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Does Moderate Intensity Exercise Help Prevent Smoking Relapse Among Women?
Basic Trial Information Trial Description Summary Further Trial Information Eligibility Criteria Trial Contact Information
Basic Trial Information
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Phase
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Type
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Status
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Age
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Sponsor
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Protocol IDs
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Phase III, Phase II
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Behavioral study
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Closed
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18 to 65
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NCI, Other
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1 R03 CA119747 NCT00420160
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Trial Description
Summary This study compares the effects of a standard smoking cessation treatment, including one-time brief counseling and provision of nicotine patch plus an 8-week moderate intensity exercise program versus the same standard smoking cessation treatment plus equivalent contact control among 60 healthy women. We hypothesize that participants in the smoking cessation plus moderate intensity exercise condition will be more likely to quit smoking than participants in the smoking cessation treament plus contact control condition. Further Study Information This study compares the effects of a standard smoking cessation treatment, including one-time brief counseling and provision of nicotine patch plus an 8-week moderate intensity exercise program versus the same standard smoking cessation treatment plus equivalent contact control among 60 healthy women. A number of techniques will be used to increase compliance with the treatment program, thus more effectively isolating the effects of exercise. These include: (1) a two-week run-in period prior to randomization; (2) use of behavioral contracting prior to participant randomization; and (3) performance of all exercise on-site. Smoking cessation outcomes (continuous abstinence and point prevalence abstinence) will be verified by carbon monoxide and saliva cotinine. Physical activity will be evaluated by attendance at the supervised sessions. We hypothesize that participants in the smoking cessation plus moderate intensity exercise condition will be more likely to quit smoking than participants in the smoking cessation treament plus contact control condition. Eligibility Criteria Inclusion Criteria: - Healthy sedentary smokers (> 4 per day for at least one year)
- Must be able to give informed consent
- Must live in the area for the next 3 months
- Willing to use the nicotine patch to attempt smoking cessation
- Must receive consent to participate from primary care physician
Exclusion Criteria: - Cannot read or write fluently in the English language
- Pregnancy or plans to attempt pregnancy
- 60 minutes or more per week of moderate or vigorous physical activity
- Smokes cigars, pipes, or uses smokeless tobacco at least once per week
- Currently in a quit smoking program
- Currently using NRT of any kind or using any other quit smoking method or treatment
- Never had an adverse reaction to the nicotine patch resulting in discontinuation of use
- Poor willingness or inability to comply with protocol requirements
- An employee of the Centers for Behavioral and Preventive Medicine
- Previous participant in Commit to Quit or Fit to Quit smoking cessation studies
- Another member of the household is or has been enrolled in this study
- Currently taking a medication that might impact heart rate response, including but not limited to:
Acebutolol Atenolol Carvedilol Metoprolol Nadolol Pindolol Propranolol Timolol Medical problems: - Cardiac disease of any kind such as angina, a history of myocardial infarction or valve disease including mitral valve prolapse. Anyone with an interventional procedure such as a stent
- Pain, discomfort (or other anginal equivalent) in the chest, neck, jaw, arms or other areas that may be due to ischemia
- Cerebrovasular disease such as stroke or history of transient ischemic attacks
- Peripheral vascular disease (such as claudication)
- Diabetes (both Type I and II)
- Chronic infectious disease (HIV, hepatitis) (hepatitis A is okay)
- Chronic obstructive pulmonary disease (COPD) (see asthma and bronchitis under questionable)
- Interstitial lung disease
- Orthopnea (difficulty breathing except in the upright position) or paroxysmal nocturnal dyspnea (sudden shortness of breath at night typically triggered by lying down)
- Current diagnosis of Chronic Fatigue Syndrome
- Current diagnosis of Fibromyalgia
- Abnormal exercise stress test
- Hypertension (anyone currently being followed and/or treated for hypertension)
- Cancer treatment (other than skin cancer) within the past 6 months
- Musculoskeletal problems such as osteoarthritis, gout, osteoporosis or back, hip or knee pain that can interfere with physical activity (i.e., walking at a brisk pace - about 3-mph)
- Any other serious medical condition that might make exercise unsafe or unwise
Psychiatric Problems - Hospitalization for a psychiatric disorder in the last 6 months
- Currently suicidal or psychotic, (or suicidal/psychotic in last 6 months)
- Self-report of more than three alcoholic drinks per day on 5 or more days; 5 or more alcoholic drinks on 3 or more days
- Taking these specific medications for psychiatric problems: Mood stabilizer (Lithium, Depakote, Neurontin), Antipsychotics (Haldol, Clozaril, Risperdal)
- Must be on other current psychiatric medications for at least three months
REQUIRES MD CONSENT FOR THE SPECIFIC CONDITION - Lightheadedness, dizziness, vertigo, or fainting
- Last electrocardiogram (EKG) performed was abnormal
- Previous ETT for medical reason with normal results
- Irregular heart beats or palpitations in the past two years
- Heart murmurs in the past two years - the person will need physician's consent and an echocardiogram showing no evidence of significant heart disease
Trial Contact Information
Trial Lead Organizations/Sponsors Miriam Hospital National Cancer Institute
David M Williams, Ph.D. | | Principal Investigator |
Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00420160 Information obtained from ClinicalTrials.gov on July 16, 2008 Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain
the same text. Minor
changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and
contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should
be directed to ClinicalTrials.gov. Back to Top |
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