NOTICE OF LIMITED COMPETITION REQUEST FOR COMPETITIVE RENEWAL APPLICATION: 
THE EARLY DETECTION RESEARCH NETWORK DATA MANAGEMENT AND COORDINATING CENTER

RELEASE DATE:  April 23, 2004

NOTICE:  NOT-CA-04-009

National Cancer Institute (NCI) 
 (http://www.nci.nih.gov)

The National Cancer Institute is requesting a competitive renewal 
application from the current awardee of the Early Detection Research 
Network Data Management and Coordinating Center.  The Early Detection 
Research Network (EDRN) promotes and supports research on the 
development, evaluation, and validation of biomarkers for earlier 
cancer detection and risk assessment.  The EDRN has four main 
components: Biomarker Developmental Laboratories, Biomarker Reference 
Laboratories, Clinical Epidemiology and Validation Centers, and a Data 
Management and Coordinating Center (DMCC).  The DMCC provides 
statistical and computational analysis, data management for network 
biomarker validation studies, and informatics infrastructure and 
coordinates network-wide meetings and conferences. 

The incumbent DMCC has made a significant contribution to establishing 
guidelines for biomarker validation, developed the operation procedures 
of the EDRN, and designed the EDRN data collection and management 
system   It is participating in the two ongoing validation trials, 
working with several EDRN investigators to develop protocols to 
validate new biomarkers, and developing an Information Technology 
infrastructure for distributed data and tools.  Maintaining the current 
DMCC would allow for continuous support of the EDRN program and 
facilitate the NCI’s efforts to validate biomarkers for early cancer 
detection.

NCI will contact the current awardee directly regarding application 
procedures and format.  Written and telephone inquiries concerning this 
may be directed to:

Sudhir Srivastava, Ph.D., M.P.H.
Chief, Cancer Biomarker Research Group
Division of Cancer Prevention
National Cancer Institute
6130 Executive Blvd, EPN Room 3142
Bethesda, MD 20892
Rockville, MD 20852 (for express/courier service)
Telephone:  (301) 435-1594
FAX:  (301) 402-8990
E-mail: srivasts@mail.nih.gov

or

Paul Wagner, Ph.D.
Program Director, Cancer Biomarker Research Group
Division of Cancer Prevention
National Cancer Institute
6130 Executive Blvd, EPN Room 3140
Bethesda, MD 20892
Rockville, MD 20852 (for express/courier service)
Telephone:  (301) 496-9424
FAX:  (301) 402-8990
E-mail: wagnerp@mail.nih.gov

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