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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
November 2, 2006
Volume 17, No. 18

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Infectious and Parasitic Diseases

Association of genetic variations in CCR5 and its ligand, RANTES with clearance of hepatitis B virus in Korea
Ahn SH, et al.
J Med Virol 2006 Oct;78(12):1564-71

           

 

Neoplasms

Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Brazil
Gomes MC, et al.
Breast Cancer Res Treat 2006 Oct

The Novel p21 Polymorphism p21G251A Is Associated with Locally Advanced Breast Cancer
Staalesen V, et al.
Clin Cancer Res 2006 Oct;12(20):6000-4

Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphism
Hedelin M, et al.
Int J Cancer 2006 Oct

Glutathione S-transferase phenotypes in relation to genetic variation and fruit and vegetable consumption in an endoscopy-based population
Tijhuis MJ, et al.
Carcinogenesis 2006 Oct

Genetic polymorphisms of alcohol and aldehyde dehydrogenases and drinking, smoking, and diet in Japanese men with oral and pharyngeal squamous cell carcinoma
Asakage T, et al.
Carcinogenesis 2006 Oct

Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study
Deming SL, et al.
Breast Cancer Res Treat 2006 Oct

Relationship between LAPTM4B gene polymorphism and susceptibility of gastric cancer
Liu Y, et al.
Ann Oncol 2006 Oct

CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish Caucasian population
Sillanpaa P, et al.
Breast Cancer Res Treat 2006 Oct

Variations of the melanocortin-1 receptor and the glutathione-S transferase T1 and M1 genes in cutaneous malignant melanoma
Mossner R, et al.
Arch Dermatol Res 2006 Oct

DNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: a study on a Portuguese population
Costa S, et al.
Breast Cancer Res Treat 2006 Oct

Genetic polymorphism of XRCC3 Thr(241)Met and breast cancer risk: case-control study in Korean women and meta-analysis of 12 studies
Lee SA, et al.
Breast Cancer Res Treat 2006 Oct

The mannose-binding lectin (MBL2) haplotype and breast cancer: an association study in African American and Caucasian women
Bernig T, et al.
Carcinogenesis 2006 Oct

Genetic polymorphisms of microsomal epoxide hydroxylase and glutathione S-transferases M1, T1 and P1, interactions with smoking, and risk for esophageal (Barrett) adenocarcinoma
Casson AG, et al.
Cancer Detect Prev 2006 Oct

Prostate cancer risk from occupational exposure to polycyclic aromatic hydrocarbons interacting with the GSTP1 Ile105Val polymorphism
Rybicki BA, et al.
Cancer Detect Prev 2006 Oct

Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non-Hispanic white women age younger than 55 years
Lu J, et al.
Cancer 2006 Oct;107(9):2245-53

Methylenetetrahydrofolate reductase polymorphisms modify BRCA1-associated breast and ovarian cancer risks
Jakubowska A, et al.
Breast Cancer Res Treat 2006 Oct

Association of MTHFR gene polymorphisms with breast cancer survival
Martin DN, et al.
BMC Cancer 2006 Oct;6(1):257

Association between the MTHFR A1298C polymorphism and increased risk of acute myeloid leukemia in Brazilian children
da Costa Ramos FJ, et al.
Leuk Lymphoma 2006 Oct;47(10):2070-5

Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma
Lan Q, et al.
Carcinogenesis 2006 Oct

Tumor necrosis factor alpha promoter polymorphism and the risk of chronic lymphocytic leukemia and myeloma in the Chinese population
Au WY, et al.
Leuk Lymphoma 2006 Oct;47(10):2189-93

Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients
Piepoli A, et al.
World J Gastroenterol 2006 Oct;12(39):6343-8

Functional plasminogen activator inhibitor-1 gene variants and breast cancer survival
Zhang X, et al.
Clin Cancer Res 2006 Oct;12(20):6037-42

A p53 genetic polymorphism of gastric cancer: Difference between early gastric cancer and advanced gastric cancer
Yi SY & Lee WJ
World J Gastroenterol 2006 Oct;12(40):6536-9

Inducible nitric oxide synthase polymorphism is associated with the increased risk of differentiated gastric cancer in a Japanese population
Goto Y, et al.
World J Gastroenterol 2006 Oct;12(39):6361-5

 

Endocrine, Nutritional and Metabolic Diseases

TCF7L2 Variation Predicts Hyperglycemia Incidence in a French General Population: The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study
Cauchi S, et al.
Diabetes 2006 Nov;55(11):3189-92

Common Variants in the ENPP1 Gene Are Not Reproducibly Associated With Diabetes or Obesity
Lyon HN, et al.
Diabetes 2006 Nov;55(11):3180-4

Combination of multiple genetic risk factors is synergistically associated with carotid atherosclerosis in Japanese subjects with type 2 diabetes
Yamasaki Y, et al.
Diabetes Care 2006 Nov;29(11):2445-51

