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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
June 19, 2008
Volume 20, No. 25

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.


Gene Variant Frequency

VNTR Polymorphism of the DRD4 Locus in Different Pakistani Ethnic Groups
Mansoor A, et al.
Genet Test 2008 Jun;12(2):299-304

Frequencies of the haemochromatosis gene (HFE) variants C282Y, H63D and S65C in 6,020 ethnic Danish men
Pedersen P, et al.
Ann Hematol 2008 Jun

 

Infectious and Parasitic Diseases

Polymorphisms within human cytomegalovirus chemokine (UL146/UL147) and cytokine receptor genes (UL144) are not predictive of sequelae in congenitally infected children
Heo J, et al.
Virology 2008 Jun

 

Neoplasms

Polymorphisms in DNA Repair Genes, Smoking, and Pancreatic Adenocarcinoma Risk
McWilliams RR, et al.
Cancer Res 2008 Jun

MnSOD Gene Polymorphism Association with Steroid-Dependent Cancer
Bica CG, et al.
Pathol Oncol Res 2008 Jun

Clinical significance of p53 alterations in surgically treated prostate cancers
Schlomm T, et al.
Mod Pathol 2008 Jun

DNA-repair genetic polymorphisms and risk of breast cancer in Cyprus
Loizidou MA, et al.
Breast Cancer Res Treat 2008 Jun

The association between genetic variants in hMLH1 and hMSH2 and the development of sporadic colorectal cancer in the Danish population
Christensen LL, et al.
BMC Med Genet 2008 Jun;9(1):52

Colorectal cancer in HNPCC: cumulative lifetime incidence, survival and tumour distribution. A report of 121 families with proven mutations
Barrow E, et al.
Clin Genet 2008 Jun

Genotyping panel for assessing response to cancer chemotherapy
Dai Z, et al.
BMC Med Genomics 2008 Jun;1(1):24

Presence of dominant negative mutation of TP53 is a risk of early recurrence in oral cancer
Hassan NM, et al.
Cancer Lett 2008 Jun

Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma
Blons H, et al.
BMC Med Genomics 2008 Jun;1(1):25

Functional IL-18 promoter gene polymorphisms in Tunisian nasopharyngeal carcinoma patients
Farhat K, et al.
Cytokine 2008 Jun

Association between Mthfr Gene Polymorphisms and Toxicity of HDMTX Chemotherapy  in Acute Lymphocytic Leukemia.
Liu JX, et al.
Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008 Jun;16(3):488-92

Polymorphisms in predicted microRNA binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker
Brendle A, et al.
Carcinogenesis 2008 Jun

Polymorphisms in VEGF and IL-8 predict tumor recurrence in stage III colon cancer
Lurje G, et al.
Ann Oncol 2008 Jun

Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk
Han J, et al.
Breast Cancer Res Treat 2008 Jun

Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer
Yuan JM, et al.
Carcinogenesis 2008 Jun

A polymorphism of EGFR extracellular domain is associated with progression free-survival in metastatic colorectal cancer patients receiving cetuximab-based  treatment
Goncalves A, et al.
BMC Cancer 2008 Jun;8(1):169

CYP1B1 variants are associated with Prostate Cancer in non-Hispanic and Hispanic  Caucasians
Beuten J, et al.
Carcinogenesis 2008 Jun

Meta-analysis: tumor invasion related genetic polymorphisms and gastric cancer susceptibility
Gao L, et al.
Aliment Pharmacol Ther 2008 Jun

ABCB1 Allele Polymorphism Is Associated with Virological Efficacy in Naive HIV-Infected Patients on HAART Containing Nonboosted PIs But Not Boosted PIs
de la Tribonniere, et al.
HIV Clin Trials 2008 May-2008 Jun;9(3):192-201

CCR5-Delta32 polymorphism and susceptibility to cervical cancer: association with early stage of cervical cancer
Singh H, et al.
Oncol Res 2008;17(2):87-91

Glutathione S-Transferase P1 Ile105Val Polymorphism is Associated with Haematological Toxicity in Elderly Rectal Cancer Patients Receiving Preoperative  Chemoradiotherapy
Agostini M, et al.
Drugs Aging 2008;25(6):531-9

 

