TABLE OF CONTENTS
Descriptive Summary
Biographical Note
Collection Summary
Index Terms
Administrative Information
Restrictions
Series Descriptions
Correspondence, 1955-1987
Lab Notebooks, 1963-1987
Autobiography: Growing Up with Virology, [1986?]
|
Archives and Modern Manuscripts Program, History of Medicine Division
Processed by Heather Lynn Willever
Machine-readable finding aid encoded by John P. Rees
| | |
|
|
| Collection Number: | MS C 491 |
| Creator | Henle, Werner, 1910-1987 |
| Title | Werner and Gertrude Henle
Papers |
| Dates: | 1955-1987 |
| Quantity: | 12.1 linear feet (29 boxes) |
| Abstract: | Werner Henle, the son of a surgeon and
grandson of anatomist-histologist Jacob Henle, was born in Dortmund, Germany. He attended the University of Munich from 1929-1930 and transferred to the University of Heidelberg in 1930 where he finished the course work needed for medical degree in 1934. Gertrude Szpingier was born in Mannheim, Germany and received her medical degree from the University of Heidelberg in 1936. The Henles are the most well known, however, for their research on Epstein-Barr virus. Their discovery of the relationship between Epstein-Barr virus and cancer demonstrated that the presence of certain viruses in the nucleus of a cell could transform a healthy cell into a malignant one. |
Werner and Gertrude Szpingier Henle were a prodigious force in
virology, immunology, and viral oncology during the second half the twentieth
century. Researching together, they explored the various mechanisms involved in
viral infection. A pragmatic research team, the Henles utilized their research
to develop methods of diagnosis and immunization from infectious diseases.
The Henles first received acclaim for their work on infectious
viruses. In 1943, they convincingly demonstrated the effectiveness of an
influenza vaccine. The development of a rapid test for diagnosing mumps and an
evaluation of a vaccine for mumps has also been credited to the Henles. In
cooperation with Dr. Joseph Stokes, Jr., the Henles demonstrated how gamma
globulin could be employed to hinder the development and proliferation of
infectious hepatitis.
In addition to their contributions to disease prevention, the Henles'
research on the mechanism of viral infections led to the discovery of three
disease states: latency, persistency, and viral interference. Their research on
viral interference laid the groundwork for the later discovery of interferon.
The Henles are the most well known, however, for their research on
Epstein-Barr virus. They demonstrated the causal relationship between
Epstein-Barr virus and infectious mononucleosis. Further research on
Epstein-Barr led the Henles to conclude that EBV aided in the development of
two human cancers, Burkitt's lymphoma and nasopharyngeal carcinoma. This
significant relationship between Epstein-Barr virus and cancer demonstrated
that the presence of certain viruses in the nucleus of a cell could transform a
healthy cell into a malignant one. Applying this discovery to current cancer
research, scientists are now studying how non-viral cancers are induced.
The Henles continued their research on Epstein-Barr virus and
disease-induced immunodeficiencies such as acquired immunodeficiency syndrome,
Hodgkins disease, ataxia-telangiectasia, Chediak-Higashi syndrome, and X-linked
lymphoproliferative syndrome until Werner's death in 1987. After his death,
Gertrude concluded their research.
Werner Henle, the son of a surgeon and grandson of
anatomist-histologist Jacob Henle, was born in Dortmund, Germany on August 27,
1910. He attended the University of Munich from 1929-1930 and transferred to
the University of Heidelberg in 1930 where he finished the course work needed
for medical degree in 1934. The Nazi regime posed threats for Werner whose
grandfather, Jacob Henle, was of Jewish descent (although baptized). Werner was
classified as 25% non-Aryan and was not permitted to finish the internship
required for the M.D. degree in any university, state or city hospital. Finding
a hospital to finish the required internship was difficult. Fortunately, Werner
was accepted at the Abteilung fur Pathologie of the Kaiser-Wilhelm-Institut fur
Medizinische Forschung in Heidelberg. After being transferred to a low-profile
department at this institute, Werner completed the needed internship for his
medical degree. It became "increasingly clear" to Werner that he could "not
stay in Germany and pursue a career to my liking." Thus, Werner came to
Philadelphia, Pennsylvania in 1936 after being granted an instructorship at the
University of Pennsylvania.
From 1936-1939, Werner served as an associate instructor in the
microbiology department at the Medical School of the University of
Pennsylvania. In 1937, Gertrude Szpingier, Werner's fiancee whom he had meet
during his years at University of Heidelberg, emigrated to the United States.
Gertrude was born in Mannheim, Germany on April 3, 1912. She received her
medical degree from the University of Heidelberg in 1936. The day after
Gertrude's arrival in America, she and Werner were married. Gertrude then
joined Werner as a faculty member in the microbiology department at the
University of Pennsylvania.
In 1939, Werner was promoted to associate professor in the virology
department, University of Pennsylvania. In 1940, he became a member of the
research team at the Children's Hospital of Philadelphia. One year later,
Gertrude joined Werner as an associate professor of virology at the University
of Pennsylvania and a member of the research staff at the Children's Hospital
of Philadelphia. After more than 45 years service to the University of
Pennsylvania, Werner and Gertrude retired from the University faculty in 1982.
They continued their research at the Children's Hospital of Philadelphia until
a few months prior to Werner's death in July 1987.
