Skip directly to: content | left navigation | search

PUBLIC HEALTH ASSESSMENT ADDENDUM

LETTERKENNY ARMY DEPOT
USA LETTERKENNY SOUTHEAST AREA
CHAMBERSBURG, FRANKLIN COUNTY, PENNSYLVANIA

AND
USA LETTERKENNY - PROPERTY DISPOSAL OFFICE AREA
CHAMBERSBURG, FRANKLIN COUNTY, PENNSYLVANIA



CONCLUSIONS

  1. ATSDR considers the Property Disposal Office Area and the Southeastern Area at Letterkenny to be Indeterminate Public Health Hazards. This determination was made because there are data gaps in on-and off-site environmental data and in site-specific health outcome data. Those data gaps are further discussed below.

  2. Potential exposure pathways both on and off site have been identified. On-site environmental characterization at Letterkenny is underway and will be reviewed when complete.

  3. Off-site potential exposure pathways include ingesting food products irrigated and farm animals (and associated products) watered with VOC-containing springs and wells. During 1993, a farm animal products study will be conducted. In addition, a hydrogeological study off-site of the SE and PDO Areas and sampling of off-site private wells with prior lead detections near the PDO Area will be conducted during 1993. Those studies will help identify the potential source of lead contamination. Those potential pathways cannot be evaluated until the results from those sampling data are available.

  4. In the past, off-site residents east of the SE Area were exposed to private well water containing VOCs at concentrations exceeding Maximum Contaminant Levels (MCLs). Those people were potentially exposed to contaminant levels which may result in adverse health effects. However, the actual concentration ranges and duration of exposure are unknown. Exposures stopped when residences with detected contamination in their wells were supplied bottled water in 1982. Possible health effects associated with past use of VOC-contaminated drinking water are unknown because of both lack of environmental exposure information and published data on health effects stemming from low-level, chronic exposure to multiple contaminants.

  5. Evaluation of two sets of health outcome data, from 1959 to 1979 and 1979 to 1981, found no elevated cancer mortality rates for either men or women of Franklin County. The knowledge of the duration of exposures together with site-specific health outcome data are necessary to determine possible adverse health effects from site-related exposures. At this time, those data are not available.

  6. This site is not being considered for dose reconstruction because of the hydrogeological conditions at Letterkenny; the underlying limestone aquifer is characterized by fracture and solution cavity-controlled permeability. Thus, intensive data collection would be necessary to accurately model the behavior of the aquifer underlying Letterkenny and beyond the boundary. Hydrogeological studies are planned for areas off-site of the SE and PDO Areas. Once those data become available, it may be feasible to conduct dose reconstruction analysis at Letterkenny.

  7. Persons associated with past exposure pathways via private wells are not being considered for inclusion in a registry because criteria for conducting such actions are not met. Persons at Letterkenny were exposed to more than one VOC, and at this time, ATSDR does not have a multiple-VOC exposure registry. Because there were a relatively small number of persons using those wells and the exposure duration is unknown, it is not feasible to include those persons in a registry at this time. If new hydrogeological data allow dose reconstruction analysis, inclusion in a registry may be reconsidered.

  8. Other off-site wells near the SE and PDO Areas were detected with carbon tetrachloride, aluminum, and lead in 1991. Those data are based on one sampling event. The maximum concentration of carbon tetrachloride has been evaluated and is not expected to result in adverse health effects. Exposure to aluminum and lead occurred for an unknown period of time, and the source of aluminum and lead may be associated with the residential piping. Lead is bioaccumulated, and any lead exposure to children may potentially add to their lead body burden.

  9. It is not possible to separate the surface water and groundwater pathway because surface waters at and near Letterkenny may either emerge at springs or submerge at sinkholes. The geologic variability of the site has precluded the definition of a contaminant plume in the unconfined, fractured limestone aquifer.

  10. Intermittent or incidental exposure may occur via dermal contact with and ingestion and inhalation of contaminants which have volatilized from surface waters in the SE and PDO Areas as well as in off-site creeks and springs. Human exposure to the previously detected concentrations of VOCs in those open areas is not likely to result in adverse health effects because of the limited duration of exposure and low levels previously detected.

