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The promise of genome projects has been a complete catalogue of genes
in a wide range of organisms. While genome projects have been
successful in providing reference genome sequences, the problem of
finding genes and their variants in genomic sequence remains an ongoing
challenge.
The sequencing of Expressed Sequence Transcripts (ESTs),
fragments of genes that have been copied from DNA to RNA,
provides the most comprehensive evidence for the existence of genes
and their structure.
The goal of The Gene Index Project is to use
the available EST and gene sequences, along with the reference
genomes wherever available, to provide an inventory of likely
genes and their variants and to annotate these with information
regarding the functional roles played by these genes and their
products.
In addition, we are attempting to use these
catalogues to find links between genes and pathways in different
species and to provide lists of features within completed genomes
that can aid in the understanding of how gene expression is regulated.
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