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Approved-By: [log in to unmask] Content-Type: TEXT/PLAIN; charset=US-ASCII; format=flowed Message-ID: <[log in to unmask]> Date: Sun, 17 Dec 2006 17:46:44 -0500 Reply-To: Ken Kraemer <[log in to unmask]> Sender: DNA Repair Interest Group <[log in to unmask]> From: "Kenneth H. Kraemer" <[log in to unmask]> Subject: DNA Repair Interest Group - UPDATE - Dec 17, 2006DNA Repair Interest Group - UPDATE - Dec 17, 2006 1 - VIDEOCONFERENCE: Tues Dec 19, 2006 - 12:30 PM - Dr. Stephen Meyn - Toronto - The human telomeric proteins TRF1, TRF2 and TIN2 participate in a novel cellular response to DNA damage 2 - NIH SEMINARS OF NOTE: TBA 3 - CONFERENCES - MGMT and Alkylating Drug Resistance - Mainz, Germany - June 13-16, 2007 4 - POST DOC AND EMPLOYMENT OPPORTUNITIES: Bethesda, MD; Boston, MA: Indianapolis, IN; Marseille, France; Baltimore, MD; San Francisco, CA; Cardiff, UK; Strasbourg, France 5 -COMMERCIAL REAGENT SOURCES 6- ELECTRONIC CONTACTS ______________________________________________________ 1.0 DNA REPAIR VIDEOCONFERENCE: Tues Dec 19, 2006 - 12:30 PM - Dr. Stephen Meyn - Univ of Toronto - The human telomeric proteins TRF1, TRF2 and TIN2 participate in a novel cellular response to DNA damage [Origin - Baltimore] VIDEOCONFERENCE LOCATIONS: Building 45 (NATCHER) Room J, Bethesda, MD; Room 1E03 GRC Baltimore, MD [origin]; NIEHS, Research Triangle Park, NC; Building 549, Conference Room A, FCRDC, Frederick, MD; Brookhaven National Labs, Upton, NY; Lawrence Livermore Labs, Livermore, CA ; Univ of Michigan, Ann Arbor; University of Pittsburgh; MD Anderson, Smithville, TX; State University of New York, Stony Brook, NY; Univ of Kentucky, Lexington, KY; Oregon Health & Science University, Portland, OR; Univ of North Carolina, Chapel Hill, NC Wake Forest Univ, Winston-Salem, NC and live on the internet at http://videocast.nih.gov 1.1 DNA REPAIR VIDEOCONFERENCE - FUTURE DATES AND VIDEO ARCHIVE [Note: A larger and more up to date list of future and past videoconferences can be found on the DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ ] 1.1.1 FUTURE VIDEOCONFERENCES: Tues Jan 16, 2007 - 12:30 PM - Dr. Dan Camerini-Ortero - NIDDK, NIH - Meiotic DNA Double-Strand Break Repair in Mice and Humans [Origin - NIH, Bethesda] Tues Feb 20, 2007 - 12:30 PM - Dr. Laura J. Niedernhofer - U of Pittsburgh - Title: Accelerated aging and cancer in ERCC1-XPF-deficient mouse models [Origin - Pittsburgh] Tues Mar 20, 2007 - 12:30 PM - Young Investigator Showcase - talks by investigators at 3 sites. Dr. Paul Wilson . Livermore . Variation in DNA double strand break repair capacity in diploid human fibroblasts after low doses of ionizing radiation; Tues Apr 17, 2007 - 12:30 PM - Dr. Masaaki (Maki) Moriya . SUNY Stonybrook . DNA repair and mutagenesis of ROS-generated lesions [Origin: Stonybrook] Tues May 15, 2007 - 12:30 PM - Dr. R. Stephen Lloyd . Portland, Oregon . Title: TBA [Origin: Portland] Tues June 19, 2007 - 12:30 PM - Dr. Sam Wilson - NIEHS - History of DNA Repair [Origin - NIEHS] 1.1.2 VIDEOARCHIVES: INTERNET ACCESS (WORLDWIDE): WE HAVE REACHED A LANDMARK! THERE ARE NOW 100 VIDEOCONFERENCES ARCHIVED. They are available for viewing at your leisure on the internet. You will need a web browser (with a high speed link) and free Real Video software. Setup details and access are available at the NIH videocast website: http://videocast.nih.gov. Go to Past events; DNA Repair Interest Group Sessions. Note: Technical improvements are made regularly on this site to increase transmission speeds and ease of access. If you were not successful in viewing these videos in the past it is worth trying again. We recently received a log of the use of these videocasts. They were downloaded nearly 10,000 times in the past two years! Nov 21, 2006 - Dr. William Kaufmann - UNC - The human intra-S checkpoint response to UV-induced DNA damage [Origin - UNC] [Note: The posting of this video is delayed at the request of the speaker] Oct 17, 2006 - Dr. Betsy Sutherland - BNL - Endogenous and Radiation-induced DNA Damage Clusters and their Repair [Origin - Brookhaven] [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] Sept 19, 2006 - Dr. Yie Liu . NIA - Repair and maintenance of eroded telomeres in mice [Origin: Baltimore] [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] June 20, 2006 - Dr. Stuart Linn - Univ of California, Berkeley - History of DNA Repair - Life in the Serendipitous Lane: Excitement and Gratification in Studying DNA Repair [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] May 23, 2006 - Dr. Yossi Shiloh . Tel Aviv University, Tel Aviv, Israel - ATM: A Sentry at the Gate of Genome Stability [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] April 18, 2006- Young Investigator Showcase - Dr. Keziban Unsal-Kacmaz - Univ North Carolina - The role of Tipin-RPA interaction in the DNA damage checkpoint response; Dr. Brian Plosky - NICHHD - Controlling the sub-cellular localization of DNA polymerases iota and eta via interactions with ubiquitin; Dr. Wen-Hsing Cheng - NIA - Werner protein participates in the cellular response to DNA double strand breaks [Note: The posting of the video is delayed at the request of the speakers] Mar 21, 2006 - 12:30 PM . Dr. Ian Hickson . Oxford Univ, UK - Genomic Instability and Cancer: Insights from analysis of Bloom syndrome [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] Feb 21, 2006 - 12:30 PM - Dr. Ben Van Houten - NIEHS - In search of damage: structure-function studies of bacterial nucleotide excision repair proteins [Note: Files with slides from this talk can be downloaded at this site.] Jan 17, 2006 - 12:30 PM - Dr. Vesna Rapic-Otrin . The UV-DDB-based ubiquit E3 ligases and NER Dec 20, 2005 - Dr. Orlando Scharer - SUNY . Mechanisms of damage recognition and dual incision in human nucleotide excision repair [Origin: SUNY] [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] Nov 15, 2005 - Dr. Susan Lees Miller - Univ of Calgary - The role of protein phosphorylation in nonhomologous end joining [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] Oct 18, 2005 - Dr. Joanne Sweasy - Yale Univ - Is There a Link Between DNA Polymerase Beta and Cancer? [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] Sept 20, 2005 - Dr. Jonathan Eisen - TIGR, Rockville, MD - More questions than answers: insights into DNA repair processes from genome sequencing projects. [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] June 14, 2005 - Dr. Kurt W. Kohn, NCI - A personal history of DNA damage and repair research 1960-2005 [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] May 18 - Dr. Steve West - Cancer Research, UK also gave a lecture in the NIH Director.s Wed Afternoon lecture series Title: Making Ends Meet: Double-strand Break Repair in Human Cells May 17, 2005 - Dr. Steve West - Cancer Research UK, London Research Institute - Title: New insights into mechanisms of BRCA2-regulated double-strand break repair [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site. The posting of the video is delayed at the request of the speaker] April 19, 2005 - Short talks by young investigators: Dr. Miguel Garcia-Diaz - NIEHS - Structural analysis of strand misalignment during DNA synthesis; [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] Dr. Kyungjae Myung - NHGRI -Suppression and formation of gross chromosomal rearrangements through cross talk between different DNA metabolisms; [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] Dr. John Hinz - Livermore, CA -Distinct genomic instabilities associated with deficiencies in homologous recombination or the Fanconi anemia FANCD2 monoubiquitination pathway [Note: The posting of the video is delayed at the request of the speaker] March 15, 2005 - Dr. Wei Yang - NIDDK - DNA repair in 3D. [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] Feb 16, 2005 Dr. Judy Campisi also gave a lecture in the NIH Director.s Wed Afternoon lecture series on the following day. Title: Cancer and aging: Rival demons? Feb 15, 2005 - Dr. Judy Campisi - Univ of California Berkeley - Title: Genome maintenance systems, cancer and aging [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] Jan 18, 2005 - Dr. Michael Seidman - NIA - Repair and Mutagenesis of Triplex Targeted Interstrand Crosslinks. [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] Through the miracle of videotape we now have been able