Genome Scans

• A genome-wide search for asthma susceptibility loci in ethnically diverse populations. The Collaborative Study on the Genetics of Asthma (CSGA). Nat Genet 1997;15:389-92.
• Daniels SE, Bhattacharrya S, James A, et al. A genome-wide search for quantitative trait loci underlying asthma. Nature 1996;383:247-50.
• Dizier MH, Besse-Schmittler C, Guilloud-Bataille M, et al. Genome screen for asthma and related phenotypes in the French EGEA study. Am J Respir Crit Care Med 2000;162:1812-8.
• Haagerup A, Bjerke T, Schiotz PO, et al. Asthma and atopy – a total genome scan for susceptibility genes. Allergy 2002;57:680-6.
• Hakonarson H, Bjornsdottir US, Halapi E, et al. A major susceptibility gene for asthma maps to chromosome 14q24. Am J Hum Genet 2002;71:483-91.
• Laitinen T, Daly MJ, Rioux JD, et al. A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population. Nat Genet 2001;28:87-91.
• Ober C, Tsalenko A, Parry R, Cox NJ. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet 2000;67:1154-62.
• Ober C, Cox NJ, Abney M, et al. Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma. Hum Mol Genet 1998;7:1393-8.
• Polvi A, Polvi T, Sevon P, et al. Physical map of an asthma susceptibility locus in 7p15-p14 and an association study of TCRG. Eur J Hum Genet 2002;10:658-65.
• Wjst M, Fischer G, Immervoll T, et al. A genome-wide search for linkage to asthma. German Asthma Genetics Group. Genomics 1999;58:1-8.
• Xu X, Fang Z, Wang B, et al. A genomewide search for quantitative-trait loci underlying asthma. Am J Hum Genet 2001;69:1271-77.
• Xu J, Meyers DA, Ober C, et al. Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma. Am J Hum Genet 2001;68:1437-46.
• Yokouchi Y, Nukaga Y, Shibasaki M, et al. Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31-q33 near the interleukin 12 B locus by a genome-wide search in Japanese families. Genomics 2000;66:152-60.

Linkage Analysis and Association Studies

• Beghe B, Barton S, Rorke S, et al. Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population. Clin Exp Allergy 2003;33:1111-7.
• Blumenthal MN, Ober C, Beaty TH et al. Genome scan for loci linked to mite sensitivity: the Collaborative Study on the Genetics of Asthma (CSGA). Genes Immun March 18 th, 2004
• Bourgain C, Hoffjan S, Nicolae R, et al. Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus. Am J Hum Genet 2003;73:612-26.
• Cookson W. A new gene for asthma: Would you ADAM and eve it? Trends in Genetics 2003;19:169-72.
• Dizier MH, Quesneville H, Besse-Schmittler C, et al. Indication of linkage and genetic heterogeneity for asthma and atopy on chromosomes 8p and 12q in 107 French EGEA families. Eur J Hum Genet 2003;11:590-6.
• Dizier MH, Besse-Schmittler C, Guilloud-Bataille M, et al. Indication of linkage and genetic heterogeneity of asthma according to age at onset on chromosome 7q in 107 French EGEA families. Eur J Hum Genet 2001;9:867-72.
• Duetsch G, Illig T, Loesgen S, et al. STAT 6 as an asthma candidate gene: Polymorphism screening, association and haplotype analysis in a Caucasian sib-pair study. Hum Mol Genetics 2002;11:613-21.
• Holroyd KJ, Martinati LC, Trabetti E, et al. Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region. Genomics 1998;52:233-35.
• Howard TD, Postma DS, Jongepier H, et al. Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. J Allergy Clin Immunol 2003;112:717-22.
• Howard TD, Koppelman GH, Xu J, et al. Gene-gene interaction in asthma: ILR4 and IL13 in a Dutch population with asthma. Am J Hum Genet 2002;70:230-6.
• Howard TD, Postma DS, Koppelman GA, et al. Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28. J Allergy Clin Immunol 2002;110:743-51.
• Immervoll T, Loesgen S, Dutsch G, et al. Fine mapping and single nucleotide polymorphism association results of candidate genes for asthma and related phenotypes. Hum Mutat 2001;18:327-36.
• Ivaschenko TE, Sideleva OG, Baranov VS. Gluathione-S-transferase u and theta gene polymorphisms as new risk factors of atopic bronchial asthma. J Mol Med 2002;80:39-43.
• Kabesch M, Carr D, Weiland S, et al. Association between polymorphisms in serine protease inhibitor, kazal type 5 and asthma phenotypes in a large German population sample. Clin Exp Allergy 2004;34:340-5.
• Laing IA, Goldblatt J, Eber E, et al. A polymorphism of the CC16 gene is associated with an increased risk of asthma. J Med Genet 1998;35:463-7.
• Leaves N, Bhattacharyya S, Wiltshire S, et al. A detailed genetic map of the chromosome 7 bronchial hyper-responsiveness locus. Eur J Hum Genet 2002;10:177-82.
• Lind DL, Choudhry S, Ung N, et al. ADAM33 is Not Associated with Asthma in Puerto Rican or Mexican Populations. Am J Respir Crit Care Med 2003.
• Lonjou C, Barnes K, Chen H, et al. A first trial of retrospective collaboration for positional cloning in complex inheritance: Assay of the cytokine region on chromosome 5 by the Consortium on Asthma Genetics (COAG). PNAS 2000;97:10941-47.
• McGinnis R, Child F, Clayton S, et al. Further support for the association of CCR5 allelic variants with asthma susceptibility. Eur J Immunogenet 2002;29:525-8.
• Ober C, Leavitt SA, Tsalenko A, et al. Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations. Am J Hum Genet 2000;66:517-26.
• Palmer LJ, Barners KC, Burton PR, et al. Meta-analysis for linkage to asthma and atopy in the chromosome 5q31-33 candidate region. Hum Molec Genet 2001;10:891-99.
• Sayers I, Barton S, Rorke S, et al. Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population. Clin Exp Allergy 2003;33:1103-10.
• Shao C, Suzuki Y, Kamada F, et al. Linkage and association of childhood asthma with the chromosome 12 genes. J Hum Genet 2004;49:115-22.
• Shin HD, Park BL, Kim LH, et al. Association of tumor necrosis factor polymorphisms with asthma and serum total IgE. Hum Mol Genet 2004;13:397-403.
• Silverman ES, Palmer LJ, Subramaniam V, et al. Transforming growth factor-beta promoter polymorphism C-509T is associated with asthma. Am J Respir Crit Care Med 2004;169:214-9.
• Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 2002;418:426-30.
• Werner M, Herbon N, Gohlke H, et al. Asthma is associated with single-nucleotide polymorphisms in ADAM33. Clin Exp Allergy 2004;34:26-31.
• Wilkinson J, Grimley S, Collins A, et al. Linkage of asthma to markers on chromosome 12 in a sample of 240 families using quantitative phenotype scores. Genomics 1998;53:251-59.
• Witte JS, Palmer LJ, O’Connor RD, et al. Relation between tumour necrosis factor polymorphism TNFalpha-308 and risk of asthma. Eur J Hum Genet 2002;10:82-5.
• Wjst M, Kruse S, Illig T, Deichmann K. Asthma and IL-4 receptor alpha gene variants. Eur J Immunogenet 2002;29:263-8.
• Zhang Y, Leaves NI, Anderson GG, et al. Positional cloning of a quantitative trait locus on chromosome 13q14 hat influences immunoglobulin E levels and asthma. Nature Genetics 2003;34:181-6.