Werner and Gertrude were members of many health organizations and
professional societies. They were active participants in the American Academia
of Microbiology, the Tissue Culture Association, and the Society for American
Microbiologists. Werner was also a member of the American Association of
Immunologists, the Society for General Microbiology, the American Public Health
Association, the New York Academia of Science, and the American Society for
Cancer Research. Werner served as a consultant for the United States Surgeon
General, the United States Army, and many different international health
committees and hospital boards. Among their many awards and honors, the Henles
received the Heart of Variety Show Bus Award in 1969; the Bristol-Meyers Award
for Distinguished Achievement in Cancer Research in 1979; the Mead Johnson
Award in 1950; the Billings Bronze Medal for Scientific Exhibit in 1953; the
Smith, Kline, and French Award for Excellence in Research in 1971; the
Robert-Koch-Medaille (one of West Germany's highest honors) in 1971; the Robert
de Villeirs Award of the Leukemia Society of America in 1975; the Founders in
Cancer Immunology Award from the Cancer Research Institute, Inc. in 1975; the
Virus Cancer Program Award from the National Cancer Institute in 1975; the
Scientific Award from the Philadelphia Chapter of the American Cancer Society
in 1977; and the Children's Hospital's Gold Medal Award in 1983.
Werner Henle Chronology
| | |
| Personal | |
| 1910 | Birth of Werner Henle in Dortmund, Germany on August 27 |
| 1936 | Emigrated to United States |
| 1937 | Marriage to Gertrude Szpingier |
| 1942 | Naturalized as an American Citizen |
| 1987 | Death of Werner Henle on July 6 |
| | |
| Education | |
| 1929-30 | University of Munich |
| 1930-34 | University of Heidelberg |
| 1934 | M.D., University of Heidelberg |
| 1935-36 | Internship, University of Heidelberg and Kaiser Wilhelm Institute |
| 1971 | Honorary doctorate, University of Basel, Switzerland |
| | |
| Professional Career | |
| 1936-39 | Instructor, Department of Medical Microbiology, School of Medicine, University of Pennsylvania |
| 1939 | Professor of Virology in Pediatrics, School of Medicine, University of Pennsylvania |
| 1939 | Director, Division of Research Virology, Children's Hospital of Philadelphia |
| 1947-63 | Director, Virus Diagnostic Laboratory, Reference Laboratory of the Department of Health, Commonwealth of Pennsylvania |
| 1947-66 | Professor Virology, Department of Public Health and Preventive Medicine, School of Medicine, University of Pennsylvania |
| 1982 | Professor Emeritus of Virology, School of Medicine, University of Pennsylvania |
| | |
| Consultantships | |
| 1951-87 | Member, World Health Organization Expert, Advisory Panel on Virus Diseases |
| 1952-55 | Consultant to the Surgeon General, U.S. Public Health Service
|
| 1958-72 | Consultant to the Surgeon General, U.S. Armed Forces. Member, Commission on Viral Infections, U.S. Armed Forces |
| 1962-70 | Chairman, Epidemiology, Hepatitis Subgroup, U.S. Armed Forces |
| 1962-66 | Viral and Rickettsial Study Sections and Training Grant Committee |
| 1962-67 | Consultant, Virus Cancer Program, National Cancer Institute |
| 1968-73 | Scientific Advisory Board, Institute for Medical Research, Camden, New Jersey |
| 1969-74 | Medical and Scientific Advisory Board, St. Jude Hospital, Memphis, Tennessee |
| 1971-73 | Medical and Scientific Advisory Board, Leukemia Society of America |
| 1974-76 | Member, National Cancer Advisory Board |
| 1983 | Member, General Motors Awards Assembly |
Return to the Table of Contents
The collection contains correspondence, lab notebooks, and the Henles'
unpublished autobiography (separately cataloged as MS C 460). The bulk of
material is from the 1970's and 1980's. A smaller portion of the collection
dates back to the 1950's and 1960's. The collection's prevalent emphasis is
professional research work and correspondence. Little personal correspondence
is included. The majority of materials are reflective of the research work
Werner and Gertrude Henle conducted at the University of Pennsylvania and the
Children's Hospital of Philadelphia. While Werner and his wife Gertrude
conducted the majority of their research jointly, the correspondence is
predominately Werner's. Gertrude's involvement, however, can be more clearly
discerned in the lab notebooks in which she appeared to record lab results as
frequently as Werner. The collection would be valuable to any scholar
researching the history of virology and its practical application to disease
prevention as well as such topics in scientific research as procuring funding
for research, the necessity for collaboration in scientific studies and the
issue of gender in scientific research.
The collection is organized into 3 series: Correspondence, 1955-1987; Lab Notebooks, 1963-1987; Autobiography: Growing Up with Virology, [1986?].
The Lab Notebooks series contains 8 subseries: Epstein-Barr Virus Associated Malignancies and Immunodeficiencies; Epstein-Barr Asssociated Malignancies and Immunodeficiencies: Burkitt's Lymphoma and CaPNS; Epstein-Barr Associated Malignancies and Immunodeficiences: Nasopharyngeal Carcinoma; Epstein-Barr Virus Serology Studies; Herpes Studies; Infectious Mononucleosis And Chronic Mononucleosis Virus; Miscellaneous Notebooks; Multiple Sclerosis.
Return to the Table of Contents
Restrictions
Restrictions
Collection is not restricted. Contact the Reference
Staff for information regarding access. For online customer service, please visit
custserv@nlm.nih.gov.
