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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
May 18, 2006
Volume 16, No. 20

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Infectious and Parasitic Diseases

Impact of CCR5 Delta32/+ Deletion on Herpes Zoster Among HIV-1-Infected Homosexual Men
Krol A, et al.
Eur J Epidemiol 2006 May

Polymorphism in the Promoter Region of the CD14 Gene and Susceptibility to Brucellosis
Haidari M, et al.
Immunol Invest 2006;35(2):239-45

 

Neoplasms

Gastrointestinal Stromal Tumors With KIT Exon 11 Deletions Are Associated With Poor Prognosis
Andersson J, et al.
Gastroenterology 2006 Jun;130(6):1573-81

Sequence variants in toll-like receptor 10 are associated with nasopharyngeal carcinoma risk
Zhou XX, et al.
Cancer Epidemiol Biomarkers Prev 2006 May;15(5):862-6

A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans
Gu J, et al.
Cancer 2006 May

Simple tandem repeat (TTTA)n polymorphism in CYP19 (aromatase) gene and breast cancer risk in Nigerian women
Okobia MN, et al.
J Carcinog 2006 May;5(1):12

Evaluation of glutathione S-transferase polymorphisms and mutagen sensitivity as risk factors for the development of second primary tumors in patients previously diagnosed with early-stage head and neck cancer
Minard CG, et al.
Cancer 2006 May

Association of interleukin-1Ra gene polymorphism in patients with bladder cancer: case control study from North India
Bid HK, et al.
Urology 2006 May;67(5):1099-104

XPD Common Variants and their Association with Melanoma and Breast Cancer Risk
Debniak T, et al.
Breast Cancer Res Treat 2006 May

CYP17 Genotype Modifies the Association between Lignan Supply and Premenopausal Breast Cancer Risk in Humans
Piller R, et al.
J Nutr 2006 Jun;136(6):1596-603

Caspase 9 Promoter Polymorphisms and Risk of Primary Lung Cancer
Park JY, et al.
Hum Mol Genet 2006 May

Common Genetic Variation at PTEN and Risk of Sporadic Breast and Prostate Cancer
Haiman CA, et al.
Cancer Epidemiol Biomarkers Prev 2006 May;15(5):1021-5

Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study
Vogel U, et al.
Cancer Lett 2006 May

Associations of Classic Kaposi Sarcoma with Common Variants in Genes that Modulate Host Immunity
Brown EE, et al.
Cancer Epidemiol Biomarkers Prev 2006 May;15(5):926-34

The EGF A61G Polymorphism Is Associated with Disease-Free Period and Survival in Malignant Melanoma
Okamoto I, et al.
J Invest Dermatol 2006 May

Role of the nijmegen breakage syndrome 1 gene in familial and sporadic prostate cancer
Hebbring SJ, et al.
Cancer Epidemiol Biomarkers Prev 2006 May;15(5):935-8

Absence of BRAF Gene Mutation in Non-Melanoma Skin Tumors
Libra M, et al.
Cell Cycle 2006 May;5(9)

NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Pro187Ser Polymorphism and the Risk of Lung, Bladder, and Colorectal Cancers: a Meta-analysis
Chao C, et al.
Cancer Epidemiol Biomarkers Prev 2006 May;15(5):979-87

Single-nucleotide polymorphisms in the RB1 gene and association with breast cancer in the British population
Lesueur F, et al.
Br J Cancer 2006 May

Association of the A870G cyclin D1 gene polymorphism with genetic susceptibility to nasopharyngeal carcinoma
Catarino RJ, et al.
Head Neck 2006 May

 

Endocrine, Nutritional and Metabolic Diseases

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
Smyth DJ, et al.
Nat Genet 2006 May

Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome
Broedl UC, et al.
Cardiovasc Diabetol 2006 May;5(1):11

Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes
Pihlajamaki J, et al.
Diabetologia 2006 May