Gene-environment interactions

• Brown A, Farmer K, MacDonald L, et al. House dust mite der p 1 downregulates defenses of the lung by inactivating elastase inhibitors. Am J Respir Cell Mol Biol 2003;29:381-9.
• Colilla S, Nicolae D, Pluzhnikov A, et al. Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure. J Allergy Clin Immunol 2003;111:840-6.
• David GL, Romieu I, Sienra-Monge JJ, et al. NAD(P)H: Quinone Oxidoreductase and glutathione s-transferase M1 polymorphisms and childhood asthma. Am J Respir Crit Care Med 2003;168:1199-1204.
• Eder W, Klimecki W, Yu L, et al. Toll-like receptor 2 as a major gene for asthma in children of European farmers. J Allergy Clin Immunol 2004;113:482-8.
• Gilliland FD, Li YF, Saxon A, et al. Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomized, placebo-controlled crossover study. Lancet 2004;363:119-25.
• Mapp CE, Fryer AA, De Marzo N, et al. Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates. J Allergy Clin Immunol 2002;109:867-72.
• Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, et al. Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City. Thorax 2004;59:8-10.
• Sayers I, Sampson AP, Ye S, et al. Promoter polymorphisms influences he effect of dexamethasone on transcriptional activation of the LTC 4 synthase gene. Eur J Hum Genet 2003;11:619-22.
• Takizawa H, Abe S, Okazaki H, et al. Diesel exhaust particles upregulate eotaxin gene expression in human bronchial epithelial cells via nuclear factor-kB-dependent pathway. Am J Physiol Lung Cell Mol Physiol 2003;284:L1055-62.
• Werner M, Topp R, Wimmer K, et al. TLR4 gene variants modify endotoxin effects on asthma. J Allergy Clin Immunol 2003;112:323-30.
• Wikman H, Piirila P, Rosenberg C, et al. N-Aceyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk. Pharmacogenetics 2002;12:227-33.