Copyright
NLM does possess copyright to the collection. Contact the Reference
Staff for information regarding use. For online customer service, please visit
custserv@nlm.nih.gov.
Return to the Table of Contents
| | |
|
|
| These terms are indexed in the National Library of Medicine's online
catalog LocatorPlus. Researchers wishing to find related materials should
search the catalog using these terms. |
| MeSH Subjects |
| | Acquired Immunodeficiency Syndrome |
| | Allergy and Immunology |
| | Burkitt Lymphoma |
| | Epstein-Barr Virus Infections |
| | Epstein-Barr Virus Nuclear Antigens |
| | Herpesvirus 4, Human |
| | Leukocytes, Mononuclear |
| | Nasopharyngeal Diseases |
| | Virology |
| | Virus Seriology |
| Personal Names |
| | Alspaugh, Margaret |
| | Biggar, Robert J. |
| | Epstein, Alan |
| | Friend, Charlotte, 1921-1987 |
| | Grose, Charles |
| | Henle, Gertrude, 1912- |
| | Ho, John H. C. |
| | Kaplan, Henry S., 1918- |
| | Koldovsky, Paul Birnbaum |
| | Levine, P. H. (Paul H.) |
| | Magrath, Ian |
| | Miller, George |
| | Niederman, James C. |
| | Pearson, Gary R. |
| | Schooley, Robert T. |
| Corporate Names |
| | Children's Hospital of Philadelphia |
| | University of Pennsylvania. School of Medicine |
| Genre Terms |
| | Laboratory Manuals |
Return to the Table of Contents
Henle, Werner. Werner and Gertrude Henle Papers. 1955-1987. Located in: Modern Manuscripts Collection, History of Medicine Division, National Library of Medicine, Bethesda, MD; MS C 491.
Gift of Mrs. Gertrude Henle, 1987-1991. Acc. #476, 687, 712.
The Henle's autobiography Growing up with virology : an annotated bibliography of Werner and Gertrude Henle : typescript, [1986?], was removed and separately cataloged as MS C 460.
Return to the Table of Contents
| | | | | | | | | | | | | |
| |
Correspondence, 1955-1987
|
| The Henles' correspondence dates from 1955 until Werner's death in 1987. The bulk of the correspondence was Werner's and is professional in
nature. A small portion of the correspondence contains personal letters or
greeting cards from family, friends, and colleagues. This series also contains
research reports and conference presentations that were placed in the original
correspondence boxes. |
|
|
|
|
| Box | Folder |
| | General Correspondence |
| | | | |
| 1 | 1 | | A,
1975-1987 |
| 1 | 2 | | Ablashi, Dharam V., 1973-1977 |
| 1 | 3 | | Ackerman, Rudolf, 1973-1977 |
| 1 | 4 | | Albeck, Henrik, 1980-1986 |
| 1 | 5 | | Alspaugh, Margaret A., 1977-1982 |
| 1 | 6 | | American Cancer Society, 1978-1987 |
| 1 | 7 | | American College of Physicians, Conference, March 17, 1972 |
| 1 | 8 | | Andersson, Jan, 1982-1986 |
| 1 | 9 | | Armstrong, Donald, 1978-1983 |
| 1 | 10 | | Ba - Be, 1973-1986 |
| 1 | 11 | | Be - Bo, 1974-1984 |
| 1 | 12 | | Br - By, 1975-1986 |
| 2 | 1 | | Bar, Robert S., 1973-1974 |
| 2 | 2 | | Bayer, Manfred E., 1980 |
| 2 | 3 | | Berkel, A. Izzet, 1976-1987 |
| 2 | 4 | | Berkow, Robert, 1975-1985 |
| 2 | 5 | | Bethge, Heinz, 1980-1982 |
| 2 | 6 | | Bieber, Charles P., 1981-1985 |
| 2 | 7 | | Biggar, Robert J., 1975-1983 |
| | | Birnbaum, Ursula |
| | | | see Koldovsky, Paul and Ursula Birnbaum |
| 2 | 8 | | Bjorkholm, Magnus, 1978-1984 |
| 2 | 9 | | Blazar, Bruce, 1981-1983 |
| 2 | 10 | | Bocker, Jorg F., 1979-1980 |
| 2 | 11 | | |
| | | Bornkamm, G. W., 1977-1986 |
| 2 | 12 | | Bruyn, Henry B., 1979-1981 |
| 2 | 13 | | Buckley, Johathan, 1983-1987 |
| 2 | 14 | | Ca - Ch, 1975-1986 |
| 3 | 1 | | Cl - Co, 1975-1986 |
| 3 | 2 | | Cr - Cu, 1975-1985 |
| 3 | 3 | | Cancer Research Institute, Inc., 1975-1976 |
| 3 | 4 | | Cantell, Kari, 1975-1986 |
