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Publications
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Vaccine Management
Vaccine Management:
Recommendations for Storage and Handling of Selected Biologicals
January
2007
Department
of Health and Human Services (DHHS)
Centers
for Disease Control and Prevention (CDC)
PDF version
formatted for print
(151.43 KB/16 pages)
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Click
on the vaccine below to jump to that area: |
- DT,
Td
- DTaP,
DTaP/Hib,
DTaP/HepB/IPV, Tdap
- HBIG
- Hepatitis
A, Hepatitis B,
Hepatitis A/B, Hepatitis B/Hib
- Hib
- IPV
- TIV
(Influenza)
- LAIV
(Influenza)
- MMR. MR, Measles Virus, Mumps Virus, Rubella Virus
|
- MMRV
- MCV4:
Meningococcal Conjugate Vaccine,
Groups A, C, Y, W-135
- MPSV4:
Meningococcal Polysaccharide
Vaccine, Groups A, C, Y, W-135
- PCV,
Pneumococcal Conjugate
(7-Valent)
- PPV,
Pneumococcal Polysaccharide
- Rotavirus
- Varicella
(Chickenpox)
- Zoster
|
Handling and storage details for each vaccine:
- DT—Pediatric: Diphtheria, Tetanus Toxoids
-
Td—Adult: Tetanus, Diphtheria Toxoids
|
Shipping
Requirements
Should be shipped in insulated container.
Maintain temperature at 35° to 46°F
(2° to 8°C). Do not
freeze or expose to freezing temperatures.
Condition upon Arrival*
Should not have been frozen or exposed
to freezing temperatures. Refrigerate
upon arrival.
*
If you have any questions about the
condition of the material at the time
of delivery, you should 1) immediately
place material in recommended storage;
and 2) notify the Quality
Control office at the vaccine manufacturer;
and 3) notify your state health department
immunization program if vaccine was publicly purchased vaccine.
Storage
Requirements
Refrigerate immediately upon arrival.
Store at 35° to 46°F (2°
to 8°C). Do not freeze
or expose to freezing temperatures.
Shelf Life
Check expiration date on vial or container.
Instructions
for Use
Shake vial vigorously before withdrawal
and use.
Shelf
Life after Opening
The vaccine should be administered shortly
after withdrawal from the vial. Unused
portions of multidose vials may be refrigerated
at 35° to 46°F (2° to 8°C)
and used until outdated, if not contaminated.
Special Instructions
Rotate stock so that the earliest dated
material is used first.
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Top
- DTaP—Pediatric:
Diphtheria Toxoid, Tetanus Toxoid,
Acellular Pertussis Vaccine
-
DTaP/Hib—Pediatric:
Diphtheria Toxoid, Tetanus Toxoid,
Acellular Pertussis Vaccine Combined
with Haemophilus influenzae
type b Conjugate Vaccine*
- DTaP/HepB/IPV—Pediatric:
Diphtheria Toxoid, Tetanus Toxoid,
Acellular Pertussis Vaccine, Hepatitis
B Vaccine, Inactivated Polio Vaccine
- Tdap—Adult:
Tetanus Toxoid, Diphtheria Toxoid,
Acellular Pertussis Vaccine
|
Shipping
Requirements
Should be shipped in insulated container.
Maintain temperature at 35° to 46°F
(2° to 8°C). Do not
freeze or expose
to freezing temperatures.
Condition upon Arrival**
Should not have been frozen or exposed
to freezing temperatures. Refrigerate
upon arrival.
Storage
Requirements
Refrigerate immediately upon arrival.
Store at 35° to 46°F (2°
to 8°C). Do not freeze
or expose to freezing temperatures.
Shelf Life
Check expiration date on vial, container,
or manufacturer-filled syringe.
Instructions for Reconstitution*
or Use
Shake well before withdrawal and use.
Do not use if resuspension does not occur
with vigorous shaking.
Shelf
Life after Reconstitution* or Opening
Single-Dose
Vials: The vaccine should be
administered
shortly after withdrawal
from the vial.
Manufacturer-Filled Syringes:
The vaccine should be
administered shortly
after the needle is attached to
the syringe.
Special Instructions
Rotate stock so that the earliest dated
material is used first.
*ActHIB®
(sanofi pasteur) should be used within
24 hours of reconstitution if used alone.
If sanofi pasteur DTaP is used to reconstitute
ActHIB®, the TriHibit® vaccine
must be used within 30 minutes of reconstitution.
Only sanofi pasteur DTaP-Tripedia®
or the diluent shipped with the product
may be used to reconstitute the sanofi
pasteur ActHIB® product. Sanofi pasteur
DAPTACEL® is not licensed for use
in reconstitution of ActHIB®.
**
If you have any questions about the condition
of the material at the time of delivery,
you should 1) immediately place material
in recommended storage; and 2) notify
the Quality Control office
at the vaccine manufacturer; and
3) notify your state health department
immunization program if vaccine was publicly purchased vaccine. |
Top
HBIG:
Hepatitis
B Immune Globulin |
Shipping Requirements
Should be shipped in insulated container.
Maintain temperature at 35° to 46°F
(2° to 8°C). Do not
freeze or expose
to freezing temperatures.
Condition upon Arrival*
Should not have been frozen or exposed
to freezing temperatures. Refrigerate
upon arrival.
*
If you have any questions about the
condition of the material at the time
of delivery, you should 1) immediately
place material in recommended storage;
and 2) notify the Quality
Control office at the vaccine manufacturer;
and 3) notify your state health department
immunization program if vaccine was publicly purchased version.
Storage Requirements
Refrigerate immediately upon arrival.
Store at 35° to 46°F (2°
to 8°C). Do not freeze
or expose to freezing temperatures.
Shelf Life
Check expiration date on vial or container.
Instructions for Reconstitution
or Use
Shake vial vigorously before withdrawal
and use.
Shelf Life after Reconstitution
or Opening
Use until outdated, if not contaminated.
Special Instructions
Rotate stock so that the earliest dated
material is used first. |
Top
Hepatitis
Vaccines: Hepatitis A, Hepatitis B, Hepatitis
A/B, Hepatitis B/Haemophilus influenzae
type b |
Shipping Requirements
Should be shipped in insulated container.
Maintain temperature at 35° to 46°F
(2° to 8°C). Do not
freeze or expose to freezing temperatures.
Condition upon Arrival*
Should not have been frozen or exposed
to freezing temperatures. Refrigerate
upon arrival.
*
If you have any questions about the
condition of the material at the time
of delivery, you should 1) immediately
place material in recommended storage;
and 2) notify the Quality
Control office at the vaccine manufacturer;
and 3) notify your state health department
immunization program if vaccine was publicly purchased version.
Storage Requirements
Refrigerate immediately upon arrival.
Store at 35° to 46°F (2°
to 8°C). Do not freeze
or expose to freezing temperatures.
Shelf Life
Check expiration date on vial, container
or manufacturer-filled syringe.
Instructions for Use
Shake vial vigorously before withdrawal
and use.
Shelf Life after Opening
Single-Dose
Vials: The vaccine should be
administered
shortly after withdrawal
from the vial.
Manufacturer-Filled Syringes:
The vaccine should be
administered shortly
after the needle is attached to
the syringe.
Special Instructions
Rotate stock so that the earliest dated
material is used first.
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Top
Hib:
Haemophilus influenzae type
b Conjugate Vaccine |
Shipping Requirements
Should be shipped in insulated container.
Maintain temperature at 35° to 46°F
(2° to 8°C). Do not
freeze or expose to freezing temperatures.
Condition upon Arrival*
Should not have been frozen or exposed
to freezing temperatures. Refrigerate
upon arrival.
Storage Requirements
Refrigerate immediately upon arrival.
Store at 35° to 46°F (2°
to 8°C). Do not freeze
or expose to freezing temperatures.
Shelf
Life
Check expiration date on vial or container.
Instructions for Reconstitution**
or Use
Shake vial vigorously before withdrawal
and use. Do not use if resuspension does
not occur with vigorous shaking.
Shelf Life after Reconstitution**
or Opening
The vaccine should be administered
shortly after withdrawal from the vial.
Special Instructions
Rotate stock so that the earliest dated
material is used first.
*
If you have any questions about the condition
of the material at the time of delivery,
you should 1) immediately place material
in recommended storage; and 2) notify
the Quality Control office
at the vaccine manufacturer; and
3) notify your state health department
immunization program if vaccine was publicly purchased vaccine.
**
ACTHIB® (sanofi pasteur) should be used
within 24 hours of reconstitution if
used alone. If sanofi pasteur DTaP is
used to reconstitute ACTHIB®, the
TriHibit® vaccine must be used within
30 minutes of reconstitution. Only sanofi pasteur DTaP-Tripedia® or the diluent
shipped with the product may be used
to reconstitute the sanofi pasteur ACTHIB®
product. Sanofi pasteur DAPTACEL®
is not licensed for use in reconstitution
of ActHIB®.
|
Top
IPV:
Inactivated
Polio Vaccine |
Shipping Requirements
Should be shipped in insulated container.
Maintain temperature at 35° to 46°F
(2° to 8°C). Do not
freeze or expose to freezing temperatures.
Condition upon Arrival*
Should not have been frozen or exposed
to freezing temperatures. Refrigerate
upon arrival.
*
If you have any questions about the
condition of the material at the time
of delivery, you should 1) immediately
place material in recommended storage;
and 2) notify the Quality
Control office at the vaccine manufacturer;
and 3) notify your state health department
immunization program if vaccine was publicly purchased vaccine.
Storage Requirements
Refrigerate immediately upon arrival. Store
at 35° to 46°F (2° to 8°C).
Do not freeze or expose
to freezing temperatures.
Shelf Life
Check expiration date on vial or container.
Instructions for Use
Multidose Vials: Shake
vial vigorously before withdrawal and
use. Withdraw 0.5 mL of vaccine into
separate sterile needle and syringe for
each immunization.
Shelf Life After Opening
The vaccine should be administered shortly
after withdrawal from the vial. Doses
remaining in the vial may be until outdated
if not contaminated.
Special Instructions
Rotate stock so that the earliest dated
material is used first. |
Top
TIV:
Trivalent
Inactivated Influenza Vaccine |
Shipping Requirements
Should be shipped in insulated container.
Maintain temperature at 35° to 46°F
(2° to 8°C). Do not
freeze or expose to freezing temperatures.
Condition upon Arrival*
Should not have been frozen or exposed
to freezing temperatures. Refrigerate
upon arrival.
*
If you have any questions about the
condition of the material at the time
of delivery, you should 1) immediately
place material in recommended storage;
and 2) notify the Quality
Control office at the vaccine manufacturer;
and 3) notify your state health department
immunization program if vaccine was publicly purchased vaccine.
Storage Requirements
Refrigerate immediately upon arrival.
Store at 35° to 46°F (2°
to 8°C). Do not freeze
or expose to freezing temperatures.
Shelf Life
Formulated for use during current influenza
season.
Instructions for Use
Shake vial vigorously before withdrawal
and use.
Shelf Life After Opening
Multidose Vials:
The vaccine should be administered
shortly after withdrawal
from the vial.
Manufacturer-Filled
Syringes: Sterile until removal
of
hub cap.
Special Instructions
Rotate stock so that the earliest dated
material is used first. |
Top
LAIV:
Live Attenuated Influenza Vaccine |
Shipping
Requirements
Should be shipped frozen in insulated container
with dry ice at 4°F (-20°C) or
colder. Shipment includes WarmMark™
temperature indicator.
Condition upon Arrival*
Should be frozen
at 4°F (-20°C) or colder; must
NOT have thawed in shipment.
(All windows in WarmMark™ indicator
should be white. If any indicator windows
are red, do not use the product. Call
the manufacturer for further instructions.)
*
If you have any questions about the
condition of the material at the time
of delivery, you should 1) immediately
place material in recommended storage;
and 2) notify the Quality
Control office at the vaccine manufacturer;
and 3) notify your state health department
immunization program if vaccine was publicly purchased online.
Storage Requirements
Upon arrival, immediately store the vaccine
in a freezer with its own exterior door.
Must
be maintained in a continuously frozen
state at 5°F (-15°C) or colder.
No freeze/thaw cycles are permitted
with this vaccine. May be stored
in either a manual defrost freezer or
in a frost-free freezer compartment.
In
order to maintain the temperature of
5°F (-15°C) or colder in the
freezer, it will be necessary in most
refrigerator/freezer models to turn the
temperature dial down to the coldest
setting. This may result in the refrigerator
compartment temperature being lowered
as well. Careful monitoring of the refrigerator
temperatures will be necessary to avoid
freezing killed or inactivated vaccines.
NOTE:
The manufacturer supplied freezer box
is not longer required for storage of
LAIV vaccine in a frost-free freezer.
Shelf Life
Formulated for use during current influenza
season.
Instructions for Use
Thaw sprayer in palm of hand before administering.
Do not roll the vaccine sprayer in your
hand, as this may dislodge the dose divider
clip. May also be thawed in a refrigerator
and stored at 35° to 46°F (2°
to 8°C) for no more than 60 hours
prior to use. Do not refreeze
after thawing.
Shelf Life After Thawing
The vaccine should be administered shortly
after thawing. Vaccine thawed in the
refrigerator and stored at 35° to
46°F (2° to 8°C) that is not
used within 60 hours must be discarded
in an impenetrable sharps container.
Special Instructions
Rotate stock so that the earliest dated
material is used first.
NOTE: All materials used for administering
live virus vaccines should be burned,
boiled, or autoclaved prior to disposal.
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Top
- MMR:
Measles/Mumps/Rubella
Vaccine,
-
MR: Measles/Rubella
Vaccine,
-
Measles Virus Vaccine,
-
Mumps Virus Vaccine,
-
Rubella Virus Vaccine
|
Shipping Requirements
Vaccine: Use insulated
container. Must be shipped with refrigerant.
Maintain at 50°F (10°C) or
less. If shipped with dry ice, diluent
must be shipped separately.
Diluent: May be shipped
with vaccine, but do not place in container
with dry ice.
Condition upon Arrival*
Maintain at 50°F (10°C) or less.
If above this temperature, see instructions
(*) below. Do not use warm
vaccine. Refrigerate upon
arrival.
*
If you have any questions about the
condition of the material at the time
of delivery, you should 1) immediately
place material in recommended storage;
and 2) notify the Quality
Control office at the vaccine manufacturer;
and 3) notify your state health department
immunization program if vaccine was publicly purchased version.
Storage Requirements
Vaccine may be stored separately from diluent.
Store as follows:
Vaccine: Refrigerate immediately upon arrival.
Store at 35° to 46°F (2°
to 8°C). Protect from light at
all times, since such exposure may
inactivate the virus.
Diluent: May be refrigerated
or stored at room temperature (68°
to 77°F [20° to 25°C]).
Do not freeze or expose
to freezing temperatures.
NOTE: Freeze-dried (lyophilized) MMR
vaccine may be maintained at freezer
temperatures.
Shelf Life
Check expiration date on container
or vial.
Instructions for Reconstitution
and Use
Reconstitute just before using. Use only
the diluent supplied to reconstitute
the vaccine. Inject diluent into the
vial of lyophilized vaccine and agitate
to ensure thorough mixing. Withdraw entire
contents into syringe and inject total
volume of vaccine subcutaneously.
Shelf
Life After Reconstitution, Thawing or
Opening
After reconstitution, use immediately
or store in a dark place at 35° to
46°F (2° to 8°C). Discard
if not used within 8 hours.
Special Instructions
Rotate stock so that the earliest dated
material is used first.
NOTE:
All materials used for administering
live virus vaccines should be burned,
boiled, or autoclaved prior to disposal.
|
Top
MMRV: Measles/Mumps/Rubella/Varicella Vaccine
|
Shipping Requirements
Vaccine: Use insulated container. Must be shipped with dry ice only, at 4°F (-20°C) or colder. Should be delivered within 2 days.
Diluent: May be shipped with vaccine, but do not place in container with dry ice.
Condition upon Arrival*
Should be frozen. Vaccine should remain at 4°F (-20°C) or colder until arrival at the healthcare facility. Dry ice should still be present in the shipping container when vaccine is delivered.
* If you have any questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) notify the Quality Control office at the vaccine manufacturer; and 3) notify your state health department immunization program if vaccine was publicly purchased version.
Storage Requirements
Freeze immediately upon arrival. Maintain vaccine in a continuously frozen state at 5°F (-15°C) or colder. No freeze/thaw cycles are allowed with this vaccine. Vaccine should only be stored in freezers or refrigerators/freezers with separate doors and compartments. Acceptable storage may be achieved in standard household freezers purchased in the last 10 years, and standard household refrigerator/freezers with a separate, sealed freezer compartment. Dormitory-style units are not appropriate for the storage of MMRV vaccine. Do not store lyophilized vaccine in the refrigerator. If lyophilized vaccine is inadvertently stored in the refrigerator, it should be discarded.
Protect the vaccine from light at all times since such exposure may inactivate the vaccine viruses.
In order to maintain temperatures of 5°F (-15°C) or colder, it will be necessary in most refrigerator/freezer models to turn the temperature dial down to the coldest setting. This may result in the refrigerator compartment temperature being lowered as well. Careful monitoring of the refrigerator temperature will be necessary to avoid freezing killed or inactivated vaccines.
Diluent: May be refrigerated or stored at room temperature (68° to 77°F [20° to 25° C]). Do not freeze or expose to freezing temperatures.
Shelf Life
Check expiration date on container or vial.
Instructions for Reconstitution and Use
Reconstitute just before using. Use only the diluent supplied to reconstitute the vaccine.
Shelf Life After Reconstitution, Thawing or Opening:
Discard reconstituted vaccine if it is not used within 30 minutes. Do not freeze reconstituted vaccine.
Special Instructions
Rotate stock so that the earliest dated material is used first.
NOTE: All materials used for administering live virus vaccines should be burned, boiled, or autoclaved prior to disposal. |
Top
MCV4:
Meningococcal
Conjugate Vaccine,
Groups A, C, Y, W-135 |
Shipping Requirements
Should be shipped in insulated container.
Maintain temperature at 35° to 46°F
(2° to 8°C). Do not
freeze or expose to freezing temperatures.
Condition upon Arrival*
Should not have been frozen or exposed
to freezing temperatures. Refrigerate upon arrival.
*
If you have any questions about the
condition of the material at the time
of delivery, you should 1) immediately
place material in recommended storage;
and 2) notify the Quality
Control office at the vaccine manufacturer;
and 3) notify your state health department
immunization program if vaccine was publicly purchased vaccine.
Storage Requirements
Refrigerate immediately upon arrival.
Store at 35° to 46°F (2°
to 8°C). Do not freeze
or expose to freezing temperatures. Protect
from light.
Shelf
Life
Check expiration date on vial or container.
Instructions
for Use
Follow manufacturer's directions.
Shelf Life After Opening
The vaccine should be administered shortly
after withdrawal from the vial.
Special Instructions
Rotate stock so that the earliest dated
material is used first. Vaccine should
be injected by the intramuscular route.
Do not inject intradermally, subcutaneously,
or intravenously.
|
Top
MPSV4
Meningococcal Polysaccharide
Vaccine,
Groups A, C, Y, W-135 |
Shipping Requirements
Should be shipped in insulated container.
Maintain temperature at 35° to 46°F
(2° to 8°C). Do not
freeze or expose to freezing temperatures.
Condition upon Arrival*
Should not have been frozen or exposed
to freezing temperatures. Refrigerate upon arrival.
*
If you have any questions about the
condition of the material at the time
of delivery, you should 1) immediately
place material in recommended storage;
and 2) notify the Quality
Control office at the vaccine manufacturer;
and 3) notify your state health department
immunization program.
Storage Requirements
Refrigerate immediately upon arrival.
Store at 35° to 46°F (2°
to 8°C). Do not freeze
or expose to freezing temperatures.
Shelf
Life
Check expiration date on vial or container.
Instructions
for Reconstitution and Use
Reconstitute gently. This is a white
powder that yields a clear, colorless
liquid when reconstituted with 0.6 ml
(single-dose vial) or 6 ml (10-dose vial)
of sterile distilled water.
Shelf Life After Reconstitution
or Opening
Single-Dose
Vials: Use within 30 minutes
of reconstitution.
Multidose
Vials: Unused portions of multidose
vials may
be refrigerated at 35°
to 46°F (2° to 8°C) and used
up
to 35 days after reconstitution.
Special Instructions
Diluent to be used is sterile, distilled
water for injection; diluent for 10-dose
vial also contains 0.01% thimerosal.
Reconstituted vaccine should be injected
subcutaneously. Do not inject intradermally,
intramuscularly, or intravenously.
Rotate
stock so that the earliest dated material
is used first.
|
Top
PCV:
Pneumococcal Conjugate Vaccine
(7-Valent) |
Shipping Requirements
Should be shipped in insulated container.
Maintain temperature at at 35°
to 46°F (2° to 8°C). Do
not freeze or expose to freezing temperatures.
Condition upon Arrival*
Should not have been frozen or exposed
to freezing temperatures. Refrigerate
upon arrival.
*
If you have any questions about the
condition of the material at the time
of delivery, you should 1) immediately
place material in recommended storage;
and 2) notify the Quality
Control office at the vaccine manufacturer;
and 3) notify your state health department
immunization program.
Storage Requirements
Refrigerate immediately upon arrival.
Store at 35° to 46°F (2°
to 8°C). Do not freeze
or expose to freezing temperatures.
Shelf Life
Check expiration date on vial or container.
Instructions for Use
Vaccine should appear as a homogenous
white suspension after vigorous shaking.
The vaccine should be administered intramuscularly
only.
Shelf
Life After Opening
The vaccine should be administered shortly
after withdrawal from the vial.
Special Instructions
This vaccine is a suspension containing
adjuvant and should not be used if the
particles cannot be resuspended after
vigorous shaking.
Rotate
stock so that the earliest dated material
is used first.
|
Top
PPV:
Pneumococcal Polysaccharide
Vaccine (Polyvalent) |
Shipping Requirements
Should be shipped in insulated container.
Maintain temperature at at 35°
to 46°F (2° to 8°C). Do
not freeze or expose to freezing temperatures.
Condition upon Arrival*
Should not have been frozen or exposed
to freezing temperatures. Refrigerate
upon arrival.
*
If you have any questions about the
condition of the material at the time
of delivery, you should 1) immediately
place material in recommended storage;
and 2) notify the Quality
Control office at the vaccine manufacturer;
and 3) notify your state health department
immunization program if vaccine was publicly purchased vaccine.
Storage Requirements
Refrigerate immediately upon arrival.
Store at 35° to 46°F (2°
to 8°C). Do not freeze
or expose to freezing temperatures.
Shelf Life
Check expiration date on vial or container.
Instructions for Use
Follow
manufacturer's directions.
Shelf Life After Opening
Single-Dose
Vials: The vaccine should be
administered
shortly after withdrawal
from the vial.
Multidose
Vials: Unused portions of multidose
vials may
be refrigerated at 35°
to 46°F (2° to 8°C) and used
until
outdated, if not contaminated.
Special Instructions
Do not inject intravenously. Intradermal
administration may cause severe local
reactions and should be avoided.
Rotate
stock so that the earliest dated material
is used first.
|
Top
Rotavirus Vaccine |
Shipping Requirements
Should be shipped in insulated container. Maintain temperature at 35° to 46°F (2° to 8°C). Do not freeze or expose to freezing temperatures.
Conditions upon Arrival*
Should not have been frozen or exposed to freezing temperatures. Refrigerate upon arrival.
* If you have any questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) notify the Quality Control office at the vaccine manufacturer; and 3) notify your state health department immunization program if vaccine was publicly purchased vaccine.
Storage Requirements
Refrigerate immediately upon arrival. Store at 35° to 46°F (2° to 8°C). Do not freeze or expose to freezing temperatures. Protect from light at all times.
Shelf Life
Check expiration date on container or vial.
Instructions for Use
Each does is supplied in a container consisting of a squeezable plastic, latex-free dosing tube with a twist-off cap, allowing for direct oral administration. The dosing tube is contained in a pouch. Remove the dosing tube from the pouch, screw the cap counter-clockwise so that the liquid can be squeezed from the tube during oral administration of the vaccine.
