NATIONAL CENTER ON SLEEP DISORDERS
RESEARCH NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Sleep Disorders Research Advisory
Board Meeting Minutes June 26, 2002
The 16th meeting of the Sleep Disorders Research
Advisory Board (SDRAB) was convened at 8:40 a.m. on Wednesday, June 26, 2002,
in the Natcher Conference Center on the campus of the National Institutes of
Health (NIH) in Bethesda, Maryland. The meeting adjourned at 3:00 p.m. Dr.
Emmanuel Mignot presided as Chair. TABLE OF
CONTENTS
Attendees Call to Order Approval of
December 5, 2001 Board Meeting Minutes Report of the NCSDR Director Sleep Research Update: National Institute of Neurological
Disorders and Stroke Presentation-
Metabolic Consequences of Sleep Restriction Sleep Academic Award Program Education Subcommittee Closed Session: Election of Chair for 2002-03 Research Subcommittee Report New
Business Organization Updates
Adjournment Certification
NCSDR Home
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Sleep Disorders
Research Advisory Board Page
BOARD MEMBERS PRESENT
Dr. Emmanuel Mignot (Chair) Dr. Gene D. Block Dr. Sarah J.
Caddick Dr. Mary Carskadon Dr. Carol A. Landis Dr. Stuart F.
Quan
EX OFFICIO MEMBERS PRESENT Dr.
Gregory Belenky Dr. Robert Wolfe Greene Dr. Carl E. Hunt, Executive
Secretary Dr. Andrew Monjan Dr. Paul Nichols
LIAISON MEMBERS PRESENT
Dr. Deborah
Ader Dr. Harold Gordon Dr. Timothy Hayes (for Dr. Israel
Lederhendler) Dr. Karin Helmers Dr. Nancy Pearson Dr. Thomas
Raslear Dr. Roger Rosa Dr. Bette Siegel Mr. David Wade
FEDERAL EMPLOYEES PRESENT
Mr. Al Golden, NHLBI Dr. Audrey
Penn, NINDS Ms. Sue Rogus, NHLBI Ms. Ellen Sommer, NHLBI Dr.
Michael Twery, NHLBI INVITED GUESTS PRESENT
Dr. Judith
Owens Dr. Eve Van Cauter Dr. David White MEMBERS OF THE
PUBLIC PRESENT Ms. Georianna Bell, Restless Legs Syndrome
Foundation Dr. Richard Bootzin, Sleep Research Society Ms. Christin
Engelhardt, American Sleep Apnea Association Ms. Judith Estrin, Prospect
Associates Mr. James Perlstrom, SSA Mr. Nathaniel Pobster, HLB
Newsletter Ms. Teresa Wilson, Prospect Associates
Return to Table of Contents I.
CALL TO ORDER - Dr. Emmanuel Mignot Dr. Emmanuel Mignot, Sleep
Disorders Research Advisory Board Chair, called the 16th meeting of the Sleep
Disorders Research Advisory Board to order at 8:40 a.m. He welcomed the Board
members, members of the public, and others in attendance. Dr. Mignot noted that
an important focus of the meeting would be a review of the research plan. Dr.
Carl Hunt called attention to the materials in the meeting book, and he asked
members to review the statement on confidentiality/ethics issues.
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II. APPROVAL OF DECEMBER 5, 2001
BOARD MEETING MINUTES Dr. Emmanuel Mignot
Approval of the minutes was moved, seconded and
approved unanimously without further discussion.
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III. REPORT OF THE DIRECTOR,
NCSDR Dr. Carl E. Hunt Dr. Hunt reviewed the 11
organizations participating in the Trans-NIH Sleep Research Coordinating
Committee (SRCC), including two new members, the National Center for
Complementary and Alternative Medicine (NCCAM) and the National Institute of
Arthritis and Musculoskeletal and Skin Diseases (NIAMS). Dr. Nancy Pearson of
NCCAM and Dr. Deborah Ader of NIAMS join the SDRAB as new liaison members. Ms.
Adrienne Oneto is the new representative of the Bureau of the Census as a
Liaison Board member. As the new Director of NIH effective May, 2002, Dr. Elias
Zerhouni becomes a new Ex Officio member of the SDRAB. Dr. Hunt
reviewed the growth of NIH funding for sleep research, from $72.815 million in
1995 to $145.083 million in 2001. This represents a 99 % growth rate, slightly
exceeding the rate for all NIH funding. He also noted the following:
· Research on the relationship of sleep to the metabolic syndrome is
part of a $16-million RFA for studies that will focus on the biologic basis of
obesity-related cardiovascular disease (CVD).
· A workshop on Cardiovascular Consequences of
Sleep-Disordered Breathing (SDB) will be held September 12-13 in Bethesda.
· The NCSDR is preparing a monograph entitled
"Sleep and Sleep Disorders in Women," to be published by the American College
of Obstetrics and Gynecology in 2003.
Dr. Hunt reported that the Sleep Research Plan
Revision Task Force met in December 2001 and April 2002, with the Trans-NIH
Sleep Research Coordinating Committee ( SRCC) playing an active role. This was
followed by conference calls and participation in an open session of the annual
meeting of the Associated Professional Sleep Societies (APSS) in Seattle in
June 2002. The latest draft of the research plan (the "June Draft") will be
sent to all sleep-related professional societies for their comment and also
will be placed on the NCSDR Web site in early July. The deadline for all public
comments will be August 23. The Task Force will meet in October to review all
comments received and to develop the final draft. After final approval by the
Trans-NIH SRCC and SDRAB, the plan will be released by January, 2003.
Dr. Hunt reported that the revised plan provides a
comprehensive summary of achievements since 1996, identifies existing gaps, and
prioritizes strategies for future programs made possible by new knowledge and
technologies. The plan will provide an enhanced focus for research and
educational program development for the sleep research community, and will
identify new opportunities for interdisciplinary sleep research partners and
academic health centers. It will also help the NIH Institutes and Centers and
other Federal agencies establish priorities for sleep funding and program
development. Other stakeholders include professional and public sleep
organizations and the Congress.
Dr. Andrew Monjan suggested that the NCSDR track the
number of grants submitted as well as those funded, using information from the
IMPACT-2 database. As a potentially useful indicator of the total size of the
sleep research pool of investigators, the Sleep Center will explore tracking
this parameter on an annual basis.
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IV. SLEEP RESEARCH UPDATE: NATIONAL INSTITUTE OF
NEUROLOGICAL DISORDERS AND STROKE (NINDS) - Dr. Audrey S. Penn
Dr. Audrey Penn, Acting Director, National Institute
of Neurological Disorders and Stroke (NINDS), described the Institute's sleep
research portfolio of 69 grants (including supplements). The research is
supported by 13 funding mechanisms, though 46 of the 69 grants are
investigator-initiated R01s. The studies fall in the following areas:
· Basic studies: 5 studies include those on
regulation of sleep and arousal, REM sleep mechanisms, dopamine pathways, and
hypocretin/orexin.
· Sleep disorders: 9 studies focus on
narcolepsy; restless legs syndrome (in the context of peripheral neuropathy,
and NINDS intramural studies and protocols); and fatal familial insomnia.
Research on neurological disorders influenced by sleep and circadian rhythm
includes studies of epilepsy, dementia (in collaboration with the National
Institute of Mental Health and the National Institute on Aging), stroke,
movement disorders, and multiple sclerosis are also funded.
· Circadian rhythm: 31 studies focus on
genetics, regulation entrainment, and plasticity; suprachiasmatic nucleus; and
melatonin.
· Instrumentation: 7 studies are devoted to
measurement of vigilance, attention, and alertness; evoked potentials and EEG;
phototherapy; and magnetoencephalography. Most of this research is part of the
Small Business Program.
Dr. Penn also described the NINDS' Specialized
Neuroscience Research Programs (SNRP) at minority academic institutions. The
goals of the SNRP are to continue the ensure the development of a diverse
neuroscience workforce, encourage the interest of potential neuroscientists
early in their education, foster research training in minority institutions,
and facilitate collaboration between researchers in minority and majority
institutions. The SNRP program has awarded 11 grants, including 3 sleep-related
studies being conducted at Howard University, the University of Alaska, and the
University of Texas at San Antonio.
Dr. Penn said that there is some NINDS research on
the relationship between neurological disorders and sleep disorders, but there
should be more. The topic of sleep will be discussed at the NINDS Extramural
Retreat in 2004. In response to a suggestion that supplements to grants could
foster add-on research on sleep, Dr. Penn said that a workshop could be held to
explore this idea.
Dr. Hunt stressed the need to study sleep disorders
and stroke (e.g., stroke as a complication of untreated sleep apnea). He
suggested that NINDS input be included in the Research Plan.
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V. METABOLIC CONSEQUENCES
OF SLEEP RESTRICTION - Dr. Eve Van Cauter Dr. Eve Van Cauter,
Professor and Research Associate at the University of Chicago, reviewed several
studies examining the impact of sleep on the regulation of metabolism. She
noted that the association between hormones and sleep was identified more than
30 years ago when it was reported that adult men secrete growth hormone during
the early phase of sleep. Since then, research has indicated a deleterious
effect of sleep loss on the endocrine system and glucose modulation.
· One study examined the effect of sleep debt
and sleep recovery on hormone concentrations and glucose tolerance (GT) in
healthy males ages 18-27. One week of sleep restriction produced dramatic
results: a 30 percent slower response to both the GT test and acute insulin
response compared with results in rested subjects. Sleep deprivation also
raised the 24-hour cortisol profile.
· Another study found that sleep deprivation
resulted in 30 percent lower levels of leptin. Amazingly, the effect is similar
to that observed with caloric restriction (3,000 calories over 3 days),
signaling a negative energy balance. A more recent study examined the effect of
10 vs. 4 hours of sleep on appetite. Subjects who slept 4 hours were always
hungry and craved starchy, sweet, and salty foods. These results suggest that
sleep deprivation produces a signal mimicking negative energy balance, inducing
people to eat and thereby predisposing to obesity. This may have implication
for sleep deprivation during sleep apnea as well, creating a vicious cycle in
these often already obese patients.
· A study to examine whether chronic sleep
restriction is a risk factor for insulin resistance and obesity examined the
effect of less than 6.5 hours of sleep vs. 7.5-8.5 hours of sleep in two groups
of healthy youth whose sleep habits were monitored. The glucose curves were
almost identical in both groups, but the short-sleep group was more
insulin-resistant.
Dr. Van Cauter said that these results indicate an
association between sleep debt, obesity and diabetes. Sleep deprivation would
affect GT and leptin levels and increase the appetite for unhealthy foods. She
noted that sleep restriction would have greater impact on obese individuals,
who have higher leptin levels to begin with, and on populations such as Mexican
Americans and older adults.
During the discussion, Dr. Van Cauter noted that the
studies were performed in males only. Because females have higher baseline
levels of some hormones (e.g. leptin), sleep restriction might have worse
effects in women than in men. An epidemiological study found an inverse
relationship between increased body mass index (BMI) and sleep duration in
women. There are no data to answer the following questions: Is sleep
deprivation related to diabetes and obesity in Native Americans? Are women on
oral contraceptives at higher risk of short sleep? Is exercise is a
countermeasure to sleep loss? Does insufficient sleep makes compliance to a
diet more difficult? All these questions are potentially related to these
recent findings.
Dr. Van Cauter also made the following observations:
(1) sleep apnea is a risk factor for diabetes while diabetes may be exacerbated
by sleep deprivation; 2) the severity of sleep apnea increases with sleep
restriction; (3) sleep deprivation may activate the sympathetic system, with
cardiovascular impact. (4) sleep debt is generally not paid back fully by
weekend sleep. Sleep deprivation may thus play a role in the metabolic syndrome
and interact with obstructive sleep apnea.
Return to Table of Contents
VI. SLEEP ACADEMIC AWARD PROGRAM
- Dr. Judith Owens
Dr. Judith Owens, Associate Professor of Pediatrics
at Brown Medical School, provided an update on the 2001-2002 Sleep Academic
Award (SAA) Program. The program, which began in 1995 and will end in 2003,
develops curriculum educational resources to advance the knowledge of sleep and
sleep disorders in medical schools at all levels, and to enhance the sleep
knowledge and skills of faculty and medical professionals.
Dr. Owens reviewed the recent accomplishments of the
SAA program in the areas of curriculum and faculty development.
· A collaborative project of the SAA program
has produced a model curriculum on Sleep and Chronobiology for medical schools,
based on four core competencies and instructional objectives.
· A discussion group on faculty development in
sleep education was presented by SAA members at the 2002 Association of
Professional Sleep Societies (APSS) meeting in Seattle. The program presented
an overview of SAA resources, a model curriculum, and "stealth techniques"-ways
to compete for curriculum time in medical school.
· MedSleep-a collaboration between American
Academy of Sleep Medicine (AASM) and SAA-develops and distributes SAA
educational resources and products free of charge on the AASM website to all
interested educators. Educational products available include slide sets, case
histories, surveys, curriculum outlines, and a CD with faculty training
materials.
· Over 120 "sleep education advocates" have
been identified by the SAA program at medical schools across the US and Canada.
These individuals advocate at their institutions, network to continue the
development and dissemination of educational materials, and provide feedback
and evaluation.
· Preliminary results of an AASM Medical
School Education Committee survey on the current state of sleep education in
medical schools revealed an average increase (from 1.2 hours to 4.1 hours)
since 1993 in teaching time for preclinical basic science about sleep. There
was also a reported increase in teaching time in sleep medicine for clinical
clerkships and in a number of subspecialty fellowship programs. Lack of
curriculum time and faculty time were identified as continued obstacles to
educational efforts. More data from the survey are expected.
Dr. Owens reported that the "Sleep, Fatigue, and
Medical Training: Optimizing Learning and the Patient Care Environment"
conference was held in October 2001 and funded by the Agency for Healthcare
Research and Quality. The planning of this conference represented the efforts
of a number of SAA members. Participants included representatives from AASM,
Sleep Research Society (SRS), NCSDR, and the American Medical Association
(AMA); a white paper summarizing the conference proceedings is in preparation.
Two review articles on the topic of sleep loss and fatigue in medical training
that are joint efforts of the SAA group will be published in Sleep and
JAMA. In addition, a collaborative focus group/survey study of residents
at six SAA sites to assess residents' perception of sleep loss and fatigue and
use of alertness management strategies is currently nearing completion. An
abstract on this project was presented at the 2002 APSS meeting.
Dr. Owens provided an in-depth look at the SAA
program at Northwestern University's School of Medicine, which offers lectures
on sleep in years 1 to 4 of training, as well as a summer research in sleep
elective, small group sessions, and an elective sleep clinic/laboratory. The
residency program offers lectures, case conferences, elective research,
fellowships, and mentored clinical research. The principal investigator is a
member of the Dean's Council on Medical Education.
Dr. Owens discussed the positive impact of the SAA,
quoting from individuals in the program. She noted that attracting young
investigators from multiple disciplines and levels increases the visibility and
impact of sleep medicine, and it also helps add to the science of sleep.
Dr. Owens made the following recommendations to
extend the impact of the SAA:
· Provide funding for career sleep education
awards (e.g., 5-year renewable awards), as well as Young Investigator Grants,
and other small grant mechanisms to attract new investigators (medical
students, residents) and researchers from other fields into sleep.
· Encourage the development of faculty
development programs to extend the impact of the SAA program at individual
institutions.
· Develop educational outcomes research
projects that will identify additional educational needs and provide data on
the effectiveness of sleep education programs in changing knowledge, attitudes,
and behaviors of physicians in training.
· Develop sleep education curriculae for
allied health professions (nursing, pharmacology, clinical psychology).
· Partner with appropriate medical
subspecialty groups for development and dissemination of education programs.
· Assess educational intervention outcomes
(knowledge, attitudes, behavior) at the continuing medical education (CME)
level. In particular, assess the impact of education interventions on the
identification of sleep disorders, appropriate management, and quality of life
in clinical practice.
Dr. Hunt discussed the possibility of conducting an
external evaluation of the SAA program. Dr. Owens suggested that a conference
be held to look at successful SAA programs and strategize for continuing the
SAA effort. Possible funding mechanisms for continuing collaborative
educational projects among the Sleep Academic awardees were discussed,
including the AASM Sleep Medical Education Research Fund (SMERF) mechanism.
Return to Table of Contents
VII. EDUCATION
SUBCOMMITTEE - Ms. Sue Rogus, Ms. Ellen Sommer
Ms. Sue Rogus provided the following update on NCSDR
education activities:
· The NHLBI and CenterNet produced "Sleep
Apnea: Is Your Patient at Risk," a continuing medical education (CME) video.
CenterNet, a joint program of the Association of Academic Health Centers and
Healthcare Management TV, will air the video for more than 1,700 hospitals, and
will offer the program for sale through its Web site, as part of its NIH Bench
to Bedside continuing education series.
· The Working Group on Sleepiness and
Adolescents/Young Adults (ages 13-22 years), co-chaired by the American Academy
of Pediatrics (AAP) and the NCSDR, has met twice and is developing two
publications for pediatricians. One summarizes the state of the science in
sleepiness and adolescents. The second paper is a practical approach to the
sleepy adolescent.
· At the upcoming American Academy of
Pediatrics (AAP) conference in October 2002 in Boston, members of the Working
Group will present a special 2-hour session, "Sleepiness and Adolescents: A
Deadly Combination." The NCSDR will also exhibit at the conference, and is
exploring a collaborative media activity in conjunction with the Garfield
campaign.
· The NCSDR and the NIH's Office of Science
Education (OSE)have produced a high school supplementary curriculum on the
biology of sleep, sleep disorders, and biological rhythms (currently in press).
The curriculum, which has been field-tested, includes a 10-day sleep diary and
five classroom lessons. It will be offered free of charge to high school
science teachers, and materials will also be available on the OSE Web site.
Objectives are to help students understand the importance of sleep to health
and the consequences of lack of sleep, to provide experience with the
scientific process, and to convey the purpose of scientific research.
Sleep Well. Do Well. Star Sleeper Campaign
Ms. Ellen Sommer reviewed the latest developments
with the Sleep Well. Do Well. Star Sleeper Campaign, which features Garfield as
its "spokescat" and targets children ages 7-11 - as well as parents, teachers
and principals, pediatricians, and school nurses - with messages about the
importance of at least nine hours of sleep each night for children to do their
best at whatever they do. An active media outreach program was initiated with
the launch of the Campaign in February 2001. Activities and products produced
since then include a "Back to Sleep Campaign," a television public service
announcement (PSA), an "End of Daylight Savings Time Campaign," a matte feature
article, a print PSA, and a "New Year's Resolution" audio news release, all of
which generated excellent coverage for the Campaign.
In addition, ongoing outreach to selected major media
has resulted in coverage in Parents' Magazine, Washington Parents, the CBS
Early Show, Sleep Savvy (a magazine of the Better Sleep Council), among other
publications, and stories will appear in the Baltimore Sun and Parade Magazine
in August. A media event held in a San Antonio elementary school in April, in
conjunction with the Annual Conference of the National Association of
Elementary School Principals, also received good media coverage.
Upcoming activities include another Back-to School
campaign, which will include a contest and winner's event; a media event
(similar to one in San Antonio) in conjunction with the AAP conference in
Boston; and updating of the Star Sleeper Website homepage. The homepage will
contain portals for teachers, parents, and kids. The portal for kids, "Mission
Z," will include games and invite visitors to join Garfield and the "Star
Sleeper Squad" to carry out a mission.
Partnership Activities
Ms. Rogus reviewed the following activities of
several partner organizations in the Garfield campaign.
· The AAP will participate in the October 2002
media event. The NCSDR and AAP are exploring the possibility of jointly
producing products for pediatricians.
· The National Association of Elementary
School Principals (NAESP) is working with the NCSDR to implement sleep
education in schools in selected states.
· The Better Sleep Council (representing
bedding manufacturers and retailers) will participate in a joint media outreach
effort, and there is a possibility that some members will carry the Garfield
doll and "fun pad" in stores.
· The National Association of School Nurses
(NASN)is now an official partner in the campaign, and is placing an article
about the program in its newsletter to all members. The NASN may participate in
the development of sleep educational materials for school nurses.
These organizations communicate with their members
through newsletters and Web sites. Several will participate in the NCSDR's
Back-to-School campaign.
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VIII CLOSED SESSION: ELECTION
OF CHAIR FOR 2002-03 Dr. Mignot/Board
During a closed session, the Advisory Board elected
Dr. Stuart Quan as Advisory Board Chair for the year beginning July 1, 2002.
Dr. Mary Carskadon was subsequently appointed as the Education Subcommittee
Chair for the year beginning July 1, 2002.
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IX RESEARCH SUBCOMMITTEE:
SLEEP RESEARCH PLAN REVISION - Dr. David White
The Research Subcommittee had the opportunity to
provide input on the 118-page "June draft" of the Revised Research Plan. To
begin, Dr. David White, chair of the Sleep Research Plan Revision Task Force,
listed the topics in the five main sections of the report: (1) Basic Sleep
Science and Methodology, (2) Education and Training (3) Sleep and Health, (4)
Restricted Sleep, and (5) Sleep Disorders
Dr. White described how the 14-member Task Force had
worked to review the issues, accomplishments, and research priorities and to
identify and fill gaps in the draft. At the APSS meeting in Seattle, it was
suggested that separate sections be created for manpower issues and for women
and sleep. Dr. White said that an executive summary is now in early draft form.
It will identify priorities within each section, and the new draft will be
circulated to Trans-NIH SRCC and SDRAB members for review.
The June draft (about 125 pages) covers the broad
field of sleep problems and disorders, with 5 or 10 pages devoted to each
discipline. The target audience is the sleep research community at large,
including investigators and scientists involved in program development. The
Board engaged in an active discussion with Trans-NIH SRCC members and other
attendees regarding suggested refinements to the June draft.
Next Steps
· The Task Force will review all public
comments after the August 23, 2002 deadline. There will be 2 conference calls
in September, following which the October draft will be prepared. At an October
meeting in Bethesda, the final draft will be developed. Advisory Board members
are requested to send their comments on the draft to Dr. Hunt or Dr. White via
e-mail, including specific suggested language. The final document will be
approved by the Trans-NIH SRCC and by the SDRAB, with final acceptance of the
revised plan scheduled for the December, 2002 meeting.
Dr. Mignot thanked the Advisory Board for its efforts
on behalf of the Research Plan. Dr. Hunt stressed the need for fresh
perspectives, noting that all comments will be carefully considered.
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X NEW BUSINESS
Dr. Hunt acknowledged the contributions of the
members of the Board who are now completing their 4-year appointments: Dr.
Mignot, Dr. James Everett, and Dr. Carol Landis. He presented them with a
certificate and letter from NHLBI Director Dr. Claude Lenfant as well as a
Garfield doll.
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XI ORGANIZATION
REPORTS/UPDATES
Board members were advised that written updates from
member organizations could be found in their Program Briefing Books. Several
participants provided additional updates of activities of their organizations.
The Narcolepsy Network representative announced that
the Network is revising its narcolepsy fact sheet. Christin Engelhardt reported
that the American Sleep Apnea Association dramatically expanded the health care
professional section of its Web site. She added that a letter to be published
in the August issue of American Family Physician advises screening for sleep
apnea before surgery.
Dr. Greene reported that the Department of Veterans
Affairs (VA) has a total of $9,101,122 in sleep-related research projects
during FY 2002. This included $3,239,102 from the VA, $4,588,117 from NIH
(including 35% from NIMH, 31% from NHLBI), $404,351 from other Federal sources,
$869,552 from external sources.
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Contents
XII ADJOURNMENT - Dr.
Mignot
Dr. Mignot thanked the participants and adjourned the
meeting at 3:00 pm.
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Contents XIII CERTIFICATION
We certify that, to the best of our knowledge, the foregoing minutes are
accurate and complete.
Emmanuel Mignot M.D., Chair
Sleep Disorders Research Advisory Board
Carl E. Hunt, M.D., Executive Secretary Sleep Disorders Research
Advisory Board Return to Table of Contents
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