The HADHSC Gene Encoding Short-Chain L-3-Hydroxyacyl-CoA Dehydrogenase (SCHAD) and Type 2 Diabetes Susceptibility: The DAMAGE Study
van Hove EC, et al.
Diabetes 2006 Nov;55(11):3193-6

Association of Pro12Ala Polymorphism in Peroxisome Proliferator-Activated Receptor {gamma} With Pre-Diabetic Phenotypes: Meta-analysis of 57 studies on nondiabetic individuals
Tonjes A, et al.
Diabetes Care 2006 Nov;29(11):2489-97

The CC genotype of the GNAS T393C polymorphism is associated with obesity and insulin resistance in women with polycystic ovary syndrome
Hahn S, et al.
Eur J Endocrinol 2006 Nov;155(5):763-70

Polymorphism in HSD17B6 is associated with key features of polycystic ovary syndrome
Jones MR, et al.
Fertil Steril 2006 Nov;86(5):1438-46

Nitric oxide synthase gene polymorphisms and nephropathy in Asians with Type 2 diabetes
Liao L, et al.
J Diabetes Complications 2006 Nov-2006 Dec;20(6):371-5

R990G polymorphism of the calcium-sensing receptor and renal calcium excretion in patients with primary hyperparathyroidism
Corbetta S, et al.
Eur J Endocrinol 2006 Nov;155(5):687-92

No Evidence of Association of ENPP1 Variants With Type 2 Diabetes or Obesity in a Study of 8,089 U.K. Caucasians
Weedon MN, et al.
Diabetes 2006 Nov;55(11):3175-9

Lack of Association of the 11{beta}-Hydroxysteroid Dehydrogenase Type 1 Gene 83,557insA and Hexose-6-Phosphate Dehydrogenase Gene R453Q Polymorphisms with Body Composition, Adrenal Androgen Production, Blood Pressure, Glucose Metabolism and Dementia
Smit P, et al.
J Clin Endocrinol Metab 2006 Oct

Genetic association of interleukin-1beta (-511C/T) and interleukin-1 receptor antagonist (86 bp repeat) polymorphisms with Type 2 diabetes mellitus in North Indians
Achyut BR, et al.
Clin Chim Acta 2006 Oct

Total Homocystine, Folate, and Cobalamin, and Their Relation to Genetic Polymorphisms, Lifestyle and Body Mass Index in Healthy Children and Adolescents
Huemer M, et al.
Pediatr Res 2006 Oct

The possible role of 10398A and 16189C mtDNA variants in providing susceptibility toT2DM in two North Indian populations: a replicative study
Bhat A, et al.
Hum Genet 2006 Oct

Polymorphic Variation in the 11{beta}-Hydroxylase Gene Associates With Reduced 11-Hydroxylase Efficiency
Barr M, et al.
Hypertension 2006 Oct

Geographic and racial/ethnic differences in HFE mutation frequencies in the Hemochromatosis and Iron Overload Screening (HEIRS) Study
Acton RT, et al.
Ethn Dis 2006 Autumn;16(4):815-21

 

Mental Disorders

COMT Val108/158Met Gene Variant, Birth Weight, and Conduct Disorder in Children With ADHD
Sengupta SM, et al.
J Am Acad Child Adolesc Psychiatry 2006 Nov;45(11):1363-9

Interaction between TPH1 and GNB3 genotypes and electroconvulsive therapy in major depression
Anttila S, et al.
J Neural Transm 2006 Oct

Association between serotonin 1D gene polymorphisms and attention deficit hyperactivity disorder comorbid or not comorbid disruptive behavior disorder
Li J, et al.
Beijing Da Xue Xue Bao 2006 Oct;38(5):492-5

Dopamine Transporter 3'-UTR VNTR Genotype and ADHD: a Pharmaco-Behavioural Genetic Study with Methylphenidate
Joober R, et al.
Neuropsychopharmacology 2006 Oct

Haplotype association study between DRD1 gene and bipolar type I affective disorder in two samples from Canada and Sardinia
Del Zompo M, et al.
Am J Med Genet B Neuropsychiatr Genet 2006 Oct

Pooling pharmacogenetic studies on the serotonin transporter: A mega-analysis
Serretti A, et al.
Psychiatry Res 2006 Oct

Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problems
Sakai JT, et al.
Drug Alcohol Depend 2006 Oct

Methylenetetrahydrofolate Reductase (MTHFR) Genetic Polymorphisms and Psychiatric Disorders: A HuGE Review
Gilbody S, et al.
Am J Epidemiol 2006 Oct

Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia
Yasuno K, et al.
Am J Med Genet B Neuropsychiatr Genet 2006 Oct

Homozygosity of the interleukin-10 receptor 1 G330R allele is associated with schizophrenia
Schosser A, et al.
Am J Med Genet B Neuropsychiatr Genet 2006 Oct

A Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia
Morita Y, et al.
Biol Psychiatry 2006 Oct

The 5-HTTLPR s/s genotype at the serotonin transporter gene (SLC6A4) increases the risk for depression in a large cohort of primary care attendees: The PREDICT-gene study
Cervilla JA, et al.
Am J Med Genet B Neuropsychiatr Genet 2006 Oct

