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Human
Genome News Archive Edition |
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Sponsored
by the U.S. Department of
Energy Human Genome Program
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Human Genome News, January-March 1996; 7(5)
The Encyclopedia of E. coli Genes and Metabolism (EcoCyc) is a collaboration of Peter D. Karp (SRI International), Monica Riley (Marine Biological Laboratory), and Kenneth Rudd [National Library of Medicine (NLM)]. Its short-term goal is to compile a large knowledge base (KB) of Escherichia coli genes and intermediary metabolism to describe each pathway, bioreaction, and enzyme of E. coli metabolism, including the enzyme's cofactors, activators, inhibitors, and subunit structure. When known, genes encoding enzyme subunits will be listed with their chromosomal map positions. Version 2.7 contains more data than previous versions and generates metabolic-pathway diagrams, genomic maps, and other graphics through WWW (http://www.ai.sri.com/ecocyc/browser.html).
In addition, the KB will characterize every chemical compound involved in each bioreaction and list molecular weight, chemical structure in many cases, and synonyms for the compound name. Some 2956 E. coli genes, 397 enzymes, 627 bioreactions in 100 pathways, and 1180 chemical compounds are depicted in EcoCyc, which links to such other databases as GenBank, SWISS-PROT, PDB, Prosite, and Medline. EcoCyc is supported by grants from the NIH National Center for Research Resources and NLM. [Installation instructions, EcoCyc publications, and links to the EcoCyc WWW server (http://www.ai.sri.com/ecocyc/ecocyc.html). Contact: Peter Karp, Fax: 415/859-3735, pkarp@ai.sri.com]
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