| 3 | 5 | | Casper, James, 1978-1986 |
| 3 | 6 | | Cheeseman, Sarah H., 1978-1979 |
| 3 | 7 | | Cheng, Y.C., 1978-1982 |
| 3 | 8 | | Children's Cancer Research Center, Minutes of
Executive Commitee, 1976-1980 |
| 3 | 9 | | Cohen, Seymor S., 1979-1982 |
| 3 | 10 | | Cold Spring Harbor Laboratory, 1979-1983 |
| 3 | 11 | | Cornfeld, David, 1975-1978 |
| 3 | 12 | | Cortner, Jean A., 1975-1980 |
| 3 | 13 | | Da - Di, 1970-1987 |
| 3 | 14 | | Do - Dw, 1975-1987 |
| 3 | 15 | | Depue, Robert H., 1971-1976 |
| 3 | 16 | | de Schryver, Andre, 1973 |
| 3 | 17 | | de The, Guy Blaudin, 1968-1971 |
| 4 | 1 | | de The, Guy Blaudin, 1972-1983 |
| 4 | 2 | | Diehl, Volker, 1975-1984 |
| 4 | 3 | | Diwan, Arwin R., 1973-1977 |
| 4 | 4 | | E, 1969-1985 |
| 4 | 5 | | Engelmann, Fritz K., 1978-1983 |
| 4 | 6 | | Epstein, Alan, 1973-1982 |
| 4 | 7 | | Epstein, M. A. (Tony), 1970-1985 |
| 4 | 8 | | Ernberg, Ingemar, 1976-1986 |
| 4 | 9 | | Escobar, Mario R., 1974-1985 |
| 4 | 10 | | Essex, Myron (Max), 1980-1986 |
| 4 | 11 | | Evans, Alfred S., 1970-1985 |
| 4 | 12 | | Evans, Joe Ann, 1976-1985 |
| 4 | 13 | | Fa - Fl, 1975-1986 |
| 51 | | Fo - Fu, 1975-1987 |
| 5 | 2 | | Falk, Lawrence, 1973-1985 |
| 5 | 3 | | Faulkner, Ruth S., 1976-1984 |
| 5 | 4 | | Federation of American Societies for Experimental
Biology, Conference, Atlantic City, April 12, 1972 |
| 55 | | | Fiala, Milan, 1973-1977 |
| 5 | 6 | | Finter, Norman, 1975-1986 |
| 5 | 7 | | Friedman, Herman, 1980-1986 |
| 5 | 8 | | Friend, Charlotte, 1973-1978 |
| 5 | 9 | | Fudenberg, Hugh H., 1979-1982 |
| 5 | 10 | | Ga - Gl, 1971-1986 |
| 5 | 11 | | Go, 1975-1984 |
| 5 | 12 | | Gr - Gu, 1975-1987 |
| 5 | 13 | | Gallo, Robert C., 1976-1982 |
| 5 | 14 | | Gatti, Richard A., 1976-1978 |
| 5 | 15 | | Geks, F.J., 1975-1985 |
| 5 | 16 | | Ginsburg, Charles M., 1975-1977 |
| 6 | 1 | | Giraldo, G., 1975-1981 |
| 6 | 2 | | Goetz, Otmar, 1975-1982 |
| 6 | 3 | | Glaser, Ronald, 1973-1983 |
| 6 | 4 | | Gotze, Heinz, 1975-1981 |
| 6 | 5 | | Granoff, Allan, 1975-1983 |
| 6 | 6 | | Greene, Mark H., 1976-1983 |
| 6 | 7 | | Grose, Charles, 1973-1986 |
| 6 | 8 | | Gross, Ludwick, 1975-1982 |
| 6 | 9 | | Groupé, Vincent, 1975-1977 |
| 6 | 10 | | Gunvén, Peter, 1979-1982 |
| 6 | 11 | | Guss, Maurice L., 1981-1983 |
| 6 | 12 | | Gutensohn, Nancy, 1975-1981 |
| 6 | 13 | | Guvén, Peter, 1970-1977 |
| 6 | 14 | | Ha, 1973-1985 |
| 6 | 15 | | He, 1974-1986 |
| 6 | 16 | | Hi - Hy, 1970-1987 |
| 7 | 1 | | Halbert, Seymour P., 1981 |
| 7 | 2 | | Hammond, Denman, 1975-1976 |
| 7 | 3 | | Hampar, Berge, 1976-1979 |
| 7 | 4 | | Henderson, Brian E., 1971-1977 |
| 7 | 5 | | Hewetson, John F., 1968-1977 |
| 7 | 6 | | Hinuma, Yorio, 1975-1981 |
| 7 | 7 | | Hirsch, Martin S., 1977-1985 |
| 7 | 8 | | Ho, John H.C., 1969-1974 |
| 7 | 9 | | Ho, John H.C., 1975-1977 |
| 7 | 10 | | Ho, John H.C., 1978-1980 |
| 7 | 11 | | Hochberg, Fred H., 1974-1985 |
| 7 | 12 | | Hollinshead, Ariel C., 1971-1974 |
| 7 | 13 | | Hong, Chang Lee, 1976-1977 |
| 7 | 14 | | Horwitz, Charles A., 1970-1975 |
| 8 | 1 | | Horwitz, Charles A., 1976-1978 |
| 8 | 2 | | Horwitz, Charles A., 1979-1981 |
| 8 | 3 | | Horwitz, Charles A., 1982-1987 |
| 8 | 4 | | Huang, Andrew T., 1975-1980 |
| 8 | 5 | | Huang, Dolly P., 1975-1979 |
| 8 | 6 | | Hummeler, Klaus, 1975-1987 |
| 8 | 7 | | Humphreys, Robert E., 1979-1980 |
| 8 | 8 | | I, 1976-1986 |
| 8 | 9 | | Infectious Mononucleosis Symposium, New York, 1972 |
| 8 | 10 | | J, 1971-1987 |
| 8 | 11 | | Johansson, Bo, 1971-1977 |
| 8 | 12 | | Joncas, Jean H., 1975-1986 |
| 8 | 13 | | Judson, Susan, 1976-1983 |
| 9 | 1 | | Ka - Ki, 1975-1986 |
| 9 | 2 | | Kl - Ky, 1975-1985 |