Association study of COMT gene Val158Met polymorphism with auditory P300 and performance on neurocognitive tests in patients with schizophrenia and their relatives
Golimbet V, et al.
World J Biol Psychiatry 2006;7(4):238-45

           

Diseases of the Nervous System and Sense Organs

The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with migraine without aura
Mazaheri S, et al.
J Neurol 2006 Oct

Alpha-adrenoceptor gene variants and autonomic nervous system function in a young healthy Japanese population
Matsunaga T, et al.
J Hum Genet 2006 Oct

 

Diseases of the Circulatory System

IGF-I gene promoter polymorphism is a predictor of survival after myocardial infarction in patients with type 2 diabetes
Yazdanpanah M, et al.
Eur J Endocrinol 2006 Nov;155(5):751-6

Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans
Bae Y, et al.
J Hum Hypertens 2006 Oct

Association of {alpha}2-Heremans-Schmid Glycoprotein (AHSG) polymorphisms with subclinical atherosclerosis
Lehtinen AB, et al.
J Clin Endocrinol Metab 2006 Oct

 

Diseases of the Respiratory System

Association of haplotypes of beta(2)-adrenoceptor polymorphisms with lung function and airway responsiveness in a pediatric cohort
Zhang G, et al.
Pediatr Pulmonol 2006 Oct;41(12):1233-41

Transforming growth factor-beta1 polymorphisms, airway responsiveness and lung function decline in smokers
Ogawa E, et al.
Respir Med 2006 Oct

 

Diseases of the Digestive System

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Duerr RH, et al.
Science 2006 Oct

Correlation between single nucleotide polymorphisms in a calprotectin subunit gene and risk of periodontitis in a Chinese population
Li Q, et al.
Ann Hum Genet 2006 Oct

Association of IL-10 and TNFalpha genotypes with ANCA appearance in ulcerative colitis
Castro-Santos P, et al.
Clin Immunol 2006 Oct

Impact of lipoprotein lipase gene polymorphisms on ulcerative colitis
Kosaka T, et al.
World J Gastroenterol 2006 Oct;12(39):6325-30

Genetic polymorphisms in glutathione S-transferases T1, M1 and P1 and susceptibility to reflux esophagitis
Liu B, et al.
Dis Esophagus 2006;19(6):477-81

 

Diseases of the Genitourinary System

Analysis of 14 candidate genes for diabetic nephropathy on chromosome 3q in European populations: strongest evidence for association with a variant in the promoter region of the adiponectin gene
Vionnet N, et al.
Diabetes 2006 Nov;55(11):3166-74

[Association between endothelial nitric oxide synthase gene 4a/b polymorphism and IgA nephropathy.]
Hong Q, et al.
Nan Fang Yi Ke Da Xue Xue Bao 2006 Oct;26(10):1421-2

Analysis of the hemochromatosis mutations C282Y and H63D in infertile men
Peterlin B, et al.
Fertil Steril 2006 Oct

Association between the apolipoprotein B signal peptide gene insertion/deletion polymorphism and male infertility
Peterlin B, et al.
Mol Hum Reprod 2006 Oct

 

Diseases of the Skin and Subcutaneous Tissue

Association of HLA haplotype with alopecia areata in Chinese Hans
Xiao FL, et al.
J Eur Acad Dermatol Venereol 2006 Nov;20(10):1207-13

The prevalence of HFE C282Y gene mutation is increased in Spanish patients with porphyria cutanea tarda without hepatitis C virus infection
Toll A, et al.
J Eur Acad Dermatol Venereol 2006 Nov;20(10):1201-6

 

Diseases of the Musculoskeletal System and Connective Tissue

Rheumatoid arthritis and genetic markers in Syrian and French populations: different impact of the shared epitope
Kazkaz L, et al.
Ann Rheum Dis 2006 Oct

Investigation of the MHC2TA gene, associated with rheumatoid arthritis in a Swedish population, in a UK rheumatoid arthritis cohort
Eyre S, et al.
Arthritis Rheum 2006 Oct;54(11):3417-22

Association of the programmed cell death 1 (PDCD1) gene polymorphism with ankylosing spondylitis in the Korean population
Lee SH, et al.
Arthritis Res Ther 2006 Oct;8(6):R163

Association analysis of the PTPN22 gene in childhood-onset systemic lupus erythematosus in Mexican population
Baca V, et al.
Genes Immun 2006 Oct

Monocyte chemotactic protein-1 single nucleotide polymorphisms do not confer susceptibility for the development of adult onset polymyositis/dermatomyositis in UK Caucasians
Chinoy H, et al.
Rheumatology (Oxford) 2006 Oct

 

Symptoms, Signs and Ill-defined Conditions

Insulin Receptor Substrate Gene Polymorphism Is Associated With Obstructive Sleep Apnea Syndrome in Men
Bayazit YA, et al.
Laryngoscope 2006 Oct

 

 

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Page last reviewed: June 8, 2007 (archived document)
Page last updated: November 2, 2007
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