to post most of the DNA Repair Interest Group videoconferences from 1998,1999, 2000, 2001, 2002 and 2003 on the web site. These include talks by Drs. Anderson, Beernik, Bogenhagen, Bohr, Bradsher, Brash, Brooks, Brosh, Chu, Cleaver, Chen, Copeland, Drotschmann, Elledge, Emmert, Essigman, Fornace, Friedberg, George, Glazer, Gordenin, Grossman, Hanawalt, Jin, Kashlev, Khan, Kowalczykowski, Kraemer, Kunkel, Lehmann, Leadon, Li, Liu, Ljungman, Marini, Matson, Matsumoto, McKay, Mitra, Nussenzweig, Olson, Pommier, Prakash, Ramsden, Rosenquist, Sarasin, Setlow, Schaaper, Schofield, Sharan, Sobol, States, Stefanini, Storici, Sung, Sutherland, Tainer, Taylor, Tomkinson, Thompson, Vasquez, Wang, Wei, Wilson, Wood, Woodgate, Yanamadala, and Yarosh. 2. NIH SEMINARS OF NOTE: TBA 3. CONFERENCES - MGMT and Alkylating Drug Resistance - Mainz, Germany - June 13-16, 2007 [Note: A larger and more up-to-date list of conferences can be found on the DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ ] 3.1 MGMT and Alkylating Drug Resistance - Mainz, Germany - June 13-16, 2007 The 2nd International Meeting on "MGMT and Alkylating Drug Resistance" will be held in Mainz, Germany, from June 13-16, 2007. Congress venue is Favorite Park Hotel. http://www.mgmt-agt.net/ Thanks and best regards, Bernd Kaina 4. POST DOC AND EMPLOYMENT OPPORTUNITIES: Bethesda, MD; Boston, MA: Indianapolis, IN; Marseille, France; Baltimore, MD; San Francisco, CA; Cardiff, UK; Strasbourg, France [Note: Check the list for more Job Opportunities on the DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ ] 4.1 NIH POST DOCTORAL FELLOWSHIP - HUMAN DISEASES WITH DEFECTIVE DNA REPAIR - BETHESDA, MD We are studying molecular, cellular and clinical abnormalities in patients with defective DNA repair and possible links of these genes to disease in the general population. Current emphasis is on xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. A postdoctoral position is available for a talented individual (M.D., Ph.D. or MD-PhD) with less than 5 years of postdoctoral experience who has knowledge of molecular biology and DNA repair. To apply, send CV and bibliography and names (with contact information) of 3 references to: Kenneth H. Kraemer, M.D. Basic Research Laboratory National Cancer Institute, NIH Building 37 Room 3E24 Bethesda, MD 20892 TEL: 301-496-9033 FAX: 301-496-8419 e-mail: [log in to unmask] DNA Repair Interest Group web site: 1.http://www.nih.gov:80/sigs/dna-rep/ Kraemer Lab web site: http://ccr.cancer.gov/staff/staff.asp?profileid=5592 NIH is an equal opportunity employer. 4.2 POSTDOCTORAL FELLOWSHIP - DNA REPAIR, BOSTON, MA A postdoctoral fellowship is available at the DNA repair laboratory in the Department of Chemistry and Chemical Biology, Northeastern University, Boston. The laboratory, directed by Professor Penny Beuning, investigates the molecular mechanisms of cellular responses to DNA damage and other replication stresses using a wide variety of biochemical and biophysical approaches. Postdoctoral associates would work in newly renovated laboratories on the following projects: specialized damage-bypass DNA polymerases; alternative processivity clamp proteins in DNA damage tolerance. Interested candidates should send a complete CV and a list of three references to: Prof. Penny Beuning: [log in to unmask] More information: http://www.chem.neu.edu/web/faculty/Beuning.html The Department of Chemistry and Chemical Biology at Northeastern University is located on the Avenue of the Arts in the heart of Boston. Northeastern University is an Equal Opportunity, Affirmative Action Educational Institution and Employer, Title IX University. 