| 9 | 3 | | Kaplan, Henry S., 1969-1978 |
| 9 | 4 | | Kaplan, Henry S., 1979-1984 |
| 9 | 5 | | Kieff, Elliott, 1976-1985 |
| 9 | 6 | | Killian, Cynthia, 1983-1984 |
| 9 | 7 | | Klein, Gunnar O., 1981-1983 |
| 9 | 8 | | Klemola, Erkki, 1969-1976 |
| 9 | 9 | | Koldovsky, Paul and Ursula Birnbaum, 1966-1985 |
| 10 | 1 | | Kottaridis, S.D., 1979-1984 |
| 10 | 2 | | Kourilsky, Francois M., 1969-1976 |
| 10 | 3 | | Kwan, H.C., 1977-1982 |
| 10 | 4 | | La-Le, 1973-1987 |
| 10 | 5 | | Li-Lu, 1970-1986 |
| 10 | 6 | | Lanier, Anne P., 1976-1979 |
| 10 | 7 | | Lanier, Anne P.,
1980-1987 |
| 10 | 8 | | Lennette, Edwin H., 1975-1986 |
| 10 | 9 | | Lenoir, Gilbert, 1978-1980 |
| 10 | 10 | | Levine, Alexandra M., 1983-1985 |
| 11 | 1 | | Levine, Paul H., 1971-1980 |
| 11 | 2 | | Levy, Jay, 1973-1986 |
| 11 | 3 | | Leyvraz, Serge, 1982-1986 |
| 11 | 4 | | Li, Frederick P.,
1975-1983 |
| 11 | 5 | | Lindahl, Tomas, 1976-1980 |
| 11 | 6 | | Ma - Me, 1975-1986 |
| 11 | 7 | | Mi - My,
1973-1985 |
| 11 | 8 | | Magrath, Ian, 1973-1987 |
| 9 | | Mangold, Francoise, 1975-1982 |
| 11 | 10 | | Maramorosh, Karl, 1975-1977 |
| 11 | 11 | | Marklund, Gunnar, 1985-1986 |
| 11 | 12 | | Mazaheri,
Bahman, 1977-1982 |
| 11 | 13 | | McAllister, Robert M., 1975-1978 |
| 11 | 14 | | McClain,
Kenneth, 1982-1983 |
| 11 | 15 | | McKee, Kelly T., 1978-1981 |
| 12 | 1 | | Menezes, Jose,
1976-1985 |
| 12 | 2 | | Merino, Fernando, 1981-1987 |
| 12 | 3 | | Mietens, Carl, 1975-1986 |
| 12 | 4 | | Milgram, Felix, 1975-1984 |
| 12 | 5 | | Miller, George, 1973-1986 |
| 12 | 6 | | Moloney, John B.,
1976-1978 |
| 12 | 7 | | Morrow, Richard H., 1968-1976 |
| 12 | 8 | | Muller, Ferdinand, 1976-1983 |
| 12 | 9 | | Na - Ny, 1975-1987 |
| 12 | 10 | | Naegele, Robert F., 1978-1982 |
| 12 | 11 | | Nahmias,
Andre J., 1976-1981 |
| 12 | 12 | | Nauts, Helen Coley, 1980-1986 |
| 12 | 13 | | Newcom, Samual,
1982-1983 |
| 12 | 14 | | Niederman, James C., 1970-1983 |
| 12 | 15 | | Nonoyama, Meihan,
1978-1986 |
| 13 | 1 | | O, 1975-1986 |
| 13 | 2 | | Oldstone, Michael B.A., 1976-1981 |
| 13 | 3 | | Olweny,
Charles, 1974-1980 |
| 13 | 4 | | Osato, Toyoro, 1976-1979 |
| 13 | 5 | | Pa - Pu, 1975-1986 |
| 13 | 6 | | Pagano, Joseph S., 1978-1985 |
| 13 | 7 | | Pearson, Gary R., 1975-1980 |
| 13 | 8 | | Pearson,
Gary R., 1981-1987 |
| 13 | 9 | | Pickering, Larry K., 1975-1979 |
| 13 | 10 | | Pike, Malcolm C.,
1968-1971 |
| 13 | 11 | | Piver, M. Steven, 1983-1984 |
| 13 | 12 | | Pollard, Morris, 1975-1981 |
| 13 | 13 | | Pope, John H., 1979-1985 |
| 13 | 14 | | Potter, Howard Phelps, 1976-1979 |
| 14 | 1 | | Powell, Donald W., 1975-1980 |
| 14 | 2 | | Purtilo, David T., 1979-1985 |
| 14 | 3 | | Q,
1977-1981 |
| 14 | 4 | | Ra - Ri, 1975-1986 |
| 14 | 5 | | Ro - Ru, 1975-1986 |
| 14 | 6 | | Rabin, Harvey,
1979-1983 |
| 14 | 7 | | Rapp, Fred, 1975-1979 |
| 14 | 8 | | Rauscher, Frank J., 1969-1979 |
| 14 | 9 | | Rawls, William E., 1975-1976 |
| 14 | 10 | | Ray, Robert Gordon, 1971-1976 |
| 14 | 11 | | Reuman,
Peter, 1976-1985 |
| 14 | 12 | | Rhoads, Jonathan E., 1975-1987 |
| 14 | 13 | | Ricken, Dieter,
1975-1983 |
| 14 | 14 | | Ringborg, Ulrik, 1978-1984 |
| 14 | 15 | | Rocchi, Giovanni, 1975-1981 |
| 14 | 16 | | Rodriguez, Jose E., 1975-1982 |
| 14 | 17 | | Roizman, Bernard, 1979-1986 |
| 14 | 18 | | Rubin, Robert H., 1977-1980 |
| 14 | 19 | | Sa - Se, 1975-1986 |
| 15 | 1 | | Sh - Sm, 1971-1986 |
| 15 | 2 | | Sn - Sw, 1975-1987 |
| 15 | 3 | | Salas, Rosalba, 1982-1986 |
| 15 | 4 | | Schooley, Robert
T., 1981-1986 |
| 15 | 5 | | Sharon, Nehama, 1977-1979 |
| 15 | 6 | | Sheek, Martha R., 1978-1979 |
| 15 | 7 | | Smith, Stephen R., 1977-1984 |
