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United States National Library of Medicine National Institutes of Health

Finding Aid to the Thomas C. Chalmers Papers, 1927-1995

TABLE OF CONTENTS


Descriptive Summary

Biographical/Historical Note

Collection Summary

Index Terms

Administrative Information

Restrictions

Series I: Personal and Biographical, 1954-1995

Series II: Subject Files, 1927-1995

Series III: Hepatitis Study (Kyoto, Japan ), 1943-1970

Series IV: Publications, 1954-1995

Series V: Conferences, 1983-1991

Series VI: Audiotapes, 1963


Archives and Modern Manuscripts Program, History of Medicine Division

Processed by Daniel J. Lavoie II; Processing Completed May 2004

Encoded by Daniel J. Lavoie II and John P. Rees


Descriptive Summary

Collection Number:MS C 542
Creator:Chalmers, Thomas C. (Thomas Clark), 1917-
Title:Thomas C. Chalmers Papers
Dates:1927-1995
Quantity:32.8 linear feet (49 boxes)
Abstract:Thomas C. Chalmers, MD, clinician- scientist- teacher- administrator- entrepreneur, played a pivotal role in the scientific development of the randomized control trial and clinical trial meta-analysis. Research files, teaching materials, correspondence, publications, conference packets and notes, audiovisuals, and personal material document his life and medical career.

Biographical/Historical Note

Thomas C. Chalmers, MD, clinician- scientist- teacher- administrator- entrepreneur, was born in Forest Hills, New York, on December 8, 1917 and played a pivotal role in the scientific development of the randomized control trial and clinical trial meta-analysis. He attended Yale College from 1936 to 1939 as an English major and received his M.D. degree from the College of Physicians and Surgeons, Columbia University in 1943. He spent the following year interning in medicine at Presbyterian Hospital in New York City and completed his residency in 1947 at Harvard Medical Services of the Boston City Hospital.

Over the next six years he served as a part-time physician of the Thorndike Memorial Laboratory while practicing medicine in Cambridge, Massachusetts. In 1951 he was the principal investigator of the hepatitis treatment research unit of Harvard Medical School in Kyoto, Japan, and his military service was spent doing research as a member of the metabolic unit of the Army Medical Services Graduate School at Walter Reed Medical Center in Washington D.C. From 1955 to 1968 he was Chief of the Medical Services of the Lemuel Shattuck Hospital in Boston and Professor of Medicine at Tufts Medical School, and lecturer at Harvard.

In 1968 Chalmers became head of the research and education program of the Veterans Administration in Washington, D.C. After 18 months, he was appointed Associate Director for Clinical Care and Director of the Clinical Center of the National Institutes of Health until 1973. During these same years he also served as Professor of Medicine at George Washington University School of Medicine also in Washington, D.C.

After his tenure at NIH, he became President, Dean, and Professor of the Mount Sinai Medical Center and School of Medicine until 1983. During his time at Mount Sinai he created and developed both the Biomathamatical Sciences and the Geriatrics and Adult Development departments.

During the latter half of the 1980s he served as Distinguished Physician at the Boston Veterans Administration Medical Center. In addition, he was also a lecturer at the Harvard School of Public Health, in Epidemiology at Boston University School of Medicine, and in Medicine at Tufts University School of Medicine.

In 1993 he co-founded MetaWorks, Inc. with Susan Ross, M. D. and served as chairman of the company until his death in 1995. Metaworks, Inc. provides evidence-based medical information and is a designated Evidence-Based Practice Center. MetaWorks specializes in acquiring, synthesizing, analyzing, interpreting and delivering medical information in a way that transforms it from raw data into meaningful, actionable evidence. Chalmers' expertise was instrumental in the training of the MetaWorks scientific team, and in establishing the systems and practice standards by which MetaWorks' methods and procedures are governed.

Chalmers held memberships in a number of professional societies, including the Association of American Physicians; the American Association for the Study of Liver Disease, of which he was president in 1959; the American Gastroenterological Association, of which he was president in 1969; and the American Society for Clinical Investigation. He was a fellow of the American College of Physicians and a member of the Institute of Medicine of the National Academy of Sciences.

Chalmers also served on review committees and advisory boards of governmental and national professional bodies, including the National Cancer Institute, National Heart and Lung Institute, National Institute of Arthritis, Metabolism, and Digestive Disease, the Food and Drug Administration, and the National Research Council.

His research interests included the methodology of clinical trials; meta-analysis; clinical gastroenterology and cardiology, and geriatrics. Chalmers realized earlier in his career that many of the treatments he was taught had been disproved by clinical trials. This ultimately changed his views on medicine and led him to pioneer and promote meta-analysis during the latter half of his career through his medical practice, research, and professorial positions. He also advocated the randomized assignment of patients in studies to avoid bias in the selection of treatment. Through his studies of randomized control trials Chalmers proved that had the trials been systematically and cumulatively synthesized, important treatments such as thrombolytic therapy for myocardial infarction would have been recognized much earlier. In addition, he also demonstrated that the advice given in textbooks and reviews articles did not correspond to the current available evidence when published.

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Collection Summary

Research files, teaching materials, correspondence, publications, conference packets and notes, audiovisuals, and personal material (1951-1995; 29 linear feet) document the life and medical career of Thomas C. Chalmers. Materials cover his career from Harvard Medical School to his final work with MetaWorks, Inc. The majority of the collection consists of subject files containing reports, articles, correspondence, and notes concerning his research interest in the methodology of clinical trials; meta-analysis; clinical gastroenterology and cardiology; and geriatrics. There also exists a small percentage of teaching materials in the subject files from Chalmers' various positions as lecturer and professor of medicine. The bulk of the collection spans the years 1951-1953 and 1970-1995.

The collection is organized into 6 series: Personal and Biographical; Subject Files; Hepatitis Study, Kyoto, Japan; Publications; Conferences; and Audiotapes.

Of significant interest in Series IV: Subject Files, is the material in the Linus Pauling and Vitamin C folders which contain information on Chalmers' debate with Pauling over the efficacy of Vitamin C as a cure for the common cold. These folders include debate transcripts, correspondence, and articles. Also of interest in this series is the MetaWorks Business Plan, 1993. This file folder includes correspondence and a 1993 summary of events relating to the company's inception. In addition, Series V: Hepatitis Study, Kyoto, Japan is also significant for its documentation of Chalmers' 1951 to 1953 hepatitis study. Chalmers later used this study to disprove the common belief that long periods of bed rest were beneficial to those suffering from acute infectious hepatitis. This series includes correspondence, reports, charts, and other data relating to this study.

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Restrictions

Restrictions

Collection is restricted according to HMD's access to health information policy. Contact the Reference Staff for information regarding access. For online customer service, please visit custserv@nlm.nih.gov.

[RESTRICTED] The sub-series "Clinical Trials" contains personal medical records and is restricted according to HMD's access to health information policy. Please consult the Manuscripts Curator for access to these materials.

[RESTRICTED] According to HMD Access to Individual Health Information Policy. Contact Manuscripts Curator for information regarding access.

Copyright

Copyright was transferred to the public domain. Contact the Reference Staff for details regarding rights. For online customer service, please visit custserv@nlm.nih.gov.

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Index Terms

These terms are indexed in the National Library of Medicine's online catalog LocatorPlus. Researchers wishing to find related materials should search the catalog using these terms.
MeSH Subjects
Cardiology
Clinical Trials
Evidence-Based Medicine
Gastroenterology
Geriatrics
Hepatitis
Meta-Analysis
Corporate Names
Boston City Hospital
George Washington University. School of Medicine
Harvard Medical School
MetaWorks, Inc
Mount Auburn Hospital
Mount Sinai School of Medicine of the City University of New York
National Institute of Health (U.S.)
New England Center Hospital
Veteran's Administration
Walter Reed Army Hospital

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Administrative Information

Preferred Citation

Chalmers, Thomas C. Thomas C. Chalmers Papers. 1927-1995. Located in: Modern Manuscripts Collection, History of Medicine Division, National Library of Medicine, Bethesda, MD; MS C 542.

Provenance

Gift, Thomas C. Chalmers Centre for Systematic Reviews, 10/19/2000. Acc #2000-48.

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Series I: Personal and Biographical, 1954-1995

This series contains correspondence, notes, and reunion materials relating to Dr. Chalmers' family and personal life. On August 31, 1942, he married his wife Frankie Talcott with whom he had four children. This series includes correspondence with his wife and son Richard, as well as general family letters which detail some of Chalmers' trips abroad. In addition, Chalmers' Philips Exeter Academy Class of 1936 50th Reunion materials are also included in this series. The series is arranged alphabetically by file folder.
BoxFolder
11 Boston City Hospital Retirement, 1954-1969
12 Compositions and Poems, 1983
13 Continuing Medical Education, AMA, MSSN, 1974-1985
14-6 Correspondence, 1973-1995
17-9 Correspondence, Family, 1970-1990
110 Correspondence, Family and Related Materials: China, 1983
111-12 Exeter Reunion, 1984-1986
113 Mount Sinai Contract Issues, 1975-1983
114 Position Appointments and Benefits, 1967-1972

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Series II: Subject Files, 1927-1995

This series contains publications, drafts, reports, charts, and notes concerning Chalmers' research interests in the methodology of clinical trials; meta-analysis; clinical gastroenterology and cardiology; and geriatrics. A small percentage of Chalmers' teaching materials that include teaching plans and syllabi can also be found in this series. The series is arranged alphabetically by file folder.
BoxFolder
115 2nd Batch of Blinded Prostate Papers, 1977-1992
21 2nd Batch of Blinded Prostate Papers (cont'd)
22 4 Randomized Control Trials to Show Corticosteroids, 1981-1986
23 5 AIDs Papers to Score for Paolo, 1989-1993
24-7 A. 166, 1986-1987
28 A Biological Consideration of Treatment of Breast Cancer, 1969
29 Abdominal Hysterectomy, 1972-1988
210 Abstracts: Gastro bleeding, ulcers, 1957-1992
211 Ace Inhibitors All Study, 1992-1995
212 Acute Cystitis, 1984-1985
213 Acute Cystitis/Urinary Tract Infection, 1984-1985
214 Acute Myocardial Infarction Slides
215 Acute Myocardial Infractions Helpers, 1991
31 Adjuvant Breast Cancer: Rx-Update, 1984-1986
32 Adjuvant Chemotherapy for Breast Cancer Update, 1986
33 Advanced Cancer, 1983
34 Age: Distribution of Meta-analyses
35 Bones and Joints, 1988-1989
36 References, Neuropsychology, 1988
Agency for Health Care Policy and Research
37 Contract, 1990-1991
38 Renewal, 1990
39 Agenda Planning Diary, 1991
310 Agendas, 1991
311 Agendas I, 1991
Aging
312 Section C, 1966-1988
313 Society, 1987-1988
314 Work, 1988-1990
315 AIDs
316-19 AIDs Immunology, 1976-1987
41 "Air Traffic Controller Health Change Study", 1978
42 Alpha I and Hypertension, Meta-analysis and Lipids, 1986
43 AMA Meta-analysis, 1983-1985
44-5 Amoxicillin Therapy, 1982-1985
46 Analytic Procedures, 1955
47 Angiography: Cholesterol, Good, 1978-1990
48 Ankle Fracture Fixture, 1987
49 Anti-arrhythmic Drugs
410 Antibiotic/Accepted Articles: Colon Surgery, 1981-1989
411-12 Antibiotic Hysterectomy, 1965-1992
51 Antibiotic Prophylactic, 1988-1991
52 Antibiotic Prophylactics in Surgery, 1973-1992
53 Antibiotic Rejected Articles, 1984-1989
54 Antibody E5, 1991-1992
55 Anti-inflammatory Drug Study, 1987
56 Apheresis Manuscript, 1980
57 Apheresis Randomized Control Trials, 1979-1983
58 Appendix: Report of the Secretary's Commission on Medical Malpractice
59 Appropriateness Research, 1987
Articles
510-12 1955-1978
61-11 1967-1989
71-8 1970-1995
81-9 1983-1995
91 1970-1974
92 Articles and Correspondence, 1993
93 Aircraft Accidents, 1974-1982
94 Clinical Trial, 1979
95 For Thomas C. Chalmers's Editorial, 1987-1988
96 Rejected for Gastrointestinal Hemorrhage Paper, 1937-1958
97 Rejected for Hemorrhage Paper, 1937-1958
98-9 Used for Gastrointestinal Hemorrhage Papers, 1942-1965
910 Ascorbic Acid, 1971-1977
911 Ascorbic Acid: National Institute of Health Study [slides], 1973
912-13 Aspirin Papers (Joe Cappelleri), 1974-1991
101-2 Asthma/Oral Drugs Back 85: Aspirin Dose Study, 1992
103 Atherosclerosis, 1951-1979
104-5 Autopsy Reprints Errors, 1953-1989
106 Aviation Accidents, 1980-1983
107-8 Bachrach, N., 1983-1989
109 Background, 1995
111 Batch 1: Peptic Ulcer Papers, 1979-1990
112 Batch 2: Peptic Ulcer Papers, 1981-1989
113 Berlin's, Dr.: Comments, 1995
114-6 Beta Blockers, 1993
117 Beta Data and Charts, 1978-1989
118-10 Beta Papers, 1988-1989
1111 Bias Paper, 1982
1112 Big vs. Small
1113 Biography and Schedules
1114 Bleeding Peptic Ulcer, 1986-1991
1115 Bleeding Ulcers, 1989-1992
1116 Blocking Agents, 1993-1994
1117 Blue Book Update: Beta, 1987-1988
1118 Blum File, 1987
1119-20 Blum, Almanac, Dec. 7, 1987
1121 Books on Errors, 1983
1122 Boston City Hospital, Out-Patient Department, 1952-1954
1123-24 Boston Meta-analysis Candidate, 1986-1987
1125 Breast Cancer Article, 1986-1987
1126 Breast Cancer Med '86, 1991
1127 Breast Cancer Screening, 1987-1992
1128 Breast Cancer-Reject Papers, 1986
1129-30 Brian, 1990
1131 Brookline Ashes, 1987
1132 Burns, 1978-1987
1133 Burrows Study, 1989
1134 Buyse, Mark, 1984
1135 Buyse, Mark: Gastric Cancer, 1977-1984
1136-37 CA B6 Meta-analysis for POARP, 1989-1991
1138 CABG Overheads
1139 CABG Summaries
1140 Cabin Air Quality, 1988
1141 Cabin Air Quality Slides
1142 Caesarean, 1993
1143 Caesarean Charts, 1972-1989
1144 Caesarean Section, 1990
1145 Caesarean Section Antibiotics
121-3 Caffeine Study, 1952-1983
124-6 Calendars, 1987-1990
127-8 Cancer Articles, 1984-1986
129 Cancer Papers, 1977-1989
131-2 Cancer Papers (cont'd.)
133 Cancer Therapy, 1977-1992
134 Cardiology, 1994
135 Carlisle, Paul and Tony Singletary [burn victim slides], 1969-1981
136 Carotid Surgery, Hefan, 1985
137 CCB Overheads
138-9 Celiac Plexus Block Papers, 1972-1992
1310-11 Chalmers, Iain, 1985-1988
1312 Chapman and Hall, 1992-1995
1313 Chapter on History of Clinical Trials, 1986-1991
1314 Charts, 1986-1993
1315 CHD Hormones, 1963-1979
1316 CHD: ICCU, 1971-1979
141 Cholesterol and Stroke, 1992-1993
142 Cholesterol: Lowering Meta-analyses, 1974-1992
143 Chronic Effects of Tolbutamide, 1972-1974
144 Ciguatera
145 Clinical and Clim Paper Gastrointestinal Hemorrhage, n.d
146 Clinical Pharmacology in Aged, 1984
147 Clinical Pharmacology in the Elderly, 1989
Clinical Trials
148-9 Clinical Trials, 1975-1988
1410 Travel time experiment, 1977-1982
1411 Grant on Technical Evolution of Literature, 1982
1412-13 Clippings, 1978-1982
1414 Clozapin Therapy for Schizophrenia, 1991
1415 Coffee Trial, 1983
1416 Cognitive Behavior Eisenberg, 1991
151 Colon Adjuvant, Recent Publication, 1985
152 Colon Cancer, 1971-1976
153 Comparison of Methods, 1992
154 Completed Forms, 1950-1976
155-6 Completed Hysterectomy Master Copies, 1973-1990
157 Computer Ethics, 1973-1976
158 Controlled Clinical Trials, 1974
159 Controlled Study Articles, 1983-1991
1510-12 Controlled Therapeutic Trials, 1970-1994
1513 Cook and Tryba Meta-Analysis, 1979-1991
161 Cook and Tryba Meta-Analysis (cont'd.)
Correspondence
162 1971
163-5 1973
166 1974-1984
167 1985-1986
168 1990-1992
169 1993-1994
1610 Correspondence and Meta-analysis, 1995
1611-12 Correspondence and Papers, 1990-1994
1613 Course: Meta-analysis, 1986
1614 Course: Case Control Etc., 1984
1615 Crohn's Scores: Meta-analysis, 1979-1984
1616 Crohn's, 1992
1617 Cumulative Meta-Analysis, 1994
1618 Cumulative Meta-Analysis: Marubini Talk in Paris, 1989
1619 Cumulative Rearrangements, 1976-1988
1620 Current Clinical Trials, 1994
CVS
1621 Acute Myocardial Infractions, 1983
1622 Angina Pectoris, 1971
1623 Arteriosclerosis, 1970-1979
171 CABG, 1982-1983
172 Cineangiograph, 1979-1982
173 Coronary Reperfusion, 1982
174 Epidemiology, 1980-1983
175 Hemostosis, 1980-1981
176 Lipids Cholesterol, 1979-1980
177 Pharmacology, 1979-1980
178 Stroke, 1983
179 Type A Behavior, 1983
1710 DA Grant, 1989
1711 Data
1712 Data and Summary of Levamisole, 1980-1990
181 Data and Summary of Levamisole (cont'd.)
182 Data(2): Hormonal Influence for Iron Absorption, 1959
183 Delays, 1985-1991
184 Delphi-1, n.d
185-6 Depression, 1988-1992
187 DHMC, 1993
188-9 Diabetes, 1984-1991
1810 Diabetes Survey, 1988-1991
1811-13 Diagnostic Errors, 1951-1988
191 Diet, Heart, Review, 1984
192 Digestive Diseases Grant, 1989
193 Dipyridamole, 1990
194 Dipyridamole Thallium, 1982-1986
195 Double-Blind Study, 1965
196 Drug Abuse, 1991
197-8 Drug Abuse Grant, 1989
199 Early PTCA, 1994
1910 ECRI Meta-analysis, 1994
1911 Edited Draft of "The Efficacy of Medical Treatments on Peripheral Diabetic Neuropathy...", 1993
1912 Effective Care in Pregnancy and Childbirth: Hormones (Iain Chalmers), 1978-1986
1913 Eisenberg #1 to Blind, 1990-1991
1914 Eisenberg Papers, 1993
1915 Eisenberg Papers for Thomas C. Chalmers, 1976-1993
1916 Electronic Journal of Meta–analysis, 1984
1917 Endoscopic Rx Hemorrhage
1918 Epidemiologic Meta-analysis Overheads
1919 Epidemiologic Survey, 1986
Errors
1920 1986-1989
1921 Airplane, 1974-1982
1922 Anesthesia, 1972-1983
1923-24 Background Reading, 1981-1983
1925 Clinicopathological Conferences, 1982
1926 Current, 1983
1927 Dates on Intensive Care Units, 1988
1928 Manuscript, 1983
1929 Manuscript II, 1983
1930 March '84, 1983-1984
1931 Medication, 1989
1932-33 More, 1954-1983
1934 Notes, 1981-1983
1935 Relating Tourniquets, 1980
1936 Reprints, 1981-1983
1937 Ethics of Randomized Clinical Trials, 1991
1938 Ethics Slides, 1972-1992
1939 Etiology of Duodenitis, 1964-1977
1940-41 Excluded, 1974-1983
1942 Exercise, 1988
1943 Expert Forms, 1991
1944 Extra Applications, 1982-1986
1945 Fawzi, Wafaie W., 1990-1993
1946 Faxes, 1988-1989
1947 Felson Study, 1991
1948 Fibrinolytic Side Effects
1949 Fibrinolytic Therapy Graphs, 1989
1950 Final Graphs for Chlor
1951 Financial Data
1952 Flouty: Nifedipine, 1995
201 Folati and Malformation, 1993
202-3 Forgotten Research, 1979-1991
204 Forms and Worksheets, Meta-analysis, 1984-1985
205 Foundations, 1987-1988
206 Foundations: Iain Chalmers, 1987-1988
207-8 FTC
209 Furberg Press Releases, 1995
Gail's Papers
2010 1978-1983
2011 Perfect References, 1983-1984
2012-13 Project #2, 1976-1983
2014-21 Study: Included, 1964-1983
2022-23 Study: Jaundice, 1978-1980
2024 Gamma Globulin in Post-transfusion Hep., 1977-1978
2025 Gastric Freezing, 1964
2026 Gastric Ulcers, 1990
2027-28 Gastroenterology International, 1988-1989
2029 Gastrointestinal Bleeding Articles, 1979-1989
Gastrointestinal Hemorrhage
2030 Gastrointestinal Hemorrhage, 1990
2031 Collins (Studies in References), 1987-1992
2032 10 and Hem. 11- Full Papers for Thomas C. Chalmers, 1983-1989
2033-34 Data, 1927-1969
2035 Log, 1985-1989
211 Meta-analysis Update File, 1971, 1990
212 Review and Thomas C. Chalmers, 1975-1987
213 Review Articles, 1981
214 Gastrointestinal Meta-analyses
215 Gastrointestinal New Rejects, 1990-1991
216 Gastroplasty, 1994
217 Genealogy, 1961-1962
218 Geneval, 1994
219 Geriatric Randomized Control Trials, 1988-1989
2110 Good Peptics 60's, 1967-1970
2111 Gray
Gray, Darryl
2112-13 1961-1987
2114 Burn Excision, 1984-1986
2115 E.G. Work Records Protocol, 1986
2116 Front Sheets, 1976-1985
2117 Greenlaw 7/5/93, 1990-1993
2118 Grey Scores, 1985
2119 Halothane: Ris/Case/Cohort Study Cur. Con., 1966-1986
Harvard School of Public Health
2120 1985-1986
2121 11/13, 1974-1986
2122 Course, Bias, Sackett, 1984
2123 Course, Illness Requiring Clinical Trials, 1981-1982
2124 Office, 1989
2125 Health Care Crisis
2126 Health Care Crisis Paper
2127 Health Effects, 1991
2128 Helicobater, 1993
2129 Hemorrhage Reference, 1981-1989
2130 Hepatitis, n.d
2131 Hepatogastroenterology, 1988-1990
2132 Home
2133 Home Randomized Control Trials, 1981-1982
2134 Home Research, 1981
2135-36 Hospice Care, 1978-1984
2137 Hyperbili Data, 1982-1986
Hypertension
2138-39 1988
2140-41 During Pregnancy, 1969-1985
2142 In Aged, 1990-1993
2143 Lovell, 1981-1992
2144-45 Meta-analysis, 1983-1992
2146-47 Papers, 1973-1993
2148-50 Study
2151 Tables, 1993
2152 Treatment
2153 Research, 1986
2154-55 Hypokaliemia and Q.T. Problems, 1982-1989
221 Iatrogenic Disease, 1955-1980
222-3 Iloprost, 1989-1990
224 Immunoterapia Advante, 1976-1986
225 Impact on Practices, 1991
226 Impact on Prostate
227 Important Squam Information: Frank Mason, 1983-1984
228 Infectious Diseases and Gastroenterology Publications, 1990-1991
229 Informed Consent, 1966-1983
2210 Intermittent Claudication other Drugs, 1984-1987
2211 Intracranial Hemorrhage, 1983-1986
2212 Ischemia and Serotonin, 1988
2213 ISI Slides, 1989
2214 ISIS II, 1988
2215 ISIS, 4 Overheads
2216 Jacquotte, Anne Papers for Scoring, 1959-1985
2217 Janssen Grant, 1988-1991
2218 Janssen Pharmaceutica, 1989
2219-20 Jenny Rejects, 1987-1988
2221 Job Seekers [Dr. Chalmers], 1966-1973
2222 Jokes
Jovell, Albert J.
2223-25 1990-1992
2226 OJCC [Slides, Transparencies, Photographs]
Kannry , Joe
2227-29 1988-1989
2230 Abstracts, 1988-1989
2231 Papers
2232-37 Project Papers, 1961-1986
Ketanserin
2238 Add, on Trials, 1987-1988
2239 Comparison with other Drugs, 1986-1989
2240 Hypertension
2241 Intermittent Claudication, 1984-1989
2242 Mechanism, 1983-1989
231-2 Mechanism, 1983-1989
233 New Reject Anti-Hypertension, 1987-1988
234 Placebo Hypertension, 1981-1987
235 Short, Meta, 1985-1988
236 Slides
237 Worksheets, 1986-1989
238 KIP,Vagotomy, 1981-1988
239 Klawansky: Practice vs. Research, 1993
2310 Lag, Background, 1962-1969
2311 Lasker Award Documents, 1988
2312 Letters to Write, 1994-1995
2313-15 Levamisole: Papers, 1978-1992
2316 Levamisole: Study, 1980-1990
2317 Leverton, Fax Transmissions, 1995
2318 License
2319-20 Lidocaine, 1970-1974
2321 Lind, James, 1953-1969
2322 Lipids, Diuretics and Hypertension, 1986-1988
2323 Liver (Diet Supplements)
2324 Liver Meta-analysis, 1992
2325 Liver Meta-analysis Chapter, 1989-1991
2326-28 Liver Reference List/Result Outline/Graph, 1927-1967
2329 M.S. Photographs, 1993
2330 MACT Bib. Quality of Clinical Trials, 1966-1984
2331 Malpractice, 1976-1984
2332 Malpractice Search, 1984-1986
2333 Mammography
2334-35 Manuel/Eric/Sylvie Urinary Tract Infection, 1971-1986
2336 Manuscripts, 1987-1988
2337 Maripa, 1974-1978
2338 Mas In Ris Database 2/18/93, 1990-1991
2339 Mason, Frank, 1983-1984
2340 Massachusetts Health Data Consortium, 1986-1987
2341 Masters in Gastroenterology, 1990-1994
2342 Matrix Results, 1989-1990
2343 Medical Data, 1980-1986
241 Medical Data, 1983-1986
242 Medical Decision Making Classics: A Reading List, 1988
243 Medical Journalism
244 Medical Journals, 1974-1978
245-6 Medical Project and Workload, 1992
247 Medicine and Mathematics Articles, 1968-1980
248 Medline, 1983
249 Medline Papers, 1980-1982
2410 Memorandum, 1992
Meta-analysis
2411-15 1964-1994
2416 Aids Literature, 1991
2417 Alcohol, 1987
2418 As a Tool for Interpreting Clinical Trials in Liver Disease, 1990
2419 Caffeine, 1983
2420 Calcium Supplements For Ecclampsia CPEP
2421 Candidates, 1988
2422 Candidates-Cor. Art. Changes After Bypass, 1975-1981
2423 Clinical Trials, 1993-1994
2424 Clinical Trials Unit, 1965-1985
2425-26 Colon Cancer, 1986
2427 Consulting Inc./ MetaWorks, Inc., 1995
2428 Descriptive
2429 Epidemiologic, 1987
2430 Esophageal Varices, 1988
2431-33 In Gastroenterology, 1977-1991
2434 In General
2435 Manuscript, 1990
2436 Methods II
2437 of Clinical Information Service Trial, 1993
2438 on Obstetrics, 1970-1989
2439-40 Papers, 1986-1988
2441 Phenobaritone S.V. Hemorrhages, 1984
2442 Pittsburgh, Slides
2443 Placebo, 1974
2444 Post MI Placebo Survival
251 Quality Studies, 1977-1983
252 Quality U.S., 1988
253 Randomized Clinical Trials Paper, 1994
254 Seminars, 1994
255 Somatostatin, 1990-1991
256 Statistical Methods
257 Steps Long Forms
258 Stroke Prevention, 1969-1988
259 to Evaluate Analgesic Interventions
2510 Topics, 1986
2511 Update, 1987
2512-13 Updates, Colon Surgery and Antibiotics, 1989
MetaWorks
2514 Business Plan, 1993
2515 Ross on Meta-analysis, 1992
2516-17 Methadone: to Be Scored
2518-19 Methodology, 1976-1988
2520 Minnesota Colon Cancer Control Study I, 1987
2521-23 Mirreadorf, 1990-1992
2524 Mosteller Renewal, 1990
2525 Mount Sinai School of Medicine Papers, 1974-1983
2526 MRI, 1988-1992
2527 MRI Grant, 1985-1989
Mt. Sinai
2528-30 Labeled by #
2531 Labeled by Trials, 1987-1991
2532 Medical Center Fax, 1989
2533 President, 1982
2534 Multiple Copies of Various Articles, 1976-1988
2535 Mutual Fund Summary, 1987
2536 Nafarelin Search 7/12/93, 1981-1992
2537 National Institute of Health: Consensus, General, 1983-1984
2538 National Institute of Health: Slides # to 400's
2539 National Library of Medicine Application, 1980
2540 National Library of Medicine Original, 1990
2541-42 National Transportation Safety Board: Reports, 1974-1978
2543 National Transportation Safety Board: Tables Statistics, 1983
2544 Neglect of Aged, 1988-1989
261 NEGM Letter, 1992
Neural Tube
262-3 1992
264 39-0207, 1985
265-6 Defects, 1983-1988
267 Defects Meta-analysis, 1980-1982
268 New Aspirin Papers to be Scored for Joe Cappelleri, 1988-1992
269 New Breast Trials, 1982-1985
2610 New Gastrointestinal Hemorrhage Paper, 1990
2611 New Hysterectomy Papers, 1980-1983
2612 New Peptic Papers, 1958-1965
2613 NIDDS Grant, National Institute of Health Meeting, 1988
Nifedipine
2614 Drafts, 1995
2615 From Yusor, Furberg, 1994
2616 Overheads, 1995
2617 No Overall Survival, 1986
2618 Non-fatal Stroke
2619 Nonoccupational Exposure to Polychlorinated Biphenyls, 1988-1990
2620 Notes
2621 NSAIDS: Slides
2622 Obesity Study, 1994
2623 Obesity/Gallstones, 1991
Observer Error
2624 1959-1974
2625 Bias, 1952-1975
2626 Bias Radiology, 1947-1977
2627 Diagnosis General, 1965-1979
2628 Diagnosis Specific, 1974-1981
2629 History Talking, 1951-1979
2630 In Endoscopy, 1961-1972
2631 Laboratories, 1970-1975
2632 Miscellaneous, 1958-1981
2633 Statistics, 1959-1977
2634 Observer Variability
2635 Observer Variability, Review, 1975
2636 Office of Medical Applications of Research, 1990-1991
2637 Old Gastrointestinal Hemorrhage Draft (VA), n.d
2638-39 Old Manuscripts, 1967-1981
2640 Old Research Publication Bias, 1978-1989
2641 Opinion Research
Options
2642-43 Null
2644 Overheads
2645-46 Poster, 1994
2647 Recommendations, 1989-1995
2648 Original Buyse, Colorectal Trials and Gastric, 1979-1984
2649 Original Case Fatality Rate Blank Chart for Peptic, 1990
2650 Orton, 1930-1942
2651-52 Otisis Media, 1989-1990
271 Outcome Research
272 Overhead
273 Overheads: Matrices, 1990
274 Overheads: Sample Sizes, 1992
275-6 Oxford Companion to Medicine Sept. 92, 1980-1982
277 Oxford Perinatal Trials
278 Pack, 1988
279 Pack I
2710 Pack II
2711 Pack Study, 1988-1989
2712-13 Papers, 1970-1992
2714 Papers: Gail's Study, 1981-1983
2715-16 Papers: Proofs for Journal Article, n.d
2717 Park Study 1989 Data and Safety and Ethics, 1989
2718 Part of Peptic Manuscript, 1987
2719 PASF Research and Articles, 1983
2720 Pashos, Chris (Port Cortin), 1990
2721 Patients, 1973-1977
2722 Paula, 1994-1995
2723 Paula Rochon, Placebo, 1995
2724 Paula, Quality, 1994-1995
2725 Pauling, Linus, Vitamin C and Common Cold, 1971-1976
2726 PDQ: All 36 Trials, 1992
2727 PDQ: Randomized Control Trials, 1992
Peer Review
2728-29 1978-1989
2730 Meeting, 1977-1988
2731 Presentation, 1988
2732 Penultimate Drafts, 1995
2733-34 Peptic, 1986-1991
Peptic Ulcer
2735 1986-1991
2736 Peptic Ulcer (Added), 1972-1990
2737-40 Articles, 1947-1993
2741 Emergency Surgery Original Paper, 1960-1990
2742-43 Hemorrhage, 1970-1990
2744 Hemorrhage Papers, 1956-1992
2745-46 Papers, 1933-1991
281-4 Papers, 1933-1991
285 Papers, Batch 3, 1965-1985
286 Peptic Ulcers, 1975-1990
287 Peptic with Out Trials Abstract, 1988-1990
Peptic
288-9 60-75, 1960-1967
2810 Fill In
2811 No Trials Abstracts, 1983-1985
2812 Reference (very old), 1985-1988
2813 Pero Material: Cholesterol, 1987
2814 Pero Material: Randomized Control Trials, 1978-1985
2815-16 Persantine Thallium, 1995
2817 Peter Kussin, 1980
2818 Phenobarb in Newborns, 1987
2819 Phototherapy, 1998
2820 Physical Examination, Observer Error, 1948-1975
2821 Pilot Error, 1982-1983
2822-23 Placebo, 1983-1994
2824 Placebo Article, 1980
2825 Placebo Hypertension, 1995
2826 Plasma Pheresis Meta-analysis, 1981-1984
2827 Plasma Prednisone, New Randomized Control Trials, 1984-1985
2828 Plasmapheresis Paper, 1981-1984
Polychlorinated Biphenyls
2829 General, 1983-1990
2830 Proposal, 1988-1989
2831 Potential Grant Applications, 1990
2832 Pre-eclampsia
2833 Pregnancy - Corticosteroids
2834 Primary Breast Cancer, 1985-1986
2835 Project, 1992
2836 Project B.P., 1988
2837-38 Project Gastric Freezing, 1948-1978
2839 Project Plasma Pheresis, 1984-1985
2840 Projects, 1973-1987
291 Prophylactic Antibiotics
292-3 Proposal, 1984-1993
294 Proposal June '88, 1973-1983
295 Prostate, 1986
Prostate Cancer
296 1989-1993
297 Bony Metastases, 1993
298 Hormone Therapy, 1993
299 Petodata, 1993
2910 PSA, 1992-1993
2911 Radiotherapy, 1993
2912 Research, 1984-1986
2913-14 Prostate Meta-analysis, 1981-1990
2915 Prostateglandins for CERU Ripening, 1990-1993
2916 Protocol Draft, 1994
2917 Protocol for Meta-analysis Papers
2918 PTCA vs. F. Lytic, 1993-1995
2919 Public Health Service Application, 1986-1989
2920-21 Publication Bias, 1985-1991
2922 Published Research, Jovell, 1985-1991
2923 Q.T. Syndrome Article, 1980-1989
2924-25 Quality of Healthcare, 1974-1981
2926-27 Quality of Randomized Control Trials, 1991
2928 Quality Scoring Forms, 1990
2929 Radiation Effects, 1967-1986
2930-31 Radiation: Normal, 1950-1966
2932 Radiotherapy, 1985
Randomized Control Trials
2933-41 1953-1987
301-7 1958-1992
308 Databases, 1990
309 Library Work
3010 Placebo, 1980
3011 Rec. Future Medline, 1989
3012 Registry of Clinical Trials, 1993
3013-14 Reject: Inadequate Follow-up, 1985-1986
3015 Reject: No Mortality Data, 1985
3016 Reject: Peptic '60's, 1966-1971
3017 Reject: Type of Surgery, 1985
311-2 Research Data [MEDLINE citations/abstracts, myocardial infarction?], 1988
313 Retirement; misc. correspondence, 1970-1989
314 RIP Ashes [fireplace ash fallout study], 1988
315 Rochon, Pauls [placebo vs. NSAID], 1995
316 Rome Talk, 1989
317 Rome, Decision Analysis Articles, 1981-1987
318 Route of Delivery Papers to Score for Cathy Spino/ Paolo Villari, 1992
319 Rutstein, David [memorial], 1986-1987
3110 Sackett, David, 1976-1982
3111 Salt Sensitivity and Hypertension, 1988
3112 Sample Size Estimates, 1954-1974
3113 Sample Size Estimation by Cumulative Meta-analysis, n.d
3114 Sampling, 1992
321 Santa Fe Overheads
322 Science In Medicine, 1988
323 Seattle, 1983-1991
324 Selection Interference and Suggestion in Clinical Trials, 1961-1978
Course in Clincal Trials and Meta-Analysis [UC Berkeley], Spring 1991
325 Session I and II
326 Session III
327-8 Session IV, V, and VII
329-10 Session VI
3211 Session VIII
3212-13 Session IX
3214 Session X
331 Session XII
332-3 Session XIII
334 Slide Material Evaluation of Magnetic Imaging
335 Slide Material: Opinions of Experts, 1991
Slides
336-10 1975-1990
3311 (old) before 1970 (No Duplicates Here), 1969
3312 for Keynote Address, 1990-1994
3313 for Talk, 1990
3314 MAC, 1977-1986
3315 Mosteller Wanted for POARP Meeting, 1986
3316 Unnumbered
3317 Small Cell Lung Cancer, 1992
3318 Solar and Electric Randomized Control Trials, 1982
3319-20 Sorbinol: Meta-analysis, 1991
3321-24 Sounding Board, 1985-1987
3325 Statistics, 1981-1988
3326 Statistics Manuel and Haenszel, 1959
3327-29 Statistics Methods, 1962-1978
3330-31 Statistics Methods I, 1967-1978
3332-36 Statistics Methods II, 1966-1981
3337 Steps in Meta-analysis
3338-39 Steroids, 1970-1986
3340 Stroke HCUA, 1987-1990
3341 Stroke Rate A-Transient Ischaemic Attack, 1978-1991
3342-43 Strokes, 1992
3344-45 Strokes: Wash, 1992
3346 Sucralfate, 1989-1992
3347 Sudden Death, 1989
3348 Sugawa Article with Referenced Papers, 1979-1990
341 Summary Charts, 1991
342 Surgery Meta-analysis, 1971-1981
343-4 Sydney/Cocaine, 1990-1992
345 TD Hyperbilirubinemia, 1983
346-8 The Boston Inter-Hospital Liver Group as an Experiment in Coop. Res., 1963-1981
349 The New England Journal of Medicine Article, 1958
3410 The Patient, 1977
3411 Thrombolytic Therapy, 1988-1990
3412 Tie Research, 1985
3413-14 To Be Filed, 1973-1995
3415 Toward Controlled Trials in Upper Gt. Bleeding Minutes, 1976
3416-17 Toxic Waste Dumps, National Research Council, NRC-NRS, 1980-1991
3418 TPA vs. Streptokinase
3419 Transcriptions, 1987-1991
Transparencies
3420 1991
3421 Materials Acute Treatments
3422 Travel, 1975-1988
3423 Treatment of Burns, 1974-1976
3424 Trials in Gastroenterology, 1970
3425-26 Unblinded Aspirin Papers, 1976-1991
University Group Diabetes Program
3427 Compliance and Mortality Project, 1974-1981
3428 FDA Survey, 1978
3429 History, 1971-1979
3430 Unsorted Slides, 1987
3431 Update: Breast Cancer Meta-analysis, 1985
3432 Updating Meta-analyses, n.d
3433 Urgent, 1991-1993
3434 Variceal Hemorrhage, 1990
Veterans Administration
3435 Clinical Epidemiology Department Lecture, 1975-1988
3436 Distinguishing Physicians, 1988
3437 Duplicates, 1986
3438 Grant, 1989
3439 Study of 20 VA Hospitals (Old Material), 1970
Vitamin C
3440-41 1956-1977
3442 Adverse Effects, 1975-1977
3443 Adverse Effects and New Articles, 1967-1976
3444 and the Common Cold, 1945-1975
3445 and the Common Cold Controlled Trials and References Used, 1942-1967
3446 Deficiency of, 1972-1975
3447 Duplicate Articles, 1969-1973
3448 General Review, 1975-1977
351 Other Diseases, 1971-1977
352-3 Vitamins Other Than C, 1971-1979
354 What's Meta-analysis, 1986-1991
355 Wilson, Cedric and H.S. Loh, 1967-1974
356 Wine, 1991
357 Wine Final, 1990
358 Wine Tasting and Meta-analysis Papers, 1990
359 Workshop on Clinical Trials, Bethesda, 1993
3510 Wright, Dan, 1981-1982

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Series III: Hepatitis Study (Kyoto, Japan ), 1943-1970

This series contains correspondence, reports, charts, and other data concerning Chalmers' Hepatitis Study in Japan. In 1951 he was the principal investigator of the hepatitis treatment research unit of Harvard Medical School in Kyoto, Japan. This study was later used by Chalmers to disprove the common belief that long periods of bed rest was beneficial to those suffering from acute infectious hepatitis. All patient records with personal identifiers have been restricted. The series is arranged alphabetically by file folder.
BoxFolder
[RESTRICTED] The sub-series "Clinical Trials" contains personal medical records and is restricted according to HMD's access to health information policy. Please consult the Manuscripts Curator for access to these materials.
BoxFolder
3511 Acute Hepatitis: Jaundice Study, 1943
3512 Choline Content and Electrolytes and Vitamins: Sample Skeleton Diets: Dietary 2nd Run, 1952-1953
3513 Clinical Data: Onset to Time of Admission
Correspondence
3514-15 1952-1953
3516 from Chalmers, 1951-1952
361 from Kyoto, Japan: from Eckhardt, 1952
362 from Sasebo, Japan, 1952-1953
363 Kyoto, Japan, 1951-1952
364 Macleod, 1952-1953
365 to Chalmers, 1951-1952
366 to Kyoto, Japan, 1952
367 to Sasebo, Japan, 1952-1953
368 Watson, 1952-1953
Data Nara
369 Final Charts and Tables
3610 Master Sheets and First Labels Thereof
Data Retrospective
3611 Null
3612 Difference in Effect by TSB
3613 Effects of Punch Card Items in Course
3614 Rising TSB
3615 Data V Clinical Bed Rest: Effects of Ambulation
3616 Data VIII Major: 4 Relapses, Etc.
Dietary Data
3617 Merme
3618 Retrospective Analyses: Old Stuff: First Run X, 1952
3619 Discharge Dates, 1st and 2nd Run, 1952
371 "The Treatment of Acute Hepatitis", J. of Clinical Inverstigation, Draft I, 1955
372 Epidemic Hemorrhagic Fever, 1951
373 First Experiment, 1950
374 Follow-up Chart, 1952-1953
375 Hepatitis Survey Group, 1952
376 Infectious Hepatitis Lecture, 1952
377 Kyoto lectures, 1951-1952
378 Kyoto Talks, 1951
379 Liver biopsy blinical reports, 1952
3710 Nara Randomization
3711 Physical fitness tests
3712-13 Preliminary Data I: Hepatitis Study: Kyoto, Japan, n.d
3714 Preliminary Data II: Hepatitis Study: Kyoto, Japan, 1951
3715 Protocols, 1952
381 First Run, 1951-1952
382 Follow-up States, 1952-1953
383 Second Run, 1952
384 Code Sheets
385 First Run Data
Randomization
386 Both Runs III
387 Data 2nd Run
388 Final Data V
389 First Run I
3810 Retrospective Data: Preliminary Labeling
3811 Study One and Two
3812 Supreme Sheet 1st and 2nd Run Data
3813-14 The Second Experiment
3815 Veterans Follow-Up, 1951
3815-17 Volunteer Study, 1953
Clinical Trial records
[RESTRICTED] According to HMD Access to Individual Health Information Policy. Contact Manuscripts Curator for information regarding access.
391 Best Rest Analysis Both Runs: Adhesive Figures
392 Case Summaries: On Patients Who Have Been Seen, 1952
393 [Computer Cards], 1952
394 Data: Weights
395 Dietary Data: Summary Master Flow Sheets: First Run
Follow-up
396 Form Letters, 1948-1953
397 NRC and Other Material, 1949-1952
398 Patients Addresses, 1952-1953
399 Study Lists, 1952
401-3 Hepatology
404 Liver Biopsies III: Personal
411 Second Study Data Graphs [transparencies]
412 Master Summary Diet Sheets: Second Run
413 Names, 1952
421-106 [Patient participation files], 1952-1953
431-2 [Patient information cards], 1952
433 [Patient notecards: Biopsi and Diagnosis Data], 1952
434 Protocols: Follow-up Sasebo, 1952-1953
435 Pts. Hospital in Interval, 1952-1953
436-11 Punch Cards: Patient Treatment Records, 1951-1952
441-4 Punch Cards: Patient Treatment Records (cont'd.), 1951-1952
445 Rocket Analysis Cards [patient treatment records]
446 Punched Card Code Sheets
447 Questionnaire Responses and Tabulations, 1952-1953
448 Sasebo Follow-up: Original Lab Worksheets, 1952-1953
449 Study Controls [exam results], 1947-1948
[Patient observation charts], [c. 1952]
451 1st Study, Ward #41
452 1st Study, Ward #23
453 1st Study, Ward #43
454 1st Study, Ward #21
461 2nd Study, Ward #23
462 2nd Study, Ward #41
463 2nd Study, Ward #43
464 2nd Study, Ward #21
465 Eosimophil Counts
466 Weight Flow Sheets
467 Miscellaneous First Run Laboratory
468 [Unidentified scraps/sheet portions]
469 [Unidentified diagnostic data, ward 21, 23, 41, 43]

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Series IV: Publications, 1954-1995

This series contains copies of Chalmers' published articles in such journals as the New England Journal of Medicine, The American Journal of Medicine, The Sciences, Controlled Clinical Trials, and The Mount Sinai Journal of Medicine. In addition, there are two bibliographies of Chalmers' publications. Among the many covered titles are clinical trials; meta-analysis; clinical gastroenterology and cardiology, and geriatrics.
BoxFolder
The series is organized into 6 sub-series covering work he authored at the Mt. Sinai Clinical Trials Unit, the Technology Assessment Group, Harvard School of Public Health, and papers submitted for publication or in press. These sub-series follow Chalmers' original order and numbering system (which is roughly chronological) as found in folder 1 of Papers, Clinical Trials Unit, Mt. Sinai, 1965-1992.
BoxFolder
Papers, Clinical Trials Unit, Mt. Sinai, 1965-1992
471 Papers Published from Clinical Trials Unit, Mt. Sinai, 1992
472 1.1 "A Note on Fatality in Serum Hepatitis", 1965
473 1.2 "The Present Status of Shunts for Portal Hypertension in Cirrhosis", 1966
474 1.3 "The Transaminase Tests in Liver Disease", 1967
475 1.5 "Controlled Studies in Clinical Cancer Research", 1972
476 1.6 "Nonevaluable Patients in Clinical Cancer Research", 1975
477 1.7 "Effects of Ascorbic Acid on the Common Cold: An Evaluation of the Evidence", 1975
478 1.8 "Randomized Controlled Clinical Trials in Diseases of the Liver"
479 1.9 "Evidence Favoring the Use of Anticoagulants in the Hospital Phase of Acute Myocardial Infarction", 1977
4710 1.10 "The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Control Trial", 1978
4711 1.11 "In Defense of the VA Randomized Control Trial of Coronary Artery Surgery", 1978
4712 1.12 "When and How to Stop a Clinical Trial: Invited Remarks", 1979
4713 1.13 "Cost and Efficacy of the Substitution of Ambulatory for Inpatient Care", 1981
4714 1.15 "The Clinical Trial", 1981
4715 1.16 "A Survey of Clinical Trials of Antibiotic Prophylaxis in Colon Surgery: Evidence Against further Use of No-treatment Controls", 1981
4716 1.17 "Randomized versus Historical Controls for Clinical Trials", 1982
4717 1.18 "Who Will Fund Clinical Trials?", 1982
4718 1.19 "Informed Consent, Clinical Research, and the Practice of Medicine", 1982
4719 1.20 "The Inadequate Evidence for Short Hospital Stay after Hernia or Varicose Vein Stripping Surgery", 1982
4720 1.21 "A Potpourri of RCT Topics", 1982
4721 1.22 "Concluding Session: A General Discussion: Conference on Recent History of Randomized Clinical Trials", 1982
4722 1.23 "Sensitivity and Specificity of Clinical Trials: Randomized vs. Historical Controls", 1983
4723 1.24 "Physician Attitudes toward Applications of Computer Data Base Systems", 1983
4724 1.25 "The Challenges of Clinical Measurement", 1983
4725 1.26 "Impact of Randomized Control Trials on the Treatment of Alcohol Withdrawal", 1983
4726 1.27 "Deficiencies of Clinical Trials of Alcohol Withdrawal", 1983
4727 1.28 "Association of Adrenocorticosteroid Therapy and Peptic-ulcer Disease", 1983
4728 1.29 "Bias in Treatment Assignment in Controlled Clinical Trials", 1983
4729 1.30 "Peer Review Using a Paired-comparison Technique", 1984
4730 1.31 "Should Mild Hypertension be Treated? An Attempted Meta–analysis of the Clinical Trials", 1985
4731 1.32 "Should the Risk of AIDS Deter Hepatitis B Vaccination?", 1984
4732 1.33 "Loss of Patients in Clinical Trials that Measure Long-term Survival following Myocardial Infarction", 1986
4733 1.34 "An Analysis of the Costs of Ambulatory and Inpatient Care", 1986
4734 1.35 "Meta-analyses of Randomized Controlled Trials", 1987
4735 1.36 "Meta-analysis of Randomized Control Trials of Nicotine Chewing-gum", 1987
4736 1.37 "The Lugano Statements on Controlled Clinical Trials", 1987
4737 1.38 "Differing Attitudes of Industry and Academia towards Controlled Clinical Trials", 1986
4738 1.41 "Publication Bias and Clinical Trials", 1987
4739 1.42 "Antiplatelet Agents and Secondary Prevention of Stroke: A Meta-analysis of the Randomized Control Trials", 1988
4740 1.43 "Dipyridamole in the Treatment of Agina Pectoris: A Meta-analysis", 1987
4741 1.44 "Organization, Review, and Administration of Cooperative Studies (Greenberg Report): A Report from the Heart Special Project Committee to the National Advisory Heart Council, May 1967", 1988
4742 1.45 "A Meta-analysis of Randomized Control Trials of Progestational Agents in Pregnancy", 1989
4743 1.46 "Endoscopic Hemostasis: An Effective Therapy for Bleeding Peptic Ulcers", 1990
47 Abstracts, Clinical Trials Unit, Mt. Sinai, 1983-1987
4744 2.24 "Good Technology and Poor Clinical Science", 1983
4745 2.41 "Technical Quality Assessment of Randomized Control Trials", 1987
47 Books and Chapters, Clinical Trials Unit, Mt. Sinai, 1981-1985
4746 3.1 "Emergency Diagnosis and Treatment of Gastrointestinal Hemorrhage", 1981
4747 3.2 "Critique of Methods and Timing", 1981
4748 3.3 "The Randomized Clinical Trial as a Basis for Therapeutic Decisions", 1982
4749 3.4 "Early Termination of the Clinical Trial", 1982
4750 3.5 "Randomized Clinical Trials and the Consumer", 1982
4751 3.6 "The Control Bias in Clinical Trials", 1983
4752 3.7 "Annotated Bibliography on the Impact of RCTs on Medical Practice", 1983
4753 3.9 "Critical Decision making in Obtaining Laboratory Data", 1984
4754 3.10 "Scientific Quality and the Journal of Holistic Medicine", 1985
4755 3.11 "The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Controlled Trials: Survey of Two Sets of 'Negative' Trials"
4756 3.12 "Meta-analysis of Randomized Control Trials: An Update of the Quality and Methodology"
47 Papers, Technology Assessment Group, Harvard School of Public Health, 1979-1992
4757 4.1 "Problems of Omissions in Communications on Clinical Trials", 1979
4758 4.2 "Reporting Standards and Research Strategies for Controlled Trials: Agenda for the Editor", 1980
4759 4.3 "Reporting on Methods in Clinical Trials"
4760 4.4 "Combination of Results of Stated Precision: I. The Optimistic Case", 1982
4761 4.5 "Reporting Clinical Trials in General Surgical Journals", 1984
4762 4.6 "Perusing the Literature", 1984
4763 4.7 "Using MEDLINE to Peruse the Literature", 1985
4764 4.8 "Perusing the Literature: Methods of Accessing MEDLINE and Related Databases", 1985
4765 4.9 "Using MEDLINE for Perusing the Literature: Software and Search Interface of Interest to the Medical Profession", 1985
4766 4.10 "Perusing the Literature: Comparison of MEDLINE Searching with a Perinatal Clinical Trials Database", 1985
4767 4.11 "Findings for Public Health from Meta-analysis", 1985
4768 4.12 "Adjuvant Chemotherapy for Breast Cancer: A Pooled Estimate Based on Published Randomized Control Trials., 1987
4769 4.13 "A Quality Assessment of Randomized Control Trials of Primary Treatment of Breast Cancer", 1986
4770 4.14 "Quality Assessment of Randomized Control Trials in Dental Research: I Methods", 1986
4771 4.15 "Quality Assessment of Randomized Control Trials in Dental Research: II Results: Periodontal Research", 1986
4772 4.16 "Look before you Quote", 1986
4773 4.17 "Meta-analysis in Clinical Medicine", 1987
4774 4.18 "Cost-effectiveness Analysis of Periodontal Disease Control", 1987
4775 4.19 "Adjuvant Therapy of Colorectal Cancer: Why We Still Don't Know", 1988
4776 4.20 "The Poor Quality of Early Evaluations of Magnetic Resonance Imaging", 1988
4777 4.21 "Commentary on Meta-analysis in Clinical Trials", 1988
4778 4.22 "More on MEDLINE Searches", 1988
4779 4.23 "Asbestos Exposure and Gastrointestinal Malignancy: Review and Meta-analysis", 1988
4780 4.24 "An Assessment of Publication Bias Using a Sample of Published Clinical Trials", 1989
4781 4.25 "A Meta-analysis of Alcohol Consumption in Relation to Risk of Breast Cancer", 1988
4782 4.26 "Meta-analysis of Randomized Control Trials as a Method of Estimating Rare Complications of Non-steroidal Anti-inflammatory Drug Therapy", 1988
4783 4.27 "Data Analysis in Gastroenterology: Vagotomy for Recurrent Duodenal Ulcer", 1988
4784 4.28 "Methodological Considerations in the Analysis of Cost-effectiveness in Dentistry", 1989
4785 4.29 "Chimiotherapie Adjuvante du Cancer Colorectal; qu' apprendre d'une Meta-analyse?"
4786 4.32 "Publication Bias: A Problem in Interpreting Medical Data", 1988
4787 4.33 "Publication Bias and Dissemination of Clinical Research", 1989
4788 4.34 "A Comparison of Statistical Methods for Combining Event Rates from Clinical Trials", 1989
4789 4.35 "The Effect of Study Design on Gain in Evaluations of New Treatments in Medicine and Surgery", 1988
4790 4.36 "How Study Design Affects Outcomes in Comparisons of Therapy: I Medical", 1989
4791 4.37 "How Study Design Affects Outcomes in Comparisons of Therapy: II Surgical", 1989
4792 4.38 "Randomized Clinical Trials of Transdermal Nitroglycerin Systems for the Treatment of Angina: A Meta-analysis", 1988
4793 4.39 "The Role of Clinical Trials in Healthcare: A Personal View", 1988
4794 4.40 "Retrospective Analyses for Hypothesis Generation: A Commentary on the PACK Trial", 1989
4795 4.42 "The Quality of Primary and Secondary Research and Meta-analysis", 1989
4796 4.43 "Meta-analysis of Branched-chain Amino Acids in Hepatic Encephalopathy (Editorial)", 1989
4797 4.44 "A Review of Clinical Research in Orthodontics", 1989
4798 4.45 "Meta-analyses in Gastroenterology", 1989
4799 4.46 "Symposium: Clinical Applications of Meta-analysis", 1989
47100 4.47 "Meta-analytic Evidence Against Prophylactic Use of Lidocaine in Acute Myocardial Infarction", 1989
47101 4.49 "A Cohort Study of Summary Reports of Controlled Trials", 1990
47102 4.52 "Updated (Cumulative or Sequential) Meta-analyses of Histamine (H2) - Blockers in the Treatment of Bleeding Peptic Ulcers", 1990
47103 4.54 "Some Statistical Methods for Combining Experimental Results", 1990
47104 4.55 "The Need for Early Randomization in the Development of New Drugs for AIDS", 1990
47105 4.57 "Split-mouth and Cross-over Designs in Dental Research", 1989
47106 4.58 "Quality Assessment and Meta-analysis of Systemic Tetracycline Use in Chronic Adult Periodontitis", 1992
47107 4.59 "Problems Induced by Meta-analysis", 1991
47108 4.60 "A Meta-analysis of Physical Activity in the Prevention of Coronary Heart Disease", 1990
47109 4.61 "An Empirical Study of the Possible Relation of Treatment Differences to Quality Scores in Controlled Randomized Clinical Trials", 1990
47110 4.62 "Measuring Outcomes in Clinical Research", 1991
47111 4.63 "Using Medical Registries and Data Sets for Technology Assessment", 1991
47112 4.64 "Technology Assessment in the Connecticut Tumor Registry", 1991
47113 4.65 "Use of the SEER Cancer Registry for Technology Assessment", 1991
47114 4.66 "Technology Assessment in the Normative Aging Study", 1991
47115 4.67 "Technology Assessment in the Veterans Administration Dental Longitudinal Study", 1991
47116 4.68 "Technology Assessment in the Coronary Artery Surgery Study", 1991
47117 4.69 "Using Medical Registries and Data Sets for Technology Assessment: An Overview of Seven Case Studies", 1991
47118 4.71 "Meta119-analysis and Quality Assessment of Local Tetracycline use in Treatment of Chronic Adult Periodontitis", 1991
47119 4.72 "Update on Technology Assessment in Dentistry", 1992
47120 4.74 "Economic Analysis in Randomized Control Trials", 1992
47121 4.75 "A Comparison of Results of Meta-analyses of Randomized Control Trials and Recommendations of Clinical Experts", 1992
47122 4.76 "Cumulative Meta-analysis of Therapeutic Trials for Myocardial Infarction", 1992
47123 4.79 "Assessment of the Efficacy and Safety of Antiarrhymic Therapy for Chronic Atrial Fibrillation: Observations on the Role of Trial Design and Implications of Drug-related Mortality", 1990
47124 4.80 "Some Progress and Problems in Meta-analysis of Clinical Trials", 1992
47 Books and Chapters, Technology Assessment Group, Harvard School of Public Health, 1954-1991
47125 6.1 "Selected Quantitative Techniques", 1954
47126 6.2 "Assessing Social Innovations: An Empirical Base for Policy", 1975
47127 6.3 "How Well do Social Innovations Work?", 1975
47128 6.4 "How Frequently Do Innovations Succeed in Surgery and Anesthesia?", 1977
47129 6.5 "Progress in Surgery and Anesthesia: Benefits and Risks of Innovative Therapy"
47130 6.6 "Combination of Results of Stated Precision: I. A More Realistic Case", 1984
47131 6.7 Medical Uses of Statistics
47132 6.8 "A Computer-driven Shift in the Practice of Medicine", n.d
47133 6.9 "Clinical Trials of Treatment", 1986
47134 6.10 "The Randomized Control Trials of Prevention of Myocardial Infarction", 1986
47135 6.11 "Meta-analysis as Applied to Post-marketing Surveillance", 1987
47136 6.12 "Randomized Control Trials and Meta-analysis of the Treatment of Cirrhosis of the Liver", 1987
47137 6.13 "Hormone Therapy for the Maintenance of Pregnancy"
47138 6.14 "Clinical Trials", 1988
47139 6.18 "The Evaluations of Surgical Therapies", 1989
47140 6.22 "Who is Interested in Clinical Trials? The Potential for and Methods of Minimizing Bias in Funded Research", 1991
47 Papers Submitted for Publication or in Press, 1990-1995
47141 7.1 "Declining Incidence of Ventricular Fibrillation", 1992
47142 7.3 "Reporting the Results of Observational Studies: The Nutrition and Periodontal Disease Relationship"
47143 7.6 "Patient Controlled Analgesia in the Postoperative Patient: Meta-analysis of Initial Randomized Control Trials", 1992
47144 7.8 "Antipsychotic Drugs: Is More Worse? A Meta-analysis of the Published Randomized Control Trials", 1990
47145 7.12 "The Design, Analysis, and Reporting of Research: Findings from Meta-analysis", 1990
47146 Chalmers Bibliography, 1993
47147 Reprints, 1992-1995

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Series V: Conferences, 1983-1991

This series contains correspondence, notes, information packets, schedules, and travel documents relating to the various conferences Chalmers attended during the 1980s and early 1990s. The series is arranged alphabetically by file folder.
BoxFolder
47148 54th Scientific Meeting, American College of Rheumatology, Seattle, Washington, 10/8-11/1, 1990
47149 62nd Scientific Sessions, 1986-1989
47150 Acapulco, 6/19-22, 1989
47151 Agency for Health Care Policy and Research, Chicago, 6/20-21, 1991
47152 Agency for Health Care Policy and Research, Moshman Associates, 7/11, 1990
47153 AIDS, Washington, D.C., 11/19-21, 1989
47154 American Association for the Advancement of Science, Annual Meeting, 2/15-16, 1990
47155 American College of Surgeons, 10/8, 1990
47156 American Medical Association, Technology PD, 10/28, 1988
47157 Association of American Physicians, American Society of Clinical Investigations, American Federation for Clinical Trials, Washington, D.C., 4/28-5/1, 1989
47158 Barcelona, 1990
47159 China, April, 1983
47160-162 Collegium Ramazzini, Italy, 1986-1991
47163 Coolfont Conference, Environmental Epidemiology Committee, MAS, Virginia, 10/14-17, 1990
47164 Copy of Washington, D.C. Trip, 1/14-15, 1988
47165 D.C. - Chicago - D.C. - Iowa City, 11/12-18, 1988
47166 Dallas, 4/14-15, 1988
47167 Data Training Workshop Papers, BWI Airport, 1990
47168 Hans Popper, New Concepts in Medical Biology, December, 1988
47169 IMA GO 90, Bologna , Italy, 4/27-29, 1989
47170 Innsbruck, Rome, Corsendonck, August- September, 1988
47171 Institute of Medicine, May 3-June 9, 1989
47172 Institute of Medicine, PO Effectiveness, 1988
47173 International Biometric Conference, Brussels, Belgium, 7/7-11, 1987-1988
47174-176 International Physicians for the Prevention of Nuclear War, Inc., Montreal (includes transparencies for Katherine Forrest), 1988
47177 Interplan Germany, 1988
47178-179 Iowa City, 1988
481 Iowa City, 1988
482 ISI, Paris, France, 8/29-9/6, 1989
483 Jassen Research Council, WASL FIB, 1988
484-5 Madrid, 1990
486 Minnesota Colon Cancer Study, 10/13-14, 1988
487 Montreal General Hospital, PD, 9/23, 1988
488 National Institutes of Health, Bethesda, MD, 10/18, 1989
489 Office of Medical Applications of Research, National Institutes of Health, Meetings on Clinical Trials, 1989-90
4810-11 Port, Agency for Health Care Policy and Research, Baltimore, 1990
4812 Posch, Chicago, O'Hare, 1988
4813 Rochester, Minnesota Meeting, 5/21-23, 1989
4814 San Francisco P., 2/13-15, 1988
4815 Schedule and Correspondence, 1988-1989
4816-17 Seattle, WA, 1989-1991
4818 Society for Clinical Trials, Minneapolis, Minnesota, 5/15-18, 1989
4819 Society of Salk Scholars 3rd Annual Scientific Conference, 10/26, 1990
4820 Taiwan, Clinical Trials Imaging Procedures, 1983
4821 The Southern Society for Pediatric Research, New Orleans, 2/3-5, 1988
491 Toronto, 1989
492 U. Gastroenterology International, Washington, D.C., 5/14, 1989
493 University of Texas Health Science Center at Dallas Medical School, Dallas, 4/14-15, 1988
494 Veterans Administration, Chicago, 1983
495 Washington, Katanserin, 3/14, 1988
496 Washington, National Leadership, PD, 3/18, 1988
497 World Congress of New Castle, New Castle, Australia, 8/29, 1990

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Series VI: Audiotapes, 1963

This series contains two reel-to-reel audiotapes. Documentation on the tapes is poor with one tape lacking any documentation. The "Pathogenesis and Medical Treatment of Ascites Thomas C. Chalmers... " tape also contains lectures by various other speakers; a table of contents is included.
BoxFolder
498 "Pathogenesis and Medical Treatment of Ascites" Thomas C. Chalmers, Internal Medicine, Vol. 10, Number 19, 10/7/1963
499 Untitled [open reel]

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Last reviewed: 04 January 2008
Last updated: 02 November 2006
First published: 18 June 2004
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