Response |
Criteria |
---|---|
Complete responseb |
(Median survival=8 yrs) |
Partial responseb |
(Median survival=4 yrs) |
Minimal responseb |
|
Disease progressionb |
|
Stable diseaseb |
No significant changes in measurements of disease meeting criteria for at least minimal response or disease progression. Bone marrow biopsy shows no change in plasma cell infiltration consistent with M protein decrease. |
Overall survivalc |
The percentage of subjects in a study who have survived for a defined period of time. Usually reported as time since diagnosis or treatment. Also called the survival rate. |
Time to progressionc |
A measure of time after a disease is diagnosed (or treated) until the disease starts to get worse. |
Progression-free survivalc |
One type of measurement that can be used in a clinical study or trial to help determine whether a new treatment is effective. It refers to the probability that a patient will remain alive, without the disease getting worse. |
Disease-free survival12 |
Length of time after treatment during which no cancer is found. Can be reported for an individual patient or for a study population. |
Event-free survivald |
Length of time after treatment that a participant in a clinical study remains free of pre-defined events. Events are defined by the study and can include adverse treatment effects, tumor recurrence/progression, or survival. |
Survival ratec |
The percentage of people in a study or treatment group who are alive for a given period of time after diagnosis. This is commonly expressed as 5-year survival. |
Notes:
a. The EBMT/IBMTR/ABMTR (a.k.a. Blade) criteria.
b. Derived from: Blade
J, Samson D, Reece D, et al., Criteria for evaluating disease response
and progression in patients with multiple myeloma treated by high-dose
therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European
Group for Blood and Marrow Transplant. Br J Haematol 102:1115-23,
1998.
c. Quoted from the NCI's Web site (http://www.cancer.gov).
d. Definition derived from http://www.intelihealth.com/IH/ihtPrint/WSIHW000/8096/8241/347567.html?d=dmtContent&hide=t&k=basePrint#efsurvival.