| 15 | 8 | | Sohier, R., 1976-1979 |
| 15 | 9 | | Spiess, H.,
1978-1983 |
| 15 | 10 | | Springer, Georg F., 1975-1977 |
| 15 | 11 | | Springer-Verlag, 1982 |
| 15 | 12 | | Steigman, Alex J., 1976-1978 |
| 15 | 13 | | Straus, Stephen E., 1983-1987 |
| 16 | 1 | | Strominger, Jack L., 1975-1984 |
| 16 | 2 | | Svedmyr, Erik, 1977-1981 |
| 16 | 3 | | Szigeti,
Robert, 1981-1986 |
| 16 | 4 | | Ta - Tw, 1972-1987 |
| 16 | 5 | | ter Muelen, Volker, 1969-1979 |
| 16 | 6 | | Terasaki, Paul I., 1977-1978 |
| 16 | 7 | | Thorley-Lawson, David A., 1980-1985 |
| 16 | 8 | | Ug - Ut, 1975-1982 |
| 16 | 9 | | Va - Vo, 1969-1986 |
| 16 | 10 | | Van Zelst, Theodore W.,
1984-1987 |
| 16 | 11 | | Vogt, Peter K., 1977-1980 |
| 16 | 12 | | Volsky, David J., 1982-1987 |
| 16 | 13 | | Wa - Wh, 1975-1987 |
| 16 | 14 | | Wi - Wu, 1969-1986 |
| 16 | 15 | | Warner, Helen B.,
1979-1983 |
| 16 | 16 | | Weaver, Harry M., 1976-1977 |
| 16 | 17 | | Weller, Thomas H., 1972-1981 |
| 16 | 18 | | Wolf, Hans, 1975-1983 |
| 16 | 19 | | Ya - Yo, 1975-1985 |
| 17 | 1 | | Za - Zv, 1976-1987 |
| 17 | 2 | | Ziegler, John L., 1968-1979 |
| 17 | 3 | | zur Hausen, Harald, 1969-1977 |
| 17 | 4 | | zur
Hausen, Harald, 1978-1986 |
| | Research Subjects, 1955-1978 |
| 18 | 1 | | Acute respiratory illnesses of children: general information and protocol, 1959 |
| 18 | 2 | | Animal research, 1977-1978 |
| 18 | 3 | | Burkitts Lymphoma, 1968-1969 |
| 18 | 4 | | Burkitts Lymphoma, [1973] |
| 18 | 5 | | Burkitts Lymphoma, patient cases, 1968-1974 |
| 18 | 6 | | Burkitts Lymphoma, prospective studies, 1968-1969 |
| 18 | 7 | | Established cell strains, 1955 |
| 18 | 8 | | Frederick Research Center conference, problems and prospects, Feburary 10 - 13, 1975 |
| 18 | 9 | | Frederick Research Center conference, R and D components of the early antigen complex, Feburary 10 -13, 1975 |
| 18 | 10 | | Frederick Research Center conference, viral capsid anitgen, Feburary 10 - 13, 1975 |
| 18 | 11 | | Human subjects/studies, 1975 |
| 18 | 12 | | Indirect immunofluorescence technique, n.d. |
| 18 | 13 | | Lab request forms, serology reports, 1968-1969 |
| 18 | 14 | | Patients included in Epstein Barr Virus research, 1968-1969 |
| 18 | 15 | | Report on stability of antibody levels to Epstein Barr Virus in the West Nile District, Uganda, 1969-1970 |
| 18 | 16 | | Third International Symposium on Oncogensis and Herpesviruses, 1977 |
| 18 | 17 | | Tumor collection proposal, 1959-1961 |
Return to the Table of Contents
| | | | | | | | | | | | | |
| |
Lab Notebooks, 1963-1987
|
| The Henles' lab notebooks span their research work from 1963 to 1987. In these lab notebooks, the Henles recorded the raw data from their
experiments. The queries directing their research and an analysis of their
findings are often included in the notebooks. The notebooks came to the library
in binders with different headings. While the binders have been removed for
preservation reasons, the integrity of the notebooks has been maintained. The
headings that appeared on the binders were diverse - some listing researchers'
names, others subject names, and still others geographical locations of the
studies. |
|
|
|
|
| To create organization in the collection, the notebooks were placed in boxes according to subject matter. Original binder headings have been
preserved on the individual folders containing the notebooks. The box subject
headings are as follows: Epstein-Barr Virus Associated Malignancies and
Immunodeficiencies - General; Epstein-Barr Virus Associated Malignancies and
Immunodeficiencies - Burkitts Lymphoma; Epstein-Barr Virus associated
Malignancies and Immunodeficiencies -Nasopharyngeal Carcinoma; Epstein-Barr
Virus Serology Studies; Herpes Studies; Infectious and Chronic Mononucleosis
Studies; Miscellaneous Notebooks; Multiple Scoliosis Studies. |
|
|
|
|
| Box | Folder |
| | Epstein-Barr Virus Associated Malignancies and Immunodeficiencies |
| 19 | 1 | | AIDS studies, 1985 |
| 19 | 2 | | American lymphocytic leukemia, 1972-1973 |
| 19 | 3 | | American lymphocytic leukemia, Children's Hospital of Philadelphia, 1981 |
| 19 | 4 | | B-cell lymphomas, 1979-1980 |
| 19 | 5 | | Clinical work, 1970-1975 |
| 19 | 6 | | Hamilton Fairley, G., Harlem Hospital, Steveson, Versuica (Hodgkins Disease and Lymphosarcoma), 1966-1970 |
| 19 | 7 | | Henderson, B.E., Newell (Hodgkin's Disease and Nasopharyngeal Cancer), 1971-1979 |
| 19 | 8 | | Immunodeficiencies: Conley, Merino, Osease, Roder, 1980-1985 |
| 19 | 9 | | Johansson, Bo #2 (Hodgkin's Diesease and Lymphoma), 1967-1978 |
| 19 | 10 | | Johansson, Bo #3 (Hodgkin's Disease and Lymphoma), 1978-1981 |
| 20 | 1 | | Johansson, Bo #4 (Hodgkin's Disease and Lymphoma), 1970-1985 |
| 20 | 2 | | Joyner, Claude R. (Iatrogenic Immunodeficiencies), 1968 |
| 20 | 3 | | Kourilsky, Francois M. (Leukemia, Hodgkin'S Disease and Lymphoproliferative Malignancies), 1966-1969 |
| 20 | 4 | | Kourilsky, Francois M., Paris (Acute Leukemia), 1967-1970 |
| 20 | 5 | | Leukemias, 1969-1971 |
| 20 | 6 | | Levine, Alexander U.S.C. (AIDS), 1983 |
| 20 | 7 | | St. Judes Hospital (Lymphoproliferative Malignancies), 1975 |
| 20 | 8 | | Stanford (hodgkin's Disease), 1969 |
| 20 | 9 | | Stanford (Hodgkin's Disease), 1970-1976 |
| 20 | 10 | | Tumors, 1969-1975 |
| | Epstein-Barr Asssociated Malignancies and Immunodeficiencies: Burkitt's Lymphoma and CaPNS |
| 21 | 1 | | Africa, 1968-1969 |
| 21 | 2 | | Africa, 1968-1978 |
| 21 | 3 | | American Burkitt's Lymphoma, 1980-1987 |
| 21 | 4 | | Early anitgen in Burkitt's Lymphoma, Kampala and Nairobi, 1970-1971 |
| 21 | 5 | | Experimental - Theresa (Burkitt's Lumphoma + CaPNS), 1969 |
| 21 | 6 | | Ghana: Depue, National Institutes of Health, 1971-1983 |
| 21 | 7 | | Ghana: Primary Infection in African Infants, 1977 |
| 21 | 8 | | Individual Cases: Burkitt's Lymphoma, 1963-1970 |
| 21 | 9 | | Magrath, National Institutes of Health, 1974-1979 |
| 21 | 10 | | Media/Inhibitors, 1965-1966 |
| 21 | 11 | | Stanford #2, 1975 |
| 22 | 1 | | Sweden #1: Klein and Old, 1965-1968 |
| 22 | 2 | | Sweden #2, 1969 |
| 22 | 3 | | Sweden #3, 1969 |
| 22 | 4 | | Sweden #4, 1970-1971 |
| 22 | 5 | | Sweden #5, 1971 |
| 22 | 6 | | Sweden #6, 1972-1974 |
| 22 | 7 | | Sweden #7, 1975-1978 |
| 22 | 8 | | Sweden #9, 1979-1981 |
| 22 | 9 | | West Nile, G.H., 1969-1974 |
| 22 | 10 | | West Nile and De The, 1969-1975 |
| | Epstein-Barr Associated Malignancies and Immunodeficiences: Nasopharyngeal Carcinoma |
| 23 | 1 | | Alaska #1, 1975-1981 |
| 23 | 2 | | Alaska #2, 1981-1984 |
| 23 | 3 | | Alaska #3, 1984-1985 |
| 23 | 4 | | Alaska #4, 1985-1987 |
| 23 | 5 | | De The and Ho, 1968-1972 |
| 23 | 6 | | "D" and "R" Antibody Studies, 1970-1971 |
| 23 | 7 | | EB2 (Studies of the damage drug concentrations have on EB2 in NPC and other cancers), 1970 |
| 23 | 8 | | Ho, Longitudinal Study, 1973-1976 |
| 23 | 9 | | Ho #2, 1976-1978 |
| 23 | 10 | | Mayo Clinic, 1981 |
| 24 | 1 | | Nasopharyngeal Carcinoma, [19--] |
| 24 | 2 | | Strander Project, 1978-1980 |
| 24 | 3 | | Sweden #8, 1975-1976 |
| 24 | 4 | | Sweden #10 (Greenland Study), 1981-1985 |
| 24 | 5 | | Sweden #11, 1985-1986 |
| 24 | 6 | | U.S. NPC, St. Judes Children's Hospital, 1977-1980 |
| | Epstein-Barr Virus Serology Studies |
