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Table 7A. Summary of Studies Evaluating Interest in or Intention to Have Genetic Counseling and Testing for Familial Colorectal Cancer (FCC)a
Study Population
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Nb
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Interest or Intention in Genetic Counseling (GC) or Genetic Testing (GT)c
|
General population (UT), RDDSd [1] |
401 |
47% very interested in GT; 35% somewhat interested in GT |
General population (UT), RDDS [2] |
383 |
47% very interested in GT; 37% somewhat interested in GT |
Unaffectedefirst-degree relatives (FDRs) of colorectal cancer (CRC) patients from tumor registry [8] |
426 |
46% GC intention; 26% definite GT intention |
Unaffected FDRs of CRC patients from hereditary colon cancer registry (HCCR) [7] |
1373 |
77% definite GT intention if free; 15% probable |
CRC patients from an oncology center and community [12] |
98 |
52% definite GT interest; 20% probable |
Unaffected FDRs of CRC patients from an oncology center and community [13] |
95 |
84% GT interest |
Focus groups of CRC patients and unaffected FDRs from an oncology center and community [14] |
28 CRCs |
CRCs: 96% GT interest before group; 89% after group |
33 FDRs |
FDRs: 82% before group; 42% after group |
General population (Ontario, Canada), RDDS [3] |
501 |
81% interested in GT if test is 80% predictive; 77% interested if test is 90% accurate; 67% interested if 1% of population inherits FCC gene mutation |
General population (Vermont, New Hampshire, Maine), RDDS [4] |
1836 |
GT intention in next 6 months: 32% probably/definitely; 19% possibly |
GT intention in next month: 19% probably/definitely; 12% possibly |
aAll studies used a cross-sectional design, with the exception of one study, which used focus groups.[14] All studies were conducted in the United States, with the exception of one Canadian study.[3]
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bIndicates number of participants older than 18 years, unless otherwise specified.
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cType of genetic test not specified.
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dRandom Digit Dial Survey with general population samples.
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eUnaffected = no previous diagnosis of colorectal cancer.
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References
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Kinney AY, Choi YA, DeVellis B, et al.: Interest in genetic testing among first-degree relatives of colorectal cancer patients. Am J Prev Med 18 (3): 249-52, 2000.
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Kinney AY, DeVellis BM, Skrzynia C, et al.: Genetic testing for colorectal carcinoma susceptibility: focus group responses of individuals with colorectal carcinoma and first-degree relatives. Cancer 91 (1): 57-65, 2001.
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