Endocrine, Nutritional and Metabolic Diseases

Adiposity Gain During Childhood, ACE I/D Polymorphisms and Metabolic Outcomes
Ponsonby AL, et al.
Obesity (Silver Spring) 2008 Jun

The SCARB1 gene is associated with lipid response to dietary and pharmacological  interventions
Liu Y, et al.
J Hum Genet 2008 Jun

Effect of the Pro12Ala polymorphism of the PPARgamma2 gene on response to pioglitazone treatment in menopausal women
Ramirez-Salazar M, et al.
Menopause 2008 Jun

The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels, and reduces type 2 diabetes risk in a prospective general French population: the D.E.S.I.R. Study
Vaxillaire M, et al.
Diabetes 2008 Jun

Replication of Genetic Effects of FTO Polymorphisms on BMI in a Korean Population
Cha SW, et al.
Obesity (Silver Spring) 2008 Jun

Further Evidence For the Role of ENPP1 in Obesity: Association With Morbid Obesity in Finns
Valli-Jaakola K, et al.
Obesity (Silver Spring) 2008 Jun

Calpain 10 SNP-44 Gene Polymorphism Affects Susceptibility to Type 2 Diabetes Mellitus and Diabetic-Related Conditions
Demirci H, et al.
Genet Test 2008 Jun;12(2):305-9

The effect of WNT5B IVS3C>G on the susceptibility to type 2 diabetes in UK Caucasian subjects
Salpea KD, et al.
Nutr Metab Cardiovasc Dis 2008 Jun

MDM2SNP309 Does Not Associate with Elevated MDM2 Protein Expression or Breast Cancer Risk
Krekac D, et al.
Oncology 2008 Jun;74(1-2):84-7

Cyclin D1 (G870A) polymorphism and risk of cervix cancer: a case control study in north Indian population
Satinder K, et al.
Mol Cell Biochem 2008 Jun

Polymorphisms in the CD36 gene modulate the ability of fish oil supplements to lower fasting plasma triacyl glycerol and raise HDL cholesterol concentrations in healthy middle-aged men
Madden J, et al.
Prostaglandins Leukot Essent Fatty Acids 2008 Jun

Association studies of the APM1 SNP T45G with type 2 diabetes in Han population  of Hubei Province.
Wang Y, et al.
Yi Chuan 2008 Jun;30(6):711-5

Polymorphisms of the FTO Gene Are Associated With Variation in Energy Intake, but not Energy Expenditure
Speakman JR, et al.
Obesity (Silver Spring) 2008 Jun

Variation in Associations between Allelic Variants of the Vitamin D Receptor Gene and Onset of Type 1 Diabetes Mellitus by Ambient Winter Ultraviolet Radiation Levels: A Meta-Regression Analysis
Ponsonby AL, et al.
Am J Epidemiol 2008 Jun

Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the DPT1 trial
Butty V, et al.
Diabetes 2008 Jun

TCF7L2 Polymorphism rs7903146 and Predisposition for Type 2 Diabetes Mellitus in  Obese Children
Roth CL, et al.
Horm Metab Res 2008 Jun

Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
Moore AF, et al.
Diabetes 2008 Jun

 

Mental Disorders

A preliminary study: novelty seeking, frontal executive function, and dopamine receptor (D2) TaqI A gene polymorphism in patients with methamphetamine dependence
Han DH, et al.
Compr Psychiatry 2008 Jul-2008 Aug;49(4):387-92

Naturalistic pharmacogenetic study of treatment resistance to typical neuroleptics in European-Brazilian schizophrenics
Kohlrausch FB, et al.
Pharmacogenet Genomics 2008 Jul;18(7):599-609

Brain derived neurotrophic factor Val66Met polymorphism, the five factor model of personality and hippocampal volume: Implications for depressive illness
Joffe RT, et al.
Hum Brain Mapp 2008 Jun

A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia
Keri S, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jun

No Evidence of an Association between Norepinephrine Transporter Gene Polymorphisms and Attention Deficit Hyperactivity Disorder. A Family-Based and Case-Control Association Study in a Korean Sample
Cho SC, et al.
Neuropsychobiology 2008 Jun;57(3):131-8

Recent adaptive selection at MAOB and ancestral susceptibility to schizophrenia
Carrera N, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jun