4.3 FACULTY POSITIONS - ENVIRONMENTAL HEALTH CENTER - INDIANAPOLIS, IN The newly established Indiana University Center for Environmental Health located in the IU School of Medicine in Indianapolis announces a search for new faculty in the area of environmental health. The Center for Environmental Health, in partnership with the Department of Pharmacology & Toxicology and the Indiana University Cancer Center seeks outstanding individuals for tenure-track faculty positions at the Assistant, Associate and Full Professor level. The Center for Environmental Health is partnering with current active programs of excellence in toxicology, cancer research, neuropharmacology, and children.s health to address mechanisms of action and genetic susceptibility to environmental influences. A Ph.D. and/or M.D. degree and at least three (3) years of postdoctoral research experience are required, and strong evidence of productivity and grant support are desirable. Competitive start-up packages include ample space and access to exceptional core research facilities. Successful candidates will be expected to develop strong extramurally supported research programs, contribute to an already strong, collaborative research environment, and to excel in mentoring graduate and postgraduate trainees. More information about the Center for Environmental Health and partner departments can be found on our websites: http://ceh.iu.edu; http://pharmtox.iusm.iu.edu and http://cancer.iu.edu. Interested individuals should submit a curriculum vita, a research prospectus, and the names and addresses of three (3) references. Application materials should be submitted electronically to the attention of Dr. James E. Klaunig, Robert B. Forney Professor of Toxicology, Director, Center for Environmental Health, IU School of Medicine at [log in to unmask] We encourage applications from women and other underrepresented groups. In addition, it is the University's policy to provide reasonable accommodations for qualified persons with disabilities. Indiana University is an EEO/AA Employer, M/F/D. 4.4 POSTDOCTORAL POSITIONS - MARSEILLE, FRANCE Genome Instability and Carcinogenesis is a newly created CNRS Unit, headed by Robert P FUCHS, that offers a stimulating and dynamic international, English speaking environment to study the mechanisms underlying genome instability and its consequences in terms of carcinogenesis. Further information can be found on our website : http://www.igc.cnrs-mrs.fr Three positions are presently available for periods between 3-4 years in the groups of : - Robert Fuchs .DNA Damage Tolerance : Translesion synthesis and mutagenesis. The present postdoctoral position is part of an integrated project focusing on the molecular mechanisms of damaged DNA replication. It entails the following aspects: lesion tolerance in vivo, structure of a blocked replication fork, biochemistry of TLS in human cells. Expertise in one of the following fields will be highly appreciated: DNA replication enzymology, large protein complex isolation, cell biology. - Vincent Gli .Telomeres, chromatin and checkpoints. The project aims to study the control of telomerase activity during cell cycle, the mechanisms of telomere protection as a function of telomere length and the cellular consequences of telomere length variations. - Pierre-Henri Gaillard .Control of structure-specific endonucleases and genome stability. Our goal is to identify the mechanisms that control a class of structure-specific DNA endonucleases involved in DNA repair/recombination pathways and assess their importance for the maintenance of genome stability. Expertise in the areas of DNA repair and/or cell-cycle control with hands on experience in yeast genetics and protein purification, or cell biology, will constitute a plus. Applicants should send a letter of interest, a full CV and the names and contact of three referees to either [log in to unmask], [log in to unmask] or [log in to unmask] 4.5 POST DOCTORAL FELLOWSHIP AND LABORATORY TECHNICIAN, NIA - BALTIMORE, MD The National Institute on Aging (NIA), a major research component of the National Institutes of Health (NIH) and the Department of Health and Human Services (HHS), is recruiting for a postdoctoral fellow and a technician position in the Laboratory of Molecular Gerontology. Projects will involve molecular, biochemical, and cellular approaches, as well as mouse models, to define the mechanisms of telomere length regulation and maintenance. Emphasis will be placed on DNA damage response to telomere erosion and maintenance of eroded telomeres. The candidate must have a Ph.D. degree or M.D. (for the postdoctoral position) or Master degree (for technical position) in a relevant field. Prior training using molecular biology, cell biology, protein