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Abstract

Grant Number:	1F37LM007699-01
Project Title:	Semantic Model of SNOMED as a Bayesian Network

PI Information:	Name	Email	Title
	ZIMMERMAN, KURT LEE.	kzimmerm@vt.edu

Abstract: DESCRIPTION (provided by applicant): Clinical pathology data provides a basis for medical decision-making. Uncertainty is introduced into medical-decision-making by irreducible Biologic variability in patient data, ambiguities in communication of data, and the cognition of the decision-making process. Controlled medical terminologies (CMT) and medical decision support systems (DSS) reduce the uncertainty contributed by the latter two sources. Medical DSS are typically comprised of: an interface for data input and output, a knowledge base (KB) for storage of facts, and an inference engine for deriving new information. CMT employ knowledge representation formats similar to those used in DSS KBs. This study will evaluate the semantic network used by the Systematized Nomenclature of Medicine (SNOMED) for use as a KB in a Bayesian DSS to classify rodent liver disorders using clinical chemistry data. The primary aims of this proposal are to 1) assess SNOMED's ability to represent liver disorder concepts, 2) develop a formal methodology for adapting the semantic network of SNOMED for use in a Bayesian network and 3) evaluate the functionality of the resulting DSS using retrospective clinical chemistry data from drug toxicity studies. If SNOMED can functional as a KB to meet these aims, other domain-specific medical DSS can be created using the methodologies developed in this study.

Public Health Relevance:
This Public Health Relevance is not available.

Thesaurus Terms:
data collection methodology /evaluation, information system, method development, veterinary medicine
clinical chemistry, computer network, drug /agent, liver disorder, pathology, toxicology
laboratory rat, postdoctoral investigator

Institution:	VIRGINIA POLYTECHNIC INST AND ST UNIV
	OFFICE OF SPONSORED PROGRAMS
	BLACKSBURG, VA 24060
Fiscal Year:	2002
Department:	BIOMEDICAL SCIENCES AND PATHOBIOLOGY
Project Start:	03-SEP-2002
Project End:	31-JUL-2004
ICD:	NATIONAL LIBRARY OF MEDICINE
IRG:	BLR

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