5-HTTLPR genotype and anxiety-related personality traits: A meta-analysis and new data
Munafo MR, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jun

Mitochondrial DNA haplogroup analysis in patients with bipolar disorder
Kazuno AA, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jun

Analysis of genetic variations in the RGS9 gene and antipsychotic-induced tardive dyskinesia in schizophrenia
Liou YJ, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jun

Association Between the Stin2 VNTR Polymorphism of the Serotonin Transporter Gene and Treatment Outcome in Alcohol-Dependent Patients
Florez G, et al.
Alcohol Alcohol 2008 Jun

Evidence for association between the 5' flank of the NOS1 gene and schizophrenia  in the Chinese population
Tang W, et al.
Int J Neuropsychopharmacol 2008 Jun:1-9

Reduced amygdala-prefrontal coupling in major depression: association with MAOA genotype and illness severity
Dannlowski U, et al.
Int J Neuropsychopharmacol 2008 Jun:1-12

Genetic association between 5'-upstream single-nucleotide polymorphisms of PDGFRB and schizophrenia in a Korean population
Kim HJ, et al.
Schizophr Res 2008 Jun

 

Diseases of the Nervous System and Sense Organs

The SH2D2A gene and susceptibility to multiple sclerosis
Lorentzen AR, et al.
J Neuroimmunol 2008 Jun

M129V polymorphism in the prion protein gene is not associated with mesial temporal lobe epilepsy in a Han Chinese population
Wang X, et al.
Eur J Neurol 2008 Jun

Differential effects of COMT on gait and executive control in aging
Holtzer R, et al.
Neurobiol Aging 2008 Jun

Haptoglobin HP2-2 genotype, alpha-thalassaemia and acute seizures in children living in a malaria-endemic area
Idro R, et al.
Epilepsy Res 2008 Jun

The clinical role of vascular endothelial growth factor (VEGF) system in the pathogenesis of retinopathy of prematurity
Kwinta P, et al.
Graefes Arch Clin Exp Ophthalmol 2008 Jun

PRNP 1368 polymorphism is not associated with sporadic Creutzfeldt-Jakob disease  in the Korean population
Jeong BH, et al.
Eur J Neurol 2008 Jun

Genotyping for Cx26 and Cx30 Mutations in Cases with Congenital Hearing Loss
Evirgen N, et al.
Genet Test 2008 Jun;12(2):253-6

The relationship between angiotensin-converting enzyme insertion/deletion polymorphism and proliferative retinopathy in type 2 diabetes
Feghhi M, et al.
Diabetes Res Clin Pract 2008 Jun

RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism
Kolsch H, et al.
J Cell Mol Med 2008 Jun

Lack of Association Between the rs2664538 Polymorphism in the MMP-9 Gene and Primary Angle Closure Glaucoma in Singaporean Subjects
Aung T, et al.
J Glaucoma 2008 Jun-2008 Jul;17(4):257-8

TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
Guerreiro RJ, et al.
PLoS ONE 2008;3(6):e2450

 

Diseases of the Circulatory System

Glutathione S-transferase variants and hypertension
Delles C, et al.
J Hypertens 2008 Jul;26(7):1343-52

Effectiveness of statins in the reduction of the risk of myocardial infarction is modified by the GNB3 C825T variant
Peters BJ, et al.
Pharmacogenet Genomics 2008 Jul;18(7):631-6

Angiotensinogen genotype predicts abnormal renal hemodynamics in young hypertensive patients
Patel TV, et al.
J Hypertens 2008 Jul;26(7):1353-9

Genetic polymorphisms in the renin-angiotensin system confer increased risk of stroke independently of blood pressure: a nested case-control study
Mollsten A, et al.
J Hypertens 2008 Jul;26(7):1367-72

Analysis of VNTRs in the Solute Carrier Family 6, Member 18 (SLC6A18) and Lack of Association with Hypertension
Yoon YH, et al.
DNA Cell Biol 2008 Jun

Enantiospecific pharmacokinetics of metoprolol in CYP2D6 ultra-rapid metabolizers and correlation with exercise-induced heart rate
Seeringer A, et al.
Eur J Clin Pharmacol 2008 Jun