  11. There are contaminated soils on site at Letterkenny. Those soils are in areas where remediation is occurring or where only limited numbers of installation and maintenance personnel would have access. Site restriction to personnel and use of appropriate protective gear during sampling, remediation, or maintenance activities would diminish the possibility of exposure.

  12. Additional environmental characterization of the SWMUs has begun. Most of the SWMUs are in the AD/AS Area, but two of them are in the SE Area. That information will determine if deer that inhabit and are hunted in the AD/AS Area are exposed to soil contaminants that may bioaccumulate in deer tissue. Until those data are collected and analyzed, potential exposure pathways cannot be delineated.

  13. As noted in the Toxicologic Evaluation section of this public health assessment, health guidelines needed to address all exposure routes (ingestion, inhalation, and dermal contact) are not available for all contaminants to which people were potentially exposed through the use of contaminated private well water. More information is needed about adverse health effects that may result from exposure to multiple chemicals, i.e., VOCs and metals.

RECOMMENDATIONS

  1. Continue to assess the hydrogeological conditions off-site of the SE, PDO, and AD/AS Areas. If environmental sampling or hydrogeological studies indicate that substances from Letterkenny may be migrating toward off-site private wells that were not supplied with municipal water, identify and periodically monitor those wells.

  2. Resample the six private wells that remain in service with lead detected at concentrations greater than the EPA action level of 15 µg/L. Current data are based on one sampling event. Samples should be collected from the wellhead and at the tap prior to and after "flushing" the piping system. The detection limit for lead should be set below the EPA action level of 15 µg/L.

  3. Educate persons with lead in their drinking water at concentrations greater than the EPA action level about corrective measures, such as flushing the water system prior to use, that can be taken to reduce lead levels in their well water.

  4. Continue to characterize Rowe Run Spring for addition of a groundwater treatment plant. Also, identify how surface waters are used in order to further evaluate potential and/or completed exposures.

  5. Continue to periodically sample fish tissue in the PDO Area in Rocky Spring Lake.

  6. Farm animals and associated products should be analyzed for the VOCs and metals previously detected in off-site private wells. Those potential food chain pathways cannot be evaluated until those data become available.

  7. Continue to characterize the SWMUs in the AD/AS and SE Areas. Monitoring should be conducted for site-related contaminants. The results from those ongoing studies will be evaluated by ATSDR upon their completion.

  8. Develop health guidelines, such as Minimal Risk Levels, for contaminants for all exposure routes (ingestion, inhalation, and dermal contact). Health guidelines are needed for 1,1,1-TCA, 1,1,2,2-PCA, 1,2-DCA, TCE, Chloroform, T-1,2-DCE, Aluminum, and Lead. Additional discussion on guidelines lacking for specific contaminants in this public health assessment are discussed in the Toxicologic Evaluation section. Validated studies should also be conducted or funded by ATSDR, EPA, or other appropriate agencies to determine possible health effects that may be associated with simultaneous exposure to multiple VOCs and to mixtures of VOCs and metals (i.e., TCE, 1,2-DCA, and lead).

  9. The data and information in the Public Health Assessment for the two NPL sites at the Letterkenny Army Depot, USA Letterkenny Southeastern Area and USA Letterkenny - PDO, have been evaluated for follow-up health activities by the ATSDR Health Activities Recommendations Panel (HARP). Community health education has been conducted by the Army through established technical review committee meetings, public meetings, and individual meetings with concerned citizens. Letterkenny continues to distribute environmental fact sheets to the public and communicate private well sampling results to homeowners whose wells have been sampled. The Army has also provided an alternate water supply to residences with wells containing concentrations of VOCs greater than MCLs. Currently, there are no indications that adverse health conditions are occurring or have occurred from past exposures to Letterkenny contaminants. Past exposures were for an unknown duration. However, if during the site-characterization and remediation process, environmental or health outcome data become available that indicate human exposure to hazardous substances is occurring at levels of public health concern, ATSDR will reevaluate the sites to determine necessary followup.