| 25 | 1 | | Alspaugh, M.A. and Silverman, S. (immunoglobulin antibody studies), 1977-1981 |
| 25 | 2 | | Cleveland family study (seroepidemiology of EBV), 1967-1969 |
| 25 | 3 | | Cocultivations, infections, U-V experiments (transmission of EBV to various host systems), 1970-1971 |
| 25 | 4 | | EB immunoglobulin studies, 1965 |
| 25 | 5 | | EB2: immunoglobulin studies (primate/animal studies), 1966-1967 |
| 25 | 6 | | EB3 (primate studies), 1967 |
| 25 | 7 | | EB (early antigen studies), 1970-1971 |
| 25 | 8 | | EBNA: Lana et al, 1973-1974 |
| 25 | 9 | | EBV serology summaries, 1972 |
| 25 | 10 | | Electric-Nucleonics Labs, Inc. (IGg antibody studies on EBV), 1981 |
| 25 | 11 | | Experiments, 1969 |
| 25 | 12 | | IGA (immunoglobulin class of antibodies), 1974-1975 |
| 25 | 13 | | Massachusetts Institute of Technology: "CF with EB Cells", 1964-1968 |
| 25 | 14 | | Nadkarnis cell lines (arginine experiments), 1968-1969 |
| 25 | 15 | | Ponten cell lines, 1969-1970 |
| 25 | 16 | | Sumaya, C.V. (seroepidemiologic study of antibodies to EBV), 1972-1975 |
| 25 | 17 | | VCA Test and EBNA, 1972, 1977 |
| | Herpes Studies |
| 26 | 1 | | Leinikki, Pauli, 1971-1972 |
| 26 | 2 | | Saimiri, H. (herpes studies on marmosets), 1972 |
| | Infectious Mononucleosis And Chronic Mononucleosis Virus |
| 27 | 1 | | Cherry; Mayo Clinic; George Klein (EBNA studies on chronic infectious mononucleosis), 1983-1986 |
| 27 | 2 | | Early antigen studies in infectious mononucleosis, Yale University, 1969-1971 |
| 27 | 3 | | Heterophil antibody response in infectious mononucleosis (Paul-Bunnell Anitgen), [19--] |
| 27 | 4 | | Horwitz, Charles A. (IM), 1970-1973 |
| 27 | 5 | | Horwitz, Charles A. (IM), 1970-1975 |
| 27 | 6 | | Horwitz, Charles A. (CMV and IM), 1979-1980 |
| 27 | 7 | | Horwitz, Charles A. (CMV and IM Studies), 1980-1985 |
| 27 | 8 | | Horwitz, Charles A. (CMV), 1985-1987 |
| 27 | 9 | | New York Virus Watch, heterophile antibody tests, cytomegalovirus, spleen and acute IM, 1967-1968 |
| 27 | 10 | | Straus, Stephen E. and Cheney, Paul (Chronic IM), 1983-1986 |
| | Miscellaneous Notebooks |
| 28 | 1 | | Collaborative studies, Texas, 1981 |
| 28 | 2 | | Collaborative studies, 1976-1982 |
| 28 | 3 | | Collaborations #3; Virolab, psychiatry, Cordis, Israel, Pagano, Kazura, Levitt, Lennette, 1980-1986 |
| 28 | 4 | | Glaser, Judson, Miller, Shope, Springer, Ziegler, 1973-1985 |
| 28 | 5 | | Lennette, Evelyne T.: experimental, 1979-1980 |
| 28 | 6 | | Notes, abstracts, miscellaneous, 1969-1973 |
| 28 | 7 | | Unusual cases, 1974-1985 |
| | Multiple Sclerosis |
| 29 | 1 | | Koln studies, 1975 |
| 29 | 2 | | Multiple sclerosis, 1969 |
| 29 | 3 | | Mice/Human Studies, 1974-1976 |
| 29 | 4 | | Polymorphonuclear leukocytes in mice sera, 1972-1973 |
| 29 | 5 | | Polymorphonuclear leukocytes in mice sera, 1973-1974 |
Return to the Table of Contents
| | | | | | | | | | | | | |
| |
Autobiography: Growing Up with Virology, [1986?]
|
| Call Number: MS C 460 |
|
|
|
|
| The Henles' autobiography appears to have been written by Werner Henle. Werner's narrative is insightful and full of personal vignettes that
give a sense of the Henles' daily lives as scientists. The autobiography also
provides an excellent chronology of their scientific research. Unfortunately,
the autobiography is limited due to the absence of Gertrude's perspective. In
his account of their professional lives, Werner did, however, address the issue
of sexism and how it influenced his wife's career. |
|
|
|
|
Return to the Table of Contents
Return to List of Manuscript Collections and Finding Aids
|
Printer-friendly Version