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Weekly Editors' Picks
Getting a Transcription Factor to Only One Nucleus Following Mitosis
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The Ace2 transcription factor from budding yeast has both a regulated nuclear localization signal and a regulated nuclear export signal, and Ace2 phosphorylation by the Cbk1 kinase results in Ace2 accumulation in daughter cells but not mothers.
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How Signaling Receptors Meet Their End
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A new study sheds light on the roles of two proteins involved in vesicle trafficking within the cell and shows that intralumenal vesicle formation in multivesicular body biogenesis can be uncoupled from lysosomal targeting.
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An Enzymatic Palimpsest
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How does nature construct complex catalysts? Molecular simulations revealed two sets of catalytic residues in the enzyme IMPDH, one of which seems to represent a primitive catalytic machinery that may be a vestige of evolution.
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A New Role for a Long-Studied DNA-Wrangling Enzyme
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Analysis of cells lacking topoisomerase II reveals that the enzyme has an essential role in the segregation of chromosomes, and specifically centromeres, at anaphase-telophase of mitosis: it prevents non-disjunction and allows activation of the Aurora B kinase, so as to correct improper attachments between microtubules and the kinetochore.
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Defining a Link between Perceptual Learning and Attention
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Takeo Watanabe and Yuko Yotsumoto explore the implications of a new study that shows that for perceptual learning of visual features involving multiple stimuli to occur, the brain needs to temporally "tag" the features, a learning process that requires paying attention.
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Where Does Bluetongue Virus Sleep in the Winter?
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Bluetongue recently spread to northern Europe for the first time. Outbreaks in temperate regions are often interrupted by cold weather, but may reappear months later. Where, then, might bluetongue virus sleep in the winter?
In PLoS ONE
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- "Thinking about Not-Thinking": Neural Correlates of Conceptual Processing during Zen Meditation
- Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study
- Low Frequency Groans Indicate Larger and More Dominant Fallow Deer (Dama dama) Males
- Integration across Time Determines Path Deviation Discrimination for Moving Objects
August 2008 Issue
PLoS Biology is a peer-reviewed open-access journal featuring research articles of exceptional significance in all areas of biological science, from molecules to ecosystems.
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