An increased coronary risk is paradoxically associated with common Cholesteryl Ester Transfer Protein Gene Variations that relate to Higher HDL Cholesterol: a Population-based Study
Borggreve SE, et al.
J Clin Endocrinol Metab 2006 May

Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population
Freathy RM, et al.
JOP 2006;7(3):295-302

The relation between size at birth and risk of type 1 diabetes is not influenced by adjustment for the insulin gene (-23HphI) polymorphism or HLA-DQ genotype
Stene LC, et al.
Diabetologia 2006 May

Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance
Nolsoe RL, et al.
Genes Immun 2006 May

Plasma Triglyceride and HDL-Cholesterol Concentrations in Vietnamese Girls Are Affected by Lipoprotein Lipase, but Not Apolipoprotein CIII Polymorphism
Thu NN, et al.
J Nutr 2006 Jun;136(6):1488-92

Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
Berge KE, et al.
Arterioscler Thromb Vasc Biol 2006 May;26(5):1094-100

 

Diseases of the Blood and Blood-Forming Organs Disorders

ABO blood group in Kuwaitis: detailed allele frequency distribution and identification of novel alleles
Yip SP, et al.
Transfusion 2006 May;46(5):773-9

 

Mental Disorders

Association between serotonin transporter gene and borderline personality disorder
Ni X, et al.
J Psychiatr Res 2006 May

Association analysis of the GSK-3beta T-50C gene polymorphism with schizophrenia and bipolar disorder
Szczepankiewicz A, et al.
Neuropsychobiology 2006;53(1):51-6

Dopamine receptor D1 gene -48A/G polymorphism is associated with bipolar illness but not with schizophrenia in a Polish population
Dmitrzak-Weglarz M, et al.
Neuropsychobiology 2006;53(1):46-50

The 5-HT2A -1438 A/G and 5-HTTLPR polymorphisms and personality dimensions in adolescent anorexia nervosa: association study
Rybakowski F, et al.
Neuropsychobiology 2006;53(1):33-9

Autism Spectrum Disorders and Attention-Deficit/Hyperactivity Disorder in Boys with the Fragile X Premutation
Farzin F, et al.
J Dev Behav Pediatr 2006 Apr;27(2 Suppl 2):S137-S144

Diplotype Trend Regression Analysis of the ADH Gene Cluster and the ALDH2 Gene: Multiple Significant Associations with Alcohol Dependence
Luo X, et al.
Am J Hum Genet 2006 Jun;78(6):973-87

The serotonin transporter gene polymorphism is not associated with smoking behavior
Trummer O, et al.
Pharmacogenomics J 2006 May

Dopamine D4 receptor polymorphism modulates cue-elicited heroin craving in Chinese
Shao C, et al.
Psychopharmacology (Berl) 2006 Jun;186(2):185-90

Lack of association between the corticotrophin-releasing hormone receptor 2 gene and panic disorder
Tharmalingam S, et al.
Psychiatr Genet 2006 Jun;16(3):93-7

C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: a meta-analysis of genetic association studies
Zintzaras E
Psychiatr Genet 2006 Jun;16(3):105-15

Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups
Minzenberg MJ, et al.
Psychiatr Genet 2006 Jun;16(3):117-24

Influence of the serotonin transporter gene on comorbid disorders among alcohol-dependent individuals
Marques FZ, et al.
Psychiatr Genet 2006 Jun;16(3):125-31

A 40-basepair VNTR polymorphism in the dopamine transporter (DAT1) gene and the rapid response to antidepressant treatment
Kirchheiner J, et al.
Pharmacogenomics J 2006 May

MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese
He G, et al.
Mol Psychiatry 2006 May

Alcohol Dehydrogenase 2 His47Arg Polymorphism Influences Drinking Habit Independently of Aldehyde Dehydrogenase 2 Glu487Lys Polymorphism: Analysis of 2,299 Japanese Subjects
Matsuo K, et al.
Cancer Epidemiol Biomarkers Prev 2006 May;15(5):1009-13

Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia
Li D, et al.
Hum Mol Genet 2006 May

No association of attention-deficit/hyperactivity disorder with genes of the serotonergic pathway in Han Chinese subjects
Li J, et al.
Neurosci Lett 2006 May

 

Diseases of the Nervous System and Sense Organs

Genetic analysis of SCA2, 3 and 17 in idiopathic Parkinson's disease
Lim SW, et al.
Neurosci Lett 2006 May

Association of Estrogen Receptor alpha (ESR1) PvuII and XbaI Polymorphisms with Sporadic Alzheimer's Disease and Their Effect on Apolipoprotein E Concentrations
Corbo RM, et al.
Dement Geriatr Cogn Disord 2006 May;22(1):67-72

Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimer's disease in Colombia
Forero DA, et al.
Neurosci Res 2006 May

Apolipoprotein E epsilon4 Allele Is Unrelated to Cognitive or Functional Decline in Alzheimer's Disease: Retrospective and Prospective Analysis
Kleiman T, et al.
Dement Geriatr Cogn Disord 2006 May;22(1):73-82

Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease
Theuns J, et al.
Am J Hum Genet 2006 Jun;78(6):936-46

Metabolic and genetic risk factors for migraine in children
Bottini F, et al.
Cephalalgia 2006 Jun;26(6):731-7

Primary role of CYP1B1 in Indian juvenile-onset POAG patients
Acharya M, et al.
Mol Vis 2006;12:399-404

C(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy
Olmos P, et al.
Diabetes Res Clin Pract 2006 May

Effects of ApoE genotype and mild cognitive impairment on implicit learning
Negash S, et al.
Neurobiol Aging 2006 May

Association study of the PIN1 gene with Alzheimer's disease
Lambert JC, et al.
Neurosci Lett 2006 May

 

Diseases of the Circulatory System

Platelet-activating factor-acetylhydrolase A379V (exon 11) gene polymorphism is an independent and functional risk factor for premature myocardial infarction
Liu PY, et al.
J Thromb Haemost 2006 May;4(5):1023-8

Analysis of the effect of multiple genetic variants of cardiovascular disease risk on insulin concentration variability in healthy adults of the STANISLAS cohort The role of FGB -455 G/A polymorphism
Maumus S, et al.
Atherosclerosis 2006 May

Antihypertensive therapy, the alpha-adducin polymorphism, and cardiovascular disease in high-risk hypertensive persons: the Genetics of Hypertension-Associated Treatment Study
Davis BR, et al.
Pharmacogenomics J 2006 May

Angiotensin II Type-1 Receptor A1166C Polymorphism is Associated With Increased Risk of Ischemic Stroke in Hypertensive Smokers
Zoltan S, et al.
J Mol Neurosci 2006;28(3):285-90

Genetic Polymorphisms of Platelet Glycoprotein Ia and the Risk for Premature Myocardial Infarction Effects on the Release of sCD40L During the Acute Phase of Premature Myocardial Infarction
Antoniades C, et al.
J Am Coll Cardiol 2006 May;47(10):1959-66

Gene Variants of VAMP8 and HNRPUL1 Are Associated With Early-Onset Myocardial Infarction
Shiffman D, et al.
Arterioscler Thromb Vasc Biol 2006 May

Risk Alleles of USF1 Gene Predict Cardiovascular Disease of Women in Two Prospective Studies
Komulainen K, et al.
PLoS Genet 2006 May;2(5):e69

Association of alpha1A adrenergic receptor gene variants on chromosome 8p21 with human stage 2 hypertension
Gu D, et al.
J Hypertens 2006 Jun;24(6):1057-64

The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand Factor multimer size
Zwicker JI, et al.
Blood 2006 May

Relationship between methylenetrahydrofolate reductase gene and ischemic stroke
Li CM, et al.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2006 May;18(5):264-7

Association of the beta2-adrenergic receptor gene with essential hypertension in the non-Han Chinese Yi minority human population
Wu H, et al.
J Hypertens 2006 Jun;24(6):1049-56

