| Version 2.5.2.0 |
|
|
Abstract
Grant Number: 5P41LM005799-07 Project Title: BIOLOGICAL MAGNETIC RESONANCE DATA BANK
PI Information: Name Title MARKLEY, JOHN L. markley@nmrfam.wisc.edu PROFESSOR Abstract: BioMagResBank (BMRB) is designed to provide the scientific community with easy access to the wealth of data on biological macromolecules derived from solution-state NMR spectroscopy. Currently about 20% of new macromolecular structures are derived from NMR data, and BMRB is the unique resource worldwide designed to collect the underlying NMR data from these structures. BMRB also has the ability to archive quantitative data from the equally large set of published biomolecular NMR studies that, although not yielding complete three-dimensional coordinate sets, provide information at atomic resolution about local structure, dynamics, and chemical properties. It is envisioned that the availability of these data (local and global structure, parameters specifying local dynamics, local structural heterogeneity, pKa values, H-exchange rates, assigned chemical shifts, coupling constants, etc.) will facilitate our understanding of macromolecular structure and function and will catalyze the development of new avenues of research. Because BMRB is designed with an open architecture and maintains a relational database, it can respond quickly to changes in the biomolecular field (data types to be stored) and in standards for data exchange. BMRB has developed interoperability with the Protein Data Bank (PDB, Brookhaven) and the Nucleic Acid Database (NDB, Rutgers). BMRB has initiated collaborations with the newly funded Research Collaboratory for Structural Bioinformatics (RCSB or 'new PDB', Rutgers/NIST/San Diego Supercomputer Facility) and the European Bioinformatics Institute (EBI). The goal of these collaborations is to provide global access to a unified macromolecular structure database. The NMR component of this unified database, maintained at BMRB and mirrored elsewhere, will provide access to a wide range of data derived from macromolecular NMR investigations. The requested budget is that needed to enable BMRB to: (l) verify, reformat, archive, and distribute new data submitted electronically, (2) maintain a productive dialogue with the users and creators of biomolecular NMR data through interactions with individuals and with the BMRB Advisory Board, (3) collaborate with data banks specializing in x-ray crystallographic data and with software developers. The goal is to present users with a unified, global, macromolecular structure database that enables the broad scientific community to use this information in meaningful ways.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
chemical information system, nuclear magnetic resonance spectroscopy, nucleic acid structure, protein structure, structural biology
Internet, archive, chemical structure function, computer network, computer program /software, information retrieval, information system analysis, thermodynamics
X ray crystallography, bioimaging /biomedical imaging
Institution: UNIVERSITY OF WISCONSIN MADISON 21 N. Park Street, Suite 6401 MADISON, WI 537151218 Fiscal Year: 2002 Department: BIOCHEMISTRY Project Start: 01-SEP-1996 Project End: 31-AUG-2004 ICD: NATIONAL LIBRARY OF MEDICINE IRG: BLR