hypertens Rep 2006 Apr;8(1):16-22

The 30-bp Deletion of Epstein-Barr Virus Latent Membrane Protein-1 Gene Has No Effect in Nasopharyngeal Carcinoma
Chang KP, et al.
Laryngoscope 2006 Apr;116(4):541-6

A study on the nature of genetic metabolic practice at a major paediatric referral centre
Glass HC, et al.
J Inherit Metab Dis 2006 Feb;29(1):175-8

The tandem mass spectrometry newborn screening experience in North Carolina: 1997-2005
Frazier DM, et al.
J Inherit Metab Dis 2006;29(1):76-85

Genetic and nutrient determinants of the metabolic syndrome
Phillips C, et al.
Curr Opin Cardiol 2006 May;21(3):185-93

Experience of parental cancer in childhood is a risk factor for psychological distress during genetic cancer susceptibility testing
van Oostrom I, et al.
Ann Oncol 2006 Apr

Genetic testing for hereditary cancers: The impact of gender on interest, uptake and ethical considerations
d'Agincourt-Canning L & Baird P
Crit Rev Oncol Hematol 2006 Apr

Genetic counseling in psychiatry
Finn CT & Smoller JW
Harv Rev Psychiatry 2006 Mar-2006 Apr;14(2):109-21

Pharmacogenetics, race, and psychiatry: prospects and challenges
Jones DS & Perlis RH
Harv Rev Psychiatry 2006 Mar-2006 Apr;14(2):92-108

Variations on a Gene: Rare and Common Variants in ABCA1 and Their Impact on HDL Cholesterol Levels and Atherosclerosis
Brunham LR & Hayden M
Annu Rev Nutr 2005 Jun

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending April 12, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Condition
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New this week

Open door workshop: Working with the Human Genome Sequence   This reference links to a non-governmental website
May 8-10, 2006 ~ Cambridge, UK
New this week

European School of Genetic Medicine 19th course in Medical GeneticsThis reference links to a non-governmental website
April 26 – May 2, 2006 ~ Bertinoro di Romagna, Italy

   
9th Annual Meeting of the American Society of Gene Therapy
May 31 - June 4, 2006 ~ Baltimore, MD
   
  Second American Congress of Epidemiology
June 21-24, 2006 ~ Seattle, WA
   
New this week The 8th International Meeting on Human Genome Variation and Complex Genome AnalysisThis reference links to a non-governmental website
September 14-16, 2006 ~ Hong Kong, China
   
New this week 9th Annual Computational Genomics ConferenceThis reference links to a non-governmental website
October 28-31, 2006 ~ Baltimore, MD
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Let's Go Surfing
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Public Health Genetics Unit, UK, Newsletter, April 2006 This reference links to a non-governmental website
The Public Health Genetics Unit (PHGU) of the United Kingdom (UK) aims to keep abreast of developments in molecular and clinical genetics, and in their ethical, legal, social and public health implications.

Disease Detective Camp 2006
CDC's Global Health Odyssey and the Office of Workforce Development are hosting two sessions of a free, 5-day Disease Detective Camp for rising high school juniors and seniors.

Applied Research Ethics Certificate ProgramThis reference links to a non-governmental website
Sarah Lawrence College is offering a new Applied Research Ethics (ARE) Certificate Program aimed at healthcare professionals who seek career change and advancement.

Public Health Genetics/Genomics Certificate ProgramThis reference links to a non-governmental website
Sarah Lawrence College is offering a new Public Health Genetics/Genomics (PHG) Certificate Program aimed at healthcare professionals who seek career change and advancement

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: April 13, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics