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A Phase I/II Clinical Trial of Vidaza With Abraxane in the Treatment of Patients With Advanced or Metastatic Solid Tumors and Breast Cancer
Basic Trial Information
Summary The purpose of this clinical trial is to test whether treatment of patients with advanced or metastatic solid tumors or breast cancer with Abraxane plus Vidaza is safe and results in good tumor response. All patients enrolling in this study will receive treatment with Abraxane and Vidaza. Safety will be assessed by adverse events, laboratory results and performance status. Tumor response will be measured by RECIST criteria. Further Study Information The phase I part of the study will enroll patients with advanced or metastatic solid tumors who have failed at least one previous treatment. The purpose of the phase I part is to assess the safety of the investigational treatment and select the recommended phase II dose-regimen. The phase II part of the study will enroll patients with advanced or metastatic HER2-negative breast cancer who have not received treatment for their metastatic disease. The purpose of the phase II part of the study is to assess safety and efficacy of the investigational treatment in breast cancer. The study doctor will determine what phase patients will be enrolled in. Eligibility Criteria Inclusion Criteria: 1. For phase I, any solid tumors, including lymphoma, that progressed or were stable as best response on at least one previous therapy and are evaluable. 2. For phase II, pathologically confirmed breast cancer, measurable disease, no prior treatments for recurrent or metastatic breast cancer. 3. Her-2/neu negative (Phase II) 4. Negative pregnancy test for female subjects 5. Women of childbearing potential should be advised to avoid becoming pregnant and men should be advised to not father a child while receiving treatment with azacitidine or nab-paclitaxel. investigator. 6. Male or female for phase I and female for phase II, >19 years of age and any race. Exclusion Criteria: 1. Major surgery, radiotherapy, chemotherapy or investigational agents within 4 weeks of treatment day 1 2. Known brain or leptomeningeal metastases 3. Prior taxanes (except for adjuvant therapy more than 6 months prior to treatment day 1) (phase II) 4. Active infection requiring antibiotic therapy 5. History of allergy or hypersensitivity to nab-paclitaxel, albumin or a taxane 6. Grade 2 or greater motor or sensory neuropathy 7. Prior cytotoxic chemotherapy for recurrent or metastatic breast cancer (phase II portion) 8. Uncontrolled hypertension, arrhythmia, congestive heart failure or angina. Patients who have had a myocardial infarction or cardiac surgery should be at least 6 months from the event and free of active symptoms. 9. Known or suspected hypersensitivity to azacitidine or mannitol 10. Pregnant or breast feeding 11. Patients with advanced malignant hepatic tumors 12. Malignancy other than breast carcinoma (phase II) 13. Known HIV infection or chronic hepatitis B or C Trial Lead Organizations/Sponsors University of South Alabama Mitchell Cancer Institute Abraxis OncologyCelgene Corporation
Trial Sites
Link to the current ClinicalTrials.gov record. Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain
the same text. Minor
changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and
contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should
be directed to ClinicalTrials.gov. Back to Top |
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