Also called: Also called: CJD
Creutzfeldt-Jakob disease (CJD) is a rare, degenerative brain disorder. Symptoms usually start around age 60. Memory problems, behavior changes, vision problems and poor muscle coordination progress quickly to dementia, coma and death. Most patients die within a year.
The three main categories of CJD are
- sporadic CJD, which occurs for no known reason
- hereditary CJD, which runs in families
- acquired CJD, which occurs from contact with infected tissue, usually during a medical procedure
Cattle can get a disease related to CJD called bovine spongiform encephalopathy (BSE) or "mad cow disease." It is possible that people can get a variant of CJD from eating beef from an infected animal.
National Institute of Neurological Disorders and Stroke
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Creutzfeldt-Jakob Disease(National Institute of Neurological Disorders and Stroke) - http://www.ninds.nih.gov/disorders/cjd/detail_cjd.htm
Also available in Spanish http://espanol.ninds.nih.gov/trastornos/laenfermedad_de_creutzfeldt_jakob.htm
- Transmissible Spongiform Encephalopathies (Prion Diseases)(National Institute of Neurological Disorders and Stroke) - Short Summary - http://www.ninds.nih.gov/disorders/tse/tse.htm
- vCJD (Variant Creutzfeldt-Jakob Disease)(Centers for Disease Control and Prevention) - http://www.cdc.gov/ncidod/dvrd/vcjd/qa.htm
- Creutzfeldt-Jakob Disease(National Institute of Neurological Disorders and Stroke) - Short Summary - http://www.ninds.nih.gov/disorders/cjd/cjd.htm
- Creutzfeldt-Jakob Disease (Mad Cow Disease)(Mayo Foundation for Medical Education and Research) - http://www.mayoclinic.com/print/creutzfeldt-jakob-disease/DS00531/METHOD=print&DSECTION=all
- Prion Diseases(National Institute of Allergy and Infectious Diseases) - http://www3.niaid.nih.gov/healthscience/healthtopics/prion/default.htm
- New Test Scans Beef for Mad Cow Disease(08/12/2008, HealthDay) - http://www.nlm.nih.gov/medlineplus/news/fullstory_68073.html
- Creutzfeldt-Jakob Disease Fact Sheet for Healthcare Workers and Morticians(National Institute of Neurological Disorders and Stroke) - http://www.ninds.nih.gov/disorders/cjd/cjdprecautions.htm
- CJD (Creutzfeldt-Jakob Disease, Classic)(Centers for Disease Control and Prevention) - http://www.cdc.gov/ncidod/dvrd/cjd/
- Prions and Transmissible Spongiform Encephalopathies(Center for Food Safety and Applied Nutrition) - http://www.cfsan.fda.gov/~mow/prion.html
- Questions and Answers on Bovine Spongiform Encephalopathy(Center for Biologics Evaluation and Research) - http://www.fda.gov/cber/bse/bseqa.htm
- vCJD (Variant Creutzfeldt-Jakob Disease)(Centers for Disease Control and Prevention) - http://www.cdc.gov/ncidod/dvrd/vcjd/
- Bovine Spongiform Encephalopathy: Production and Inspection(Dept. of Agriculture, Food Safety and Inspection Service) - http://www.fsis.usda.gov/Fact_Sheets/Bovine_Spongiform_Encephalopathy_Mad_Cow_Disease/index.asp
- Creutzfeldt-Jakob Disease (Variant) and Bovine Spongiform Encephalopathy (Prion Diseases): Health Information for International Travel(Centers for Disease Control and Prevention) - http://wwwn.cdc.gov/travel/yellowBookCh4-VariantPrions.aspx
- Information for People Treated with Human Growth Hormone (Summary)(National Institute of Diabetes and Digestive and Kidney Diseases) - http://www.endocrine.niddk.nih.gov/pubs/creutz/update.htm
- ClinicalTrials.gov: Creutzfeldt-Jakob Syndrome(National Institutes of Health) - http://clinicaltrials.gov/search/open/condition=%22Creutzfeldt-Jakob+Syndrome%22
- ClinicalTrials.gov: Prion Diseases(National Institutes of Health) - http://clinicaltrials.gov/search/open/condition=%22Prion+Diseases%22
- Genetics Home Reference: Prion disease(National Library of Medicine) - http://ghr.nlm.nih.gov/condition=priondisease
- Pressure Combined with Heat Reduces Prion Infectivity in Processed Meats(National Institute of Neurological Disorders and Stroke) - http://www.ninds.nih.gov/news_and_events/press_releases/pressrelease_prion_infectivity_050503.htm
- Prion Diseases: Basic Research(National Institute of Allergy and Infectious Diseases) - http://www3.niaid.nih.gov/topics/prion/basicResearch.htm
- Article: The problem in setting research priorities: a layman's experience. - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=18614461&tool=MedlinePlus
- Article: Implications for Creutzfeldt-Jakob disease (CJD) in dentistry: a review of... - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=18502958&tool=MedlinePlus
- Article: Systematic review of therapeutic interventions in human prion disease. - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=18391159&tool=MedlinePlus
- Creutzfeldt-Jakob Disease -- see more articles - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=creutzfeldt-jakob+syndrome[majr]+AND+humans[mh]+AND+english[la]+AND+(jsubsetaim[text]+OR+jsubsetn[text]+OR+jsubsetk[text]+OR+review[pt]+OR+guideline[pt]+OR+clinical+trial[pt]+OR+patient+education+handout[pt]+OR+systematic[sb])+NOT+(editorial[pt]+OR+letter[pt]+OR+case+reports[pt])&doptcmdl=summary&cmd_current=Limits&pmfilter_EDatLimit=last+1+Year&tool=MedlinePlus
- Mad cow disease -- see more articles - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=encephalopathy,bovine+spongiform[majr]+AND+english[la]+NOT(case+reports[pt]+OR+editorial[pt]+OR+letter[pt])&doptcmdl=summary&cmd_current=Limits&pmfilter_EDatLimit=last+1+Year&tool=MedlinePlus
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Centers for Disease Control and Prevention - http://www.cdc.gov/
Also available in Spanish http://www.cdc.gov/spanish/
- Dept. of Agriculture, Animal and Plant Health Inspection Service - http://www.aphis.usda.gov/
- Food and Drug Administration - http://www.fda.gov/
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National Institute of Neurological Disorders and Stroke - http://www.ninds.nih.gov/
Also available in Spanish http://espanol.ninds.nih.gov/
- USDA's BSE Surveillance Efforts(Dept. of Agriculture) - Links to PDF - http://www.aphis.usda.gov/publications/animal_health/content/printable_version/fs_BSE_ongoing_vs.pdf
- BSE (Bovine Spongiform Encephalopathy, or Mad Cow Disease)(Centers for Disease Control and Prevention) - http://www.cdc.gov/ncidod/dvrd/bse/
- Mad Cow Disease(Nemours Foundation) - http://kidshealth.org/parent/infections/bacterial_viral/mad_cow_disease.html
- What's Mad Cow Disease?(Nemours Foundation) - http://kidshealth.org/kid/talk/qa/mad_cow_disease.html
- Mad Cow Disease(Nemours Foundation) - http://kidshealth.org/teen/infections/bacterial_viral/mad_cow_disease.html
- Brain and Nerves - http://www.nlm.nih.gov/medlineplus/brainandnerves.html
The primary NIH organization for research on Creutzfeldt-Jakob Disease is the National Institute of Neurological Disorders and Stroke - http://www.ninds.nih.gov/