 Pharmacogenomics

• Boushey HA. New and exploratory therapies for asthma. Chest 2003;123:439S-45S.
• Dewar JC, Hall IP. Personalised prescribing for asthma – is pharmacogenetics the answer? J Pharm Pharmacol 2003;55:279-89.
• Fenech A, Hall IP. Pharmacogenetics of asthma. Br J Clin Pharmacol 2002;53:3-15.
• Hochhause G, Brookman L, Fox H, et al. Pharmacodynamics of omalizumab: implications for optimised dosing strategies and clinical efficacy in the treatment of allergic asthma. Curr Med Res Opin 2003;19:491-8.
• Palmer LJ, Silverman ES, Weiss ST, et al. Pharmacogenetics of asthma. Am J Respir Crit Care Med 2002;165:861-86.
• Robinson DS. New therapies for asthma: Where next? Pediatric Pulmonology 2003;36:369-75.
• Szefler SJ. Pediatric asthma: an approach to pharmacogenetics analysis. Chest 2003;123:434S-8S.
• Vandebriel RJ. Gene polymorphisms wihin he immune system that may underlie drug allergy. Naunyn Schmiedebergs Arch Pharmacol 2004 Jan;369:125-32.
• Whelan GJ, Blake K, Kissoon N, et al. Effect of montelukast on time-course of exhaled nitric oxide in asthma: influence of LTC4 synthase A(-444)C polymorphism. Pediatr Pulmonol 2003;36:413-20.

Reviews

• Barnes KC. Atopy and asthma genes – where do we stand? Allergy 2000;55:803-17.
• Bleecker ER. Mapping susceptibility genes for asthma and allergy. Clin Exp Allergy 1998;28 Suppl 5:6-12; discussion 26-8.
• Blumenthal JB, Blumenthal MN. Genetics of asthma. Med Clin North Am 2002;86:937-50.
• Borish L. Genetics of allergy and asthma. Ann Allergy Asthma Immunol 1999;82:413-26.
• Bracken MB, Belanger K, Cookson WO, et al. Genetic and perinatal risk factors for asthma onset and severity: A review and theoretical analysis. Epidemiol Rev 2002;24:176-89.
• Castro J, Telleria JJ, Blanco-Quiros A. Susceptibility genes for asthma and allergy: Hits and questions. J Investig Allergol Clin Immunol 2001;11:73-8.
• Cookson W. Genetics and genomics of asthma and allergic diseases. Immunol Rev 2002;190:195-206.
• Cookson W. Asthma Genetics. Chest 2002;121:7S-13S.
• Hakonarson H, Halapi E. Genetic analyses in asthma: current concepts and future directions. Am J Pharmacogenomics 2002;2:155-66.
• Hakonarson H, Wjst M. Current concepts on the genetics of asthma. Curr Opin Pediatr 2001;13:267-77.
• Halapi E, Hakonarson H. Recent development in genomic and proteomic research for asthma. Curr Opin Pulm Med 2004;10:22-30.
• Hall IP. Genetics and pulmonary medicine: asthma. Thorax 1999;54:65-9.
• Hoffjan S, Ober C. Present status on the genetic studies of asthma. Curr Opin Immunol 2002;14:709-17.
• Holgate ST, Davies DE, Murphy G, et al. ADAM 33: just another asthma gene or a breakthrough in understanding the origins of bronchial hyperresponsiveness? Thorax 2003;58:466-9.
• Holloway JW, Beghe B, Holgate ST. The genetic basis of atopic asthma. Clin Exp Allergy 1999;29:1023-32.
• Howard TD, Meyers DA, Bleecker ER. Mapping susceptibility genes for asthma and allergy. J Allergy Clin Immunol 2000;105:S477-81.
• Illig T, Wjst M. Genetics of asthma and related phenotypes. Paediatr Respir Rev 2002; 3:47-51.
• Lemanske RF and WW Busse. Allergic disorders: Chapter 6. Asthma. J Allergy Clin Immunol 2003;111:S502-S19.
• Los H, Koppelman GH, Postma DS. The importance of genetic influences in asthma. Eur Respir J 1999;14:1210-27.
• Palmer LJ, Cookson WO. Genomic approaches to understanding asthma. Genome Res 2000;10:1280-7.
• Patino CM, Marinez FD. Interactions between genes and environment in the development of asthma. Allergy 2001;56:279-86.
• Weiss ST, Raby BA. Asthma genetics 2003. Hum Mol Genet 2004;13:R83-89.

Miscellaneous

• Burke W, Fesinmeyer M, Reed K, et al. Family history as a predictor of asthma risk. Am J Prev Med 2003;24:160-9.
• Immervoll T and Wjst M. Current status of the asthma and allergy database. Nucleic Acids Res 1999;27:213-214.
• Palmer LJ, Lonjou C, Barnes K, et al. A retrospective collaboration on chromosome 5 by the International Consortium on Asthma Genetics (COAG). Clin Exp Allergy 2001;31:152-4.
• Whittaker PA. Genes for asthma: much ado about nothing? Curr Opin Pharmacol 2003;3:212-9.
• Wjst M and Immervoll T. An Internet linkage and mutation database for the complex phenotype asthma. Bioinformatics 1998;14:827-828.