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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
December 14, 2006
Volume 17, No. 23

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Infectious and Parasitic Diseases

Interaction between allelic variation in IL12B and CCR5 affects the development of AIDS: IL12B/CCR5 interaction and HIV/AIDS
Gabutero E, et al.
AIDS 2007 Jan;21(1):65-9

Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection
Schott E, et al.
J Hepatol 2006 Nov

Interleukin-10 and Tumor Necrosis Factor-alpha Single Nucleotide Gene Polymorphism Frequency in Paracoccidioidomycosis
Bozzi A, et al.
Hum Immunol 2006 Nov;67(11):931-9

Polymorphism of the C-reactive protein gene is associated with mortality in bacteraemia
Eklund C, et al.
Scand J Infect Dis 2006;38(11):1069-73

Association of susceptibility to brucellosis and interleukin-4 promoter polymorphism
Rezazadeh M, et al.
Scand J Infect Dis 2006;38(11):1045-9           

 

Neoplasms

Polymorphisms in Genes Related to Oxidative Stress (CAT, MnSOD, MPO, and eNOS) and Acute Toxicities from Radiation Therapy following Lumpectomy for Breast Cancer
Ahn J, et al.
Clin Cancer Res 2006 Dec;12(23):7063-70

Population BRCA1 and BRCA2 Mutation Frequencies and Cancer Penetrances: A Kin-Cohort Study in Ontario, Canada
Risch HA, et al.
J Natl Cancer Inst 2006 Dec;98(23):1694-706

Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers
Osswald E, et al.
Eur J Clin Pharmacol 2006 Dec

Methyl group metabolism gene polymorphisms as modifier of breast cancer risk in Italian BRCA1/2 carriers
Pepe C, et al.
Breast Cancer Res Treat 2006 Dec

Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer
Tan W, et al.
Carcinogenesis 2006 Dec

Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma
Lan Q, et al.
Hum Genet 2006 Dec

Association of Smoking, CpG Island Methylator Phenotype, and V600E BRAF Mutations in Colon Cancer
Samowitz WS, et al.
J Natl Cancer Inst 2006 Dec;98(23):1731-8

Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival
Spinola M, et al.
Lung Cancer 2006 Dec

Haplotypes in matrix metalloproteinase gene cluster on chromosome 11q22 contribute to the risk of lung cancer development and progression
Sun T, et al.
Clin Cancer Res 2006 Dec;12(23):7009-17

Late Toxicity Is Not Increased in BRCA1/BRCA2 Mutation Carriers Undergoing Breast Radiotherapy in the United Kingdom
Shanley S, et al.
Clin Cancer Res 2006 Dec;12(23):7025-32

Acute Chemotherapy-Related Toxicity Is Not Increased in BRCA1 and BRCA2 Mutation Carriers Treated for Breast Cancer in the United Kingdom
Shanley S, et al.
Clin Cancer Res 2006 Dec;12(23):7033-8

Polymorphisms within inflammatory genes and colorectal cancer
Landi S, et al.
J Negat Results Biomed 2006;5:15

Evaluation of the diagnostic value of serum tumor markers, and fecal k-ras and p53 gene mutations for pancreatic cancer
Wu X, et al.
Chin J Dig Dis 2006;7(3):170-4

 

Endocrine, Nutritional and Metabolic Diseases

The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females
Yang F, et al.
Hum Genet 2006 Dec

Association of PTPN22 haplotypes with Graves' disease
Heward J, et al.
J Clin Endocrinol Metab 2006 Dec

beta2-adrenergic receptor and UCP3 variants modulate the relationship between age and type 2 diabetes mellitus
Pinelli M, et al.
BMC Med Genet 2006 Dec;7(1):85

Interaction of KIR Genes and G1M Immunoglobulin Allotypes Confer Susceptibility to Type 2 Diabetes in Puerto Rican Americans
Zuniga J, et al.
Hum Immunol 2006 Nov;67(11):907-14

 

Mental Disorders

Catechol O-methyltransferase Val158Met Genotype and Neural Mechanisms Related to Affective Arousal and Regulation
Drabant EM, et al.
Arch Gen Psychiatry 2006 Dec;63(12):1396-406