Genetic Polymorphisms Impact the Risk of Acute Rejection in Pediatric Heart Transplantation: A Multi-Institutional Study
Girnita DM, et al.
Transplantation 2008 Jun;85(11):1632-9

Interaction of G-protein beta(3) Subunit and Nitric Oxide Synthase Gene Polymorphisms on Carotid Artery Intima-media Thickness in Young Adults: The Bogalusa Heart Study
Bhuiyan AR, et al.
Am J Hypertens 2008 Jun

Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study
Kivimaki M, et al.
Eur Heart J 2008 Jun

Renin-Angiotensin System Polymorphisms and Risk of Hypertension: Influence of Environmental Factors
Forman JP, et al.
J Clin Hypertens (Greenwich) 2008 Jun;10(6):459-66

Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke
Enquobahrie DA, et al.
Am J Cardiol 2008 Jun;101(12):1683-8

Val/Met Polymorphism of the COMT Gene Moderates the Association Between Job Strain and Early Atherosclerosis in Young Men
Hintsanen M, et al.
J Occup Environ Med 2008 Jun;50(6):649-57

A variant of the IGF1 gene is associated with blood pressure but not with left heart dimensions at the age of 2 years. The Generation R Study
van Houten V, et al.
Eur J Endocrinol 2008 Jun

 

Diseases of the Respiratory System

Association of IL-13 polymorphisms with leukotriene receptor antagonist drug responsiveness in Korean children with exercise-induced bronchoconstriction
Kang MJ, et al.
Pharmacogenet Genomics 2008 Jul;18(7):551-8

Polymorphic variation in surfactant protein B is associated with COPD exacerbations
Foreman MG, et al.
Eur Respir J 2008 Jun

Toll-like receptor heterodimer variants protect from childhood asthma
Kormann MS, et al.
J Allergy Clin Immunol 2008 Jun

The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility
Holloway JW, et al.
Allergy 2008 Jun

Genetic polymorphism of surfactant protein A in neonatal respiratory distress syndrome.
Zhai L, et al.
Zhongguo Dang Dai Er Ke Za Zhi 2008 Jun;10(3):295-8

Association of cytokine gene polymorphisms with rate of decline in lung function
Yucesoy B, et al.
J Occup Environ Med 2008 Jun;50(6):642-8

Association of Interleukin (IL)-12 and IL-27 Gene Polymorphisms with Chronic Obstructive Pulmonary Disease in a Chinese Population
Huang N, et al.
DNA Cell Biol 2008 Jun

 

Diseases of the Digestive System

Transforming growth factor beta1 gene variants increase transcription and are associated with liver cirrhosis in Chinese
Wang H, et al.
Cytokine 2008 Jun

 

Diseases of the Genitourinary System

Haplotype analysis of the matrix metalloproteinase-9 gene associated with advanced-stage endometriosis
Han YJ, et al.
Fertil Steril 2008 Jun

Polymorphisms in the human cysteine-rich secretory protein 2 (CRISP2) gene in Australian men
Jamsai D, et al.
Hum Reprod 2008 Jun

COL1A1 Sp1-binding site polymorphism as a risk factor for genital prolapse
Rodrigues AM, et al.
Int Urogynecol J Pelvic Floor Dysfunct 2008 Jun

 

Complications of Pregnancy, Childbirth, and the Puerperium

The Polymorphism of HLA-DR and -DQ Allelic Genes Associated with Intrahepatic Cholestasis of Pregnancy
Ding Y, et al.
Genet Test 2008 Jun;12(2):215-20

 

Diseases of the Musculoskeletal System and Connective Tissue

Association of HLA-DQB1 Allelic Sequence Variation with Susceptibility to Systemic Lupus Erythematosus
Rezaieyazdi Z, et al.
Iran J Allergy Asthma Immunol 2008 Jun;7(2):91-5

Lack of association between Fc receptor-like 3 gene polymorphisms and systemic lupus erythematosus in Chinese population
You Y, et al.
J Dermatol Sci 2008 Jun

 

Congenital Anomalies

Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida
Lu W, et al.
Birth Defects Res A Clin Mol Teratol 2008 Jun

 

 

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Page last reviewed: June 19, 2008 (archived document)
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