PUBLIC HEALTH ACTION PLAN

The public health action plan for the Letterkenny Army Depot sites contains a description of actions to be taken by ATSDR and/or other governmental agencies at and in the vicinity of the sites after completing this public health assessment. The purpose of the public health action plan is to ensure that the public health assessment not only identifies public health hazards, but provides a plan of action designed to mitigate and prevent adverse human health effects resulting from exposure to hazardous substances in the environment. Included is ATSDR's commitment to follow up on the plan and ensure that it is implemented. Public health actions to be implemented are as follows:

A. Actions Undertaken

  1. Letterkenny Army Depot has provided the community with alternate water supplies (bottled water and connections to municipal water supplies) for potable use when VOCs greater than MCLs were detected in residential wells, off-site and adjacent to the SE Area.

  2. Community health activities undertaken by Letterkenny Army Depot include the preparation and distribution of quarterly, environmental fact sheets, communication of sampling results to private well owners, and meeting with community members to discuss remediation and environmental sampling planned for Letterkenny or the surrounding area. The environmental fact sheets discuss the developments under the Installation Restoration Program at Letterkenny to enable the community to become more involved with the environmental cleanup program. The fact sheets are entitled "Environmental Issues" and began in 1991. There are approximately 475 readers currently on the fact sheet mailing list. Estimated distribution dates are January, April, July, and October for 1993 (106).

  3. The Groundwater Treatment Plant near the IWTP lagoon in the SE Area has been in operation at Letterkenny since 1989. Remediation of the IWTP lagoon is completed, and closure certification is expected in 1993.

Actions Planned

  1. Letterkenny Army Depot, various Army agencies, EPA, PADH, PADER, and ATSDR will continue to provide current health information to the community to assess any possible adverse health outcomes associated with exposure to hazardous substances.

  2. In 1993, low temperature treatment of the K Area soils in the SE Area will be conducted. Further investigation at the Solid Waste Management Units primarily in the AD/AS Area will be conducted during 1993 (106). A groundwater treatment plant will be considered for Rowe Run Spring near the SE Area, if indicated by environmental sampling results and hydrogeological studies being conducted in 1993 (118).

  3. Letterkenny Army Depot in conjunction with various Army agencies will continue to perform field studies to evaluate the potential for uptake of contaminants into farm animals and their by products from Rowe Run Spring, off-site near the SE Area. Also, fish tissue in the Rocky Spring Lake system will also be analyzed for potential contaminant uptake. Those studies will be conducted during 1993.

  4. ATSDR will reevaluate and expand the public health action plan when needed. New environmental, toxicologic, or health outcome data, or the results of implementing the above proposed actions may determine the need for additional actions at the Letterkenny Army Depot NPL sites.

PREPARERS OF REPORT

Linda K. West, M.S.P.H.
Environmental Health Scientist

W. Mark Weber, Ph.D.
Geologist

Mark W. Evans, Ph.D.
Environmental Geologist

ATSDR Regional Representative:
Jack Kelly
Field Operations Branch
EPA Region III


REVIEWERS OF REPORT:

C. Virginia Lee, M.D., M.P.H.
Medical Officer
Federal Programs Branch
Division of Health Assessment and Consultation

Gary H. Campbell, Ph.D.
Environmental Health Scientist
Chief, Army Unit, Defense Facilities Assessment Section
Federal Programs Branch
Division of Health Assessment and Consultation

John E. Abraham, Ph.D., M.P.H.
Chief, Defense Facilities Assessment Section
Federal Programs Branch
Division of Health Assessment and Consultation


REFERENCES

  1. SMC Martin Inc. Evaluation of Alternatives for Solving Individual Well Contamination Problems Near Letterkenny Army Depot. February 1983.

  2. Environmental and Science and Engineering, Inc. Remedial Investigation of the Southeastern (SE) Area at Letterkenny Army Depot. December 1987.

  3. Environmental Science and Engineering, Inc. Remedial Investigation of the Property Disposal Office Area at Letterkenny Army Depot. September 1987.

  4. Roy F. Weston, Inc. Pilot Investigation of Low Temperature Thermal Stripping of Volatile Organic Compounds (VOC's) From Soil. June 1986.

  5. Environmental Science and Engineering, Inc. Interpretation of Dye-Traces from the Industrial Wastewater Treatment Plant Lagoon and the Disposal Area to Rowe Spring. October 1990.

  6. Hunter/Environmental Science and Engineering, Inc. Public Involvement and Response Plan for Letterkenny Army Depot. September 1990.

  7. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Arleen Ott, Chambersburg Chamber of Commerce. June 3, 1991.

  8. Administrative Files of Letterkenny Army Depot. Status of the Federal Facilities Interagency Agreement for the National Priorities List Sites of Letterkenny. January 9, 1991.

  9. U.S. Bureau of the Census. County and City Data Book, 1988. U.S. Government Printing Office, 1988.

  10. Administrative Files of Letterkenny Army Depot. Federal Facility Interagency Agreement - Fourth Quarter Progress Report. October - November 1990.

  11. Administrative Files of Letterkenny. Federal Facility Interagency Agreement - Progress Report. December 12, 1989.

  12. U.S. Army Toxic and Hazardous Materials Agency. Initial Assessment Report of Letterkenny Army Depot, Report No. 161. January 1980.

  13. Associated Chemical and Environmental Services. Letterkenny Army Depot Plant Lagoon Closure. February 1989.

  14. Bureau of the Census. 1990. Census of Population and Housing, Summary Tape 1B Extract on CD-ROM (Pennsylvania) [Machine-Readable Data Files]. Prepared by the Bureau of the Census, Washington, D.C: The Bureau [Producer and Distributor] 1991.

  15. Administrative Files of Letterkenny Army Depot. Public Meeting of Letterkenny Proposed Plans. May 14, 1991.

  16. CEH. 1985. CEH product review. Chlorinated methanes. Chemical Economic Handbook-SRI International, pp. 635.2020A to 635.2022B.

  17. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Cindy Myers, Chambersburg Area School District. August 7, 1991.

  18. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Lisa Myers, Civilian Personnel Office, Letterkenny Army Depot. June 13, 1991.

  19. Agency for Toxic Substances and Disease Registry. Case Studies in Environmental Medicine: Lead Toxicity. June 1990.

  20. Agency for Toxic Substances and Disease Registry. Site Observations of Letterkenny Army Depot. January 9-11, 1991.

  21. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Staff Sergeant Blackmon, Public Affairs Office, Letterkenny Army Depot. July 3, 1991.

  22. Agency for Toxic Substances and Disease Registry. Public Health Assessment for Letterkenny Army Depot: The Property Disposal Office Area and Southeastern Area. September 30, 1988.

  23. Cumberland Valley Map. Cumberland Valley Visitors' Council. January 1991.

  24. Pennsylvania Department of Health, State Health Data Center, Division of Health Statistics. Observed and Expected Total Deaths, Total Cancer Deaths, and Eight Standard Cancer Groupings for Greene, Hamilton, and Letterkenny Townships: 1979-1989.

  25. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Trichloroethylene. Atlanta: ATSDR, DHHS (PHS). October 1989.

  26. NUS Corp. Hydrogeologic Study of Letterkenny Army Depot. Philadelphia, PA: United States Environmental Protection Agency, Hazardous Site Control Division, TDD No. F3-8211-05. 1983.

  27. Orange County Water District. Results of an Investigation of TCE Removal During Sprinkler and Drip Irrigation in the Irvine Area. March 1989.

  28. Letterkenny Army Depot. Initial Release Comments; Letterkenny Army Depot Public Health Assessment, Peggy Gieseking, Letterkenny Army Depot, NPL Project Officer. March 3, 1992.

  29. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Paul Stone, U.S. Army Toxic and Hazardous Materials Agency (USATHAMA). April 1, 1992.

  30. Letterkenny Army Depot. Draft Statement of Work: In Support of the PDO and SE Remedial Investigations. March 27, 1992.

