TABLE 1:Characteristics of respondents overall and by familial coronary heart disease risk categories (HealthStyles 2003 Survey of Health-related Attitudes and Behaviors
Among the U.S. Adult Population)^a

CHD, coronary heart disease.
^a Early-onset CHD, disease at or before age 60 years; late-onset CHD, disease after age 60 years.
^b Mean age (standard deviation) for total population, 48.4 years (14.4); for strong familial risk, 52.2 years (13.7), P<.0001; moderate familial risk, 51.0 years (13.6),
P < .0001; and weak familial risk, 45.7 (14.5), P < .0001. P values compared mean values with the mean age (48.4 years) among all respondents.
^c Educational status missing for 272 respondents.
^d Significant (<.05) P values corrected for 81 comparisons of frequencies of characteristics with frequencies among all respondents.

TABLE 2: Associations between familial coronary heart disease risk categories and early-onset coronary heart disease

CHD, coronary heart disease; early-onset CHD, disease at or before age 60 years; late-onset CHD, disease after age 60 years; OR, odds ratio; CI, confidence interval.
^aAdjusted for age, sex, ethnicity, marital status, education, and income.
^bAdjusted for age, sex, ethnicity, marital status, education, income, and personal history of stroke at any age of onset.
^cAdjusted for age, sex, ethnicity, marital status, education, income, and personal history of obesity, hypertension, hypercholesterolemia, and diabetes.
^dAdjusted for age, sex, ethnicity, marital status, education, income, and personal history of stroke, obesity, hypertension, hypercholesterolemia, and diabetes.

TABLE 3: Associations between familial coronary heart disease risk categories and the related conditions of obesity, hypertension, hypercholesterolemia, and diabetes

CHD, coronary heart disease; OR, odds ratio; CI, confidence interval.
^aAdjusted for age, sex, ethnicity, marital status, education, and income.
^bAdjusted for age, sex, ethnicity, marital status, education, income, and personal history of CHD at any age of onset and stroke at any age of onset.

TABLE 4: Early-onset coronary heart disease associated with weak, moderate, and strong familial coronary heart disease risk and increasing number of related conditions including obesity, hypertension, hypercholesterolemia, and diabetes

CHD, coronary heart disease; early-onset CHD, disease at or before age 60 years; OR, odds ratio; CI, confidence interval. Related conditions indicate obesity, hypertension, hypercholesterolemia, and diabetes.
^aAdjusted for age, sex, ethnicity, marital status, education, and income.

TABLE 5: Ability of different coronary heart disease risk assessment models to identify people with early-onset coronary heart disease

CHD, coronary heart disease; early-onset CHD, disease at or before age 60 years; AUC, area under the curve.
Demographics include age, sex, ethnicity, marital status, education, and income. Related conditions include diabetes, hypercholesterolemia, hypertension, and obesity. AUC statistics were calculated for each risk assessment model using multivariate logistic regression with personal history of earlyonset CHD as the outcome of interest. AUC values greater than 70% suggest good discriminatory ability. Model 1 includes familial risk assessment for CHD, demographic factors, and related conditions. Model 2 includes familial risk assessment and related conditions. Model 3 includes demographics and related conditions. Model 4 includes familial risk assessment and demographics. Model 5 includes only related conditions. Model 6 includes only demographic factors. Model 7 includes only familial risk assessment.