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Critical Care: Applying Genomics to Inflammation Outcomes Charles W. Schmidt Abstract
Inflammation is a natural immune response to injury and infection that normally protects but sometimes endangers or kills patients. Scientists are working to identify the genes that regulate inflammation as well as biomarkers from throughout the course of inflammation in order to better understand why some patients recover normally from inflammation and some don’t. The National Institute of General Medical Sciences funds a multidisciplinary “glue grant” program supporting genomic and proteomic studies of inflammation at 22 clinical centers throughout the country ; research results from the program are revealing the complex nature of the body’s inflammatory response. Important challenges still exist in establishing a genomics-suitable research culture in emergency room and intensive care unit settings.
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