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Message-ID:  <[log in to unmask]>
Date:         Sun, 17 Dec 2006 17:46:44 -0500
Reply-To:     Ken Kraemer <[log in to unmask]>
Sender:       DNA Repair Interest Group <[log in to unmask]>
From:         "Kenneth H. Kraemer" <[log in to unmask]>
Subject:      DNA Repair Interest Group - UPDATE - Dec 17,  2006

DNA Repair Interest Group - UPDATE - Dec 17,  2006

1 - VIDEOCONFERENCE:	 Tues Dec 19, 2006 - 12:30 PM - Dr. Stephen Meyn - 
Toronto - The human telomeric proteins TRF1, TRF2 and TIN2 participate in 
a novel  cellular response to DNA damage

2 - NIH SEMINARS OF NOTE: TBA

3 - CONFERENCES - MGMT and Alkylating Drug Resistance - Mainz, Germany - 
June 13-16, 2007

4 - POST DOC AND EMPLOYMENT OPPORTUNITIES: Bethesda, MD; Boston, MA: 
Indianapolis, IN; Marseille, France;  Baltimore, MD; San Francisco, CA; 
Cardiff, UK; Strasbourg, France

5 -COMMERCIAL REAGENT SOURCES

6- ELECTRONIC CONTACTS
______________________________________________________


1.0	DNA REPAIR VIDEOCONFERENCE:
Tues Dec 19, 2006 - 12:30 PM - Dr. Stephen Meyn - Univ of Toronto - The 
human telomeric proteins TRF1, TRF2 and TIN2 participate in a novel 
cellular response to DNA damage  [Origin - Baltimore]

VIDEOCONFERENCE LOCATIONS:  Building 45 (NATCHER) Room J, Bethesda, MD; 
Room 1E03 GRC Baltimore, MD [origin]; NIEHS, Research Triangle Park, NC; 
Building 549, Conference Room A,  FCRDC, Frederick, MD; Brookhaven 
National Labs, Upton, NY; Lawrence Livermore Labs, Livermore, CA ; Univ of 
Michigan, Ann Arbor; University of Pittsburgh; MD Anderson, Smithville, 
TX; State University of New York, Stony Brook, NY; Univ of Kentucky, 
Lexington, KY; Oregon Health & Science University, Portland, OR; Univ of 
North Carolina, Chapel Hill, NC Wake Forest Univ, Winston-Salem, NC and 
live on the internet at http://videocast.nih.gov


1.1	DNA REPAIR VIDEOCONFERENCE - FUTURE DATES AND VIDEO ARCHIVE
[Note: A larger and more up to date list of future and past 
videoconferences can be found on the DNA Repair Interest Group web site: 
http://www.nih.gov:80/sigs/dna-rep/ ]

1.1.1 FUTURE VIDEOCONFERENCES:
Tues Jan 16, 2007 - 12:30 PM   - Dr. Dan Camerini-Ortero - NIDDK, NIH - 
Meiotic DNA Double-Strand Break Repair in Mice and Humans [Origin - NIH, 
Bethesda]

Tues Feb 20, 2007 - 12:30 PM - Dr. Laura J. Niedernhofer - U of Pittsburgh 
- Title: Accelerated aging and cancer in ERCC1-XPF-deficient mouse models 
[Origin - Pittsburgh]

Tues Mar 20, 2007 - 12:30 PM - Young Investigator Showcase - talks by 
investigators at 3 sites. Dr. Paul Wilson . Livermore . Variation in DNA 
double strand break repair capacity in diploid human fibroblasts after low 
doses of ionizing radiation;

Tues Apr 17, 2007 - 12:30 PM - Dr. Masaaki (Maki) Moriya . SUNY Stonybrook 
. DNA repair and mutagenesis of ROS-generated lesions [Origin: Stonybrook]
Tues May 15, 2007 - 12:30 PM - Dr.  R. Stephen Lloyd . Portland, Oregon . 
Title: TBA [Origin: Portland]

Tues June 19, 2007 - 12:30 PM - Dr. Sam Wilson - NIEHS - History of DNA 
Repair [Origin - NIEHS]


1.1.2 VIDEOARCHIVES: INTERNET ACCESS (WORLDWIDE):
WE HAVE REACHED A LANDMARK!  THERE ARE NOW 100 VIDEOCONFERENCES ARCHIVED.
They are available for viewing at your leisure on the internet. You will 
need a web browser (with a high speed link) and free Real Video software. 
Setup details and access are available at the NIH videocast website: 
http://videocast.nih.gov. Go to Past events; DNA Repair Interest Group 
Sessions.

Note: Technical improvements are made regularly on this site to increase 
transmission speeds and ease of access. If you were not successful in 
viewing these videos in the past it is worth trying again.   We recently 
received a log of the use of these videocasts. They were downloaded nearly 
10,000 times in the past two years!

Nov 21, 2006 - Dr. William Kaufmann - UNC - The human intra-S checkpoint 
response to UV-induced DNA damage [Origin - UNC] [Note: The posting of 
this video is delayed at the request of the speaker]


Oct 17, 2006 - Dr. Betsy Sutherland - BNL - Endogenous and 
Radiation-induced DNA Damage Clusters and their Repair [Origin - 
Brookhaven] [Note: Adobe Acrobat files with slides from this talk can be 
downloaded at this site.]

Sept 19, 2006 - Dr. Yie Liu . NIA - Repair and maintenance of eroded 
telomeres in mice   [Origin: Baltimore] [Note: Adobe Acrobat files with 
slides from this talk can be downloaded at this site.]

June 20, 2006 - Dr. Stuart Linn - Univ of California, Berkeley - History 
of DNA Repair - Life in the Serendipitous Lane:  Excitement and 
Gratification in Studying DNA Repair [Note: Adobe Acrobat files with 
slides from this talk can be downloaded at this site.]

May 23, 2006 - Dr. Yossi Shiloh . Tel Aviv University, Tel Aviv, Israel - 
ATM: A Sentry at the Gate of Genome Stability [Note: Adobe Acrobat files 
with slides from this talk can be downloaded at this site.]

April 18, 2006- Young Investigator Showcase - Dr. Keziban Unsal-Kacmaz - 
Univ North Carolina - The role of Tipin-RPA interaction in the DNA damage 
checkpoint response; Dr. Brian Plosky - NICHHD  - Controlling the 
sub-cellular localization of DNA polymerases iota and eta via interactions 
with ubiquitin; Dr. Wen-Hsing Cheng - NIA - Werner protein participates in 
the cellular response to DNA double strand breaks [Note: The posting of 
the video is delayed at the request of the speakers]

Mar 21, 2006 - 12:30 PM . Dr. Ian Hickson . Oxford Univ, UK - Genomic 
Instability and Cancer: Insights from analysis of Bloom  syndrome [Note: 
Adobe Acrobat files with slides from this talk can be downloaded at this 
site.]

Feb 21, 2006 - 12:30 PM - Dr. Ben Van Houten - NIEHS  - In search of 
damage: structure-function studies of bacterial nucleotide excision repair 
proteins [Note: Files with slides from this talk can be downloaded at this 
site.]

Jan 17, 2006 - 12:30 PM - Dr. Vesna Rapic-Otrin . The UV-DDB-based ubiquit 
E3 ligases and NER

Dec 20, 2005 - Dr. Orlando Scharer - SUNY . Mechanisms of damage 
recognition and dual incision in human nucleotide excision repair 
[Origin: SUNY]
[Note: Adobe Acrobat files with slides from this talk can be downloaded at 
this site.]

Nov 15, 2005 - Dr. Susan Lees Miller - Univ of Calgary - The role of 
protein phosphorylation in nonhomologous end joining [Note: Adobe Acrobat 
files with slides from this talk can be downloaded at this site.]

Oct 18, 2005 -  Dr. Joanne Sweasy - Yale Univ - Is There a Link Between 
DNA Polymerase Beta and Cancer? [Note: Adobe Acrobat files with slides 
from this talk can be downloaded at this site.]

Sept 20, 2005 - Dr. Jonathan Eisen - TIGR, Rockville, MD - More questions 
than answers: insights into DNA repair processes from genome sequencing 
projects. [Note: Adobe Acrobat files with slides from this talk can be 
downloaded at this site.]

June 14, 2005 - Dr. Kurt W. Kohn, NCI - A personal history of DNA damage 
and repair research 1960-2005 [Note: Adobe Acrobat files with slides from 
this talk can be downloaded at this site.]

May 18 - Dr. Steve West - Cancer Research, UK also gave a lecture in the 
NIH Director.s Wed Afternoon lecture series Title:  Making Ends Meet: 
Double-strand Break Repair in Human Cells

May 17, 2005 - Dr. Steve West - Cancer Research UK, London Research 
Institute - Title: New insights into mechanisms of BRCA2-regulated 
double-strand break repair
[Note: Adobe Acrobat files with slides from this talk can be downloaded at 
this site. The posting of the video is delayed at the request of the 
speaker]

April 19, 2005 - Short talks by young investigators:
Dr. Miguel Garcia-Diaz - NIEHS - Structural analysis of strand 
misalignment during DNA synthesis; [Note: Adobe Acrobat files with slides 
from this talk can be downloaded at this site.]

Dr. Kyungjae Myung - NHGRI -Suppression and formation of gross chromosomal 
rearrangements through cross talk between different DNA metabolisms; 
[Note: Adobe Acrobat files with slides from this talk can be downloaded at 
this site.]

Dr. John Hinz - Livermore, CA -Distinct genomic instabilities associated 
with deficiencies in homologous recombination or the Fanconi anemia FANCD2 
monoubiquitination pathway [Note: The posting of the video is delayed at 
the request of the speaker]

March 15, 2005 - Dr. Wei Yang - NIDDK - DNA repair in 3D.  [Note: Adobe 
Acrobat files with slides from this talk can be downloaded at this site.]

Feb 16, 2005 Dr. Judy Campisi also gave a lecture in the NIH Director.s 
Wed Afternoon lecture series on the following day. Title: Cancer and 
aging: Rival demons?

Feb 15, 2005 - Dr. Judy Campisi - Univ of California Berkeley - Title: 
Genome maintenance systems, cancer and aging  [Note: Adobe Acrobat files 
with slides from this talk can be downloaded at this site.]

Jan 18, 2005 - Dr. Michael Seidman - NIA - Repair and Mutagenesis of 
Triplex Targeted Interstrand Crosslinks. [Note: Adobe Acrobat files with 
slides from this talk can be downloaded at this site.]

Through the miracle of videotape we now have been able to post most of the 
DNA Repair Interest Group videoconferences from 1998,1999, 2000, 2001, 
2002 and 2003 on the web site.  These include talks by Drs. Anderson, 
Beernik, Bogenhagen, Bohr, Bradsher, Brash, Brooks, Brosh, Chu, Cleaver, 
Chen, Copeland, Drotschmann, Elledge, Emmert, Essigman, Fornace, 
Friedberg, George, Glazer, Gordenin, Grossman, Hanawalt, Jin, Kashlev, 
Khan, Kowalczykowski, Kraemer, Kunkel, Lehmann, Leadon, Li, Liu, Ljungman, 
Marini, Matson, Matsumoto,  McKay, Mitra, Nussenzweig, Olson, Pommier, 
Prakash, Ramsden, Rosenquist, Sarasin, Setlow, Schaaper, Schofield, 
Sharan, Sobol, States, Stefanini, Storici,  Sung, Sutherland, Tainer, 
Taylor, Tomkinson, Thompson, Vasquez,  Wang, Wei, Wilson, Wood, Woodgate, 
Yanamadala, and Yarosh.

2. NIH SEMINARS OF NOTE: TBA


3.    CONFERENCES - MGMT and Alkylating Drug Resistance - Mainz, Germany - 
June 13-16, 2007

[Note: A larger and more up-to-date list of conferences can be found on 
the DNA Repair Interest Group web site: 
http://www.nih.gov:80/sigs/dna-rep/ ]

3.1  MGMT and Alkylating Drug Resistance - Mainz, Germany - June 13-16, 
2007
The 2nd International Meeting on "MGMT and Alkylating Drug Resistance" 
will be held in Mainz, Germany, from June 13-16, 2007. Congress venue is 
Favorite Park Hotel.
http://www.mgmt-agt.net/
Thanks and best regards,
Bernd Kaina





4.	POST DOC AND EMPLOYMENT OPPORTUNITIES: Bethesda, MD; Boston, MA: 
Indianapolis, IN; Marseille, France;  Baltimore, MD; San Francisco, CA; 
Cardiff, UK; Strasbourg, France
[Note: Check the list for more Job Opportunities on the DNA Repair 
Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ ]


4.1 NIH POST DOCTORAL FELLOWSHIP - HUMAN DISEASES WITH DEFECTIVE DNA 
REPAIR - BETHESDA, MD
We are studying molecular, cellular and clinical abnormalities in patients 
with defective DNA repair and possible links of these genes to disease in 
the general population. Current emphasis is on xeroderma pigmentosum, 
Cockayne syndrome and trichothiodystrophy.  A postdoctoral position is 
available for a talented individual (M.D., Ph.D. or MD-PhD) with less than 
5 years of postdoctoral experience who has knowledge of molecular biology 
and DNA repair.

To apply, send CV and bibliography and names (with contact information) of 
3 references to:

Kenneth H. Kraemer, M.D.
Basic Research Laboratory
National Cancer Institute, NIH
Building 37 Room 3E24
Bethesda,  MD 20892
TEL: 301-496-9033    FAX: 301-496-8419
e-mail: [log in to unmask]
DNA Repair Interest Group web site:
1.http://www.nih.gov:80/sigs/dna-rep/
Kraemer Lab web site:
http://ccr.cancer.gov/staff/staff.asp?profileid=5592

NIH is an equal opportunity employer.

4.2 POSTDOCTORAL FELLOWSHIP - DNA REPAIR,  BOSTON, MA

A postdoctoral fellowship is available at the DNA repair laboratory in the
Department of Chemistry and Chemical Biology, Northeastern University,
Boston. The laboratory, directed by Professor Penny Beuning, investigates
the molecular mechanisms of cellular responses to DNA damage and other
replication stresses using a wide variety of biochemical and biophysical
approaches. Postdoctoral associates would work in newly renovated
laboratories on the following projects: specialized damage-bypass DNA
polymerases; alternative processivity clamp proteins in DNA damage
tolerance.

Interested candidates should send a complete CV and a list of three
references to:
Prof. Penny Beuning: [log in to unmask]
More information: http://www.chem.neu.edu/web/faculty/Beuning.html

The Department of Chemistry and Chemical Biology at Northeastern
University is located on the Avenue of the Arts in the heart of Boston.
Northeastern University is an Equal Opportunity, Affirmative Action
Educational Institution and Employer, Title IX University.

4.3 FACULTY POSITIONS  - ENVIRONMENTAL HEALTH CENTER - INDIANAPOLIS, IN

The newly established Indiana University Center for Environmental Health 
located in the IU School of Medicine in Indianapolis announces a search 
for new faculty in the area of environmental health.  The Center for 
Environmental Health, in partnership with the Department of Pharmacology & 
Toxicology and the Indiana University Cancer Center seeks outstanding 
individuals for tenure-track faculty positions at the Assistant, Associate 
and Full Professor level.  The Center for Environmental Health is 
partnering with current active programs of excellence in toxicology, 
cancer research, neuropharmacology, and children.s health to address 
mechanisms of action and genetic susceptibility to environmental 
influences.

A Ph.D. and/or M.D. degree and at least three (3) years of postdoctoral 
research experience are required, and strong evidence of productivity and 
grant support are desirable.  Competitive start-up packages include ample 
space and access to exceptional core research facilities.  Successful 
candidates will be expected to develop strong extramurally supported 
research programs, contribute to an already strong, collaborative research 
environment, and to excel in mentoring graduate and postgraduate trainees.

More information about the Center for Environmental Health and partner 
departments can be found on our websites:  http://ceh.iu.edu; 
http://pharmtox.iusm.iu.edu and http://cancer.iu.edu.   Interested 
individuals should submit a curriculum vita, a research prospectus, and 
the names and addresses of three (3) references.  Application materials 
should be submitted electronically to the attention of Dr. James E. 
Klaunig, Robert B. Forney Professor of Toxicology, Director, Center for 
Environmental Health, IU School of Medicine at [log in to unmask] We 
encourage applications from women and other underrepresented groups. In 
addition, it is the University's policy to provide reasonable 
accommodations for qualified persons with disabilities. Indiana University 
is an EEO/AA Employer, M/F/D.


4.4 POSTDOCTORAL POSITIONS - MARSEILLE, FRANCE

Genome Instability and Carcinogenesis is a newly created CNRS Unit, headed 
by Robert P FUCHS, that offers a stimulating and dynamic international, 
English speaking environment to study the mechanisms underlying genome 
instability and its consequences in terms of carcinogenesis.
Further information can be found on our website : 
http://www.igc.cnrs-mrs.fr

Three positions are presently available for periods between 3-4 years in 
the groups of :

- Robert Fuchs .DNA Damage Tolerance : Translesion synthesis and 
mutagenesis. The present postdoctoral position is part of an integrated 
project focusing on the molecular mechanisms of damaged DNA replication. 
It entails the following aspects: lesion tolerance in vivo, structure of a 
blocked replication fork, biochemistry of TLS in human cells. Expertise in 
one of the following fields will be highly appreciated: DNA replication 
enzymology, large protein complex isolation, cell biology.

- Vincent Gli  .Telomeres, chromatin and checkpoints.
The project aims to study the control of telomerase activity during cell 
cycle, the mechanisms of telomere protection as a function of telomere 
length and the cellular consequences of telomere length variations.

- Pierre-Henri Gaillard .Control of structure-specific endonucleases and 
genome stability. Our goal is to identify the mechanisms that control a 
class of structure-specific DNA endonucleases involved in DNA 
repair/recombination pathways and assess their importance for the 
maintenance of genome stability.  Expertise in the areas of DNA repair 
and/or cell-cycle control with hands on experience in yeast genetics and 
protein purification, or cell biology, will constitute a plus.

Applicants should send a letter of interest, a full CV and the names and 
contact of three referees to either [log in to unmask], 
[log in to unmask] or [log in to unmask]


4.5 POST DOCTORAL FELLOWSHIP AND LABORATORY TECHNICIAN, NIA - BALTIMORE, 
MD

The National Institute on Aging (NIA), a major research component of the 
National Institutes of Health (NIH) and the Department of Health and Human 
Services (HHS), is recruiting for a postdoctoral fellow and a technician 
position in the Laboratory of Molecular Gerontology. Projects will involve 
molecular, biochemical, and cellular approaches, as well as mouse models, 
to define the mechanisms of telomere length regulation and maintenance. 
Emphasis will be placed on DNA damage response to telomere erosion and 
maintenance of eroded telomeres.

The candidate must have a Ph.D. degree or M.D. (for the  postdoctoral 
position) or Master degree (for technical position) in a relevant field. 
Prior training using molecular biology, cell biology, protein 
biochemistry, mammalian cell culture techniques is mandatory; some 
experience with mouse investigations is advantageous. Salary is 
commensurate with experience and accomplishments.

To be considered, applicants should send curriculum vitae, along with 
names of three references to: Yie Liu, Laboratory of Molecular 
Gerontology, Box 1; 5600 Nathan Shock Drive; Baltimore, MD 21224. Email: 
[log in to unmask] Applications will be accepted until the position 
is filled

HHS and NIH are equal opportunity employers


4.6 POST-DOCTORAL FELLOW, NATIONAL INSTITUTE ON AGING, BALTIMORE, MD

The National Institute on Aging (NIA), a major research component of the 
National Institutes of Health (NIH) and the Department of Health and Human 
Services (HHS), is recruiting for a postdoctoral position in the 
Laboratory of Molecular Gerontology (LMG). Projects will involve 
molecular, biochemical, and cellular approaches, as well as mouse models, 
to define the mechanisms of base excision and single-strand break repair. 
Emphasis will be placed on interrogating the contribution of oxidative DNA 
damage to aging and age-related disease, namely cancer and 
neurodegeneration.

The candidate must have a Ph.D. degree or M.D. in a relevant field with 
five years or less of postdoctoral experience. Prior training using 
molecular biology and mammalian cell culture techniques is mandatory; some 
experience with mouse investigations is advantageous. Salary is 
commensurate with experience and accomplishments.

To be considered, applicants should send curriculum vitae, along with 
names of three references to: David M. Wilson, III, Laboratory of 
Molecular Gerontology, Box 1; 5600 Nathan Shock Drive; Baltimore, MD 
21224. Email: [log in to unmask] 
(http://www.grc.nia.nih.gov/branches/lmg/dwilson.htm). Applications will 
be accepted until the position is filled. HHS and NIH are equal 
opportunity employers


4.7 POST DOCTORAL FELLOWSHIP - UNIV OF CALIFORNIA, SAN FRANCISCO
Organization Unit:	University of California, San Francisco, 
Department of Dermatology
Title of Position: Postdoctoral position available Qualifications 
Required: PhD degree in a related research field   Responsibilities:The 
candidate will perform research in the laboratory of Dr James E. Cleaver, 
UCSF Cancer Center, San Francisco, CA.  The incumbent is to work on 
neurodegeneration in Cockayne syndrome and xeroderma pigmentosum.  The 
position is funded for two years, with extension possible according to 
performance.  Preference will be given to a Candidate with experience 
working with genetically modified mice, tissue culture of neural tissue, 
oxidative damage and 	DNA repair.  The UCSF Cancer Center is a 
designated NCI Comprehensive Cancer Center, with core services for DNA 
sequencing, molecular cytometry, flow cytometry, fluorescent techniques, 
and transgenic animals. Start Date:	September 1, 2006 or sooner 
Salary:  Depending on the years of postdoctoral experience Contact: Please 
submit a letter of interest, curriculum vitae and the names and addresses 
of two references to:
 	James Cleaver, PhD, Professor
 	UCSF Cancer Center . Box 0808
 	San Francisco 94143-0808
 	Email: [log in to unmask]
 	Phone: (415) 476-4563 Fax: (415) 476-8218

The University of California is an Affirmative Action/Equal Opportunity 
Employer.  The University undertakes affirmative action to assure equal 
employment opportunity for underutilized minorities and women, for persons 
with disabilities, and for Vietnam-era veterans and special disabled 
veterans.


4.8 EMPLOYMENT OPPORTUNITIES CARDIFF UNIVERSITY MEDICAL SCHOOL

Cancer studies in the Medical School at Cardiff University are looking to 
appoint academic staff from research fellows, lecturers to professors in 
genome stability, chromatin structure and cell stress. The group gained a 
prestigious 5* rating in the UK-wide 2001 Research Assessment Exercise.

The cancer studies section has an exceptionally strong basic sciences 
section researching DNA nucleotide excision repair (Raymond Waters, Simon 
Reed and Christopher Jones); telomeres and cell ageing (David Kipling and 
Duncan Baird with), base excision repair and colon cancer (Julian Sampson 
and Jerry Cheadle); cell imaging (Paul smith and Rachel Errington); and 
the progression from normal to cancer cells (Wynford Thomas and 
Poghosyan).

The funding for basic research includes programme and project awards from 
the MRC, CRUK,  BBSRC, and joint research councils. This section is 
exceptionally well equipped with core facilities for transcriptome 
analysis and mass spectrometry.

Additionally, there are considerable strengths in translational research 
with the emphasis on leukaemia (Alan Burnett), colon cancer (Tim Maughan 
and Julian Sampson) and prostate cancer (Malcolm Mason and Wen Jiang).

Researchers in cancer studies works closely with those in other 
departments at CU, such as Alan Clarke (Mouse models and colon cancer) and 
Trevor Dale (Wnt signalling), in Biosciences, and Chris McGuigan and Ruth 
Duncan in Pharmacy who both work on drug delivery.

This vibrant and progressive atmosphere at CU is a superb environment for 
research and new appointments have little or no teaching or administrative 
duties.

Interested parties should contact:

Professor Ray Waters, Pathology Department
Medical School, Cardiff University, Heath Park,
Cardiff CF14 4XN, UK  e-mail:  [log in to unmask]
tel: +44 [0]2920 744848

www.cardiff.ac.uk/medicine/research/irg/cancer/index.htm



4.9 POST DOCTORAL POSITION IN CELLULAR RESPONSES TO DNA DAMAGE AND POLY 
(ADP-RIBOSYL)ATION.  CNRS, UNIVERSIT LOUIS PASTEUR, STRASBOURG, FRANCE.

Poly(ADP-ribosyl)ation is an immediate but transient DNA-damage-dependent 
post-translational modification of histones and other nuclear proteins 
catalysed by Poly(ADP-ribose) polymerases 1 and 2 (Parp-1 and Parp-2) that 
contributes to the survival of injured cells. The goal of the 
post-doctoral project will be to generate a cellular model as well as a 
mouse model deficient in both Parp-1 and Parp-2 and investigate the in 
vivo role of poly(ADP-ribosyl)ation in genome integrity. The cellular 
model will be generated by down regulating Parp-2 gene using the siRNA 
technology in Parp-1 deficient mouse embryonic fibroblasts. This model 
will help to elucidate the role of poly(ADP-ribosyl)ation in centromeric 
and telomeric heterochromatin integrity as well as in the recruitment of 
DNA repair factors and enzymes involved in poly(ADP-ribose) metabolism to 
the site of the lesion. In collaboration with ICS (Illkirch), a mouse with 
a conditional targeted disruption of Parp-2 in the keratinocytes, will be 
generated in a Parp-1 deficient background using the Cre/lox system. This 
animal model will be used to study the role of Parp-1, Parp-2 and 
poly(ADP-ribosyl)ation activity in cellular proliferation, differentiation 
and carcinogenesis. Experience in standard molecular and cellular biology 
techniques, epifluorescence microscopy and knockout/transgenic mice is 
highly desirable. Start date: on or after September 1, 2006, (18 months 
duration). Interested candidates should send a curriculum vitae, 
description of relevant research experience and contact information for 
three references to :

Dr. Gilbert de Murcia
Dpartement Intgrit du Gnome de l'UMR 7175, CNRS
Laboratoire Conventionn avec le Commissariat  l'Energie Atomique
Ecole Suprieure de Biotechnologie de Strasbourg
Boulevard Sebastien Brant, BP 10413
67412 Illkirch-Cedex, France

tel  33 3 90 24 47 07 fax 33 3 90 24 46 86
e-mail : [log in to unmask]
http://idg.u-strasbg.fr/  http://parplink.u-strasbg.fr





5.0  COMMERCIAL REAGENT SOURCES
[Note: There are more commercial reagent sources listed on the DNA Repair 
interest group website: http://www.nih.gov:80/sigs/dna-rep/    These 
sources are listed as a convenience to our readers and do not constitute 
an endorsement of any of these companies or their products.]

5.1 MBL International offers many kits and reagents for research on DNA 
Damage
and Repair. MBL is especially excited to introduce two unique monoclonal
antibodies that can detect the major classes of UV-induced photolesions:
Cyclobutane Pyrimidine Dimers (CPD) or pyrimidine-[6-4]-pyrimidinone
photoproducts (6-4 PP). These antibodies were established by Dr. T. Mori 
et
al. in Japan.

For more information on these antibodies, please visit the following links
http://www.mblintl.com/mbli/catalog/pdf/d195-1.pdf (anti-6-4PP)
http://www.mblintl.com/mbli/catalog/pdf/d194-1.pdf (anti-CPD)

or contact

Suzan Oberle, Ph.D.
Product Manager/Technical Service Manager
MBL International
800-200-5459
[log in to unmask]
www.mblintl.com


5.2 Biocompare - This website www.biocompare.com calls itself .The Buyer.s 
Guide for Life Scientists. This site includes comparisons of many reagents 
that are useful for DNA repair studies including a listing of antibodies.

5.3 Genetex - Antibodies for DNA repair www.genetex.com Located in Texas.

5.4 Operon Biotechnologies -  Operon is asking researchers who are 
interesting in CPD oligos cis-syn thymine dimers or cissyn cyclobutane 
pyrimidine dimers (CPDs) to contact us. We are looking to make these 
modified oligos available and are extremely interested in speaking with 
you about your specific requirements. Our technology, experience, and 
capacity are unparalleled in the industry, resulting in unsurpassed 
quality and service for 20 years. Operon offers custom synthesis of 
affordable, high-quality oligonucleotides - including a full range of 
longmers and modified oligos - in a variety of scales, concentrations, 
formats, and purification levels. Every effort will be made to help in 
your research efforts.

Please contact:
Michael Melch
Operon Biotechnologies, Inc.
Southeast Business Manager
Cell: (301) 814-1292
Fax: (251) 252-7753
Email: [log in to unmask] or [log in to unmask]
Website:  http://operon.com


5.5 Abcam Ltd ( www.abcam.com ) - At present, we have a fairly substantial 
range of products including those relating to DNA damage and repair (246 
in total), and are actively developing this as we speak.

Please find a hyperlink provided below for your review.

http://www.abcam.com/index.html?pageconfig=catalog_byclass&intClassID=6

Thank you in advance for your time and kind consideration.

Miss Lesa Rodgers
Marketing Assistant
Abcam Ltd
21 Cambridge Science Park
Milton Road, Cambridge,
Cambridgeshire CB4 0TP
United Kingdom
www.abcam.com


5.6 Bethyl Laboratories, Inc. - Antibodies for DNA Damage/Repair and 
related research (www.bethyl.com)  New antibodies include SDS3, DMAP1, 
KIF14, DIS, MCM2, MCM3, MCM4, MCM6, MCM7, MCM10, Claspin, BRD2, Pumilio 1, 
Pescadillo, Mre11, NBS1, SERCA2, AMPK and RFC1. http://www.bethyl.com

5.7 Reliable Biopharmaceutical Corporation - As the leading U.S. 
manufacturer of modified nucleic acids, we wanted to introduce you to our 
newest product: cis-syn TpT Cyclobutane Dimer Phosporamidite. Specially 
developed for the DNA repair and research markets. You can see our 
homepage and our TpT Dimer Amidite webpage to better understand our 
company and products. If I or my staff can answer any of your specific 
questions, please call at your convenience.

Sincerely,
Sourena Nadji, Ph.D.
Reliable Biopharmaceutical Corporation
Director of Research and Development
(314)429-7700
http://www.reliablebiopharm.com/

5.8 Novus Biologicals, Inc, Littleton, CO - Antibodies for DNA Repair
Research (http://www.novus-biologicals.com/research.php/8) and other
research applications (www.novusbio.com). New antibodies include RNase L,
ATRIP, CTR1, BRCA1, 14-3-3 gamma, DHX15, phospho-CREB [Ser121], FANCD2, 
BRIP
1, carbonic anhydrase IX, and p73.
For more information contact:
Novus Biologicals, Inc.
303-730-1950  [log in to unmask]

5.9 Santa Cruz Biotechnology, Inc, Santa Cruz, CA - Antibodies for 
research applications.  Please find specific product information at 
http://www.scbt.com

5.10 Cascade Bioscience - Antibodies to various FANC proteins.  Here is a 
link to a website we have in development featuring FANC antibodies. 
http://www.cascadebioscience.com
Patrick Foley, President, Cascade Bioscience, Inc, 37 Pierrepont Rd, 
Winchester, MA 01890, Phone 781-721-4758 Fax 781-729-4731

5.11 Rockland - the leader in antibody based products is located near 
Philadelphia, PA. Primary antibodies include Apolipoproteins, Collagens, 
Cytokines and Transcription Factors. Secondary antibodies are conjugated 
to a broad range of enzymes and fluorphors. ROCKLAND has developed new 
antibodies to study Signaling Pathways. We produce our own antibodies. It 
is for this reason researchers choose us for their custom antibody needs. 
Primary Antibodies AKT Signaling Antibodies; Phospho and Pan reactive 
antibodies involved in the PI-3 kinase pathway DNA Damage and Repair 
AntibodiesPhospho ATM antibodies, mTOR antibodies and many more Cancer 
Research Antibodies; Antibodies directed against Cell Cycle proteins, 
Chromatin and Apoptosis targets Neuroscience Antibodies; Beta Amyloid, 
Dab1, Superoxide Dismutase antibodies are just a few Ubiquitin & UBL; High 
quality antibodies like SUMO, ISG15 and Ubiquitin Epitope Tag Antibodies; 
6X HIS, HA, GST, Myc, RFP, Biotin, GFP and their conjugates Special 
(United States and Canada only)

Our product listing [ http://www.rockland-inc.com ] currently contains 
thousands of antibodies. You may also search for your favorite antibody in 
our ever growing database. To complete your experiment, we also have a 
number of other products and services that may interest you, to visit our 
web site click here. To obtain a Rockland catalog, please click here.
Are you looking for an antibody that you just cant find? Get a quote for 
Custom Antibody Production.
Custom Monoclonal Antibody Production
Custom Polyclonal Antibody Production
Regards,
Tabitha A. Bauman
Rockland Immunochemicals, Inc.
650 Englesville Road
Boyertown, PA 19512

5.12 Trevigen is a leading supplier of DNA damage research tools, 
including CometAssay. Kits and Slides, FLARE Kits, PARP and PARG products, 
DNA repair enzymes, antibodies to DNA damage adducts, and antibodies for 
oxidative damage detection (8-oxo-dG antibodies). In 2006, Trevigen will 
be launching Comet Assay Control Cells and a UVssDNA ELISA Kit, as well as 
other highly anticipated products. Trevigen looks forward to serving your 
DNA damage research needs. For more information, please call 
1-800-873-8443 or visit our website at: http://www.trevigen.com

Thanks,
Michael Elliott
Trevigen,Inc.

6	ELECTRONIC CONTACTS:
6.1	Check out the DNA Repair Interest Group web site: 
http://www.nih.gov:80/sigs/dna-rep/
You can find the schedule for future DNA Repair Interest Group 
videoconferences and a listing of past videoconferences (with links to the 
videoarchive) as well as a current list of JOB OPPORTUNITIES in DNA repair 
and MEETING NOTICES.

6.2	Encourage your colleagues who are interested in DNA Repair to 
request that they be added to this DNA Repair Interest Group listserve 
e-mail list by sending a request by e-mail to: [log in to unmask] 
Leave the subject  blank. In the message field, type in: subscribe 
DNARepair-L your name

 	Alternatively, by filling out the form on the website 
(http://www.nih.gov:80/sigs/dna-rep/ ) you can both add your name to the 
e-mail list and have your name posted on the website.  If you want your 
name to be listed you can fill out the .Join the SIG. form on the web site 
and add your name to the listing of members.  If you are not at NIH then 
be sure to click the .other. box and then fill in the name of your 
institution.

6.3	Archives of these listserve mailings can be found at
 	http://list.nih.gov/archives/dnarepair-l.html  or via links from 
the DNA Repair Interest Group web site: 
http://www.nih.gov:80/sigs/dna-rep/

6.4	I will be happy to relay information about post-doctoral 
positions, jobs and meetings and other information related to DNA Repair. 
Please send me an e-mail message ([log in to unmask]) and I will incorporate 
it into the next announcement list and post it on the DNA Repair Interest 
Group web site: http://www.nih.gov:80/sigs/dna-rep/ .

(This list goes to nearly 1500 scientists around the world who are 
interested in DNA repair.)


Kenneth H. Kraemer, M.D.
Chief, DNA Repair Section
Basic Research Laboratory
National Cancer Institute
Building 37 Room 3E24
Bethesda,  MD 20892
301-496-9033    FAX: 301-496-8419
e-mail: [log in to unmask]
DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/

Center for Information Technology National Institutes of Health Bethesda, Maryland 20892 301 594 6248 (v) 301 496 8294 (TDD) Comments and Assistance Accessibility