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Perspective
Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease: Background, Evolution, and Current Concerns
Paul Brown,* Robert G. Will,† Raymond Bradley,‡ David M. Asher,§ and Linda
Detwiler¶
*National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA; †National Creutzfeldt-Jakob
Disease Surveillance Unit, Western General Hospital, Edinburgh, Scotland; ‡Central Veterinary Laboratory, New Haw,
Addlestone, UK; §Center for
Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; ¶Animal and Plant Health Inspection Service, U.S.
Department of Agriculture, Robbinsville, New Jersey, USA
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Figure. Time course of epidemic bovine spongiform encephalopathy in the United Kingdom, 1986-2000, with dates of major precautionary
interventions. The mammalian ban on meat and bone meal in March 1996 extended a 1994 ban for farmed food animal species to include all
mammalian species. SBO = specified bovine offals (brain, spinal cord, thymus, tonsil, spleen, and intestines from cattle >6 months of age); MBM =
meat and bone meal (protein residue produced by rendering).
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