  31. J.L. Spinks, Hunting and Fishing Military Lands. Stackpole Books, Harrisburg, PA. 1991.

  32. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Dr. Bobby Jones, Pennsylvania Department of Health. June 3, 1991.

  33. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Daxel Varner, Hood College. June 3, 1991.

  34. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Dr. Wally Tcilkowsky, School of Forest Resources, Penn State University. May 31, 1991.

  35. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Bob Surridge, Penn State Data Center. May 31, 1991.

  36. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Dr. Sivarajah and Tom Hartman, Division of Environmental Health, Pennsylvania Department of Health. June 7 and June 18, 1991.

  37. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Citizen. September 10, 1991.

  38. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Citizen. September 10, 1991.

  39. U.S. Bureau of the Census. Census of Population and Housing, 1990: Summary Tape File 1 (Pennsylvania). Washington, D.C. 1991.

  40. U.S. Geological Survey. Element Concentrations in Soils and Other Surficial Materials of the Conterminous United States: U.S.G.S. Professional Paper 1270. Hansford T. Shacklette and Josephine Boerngen. U.S. Government Printing Office, Washington, 1984. Cited in Draft RI for PDO, April 16, 1992.

  41. Letterkenny Army Depot. Memorandum to U.S. Army Environmental Hygiene Agency: Request Assistance in Installation Restoration Program at Letterkenny Army Depot. April 17, 1992.

  42. U.S. Army Environmental Hygiene Agency. Water Quality Biological Study No. 32-24-0734-88: Water Quality Evaluation of Rocky Spring Lake, Letterkenny Army Depot. December 3, 1986 - September 16, 1987.

  43. U.S. Environmental Protection Agency, Region IV. National Primary Drinking Water Regulations. Code of Federal Regulations. August 7, 1991.

  44. U.S. Environmental Protection Agency, Technical Support Section, Region III. Risk-Based Concentration Tables: Second Quarter 1992. April 14, 1992.

  45. EA Engineering, Science, and Technology. Final Report, Site Investigation of Letterkenny Army Depot. Volume 1-3. November 1991.

  46. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Marianne Merritt, NPL Project Officer, Letterkenny Army Depot. July 13, 1992.

  47. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Marianne Merritt, NPL Project Officer, Letterkenny Army Depot. July 22, 1992.

  48. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Marianne Merritt, NPL Project Officer, Letterkenny Army Depot. June 3, 1992.

  49. U.S. EPA. U.S. Cancer Mortality Rates and Trends, 1950-1979: Volume IV - Maps. EPA/600/1-83/015e. U.S. Government Printing Office, Washington, D.C. September, 1987.

  50. Letterkenny Army Depot. Initial Release Comments; Letterkenny Army Depot Public Health Assessment, Peter B. Gearhart, Pennsylvania Health Department, South Central District. May 4, 1992.

  51. Agency for Toxic Substances and Disease Registry. Toxicological Profile for 1,1-Dichloroethylene. Atlanta: ATSDR, DHHS (PHS). December 1989.

  52. Otto WH. 1990. Inhalation exposure from volatile organic compounds found in drinking water. In: Proceedings of the Fourth National Environmental Health Conference. Environmental Issues: Today's Challenge for the Future, U.S. Department of Health and Human Services, 69-78.

  53. McKone TE. 1987. Human exposure to volatile organic compounds in household tap water: The inhalation pathway. Environ Sci Technol 21:1194-1201.

  54. NIOSH. 1976. National Occupational Hazard Survey. Cincinnati, Ohio: National Institute of Occupational Safety and Health, U.S. Department of Health and Human Services.

  55. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Cis and Trans 1,2-Dichloroethene. Atlanta: ATSDR, DHHS (PHS). December 1990.

  56. Witmer C, Cooper K, Jowa L, Post G. 1990. Oral toxicity of trans-1,2-dichloroethylene (DCE) and 1,1,1-trichloroethane (TCE) given alone and in combination to rats [Abstract]. Toxicologist 10:51.