Functional variants of the angiotensinogen gene determine antihypertensive responses to angiotensin-converting enzyme inhibitors in subjects of African origin
Woodiwiss AJ, et al.
J Hypertens 2006 Jun;24(6):1065-73

Associations between RAS Gene Polymorphisms, Environmental Factors and Hypertension in Mongolian People
Gui-Yan W, et al.
Eur J Epidemiol 2006;21(4):287-92

Research on association between atherosclerotic brain infarction and human leukocyte antigen DR gene
Zhang SY, et al.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2006 May;18(5):300-2

Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism
Kranzhofer R & Ruef J
Platelets 2006 May;17(3):163-9

Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel
Suh JW, et al.
CMAJ 2006 May

 

 

Diseases of the Respiratory System

Lack of association between NOS2 pentanucleotide repeat polymorphism and asthma phenotypes or exhaled nitric oxide concentration
Leung TF, et al.
Pediatr Pulmonol 2006 May

Polymorphism within the Interferon Gamma/Receptor Complex is Associated with Pulmonary Tuberculosis
Cooke GS, et al.
Am J Respir Crit Care Med 2006 May

Polymorphisms of p53 and p21 genes in chronic obstructive pulmonary disease
Lee YL, et al.
J Lab Clin Med 2006 May;147(5):228-33

Variants in the Glutamate-Cysteine-Ligase Gene are Associated with Cystic Fibrosis Lung Disease
McKone EF, et al.
Am J Respir Crit Care Med 2006 May

 

Diseases of the Digestive System

A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis
Witt H, et al.
Nat Genet 2006 May

Combined polymorphisms of tumour necrosis factor alpha and interleukin-10 genes in patients with alcoholic hepatitis
Richardet JP, et al.
Eur J Gastroenterol Hepatol 2006 Jun;18(6):673-9

Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C
Huang H, et al.
Gastroenterology 2006 Jun;130(6):1679-87

 

Diseases of the Genitourinary System

Analysis of a uteroglobin gene polymorphism in childhood Henoch-Schonlein purpura
Eisenstein EM & Choi M
Pediatr Nephrol 2006 Jun;21(6):782-4

Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization
Ferlin A, et al.
Mol Hum Reprod 2006 May

 

Complications of Pregnancy, Childbirth, and the Puerperium

Intrahepatic cholestasis of pregnancy: three novel MDR3 gene mutations
Floreani A, et al.
Aliment Pharmacol Ther 2006 Jun;23(11):1649-53

Impact of genetic variation of tumor necrosis factor-alpha on gestational hypertension
Chen YP, et al.
Chin Med J (Engl) 2006 May;119(9):719-24

 

Diseases of the Skin and Subcutaneous Tissue

Lack of association with TNF-alpha-308 promoter polymorphism in patients with vitiligo
Yazici AC, et al.
Arch Dermatol Res 2006 Jun;298(1):46-9

 

Diseases of the Musculoskeletal System and Connective Tissue

Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population
Ikari K, et al.
Rheumatology (Oxford) 2006 May

Decreased density of serotonin 5-HT2A receptors in rheumatoid arthritis
Kling A, et al.
Ann Rheum Dis 2006 Jun;65(6):816-9

Valine/Leucine247 polymorphism of beta2-glycoprotein I in patients with antiphospholipid syndrome: lack of association with anti-beta2-glycoprotein I antibodies
Swadzba J, et al.
Lupus 2006;15(4):218-22

Variation in the ciliary neurotrophic factor gene and muscle strength in older caucasian women
Arking DE, et al.
J Am Geriatr Soc 2006 May;54(5):823-6

 

Congenital Anomalies

Mutation analysis of the MSX1 gene exons and intron in patients with nonsyndromic cleft lip and palate
Lace B, et al.
Stomatologija 2006;8(1):21-4

 

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Page last reviewed: June 8, 2007 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics