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Announcements Archive
April 2004
- New Resource for Understanding Human Gene Function.
Results of an ongoing effort to analyze tens of thousands of human
genes are reported at http://www.plosbiology.org/
archive/ 1545-7885/2/6/ pdf/10.1371_journal.pbio.0020162-p-S.pdf.
This effort was coordinated by the Integrated Molecular Analysis
of Genome Expression (IMAGE) consortium,
http://image.llnl.gov/, a project initiated by the DOE Human Genome
Program and now funded
by the National Institutes of Health. This remarkable new resource
will speed discovery and understanding of human genes for both disease
and normal physiologic function.
- Sequencing Targets: Recommendations Sought for Sequencing
Targets in Support of the Science Missions of the Office of Biological
and Environmental Research (BER). Candidates due by July 1, 2004. Federal
Register notice available
here (see bottom of page) or as web-browsable
html.
March 2004
- Human Chromosome 19 Sequence Completed
The DOE Joint Genome Institute and Stanford University completed the
sequencing of the 55.8 million bases of human chromosome 19, the
most gene-rich of all human chromosomes. For more information see this
article and the press
release.
- Chromosome 13 Sequence Completed
The high quality sequence of chromosome 13 was reported in Nature (April
1, 2004). This 95.5 million base chromosome carries genes involved
in breast cancer type two and other cancers, as well as the region
frequently associated with bipolar disorder and schizophrenia. Chromosome
13 has one of the lowest gene densities among all human chromosomes,
with some 633 genes identified by the team.
September 2003
- On September 10, Secretary of Energy Spencer Abraham presented Ari Patrinos
and Francis Collins with the Secretary's Gold Award for their leadership
of the public Human Genome Project. The Gold Award is DOE's highest honorary
award. For more information see the press
release.
May 2003
- DOE is seeking nominations of microbes, microbial consortia, and small
organisms to be sequenced by the Joint Genome Institute. More.
. .
- JGI and Diversa Announce Collaboration on Microbes
The U.S. Department of Energy’s Joint Genome Institute
and Diversa Corporation are collaborating to discover and sequence novel
microbial genomes found in a diverse range of unique habitats. Read
more.
April 2003
- First phase of Environmental Genome Project Completed
The National Institute of Environmental Health Sciences (NIEHS) has
announced the completion of the first phase of the Environmental Genome
Project, which seeks to characterize genes that confer susceptibility
to such leading causes of death and illness as cancer, heart disease,
diabetes, and asthma. NIEHS researchers have resequenced and cataloged
200 environmentally responsive genes, identifying links to vascular
disease, leukemia, and other conditions that affect the quality and
length of life of many Americans.
- DOE Will Increase Funding to IBEA
Secretary of Energy Spencer Abraham said that the department will increase
its funding to the Institute for Biological Energy Alternatives (IBEA).
The money will be used for research to better understand microbial communities
and to develop new biological methods for capturing carbon dioxide from
the atmosphere and producing hydrogen. Read more.
- Celebration of the Genome
Fifty years ago this month, researchers Francis Crick and James Watson
published their historic paper describing the double-helix structure
of DNA. For their achievement, Drs. Watson and Crick were awarded
the Nobel Prize in 1962.
Seventeen years ago this spring, at the recommendation of one of
its scientists, the Department of Energy launched the effort to determine
the DNA sequence of the human genome. This month, representatives
of DOE and the National Institutes of Health will announce the completion
of the sequencing of the human genome.
The 50th anniversary of the Watson-Crick discovery of DNA and the
successful completion of the Human Genome Project are being celebrated
around the world throughout April 2003 - and in particular, at joint
NIH-DOE symposia in Washington, D.C., on April 14-15. There, still
another DOE contribution to the advancement of science also will be
discussed: the Office of Science's Genomes to Life program. As part
of DOE's Celebration of the Genome, Secretary
of Energy Spencer Abraham will make a statement.
