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 Thursday, Nov. 17, 2005     Volume 15   Number 20  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
Happy Thanksgiving
Due to the Thanksgiving holiday, CDC's Office of Genomics and Disease Prevention (OGDP)
will not be posting or sending the Genomics and Health Weekly Update next week.
Spotlight
view the current Update
photo of an Asian family

The U.S. Surgeon General, in collaboration with CDC and other HHS agencies, released an updated, Web-based version of “My Family Health Portrait”— a free, computerized tool that organizes family health information into a printout that people can take to health care professionals to help determine whether they are at higher risk for certain diseases.
Learn more

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CDC Announcements
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What's New in HuGENet™
November 2005
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New HuGE Review
Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review  you will need a free Acrobat reader to view this file(934KB)
Rayjean J. Hung et al.
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“U.S. Surgeon General Urges Americans To Know Their Family Health History”
(November 15) HHS News reports, “Calling on all Americans to "know their family history," U.S. Surgeon General Richard H. Carmona, M.D., M.P.H., today unveiled an updated version of a computerized tool designed to help families gather their health information, and praised Brigham and Women's Hospital in Boston for joining in to expand the Surgeon General's Family Health Initiative.”

“Genetic disorders may cause cerebral palsy” This reference links to a non-governmental website
(November 16) ABC News Online reports, “Researchers from the University of Adelaide say they have discovered that cerebral palsy is more likely to be caused by genetic disorders rather than problems at birth.”

“Radiation therapy genetic switch found” This reference links to a non-governmental website
(November 16) WebIndia123.com reports, “Scientists reportedly have found a genetic switch that causes cancer cells to be more sensitive to a drug given to enhance radiation therapy effectiveness.”

“Online family health history tracker gets an update” This reference links to a non-governmental website (last accessed 2/2008)
(November 15) Healthcare IT News reports, “The government today introduced an updated version of a Web-based family health history tool to encourage more Americans to collect information about their family's health history.”

“Program Maps Genetic History, Pinpoints Health Risks” This reference links to a non-governmental website
(November 15) Boston Channel.com report, “Knowing your family's medical history can save your life, but tracking that all-important genetic data can be difficult.”

“How do you feel? Genetics are partly to blame” This reference links to a non-governmental website
(November 15) EurekAlert! reports, “You can blame your parents for your hair that frizzes in high humidity and for your short stature. And now researchers at Saint Louis University School of Public Health say your genetic makeup partly dictates how physically and mentally healthy you feel.”

“New study to find cause of former President's hand disease” This reference links to a non-governmental website
(November 15) EurekAlert! reports, “A crippling condition that can result in sufferers losing their fingers is to be investigated by scientists in one of the most detailed studies into the genetic causes of the disease ever carried out.”

“Australian study highlights lateral genetic transfer” This reference links to a non-governmental website
(November 14) News-Medical.Net reports, “A University of Queensland study mapping the evolution of genes has shed light on the role of gene transfer in bacterial diseases.”

“Genetic Analysis of Glioblastoma Brain Tumors Can Aid in Treatment Decisions” This reference links to a non-governmental website
(November 13) eMaxHealth reports, “Screening glioblastoma brain tumors for two gene variations can reliably predict which tumors will respond to a specific class of drugs, a new study shows.”

“Heart risk gene hits African Americans hardest” This reference links to a non-governmental website
(November 11) myDNA News reports, “A paper by a deCODE-led team of scientists published today presents the discovery of a gene variant conferring increased risk of myocardial infarction, or heart attack.

“Harnessing genome research” This reference links to a non-governmental website
(November 11) myDNA News reports, “Regeneration of spinal nerve cells, a new way to personalize breast cancer treatment, rapid near-patient diagnosis of meningitis, MRSA and Chlamydia and effective vaccines to protect against salmonella are all important applications to have benefited from a research program built around harnessing knowledge of the human and other genomes.”

“Genes suppress pediatric tumor development” This reference links to a non-governmental website
(November 11) myDNA News reports, “The Ink4c and Ptch1 genes collaborate to suppress the development of medulloblastoma, the most common pediatric brain tumor, according to investigators at St. Jude Children's Research Hospital, Rockefeller University, Johns Hopkins University and the University of Newcastle (in the United Kingdom).”

 
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Genomics in Scientific Literature
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Family history assessment to detect increased risk for colorectal cancer: conceptual considerations and a preliminary economic analysis
Ramsey SD , et al.
Cancer Epidemiol Biomarkers Prev 2005 Nov;14(11):2494-500

The case for strategic international alliances to harness nutritional genomics for public and personal healthdagger
Kaput J, et al.
Br J Nutr 2005 Nov;94(5):623-32

Statin pharmacogenomics: what have we learned, and what remains unanswered?
Kajinami K, et al.
Curr Opin Lipidol 2005 Dec;16(6):606-13

Of genomics and public health: Building public "goods"?
Knoppers BM
CMAJ 2005 Nov;173(10):1185-6

Genetic polymorphisms and multifactorial diseases: facts and fallacies revealed by the glucocorticoid receptor gene
van Rossum EF, et al.
Trends Endocrinol Metab 2005 Nov

Modifier genes and cystic fibrosis
Corvol H, et al.
Arch Pediatr 2005 Nov

Pharmacogenomics--can genetics help in the care of psychiatric patients?
Bolonna AA, et al.
Int Rev Psychiatry 2004 Nov;16(4):311-9

Genetic association studies in mood disorders: issues and promise
Detera-Wadleigh SD & McMahon FJ
Int Rev Psychiatry 2004 Nov;16(4):301-10

Age of uptake of early cancer detection facilities by low-risk and high-risk patients with familial breast and ovarian cancer
Lux MP, et al.
Eur J Cancer Prev 2005 Dec;14(6):503-11

Genetic contributors toward increased risk for ischemic heart disease
Nordlie MA, et al.
J Mol Cell Cardiol 2005 Oct;39(4):667-79

Psychological impact of genetic testing for hereditary non-polyposis colorectal cancer
Meiser B, et al.
Clin Genet 2004 Dec;66(6):502-11

Hereditary breast and ovarian cancer: review and future perspectives
Lux MP, et al.
J Mol Med 2005 Nov

Progress toward discerning the genetics of cleft lip
Lidral AC & Moreno LM
Curr Opin Pediatr 2005 Dec;17(6):731-9

The use of genetic testing in the evaluation of hearing impairment in a child
Robin NH, et al.
Curr Opin Pediatr 2005 Dec;17(6):709-12

Genetic Studies of IgA Nephropathy
Maxwell PH & Wang Y
Nephron Exp Nephrol 2005 Nov;102(3-4):e76-e80

Increased Risk of Cancer among Relatives of Patients with Lung Cancer in China
Jin Y, et al.
BMC Cancer 2005 Nov;5(1):146

Genetic basis of diabetic nephropathy
Rincon-Choles H, et al.
Am J Ther 2005 Nov-2005 Dec;12(6):555-61

Power and sample size calculations for genetic case/control studies using gene-centric SNP maps: application to human chromosomes 6, 21, and 22 in three populations
De La Vega FM, et al.
Hum Hered 2005;60(1):43-60

The UMD TP53 database and website: update and revisions
Hamroun D, et al.
Hum Mutat 2005 Nov

 
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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending November 16, 2005, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

 
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Upcoming Events
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New this week

Developing Biomarker-based Tools for Cancer Screening, Diagnosis, & Therapy: The State of the Science, Evaluation, Implementation, and Economics This reference links to a non-governmental website
March 20-22, 2006 ~ Washington, DC

New this week

Gene and cell therapy This reference links to a non-governmental website
December 1-2, 2005 ~ Paris, France

   
New this week

Tapestry of Life: Lateral Transfers of Heritable Elements This reference links to a non-governmental website
December 12-13, 2005 ~ Irvine, California

   
 

The TGF-ß Family in Cancer and Other Diseases
February 8-12, 2006 ~ La Jolla, CA

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Let's Go Surfing
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The Wellcome Trust Sanger Institute This reference links to a non-governmental website
Projects at the Sanger Institute include genome annotation, development of new resources and technology, and their application to genetic disease.

National Cancer Policy Forum This reference links to a non-governmental website
The Institute of Medicine (IOM) has established a National Cancer Policy Forum (the Forum), effective on May 1, 2005, to succeed the existing National Cancer Policy Board (1996-2005, the Board).  IOM forums are designed to allow government, industry, academic, and other representatives to meet and confer privately on subject areas of mutual interest.

The 21st Century Community Schoolhouse This reference links to a non-governmental website
Websites for Genetic Disorders

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: November 17, 2005 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics