| 1948 | Start of the Framingham Heart Study |
| 1956 | Findings on progression of rheumatic heart disease |
| 1959 | Factors found that increase the likelihood of heart disease |
| | Some heart attacks discovered to be "silent" (causing no pain) |
| 1960 | Cigarette smoking found to increase the risk of heart disease |
| 1961 | Cholesterol level, blood pressure, and electrocardiogram abnormalities found to
increase the risk of heart disease |
| 1965 | First Framingham Heart Study report on stroke |
| 1967 | Physical activity found to reduce the risk of heart disease and obesity to
increase the risk of heart disease |
| 1970 | High blood pressure found to increase the risk of stroke |
| 1971 | Framingham Offspring Study begins |
| | Progression of congestive heart failure described |
| 1974 | Overview of diabetes and its complications |
| 1976 | Menopause found to increase the risk of heart disease |
| 1977 | Effects of triglycerides and LDL and HDL cholesterol described |
| 1978 | Psychosocial factors found to affect heart disease |
| | Atrial fibrillation (condition in which the heart beats irregularly) found to increase
the risk of stroke |
| 1981 | Filter cigarettes found to give no protection against coronary heart disease |
| | Major report issued on relationship of diet and heart disease |
| 1983 | Reports on mitral valve prolapse (which causes a backward leak of blood
between heart chambers) |
| 1986 | First report on dementia |
| 1987 | High blood cholesterol levels found to correlate directly with risk of death in
young men |
| | Fibrinogen (allows blood to clot more easily) found to increase the risk of heart
disease |
| | Estrogen replacement therapy found to reduce risk of hip fractures in
post-menopausal women |
| 1988 | High levels of HDL cholesterol found to reduce risk of death |
| | Type "A" behavior associated with heart disease |
| | Isolated systolic hypertension found to increase risk of heart disease |
| | Cigarette smoking found to increase risk of stroke |
| 1990 | Homocysteine (an amino acid) found as possible risk factor for heart disease |
| 1991 | Heart disease risk prediction models produced |
| 1993 | Mild isolated systolic hypertension shown to increase risk of heart disease |
| | Major report predicts survival after diagnosis of heart failure |
| 1994 | Enlarged left ventricle (one of two lower chambers of the heart) shown to
increase the risk of stroke |
| | Lipoprotein (a) found as possible risk factor for heart disease |
| | Risk factors for atrial fibrillation described |
| | Apolipoprotein E found as possible risk factor for heart disease |
| 1995 | First Framingham report on diastolic heart failure |
| | Start of the OMNI Study of Minorities |
| 1996 | Progression from hypertension to heart failure described |
| 1997 | Report on the cumulative effects of smoking and high cholesterol on the risk for
atherosclerosis |
| | Investigation of the impact of an enlarged left ventricle and risk for heart failure
in asymptomatic individuals |
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