The Dopamine D4 Receptor Gene and Moderation of the Association Between Externalizing Behavior and IQ
Deyoung CG, et al.
Arch Gen Psychiatry 2006 Dec;63(12):1410-6

Dopamine transporter (DAT) genotype (VNTR) and phenotype in extrapyramidal symptoms induced by antipsychotics
Lafuente A, et al.
Schizophr Res 2006 Dec

A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder
Kim CH, et al.
Proc Natl Acad Sci U S A 2006 Dec

Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients
Serretti A, et al.
Mol Psychiatry 2006 Dec

Differentiation of obsessive-compulsive-, panic-, obsessive-compulsive personality-, and non-disordered individuals by variation in the promoter region of the serotonin transporter gene
Perez M, et al.
J Anxiety Disord 2006;20(6):794-806

 

Diseases of the Nervous System and Sense Organs

5-HTTLPR Genotype-Specific Phenotype in Children and Adolescents With Autism
Brune CW, et al.
Am J Psychiatry 2006 Dec;163(12):2148-56

Infant C677T MTHFR polymorphism and severe mental retardation
Shaw GM, et al.
Birth Defects Res A Clin Mol Teratol 2006 Dec

Genetic variation in p53 and ATM haplotypes and risk of glioma and meningioma
Malmer BS, et al.
J Neurooncol 2006 Dec

Brief Report: High Frequency of Biochemical Markers for Mitochondrial Dysfunction in Autism: No Association with the Mitochondrial Aspartate/Glutamate Carrier SLC25A12 Gene
Correia C, et al.
J Autism Dev Disord 2006 Dec

R1514Q substitution in Lrrk2 is not a pathogenic Parkinson's disease mutation
Nichols WC, et al.
Mov Disord 2006 Dec

NO ASSOCIATION OF COMPLEMENT FACTOR H GENE POLYMORPHISM AND AGE-RELATED MACULAR DEGENERATION IN THE JAPANESE POPULATION
Uka J, et al.
Retina 2006 Nov-2006 Dec;26(9):985-7

Polymorphism in the IL-1alpha (-889) locus associated with elevated risk of primary open angle glaucoma
Wang CY, et al.
Mol Vis 2006;12:1380-5

 

Diseases of the Circulatory System

HFE Genotype, Particulate Air Pollution, and Heart Rate Variability. A Gene-Environment Interaction
Park SK, et al.
Circulation 2006 Dec

Angiotensinogen M235T and T174M Gene Polymorphisms in Combination Doubles the Risk of Mortality in Heart Failure
Pilbrow AP, et al.
Hypertension 2006 Dec

 

Diseases of the Respiratory System

Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis
Szeszko JS, et al.
Hum Genet 2006 Dec

 

Diseases of the Genitourinary System

NADPH Oxidase p22phox and Catalase Gene Variants Are Associated with Biomarkers of Oxidative Stress and Adverse Outcomes in Acute Renal Failure
Perianayagam MC, et al.
J Am Soc Nephrol 2006 Dec

 

Complications of Pregnancy, Childbirth, and the Puerperium

Role of single nucleotide polymorphisms of cytokine genes in spontaneous preterm delivery
Speer EM, et al.
Hum Immunol 2006 Nov;67(11):915-23

 

Diseases of the Musculoskeletal System and Connective Tissue

Osteoprotegerin Plasma Levels are Strongly Associated with Polymorphisms in Human Homologue of the Mouse Progressive Ankylosis (ANKH) Gene
Vistoropsky Y, et al.
Ann Hum Genet 2006 Nov

 

Congenital Anomalies

Screening for novel PAX3 polymorphisms and risks of spina bifida
Lu W, et al.
Birth Defects Res A Clin Mol Teratol 2006 Dec

 

Symptoms, Signs and Ill-defined Conditions

CCR5 deletion mutation and its association with the risk of developing acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Bogunia-Kubik K, et al.
Haematologica 2006 Dec;91(12):1628-34

 

 

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Page last reviewed: June 8, 2007 (archived document)
Page last updated: November 2, 2007
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