Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Published Results
Trial Contact Information
Related Information
Registry Information

Alternate Title

Immunotherapy Using Cyclosporine, Interferon gamma, and Interleukin-2 After High-Dose Myeloablative Chemotherapy With Autologous Stem Cell Transplantation in Treating Patients With Refractory or Relapsed Hodgkin's Lymphoma

Basic Trial Information

Phase Type Status Age Sponsor Protocol IDs Phase III, Phase II Treatment Closed Under 30 NCI COG-AHOD0121 NCT00070187, AHOD0121

Objectives

Primary

Phase II

1. Determine the feasibility and toxicity of immunotherapy comprising cyclosporine, interferon gamma, and interleukin-2 after high-dose myeloablative chemotherapy with autologous stem cell transplantation (ASCT) in patients with refractory or relapsed Hodgkin's lymphoma.

Phase III

1. Compare the event-free and overall survival of patients treated with vs without this immunotherapy regimen.

Secondary

1. Determine the event-free and overall survival rates, toxic effects, and response rates to reinduction chemotherapy followed by hyperfractionated involved-field radiotherapy, high-dose chemotherapy comprising carmustine, etoposide, cytarabine, and melphalan, and ASCT in these patients.
2. Correlate tumor biologic characteristics with response in patients treated with these regimens.
3. Determine the effectiveness of this immunotherapy regimen in producing autologous graft-vs-host disease (GVHD) and auto-reactive cytotoxic T-lymphocyte activity in these patients.
4. Correlate greater levels of autologous GVHD and in vitro cytolytic activity with improved event-free and overall survival in patients treated with these regimens.
5. Determine whether treatment with immunotherapy can overcome the negative prognostic significance of p53 mutation and high serum levels of interleukin-10 and interleukin-2 receptor in these patients.
6. Determine the genotoxicity of retrieval therapy and the incidence of hypermutability by longitudinal genotoxic biomonitoring in these patients.
7. Correlate HLA class II invariant peptide (CLIP) expression in tumor cells with improved event-free and overall survival in patients treated with immunotherapy regimen.

Entry Criteria

Disease Characteristics:

• Diagnosis of Hodgkin's lymphoma
  • Histologically confirmed at original diagnosis AND at relapse or disease progression
  • Relapsed or refractory to conventional therapy



• No recurrence without B symptoms or bulky disease at least 1 year after completion of minimal systemic therapy defined by either of the following:
  • Stage IA/IIA with nodal disease previously treated with radiotherapy only
  • Stage IA/IIA with nodal disease previously treated with less than 3 courses of standard dose chemotherapy



• Concurrently enrolled on the COG-AHOD00P1 salvage chemotherapy study OR received other appropriate salvage therapy (e.g., ifosfamide and vinorelbine)

Prior/Concurrent Therapy:

Biologic therapy

• Recovered from prior immunotherapy
• At least 1 week since prior antineoplastic biologic agents
• More than 1 week since prior growth factors
• No prior stem cell transplantation
• No other concurrent immunomodulating agents

Chemotherapy

• See Disease Characteristics
• More than 2 weeks since prior myelosuppressive chemotherapy (4 weeks for nitrosoureas) and recovered
• No other concurrent anticancer chemotherapy

Endocrine therapy

• No concurrent steroids, including dexamethasone as an antiemetic

Radiotherapy

• See Disease Characteristics
• Recovered from prior radiotherapy

Surgery

• Not specified

Other

• No concurrent participation in another COG therapeutic study

Patient Characteristics:

Age

• Under 30

Performance status

• ECOG 0-2 (for adults)
• Lansky 50-100% (for children)

Life expectancy

• At least 2 months

Hematopoietic

• Absolute neutrophil count at least 500/mm³

Hepatic

• Bilirubin no greater than 1.5 times normal
• SGPT less than 2.5 times normal

Renal

• Creatinine no greater than 1.5 times normal

  OR

• Creatinine clearance or radioisotope glomerular filtration rate at least 70 mL/min/1.73 m²

Cardiovascular

• Shortening fraction at least 27% by echocardiogram

  OR

• Ejection fraction at least 50% by MUGA

Pulmonary

• No evidence of dyspnea at rest
• No exercise intolerance
• DLCO at least 50% (patients 8 years of age and over)

Other

• Not pregnant or nursing
• Negative pregnancy test
• No concurrent serious illness

Expected Enrollment

A total of 156 patients (25 for phase II and 131 for phase III) will be accrued for this study within 5.4 years.