  57. Freundt KJ, Liebaldt GP, Lieberwirth E. 1977. Toxicity studies on trans-1,2-dichloroethylene. Toxicology 7:141-153.

  58. Stevens VL. 1979. 1,2-Dichloroethylene. In: Kirk-Othmer encyclopedia of chemical technology, 3rd ed. Vol 5. Grayson M, Eckroth D, eds. New York, NY: John Wiley and Sons, 742-745.

  59. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Chloroform. Atlanta: ATSDR, DHHS (PHS). February 1992.

  60. Heywood R, Sortwell RJ, Noel PRB, et al. 1979. Safety evaluation of toothpaste containing chloroform. III. Long-term study in beagle dogs. J Environ Pathol Toxicol 2:835:851.

  61. Bomski H, Sobolewska A, Strakowski A. 1967. Toxic damage of the liver by chloroform in chemical industry workers. Int Arch F Gewerbepathologie u. Gewerbehygiene 24:127-134.

  62. Deshon HD. 1979. Carbon tetrachloride. In: Grayson M, Eckroth D, Ed. Kirk-Othmer Encyclopedia of Chemical Technology, 3rd ed. Vol 5. New York: John Wiley and Sons, 693-703.

  63. Windholz M, Ed. 1983. The Merck index. 10th ed. Rahway, NJ: Merck and Co., 300-301.

  64. Tsurata H. 1975. Percutaneous absorption of organic solvents: Comparative study of the in vivo percutaneous absorption of chlorinated solvents in mice. Ind Health 13:227-236.

  65. Agency for Toxic Substances and Disease Registry. Toxicological Profile for 1,1,1-Trichloroethane. Atlanta: ATSDR, DHHS (PHS). December 1990.

  66. Quast JF, Calhoun LL, Frauson LE. 1988. 1,1,1-Trichloroethane formulation: A chronic inhalation toxicity and oncogenicity study in Fischer 344 rats and B6C3F1 mice. Fund Appl Toxicol 11:611-625.

  67. Maroni M, Bulgheroni C, Grazia CM, et al. 1977. A clinical, neurophysiological and behavioral study of female workers exposed to 1,1,1-trichloroethane. Scand J Work Environ Health 3:16-22.

  68. Maltoni C, Cotti G, Patella V. 1986. Results of long-term carcinogenicity bioassays on Sprague-Dawley rats of methyl chloroform, administered by ingestion. ACTA Oncol 7:101-117.

  69. Priestly BG, Plaa GL. 1976. Hepatic function after acute or subchronic nicotine administration in untreated mice and mice treated with hepatotoxic chemicals. Arch Int Pharmacodyn Ther 223:132-141.

  70. Woolverton WL, Balster RL. 1981. Behavioral and lethal effects of combinations of oral ethanol and inhaled 1,1,1-trichloroethane in mice. Toxicol Appl Pharmacol 59:1-7.

  71. Carlson GP. 1973. Effect of phenobarbital and 3-methylchoanthrene pretreatment on the hepatotoxicity of 1,1,1-trichloroethane and 1,1,2-trichloroethane. Life Sci (United States) 13:67-73.

  72. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Trichloroethylene. Atlanta: ATSDR, DHHS (PHS). February 1992.

  73. Bauer M, Rabens SF. 1974. Cutaneous manifestations of trichloroethylene toxicity. Arch Dermatol 110:886-890.

  74. Goh CL, Ng SK. 1988. A cutaneous manifestation of trichloroethylene toxicity. Contact Dermatitis 18:59-61.

  75. Agency for Toxic Substances and Disease Registry. Toxicological Profile for 1,1,2,2-Tetrachloroethane. Atlanta: ATSDR, DHHS (PHS). December 1990.

  76. National Cancer Institute. 1978. Bioassay of 1,1,2,2-Tetrachloroethane for possible carcinogenicity. NTIS PB277 4537GA, DHEW/PUB/NIH-78-827, 90.

  77. Theiss JC, Stoner GD, Shimkin MB, et al. 1977. Test for carcinogenicity of organic contaminants of United States drinking waters by pulmonary tumor response in strain A mice. Cancer Res 37/8:2717-2720.

  78. Norman, JE, Jr, Robinette CD, Fraumeni JF, Jr. 1981. The mortality experience of Army World War II chemical processing companies. J Occ Med 23:818-822.

  79. U.S. EPA. 1988. U.S. Environmental Protection Agency, Integrated Risk Information System (IRIS). Risk Estimate for Carcinogenicity for Tetrachloroethane. Online. (Revised; Verification date 6/236/86). Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH.

  80. Lobo-Mendonca R. 1963. Tetrachloroethane - A survey. Br J Ind Med 20:51-56.

  81. U.S. EPA. 1985. Health assessment document for 1,2-dichloroethane. Final Report. Office of Health and Environmental Assessment, U.S. Environmental Protection Agency, Washington, DC. EPA 600/8-84-006F.

  82. Agency for Toxic Substances and Disease Registry. Toxicological Profile for 1,2-Dichloroethane. Atlanta: ATSDR, DHHS (PHS). December 1989.

  83. Van Duuren BL, Goldschmidt BM, Loewengart G, et al. 1979. Carcinogenicity of halogenated olefinic and aliphatic hydrocarbons in mice. J Natl Cancer Inst 63 (6):1433-1439.

  84. Munson AE, Sanders VM, Douglas KA, et al. 1982. In vivo assessment of immunotoxicity. Environ Health Perspect 43:41-52.

  85. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Chlorobenzene. Atlanta: ATSDR, DHHS (PHS). December 1990.

  86. National Toxicology Program. 1985. Toxicology and carcinogenesis studies of chlorobenzene (CAS No. 108-90-70) in F344/N rats and B6C3F mice (gavage studies). Technical report series No. 261. Research Triangle Park: U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Toxicology Program. NIH Publication No. 86-2517.

  87. U.S. EPA. 1987. Chlorobenzene. Health advisory. Washington, DC: U.S. Environmental Protection Agency, Office of Drinking Water.

  88. Nair RS, Barter JA, Schroeder RE, et al. 1987. A two generation reproduction study with monochlorobenzene vapor in rats. Fundam Appl Toxicol 9:678-686.

  89. U.S. EPA. 1980. Ambient water quality criteria for: Chlorinated benzenes. Washington, DC: U.S. Environmental Protection Agency, Office of Water Regulations and Standards. EPA-440/5-80-028. NTIS No. PB81-117392.

  90. Hughes CS, Cox W, Kamatari O. 1983. CEH product review: Chlorobenzenes. In: Chemical economics handbook. Menlo Park, CA: SRI International.

  91. United States International Trade and Commission. 1988. Synthetic organic chemicals: United States production and sales, 1987. Washington, DC: United States International Trade and Commission. USITC Publication 2118.

  92. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Marianne Merritt, NPL Project Officer, Letterkenny Army Depot. September 3-4, 1992.

  93. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Carbon Tetrachloride.

  94. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Aluminum. Atlanta: ATSDR, DHHS (PHS). October 1990.

  95. Ondreicka R, Ginter E, Kortus J. 1966. Chronic toxicity of aluminum in rats and mice and its effects on phosphorus metabolism. British Journal of Industrial Medicine 23:305-312.

  96. Shore D, Wyatt RJ. 1983. Aluminum and Alzheimer's disease. J Nerv Ment Dis 171:553-558.

  97. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Lead. Atlanta: ATSDR, DHHS (PHS). October 1991.

  98. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Marianne Merritt, NPL Project Officer, Letterkenny Army Depot. September 11, 1992.

  99. Maltoni C, Lefemine P, Cotti, et al. ed. 1985. Experimental research on vinylidene chloride carcinogenesis. Archives of Research on Industrial Carcinogenesis. Vol. 3, Princeton, NJ: Princeton Scientific Publishers.

  100. Byers, VS, Levin, AS, Ozonoff, DM, and Baldwin, RW. 1988. Association between clinical symptoms and lymphocyte abnormalities in a population with chronic domestic exposure to industrial solvent-contaminated domestic water supply and a high incidence of leukaemia. Cancer Immunol Immunother 27:77-81.

  101. Lagakos, SW, Wessen, BJ, and Zelen, M. 1986. An analysis of contaminated well water and health effects in Woburn, Massachusetts. Journal of the American Statistical Association, Vol. 81, No. 395:583-614.

  102. Mallin, K. 1990. Investigation of a bladder cancer cluster in northwestern Illinois. American Journal of Epidemiology Vol. 132, Suppl., No. 1: S96-S106.

  103. Vinels, P, Avanzi, GC, Glovinazzo, B, Ponzlo, G, Cambrin, GR, and Ciccone, G. 1990. Cytogenetics and occupational exposure to solvents: A pilot study on leukemias and myelodysplastic disorders. Tumori 76:350-352.

  104. Hong, HL, Yang, RSH, and Boorman, GA. 1991. Residual damage to hematopoietic system in mice exposed to a mixture of groundwater contaminants. Toxicology Letters 57:101-111.

  105. Hernberg, S, Kauppinen, T, Riala, R, Korkala, ML, and Asikainen, U. 1988. Increased risk for primary liver cancer among women exposed to solvents. Scand J Work Environ Health 14:356-365.

  106. Letterkenny Army Depot. Public Release Comments; Letterkenny Army Depot Public Health Assessment. February 5, 1993.

  107. Letterkenny Army Depot. Fourth Quarter Progress Report. January 6, 1993.

  108. Letterkenny Army Depot. Letter to U.S. EPA Region III Remedial Project Manager. Work to be Performed for Site Investigation, Part J. Date Unknown.

  109. Agency for Toxic Substances and Disease Registry. Record of Activity for Telephone Communication with Marianne Merritt, NPL Project Officer, Letterkenny Army Depot. June 2, 1992.

  110. Letterkenny Army Depot. Record of Decision: Accelerated Remedial Action for the Property Disposal Office Area: Operable Unit One. June 27, 1991.

  1. Letterkenny Army Depot. Personal Phone Conversation with Letterkenny Public Affairs Officer, Alicia Garges. March 8, 1993.

  2. Letterkenny Army Depot. Record of Decision: Southeast Area. August 2, 1991.

  3. State of Maine. 1992. Guidance Manual for Human Health Risk Assessments at Hazardous Waste Sites: Draft. Department of Environmental Protection and Department of Human Services. September 1, 1992.

  4. Andelman, J. B. 1985. Human Exposures to Volatile Halogenated Organic Chemicals in Indoor and Outdoor Air. Environmental Health Perspectives 62:313-318.

  5. Jo, W.K., Weisel, C.P., and Lioy, P.J. 1990. Routes of Chloroform Exposure and Body Burden From Showering With Chlorinated Tap Water. Risk Analysis 10(4):575-580.

  6. Jo, W.K., Weisel, C.P., and Lioy, P.J. 1990. Chloroform Exposure and the Health Risk Associated With Multiple Uses of Chlorinated Tap Water. Risk Analysis 10(4)581-585.

  7. Letterkenny Army Depot. 1993. Progress Report for the First Quarter of Calendar Year 1993. April 9, 1993.

  8. U.S. Army Environmental Hygiene Agency. Public Release Comments; Letterkenny Army Depot Public Health Assessment. February 15, 1993.

  9. Letterkenny Army Depot. Draft Remedial Investigation of the Southeastern Area. 1992.

  10. Letterkenny Army Depot. Draft Remedial Investigation of the Property Disposal Area. 1992.

  11. Maxwell, N.I., Burnmaster, D.E., and Ozonoff, D. 1991. Trihalomethanes and Maximum Contaminant Levels: The Significance of Inhalation and Dermal Exposures to Chloroform in Household Water. Regulatory Toxicology and Pharmacology 14:297-312.

Next Section          Table of Contents






Agency for Toxic Substances and Disease Registry, 1825 Century Blvd, Atlanta, GA 30345
Contact CDC: 800-232-4636 / TTY: 888-232-6348
 
USA.gov: The U.S. Government's Official Web Portal