- "Realizing
the Potential of the Genome Revolution: The Genomes to Life Program,"Marvin
E. Frazier, Gary M. Johnson, David G. Thomassen, Carl E. Oliver, Aristides
Patrinos
Science 300, 290 (2003)
- 2003: 50 Years of the Double
Helix: Celebrating 50 years of the discovery of the double
helix DNA structure and the anticipated completion of the Human Genome
Project
- Research abstracts from the New
Horizons in Genomics meeting held March 30-April 1, 2003,
Santa Fe, New Mexico. Prepared for the U.S. Department of Energy Joint
Genome Institute.
March 2003
Call for Papers
The IEEE is calling for submission of papers for the 2003 IEEE Computer
Society Bioinformatics Conference to be held August 11–13 at Stanford,
California. The meeting will cover such topics as machine learning,
data mining, robotics, regulatory networks, pattern recognition, Genomes
to Life, genomics and proteomics, and gene-expression pathways. Submission
date for papers is April 1, 2003. Queries and submissions may be sent
to bioinformatics@computer.org.
[Information]
Funding
Opportunities at NHGRI
• Determination of All Functional Elements in Human DNA: Solicit
participants for a Research Network that will conduct a pilot project
to test and compare methods for identifying all the functional elements
in a limited (~1%) region of the human genome.
• Identification and Verification of Functional Elements: Develop
new and improved technologies for the efficient, comprehensive, high-throughput
identification and verification of all types of sequence-based functional
elements, particularly those other than coding sequences, for which
adequate methods do not currently exist. This effort is part of a new
public research consortium, the Encylopedia of DNA Elements (ENCODE),
the intent of which is eventually to identify all functional elements
in the human genome sequence.
Due Dates: Letters of Intent, April 13, 2003; Applications,
May 13, 2003
February 2003
BSCS Develops Fifth Module
The Biological Sciences Curriculum Study, with the support of the Department
of Energy, has developed a new curriculum for high school biology that
explores how scientists extract useful information from the Human Genome
Project (HGP). “Bioinformatics and the Human Genome Project,”
BSCS's fifth module related to HGP, includes background information
for teachers and five classroom lessons. Lessons use both print and
Web-based activities to help students learn how computers are used to
assemble DNA sequences, locate genes, and obtain clues about gene functions.
In this context, the ethical, social, and legal implications of genetic
databases and informed consent are considered.
Interested teachers can visit the BSCS
Web site to reserve a free copy. The modules are expected to be
shipped to requestors the last week of March. After that, the curriculum
will be available in PDF on the BSCS Web site or can be obtained from
BSCS for $5.00.
January 2003
Eddy Rubin Named JGI Director
Internationally known geneticist and medical researcher Dr. Edward M.
(Eddy) Rubin has been named Director of the U.S. Department of Energy's
Joint Genome Institute (JGI). Rubin was also named Director of the Genomics
Division at Lawrence Berkeley National Laboratory (LBNL). Read more.
Fourth Human Chromosome Finished: Genes Implicated in Immune
Response, Ovarian Cancer, Alzheimer’s
Chromosome 14 has been completely sequenced by a team of French and
American scientists with the elimination of gaps and inconsistencies
present in the draft sequence of the human genome published in February
2001. With more than 87 million nucleotides, this is the fourth and
largest human chromosome finished to the high quality specified by the
Human Genome Project. Others completed thus far are 22, 21, and 20,
which were published in December 1999, May 2000, and December 2001,
respectively.
In addition to the 506 genes already known to exist on chromosome
14, the research team at Genoscope, France’s National Sequencing
Center, was able to identify 344 more genes. Two genes linked to chromosome
14 play important roles in the immune response. About 60 genes on this
chromosome have been associated with a variety of genetic disorders
such as early-onset Alzheimer’s, leukemia, Graves disease, spastic
paraplegia, and ovarian cancer. A paper reporting the work was published
electronically January 1, 2003, by Nature.
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