Outcomes

Event-free survival at 3 years after stem cell rescue
Overall survival at 3 years after stem cell rescue

Non-relapse mortality at 100 days after stem cell rescue
Graft-vs-host disease at 100 days after stem cell rescue
T-lymphocyte activity at 100 days after stem cell rescue
Invariant peptide expression at 100 days after stem cell rescue

Outline

This is a nonrandomized, multicenter phase II study followed by a randomized, multicenter phase III study. Patients are stratified according to study phase (II vs III).

Patients receive 2 courses of salvage induction therapy on COG-AHOD00P1 or equivalent. Within 2-5 weeks after completion of salvage induction therapy, patients receive protocol therapy.

• Phase II: All patients receive the following treatment:
  • Hyperfractionated involved-field radiotherapy: Patients who have completed prior salvage induction therapy and have not received full tissue tolerance from prior radiotherapy may receive hyperfractionated involved-field radiotherapy twice daily for 7 days.
  
  
  
  • High-dose preparative regimen: Beginning within 7 days after radiotherapy, patients receive carmustine IV over 3 hours on day -6; etoposide IV over 1 hour and cytarabine IV over 1 hour on days -5 to -2; and melphalan IV over 30 minutes on day -1.
  
  
  
  • Autologous stem cell transplantation: Patients undergo autologous bone marrow or peripheral blood stem cell transplantation on day 0. Patients then receive filgrastim (G-CSF) subcutaneously (SC) or IV beginning on day 1 and continuing until blood counts recover.
  
  
  
  • Immunotherapy: Patients receive cyclosporine IV twice daily beginning on day 0 and continuing until the completion of the course of interferon gamma and interleukin-2. When sufficiently recovered, patients also receive interferon gamma SC every other day for 10 doses. Beginning 2 days after the start of interferon gamma, patients also receive interleukin-2 SC once daily for 18 days.
  
  
  



• Phase III: Patients who respond to prior salvage induction therapy are randomized to 1 of 2 treatment arms. Patients who have progressive disease after 2 courses of prior salvage induction therapy are assigned to arm I.
  • Arm I: Patients receive treatment as in phase II.
  
  
  
  • Arm II: Patients receive treatment as in phase II without immunotherapy.
  
  
  

In both phases, treatment continues in the absence of disease progression or unacceptable toxicity.

Patients are followed at 1 year.

Chen AR, Hutchison R, Hess A, et al.: Clinical outcomes of patients with recurrent/refractory Hodgkin disease receiving cyclosporine, interferon-, and interleukin-2 immunotherapy to induce auto-reactivity after autologous stem cell transplantation with BEAM: a COG study. [Abstract] Blood 110 (11): A-1896, 2007.

Trial Contact Information

Trial Lead Organizations

Children's Oncology Group

Allen Chen, MD, PhD, MHS, Protocol chair		Ph: 410-955-7385
Sharon Gardner, MD, Protocol co-chair		Ph: 212-263-8520 Email: sharon.gardner@med.nyu.edu

Related Information

PDQ® clinical trial COG-AHOD00P1

Registry Information
Official Title		A Phase II/III Study of Immunomodulation After High Dose Myeloablative Therapy with Autologous Stem Cell Rescue for Refractory/Relapsed Hodgkin Disease
Trial Start Date		2003-11-03
Registered in ClinicalTrials.gov		NCT00070187
Date Submitted to PDQ		2003-08-15
Information Last Verified		2007-06-04
NCI Grant/Contract Number		CA13539, CA98543