Shelf Life After Opening
Single-Dose Pouches: The vaccine should be administered
shortly after withdrawal from the refrigerator. The dosing tube
should not be returned to the refrigerator once the screw cap
has been removed.
Special Instructions
Rotate stock so that the earliest dated material is used first.
NOTE: All materials used for administering live virus vaccines should be burned, boiled, or autoclaved prior to disposal. |
Top
Varicella
(Chickenpox) Vaccine
|
Shipping
Requirements
Vaccine: Use insulated
container. Must be shipped with dry
ice only, at 4°F (-20°C) or
colder. Should be delivered within
2 days.
Diluent: May be shipped with vaccine, but do
not place in container with dry ice.
Conditions upon Arrival*
Should be frozen. Vaccine should remain
at 4°F (-20°C) or colder until
arrival at the healthcare facility. Dry
ice should still be present in the shipping
container when vaccine is delivered.
*
If you have any questions about the
condition of the material at the time
of delivery, you should 1) immediately
place material in recommended storage;
and 2) notify the Quality
Control office at the vaccine manufacturer;
and 3) notify your state health department
immunization program if vaccine was publicly purchased vaccine.
Storage
Requirements
Vaccine: Freeze immediately
upon arrival. Maintain vaccine in a
continuously frozen state at 5°F
(-15°C) or colder. No
freeze/ thaw cycles are allowed with
this vaccine. Vaccine
should only be stored in freezers or
refrigerator/freezers with separate
doors and compartments. Acceptable
storage may be achieved in standard
household freezers purchased in the
last 10 years, and standard household
refrigerator/freezers with a separate,
sealed freezer compartment. "Dormitory-style"
units are not appropriate for the storage
of varicella vaccine.
In
order to maintain temperatures of 5°F
(-15°C) or colder, it will be necessary
in most refrigerator/freezer models
to turn the temperature dial down to
the coldest setting. This may result
in the refrigerator compartment temperature
being lowered as well. Careful monitoring
of the refrigerator temperature will
be necessary to avoid freezing killed
or inactivated vaccines.
Diluent: May be refrigerated or stored at room
temperature [68°F to 77°F (20°C
to 25°C)]. Do not freeze
or expose to freezing temperatures.
Shelf Life
Check expiration date on container or
vial.
Instructions
for Reconstitution and Use
Reconstitute just before using. Use only
the diluent supplied to reconstitute
the vaccine.
Shelf
Life After Reconstitution, Thawing, or
Opening
Protect from light. Discard if not used
within 30 minutes
of reconstitution.
Special Instructions
If this vaccine is stored at a temperature
warmer than 5°F
(-15°C), it will result in a loss
of potency and a reduced shelf life.
If a power outage or some other situation
occurs that results in the vaccine storage
temperature rising above the recommended
temperature, the healthcare provider
should contact Merck, the vaccine manufacturer,
at 1-800-609-4618 for a reevaluation
of the product's potency before using
the vaccine. Rotate
stock so that the earliest dated material
is used first.
Single-antigen varicella vaccine only may be stores at refrigerator temperature 36°-46°F (2°-8°C), for up to 72 continuous hours prior to reconstitution. Single-antigen varicella vaccine stored at 36°-46° F (2°-8°C) that is not used within 72 hours of removal from 5°F (-15°C) storage should be discarded.
NOTE:
All materials used for administering
live virus vaccines should be burned,
boiled, or autoclaved prior to disposal. |
Top
Zoster (Shingles) Vaccine |
Shipping Requirements
Vaccine: Use insulated container. Must be shipped with dry ice only, at 4°F (-20°C) or colder. Should be delivered within 2 days.
Diluent: May be shipped with vaccine, but do not place in container with dry ice.
Condition upon Arrival*
Should be frozen. Vaccine should remain at 4°F (-20°C) or colder until arrival at the healthcare facility. Dry ice should still be present in the shipping container when vaccine is delivered.
* If you have any questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) notify the Quality Control office at the vaccine manufacturer; and 3) notify your state health department immunization program if vaccine was publicly purchased version.
Storage Requirements
Vaccine: Freeze immediately upon arrival. Maintain vaccine in a continuously frozen state at 5°F (-15°C) or colder. No freeze/thaw cycles are allowed with this vaccine. Vaccine should only be stored in freezers or refrigerators/freezers with separate doors and compartments. Acceptable storage may be achieved in standard household freezers purchased in the last 10 years, and standard household refrigerator/freezers with a separate, sealed freezer compartment. Dormitory-style units are not appropriate for the storage of Zoster vaccine. Do Not Store lyopilized vaccine in the refrigerator. Protect the vaccine from light at all times since such exposure may inactivate the vaccine viruses.
In order to maintain temperatures of 5°F (-15°C) or colder, it will be necessary in most refrigerator/freezer models to turn the temperature dial down to the coldest setting. This may result in the refrigerator compartment temperature being lowered as well. Careful monitoring of the refrigerator temperature will be necessary to avoid freezing killed or inactivated vaccines.
Diluent: May be refrigerated or stored at room temperature (68° to 77°F [20° to 25° C]). Do not freeze or expose to freezing temperatures.
Shelf Life
Check expiration date on container or vial.
Instructions for Reconstitution and Use
Reconstitute just before using. Use only the diluent supplied to reconstitute the vaccine.
Shelf Life After Reconstitution, Thawing or Opening
Discard reconstituted vaccine if it is not used within 30 minutes.
Do not freeze reconstituted vaccine.
Special Instructions
If this vaccine is stored at a temperature warmer than 5°F (15°C), it will result in a loss of potency and a reduced shelf life. If a power outage or some other situation occurs that results in the vaccine storage temperature rising above the recommended temperature, the healthcare provider should contact Merck, the vaccine manufacturer, at 1-800-MERCK-90 for a reevaluation of the product potency before using the vaccine. Rotate stock so that the earliest dated material is used first.
NOTE: All materials used for administering live virus vaccines should be burned, boiled, or autoclaved prior to disposal. |
Manufacturer
Quality Control Office Telephone
Numbers |
sanofi
pasteur
Website:
www.sanofipasteur.us
Telephone:
800-822-2463
Products: DTap, DTaP-Hib, DT, Td,
TT, Hib, Influenza (TIV), IPV,
MCV4, MPSV4 |
Talecris Biotherapeutics
Website: www.talecrisusa.com
Telephone: 800-520-2807
Products: HBIG, IGIM, RIG, TIG
|
Centers
for Disease Control and Prevention
Drug Service
Website: www.cdc.gov/ncidod/srp/drugs/drug-service.html
Telephone: 404-639-3670
Distributor for Diphtheria antitoxin
|
Novartis
Website: www.novartis-vaccines.com/products/index.shtml
Telephone: 800-244-7668
Products:
Influenza (TIV) |
GlaxoSmithKline
Website: www.gsk.com/products/vaccines.jsp
Telephone: 866-475-8222
or 888-825-5249 (customer support)
Products: DTaP, DTaP-HepB-IPV, Tdap, HepA,
HepB, HepA-HepB,
Influenza (TIV) |
Massachusetts
Biological Labs
Telephone: 617-983-6400
Products: Td,
TT, IGIM
|
MedImmune,
Inc.
Website: www.medimmune.com
Telephone: 877-358-6478 (LAIV
customer support)
877-633-4411 (general customer support)
Products: Influenza (LAIV)
|
Merck
Website: www.merckvaccines.com
Telephone: 800-609-4618
or 800-672-6372
(customer support)
Products: Hib,
Hib-HepB, PPV23, HepA, HepB, HPV,
Measles,
Mumps, Rubella, MMR, MMRV, PPV23, Rotavirus,
Varicella, Zoster |
Nabi
Biopharmaceuticals
Website: www.nabi.com
Telephone: 800-635-1766
Product: HBIG
|
Wyeth
Website: www.wyeth.com
Telephone: 800-999-9384
(storage)
800-934-5556
or 800-666-7248 (customer support)
Products: Hib, PCV7 |
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This
page last modified on January 18, 2007
Content on this page last reviewed on January 18, 2007 |
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