biochemistry, mammalian cell culture techniques is mandatory; some experience with mouse investigations is advantageous. Salary is commensurate with experience and accomplishments. To be considered, applicants should send curriculum vitae, along with names of three references to: Yie Liu, Laboratory of Molecular Gerontology, Box 1; 5600 Nathan Shock Drive; Baltimore, MD 21224. Email: [log in to unmask] Applications will be accepted until the position is filled HHS and NIH are equal opportunity employers 4.6 POST-DOCTORAL FELLOW, NATIONAL INSTITUTE ON AGING, BALTIMORE, MD The National Institute on Aging (NIA), a major research component of the National Institutes of Health (NIH) and the Department of Health and Human Services (HHS), is recruiting for a postdoctoral position in the Laboratory of Molecular Gerontology (LMG). Projects will involve molecular, biochemical, and cellular approaches, as well as mouse models, to define the mechanisms of base excision and single-strand break repair. Emphasis will be placed on interrogating the contribution of oxidative DNA damage to aging and age-related disease, namely cancer and neurodegeneration. The candidate must have a Ph.D. degree or M.D. in a relevant field with five years or less of postdoctoral experience. Prior training using molecular biology and mammalian cell culture techniques is mandatory; some experience with mouse investigations is advantageous. Salary is commensurate with experience and accomplishments. To be considered, applicants should send curriculum vitae, along with names of three references to: David M. Wilson, III, Laboratory of Molecular Gerontology, Box 1; 5600 Nathan Shock Drive; Baltimore, MD 21224. Email: [log in to unmask] (http://www.grc.nia.nih.gov/branches/lmg/dwilson.htm). Applications will be accepted until the position is filled. HHS and NIH are equal opportunity employers 4.7 POST DOCTORAL FELLOWSHIP - UNIV OF CALIFORNIA, SAN FRANCISCO Organization Unit: University of California, San Francisco, Department of Dermatology Title of Position: Postdoctoral position available Qualifications Required: PhD degree in a related research field Responsibilities:The candidate will perform research in the laboratory of Dr James E. Cleaver, UCSF Cancer Center, San Francisco, CA. The incumbent is to work on neurodegeneration in Cockayne syndrome and xeroderma pigmentosum. The position is funded for two years, with extension possible according to performance. Preference will be given to a Candidate with experience working with genetically modified mice, tissue culture of neural tissue, oxidative damage and DNA repair. The UCSF Cancer Center is a designated NCI Comprehensive Cancer Center, with core services for DNA sequencing, molecular cytometry, flow cytometry, fluorescent techniques, and transgenic animals. Start Date: September 1, 2006 or sooner Salary: Depending on the years of postdoctoral experience Contact: Please submit a letter of interest, curriculum vitae and the names and addresses of two references to: James Cleaver, PhD, Professor UCSF Cancer Center . Box 0808 San Francisco 94143-0808 Email: [log in to unmask] Phone: (415) 476-4563 Fax: (415) 476-8218 The University of California is an Affirmative Action/Equal Opportunity Employer. The University undertakes affirmative action to assure equal employment opportunity for underutilized minorities and women, for persons with disabilities, and for Vietnam-era veterans and special disabled veterans. 4.8 EMPLOYMENT OPPORTUNITIES CARDIFF UNIVERSITY MEDICAL SCHOOL Cancer studies in the Medical School at Cardiff University are looking to appoint academic staff from research fellows, lecturers to professors in genome stability, chromatin structure and cell stress. The group gained a prestigious 5* rating in the UK-wide 2001 Research Assessment Exercise. The cancer studies section has an exceptionally strong basic sciences section researching DNA nucleotide excision repair (Raymond Waters, Simon Reed and Christopher Jones); telomeres and cell ageing (David Kipling and Duncan Baird with), base excision repair and colon cancer (Julian Sampson and Jerry Cheadle); cell imaging (Paul smith and Rachel Errington); and the progression from normal to cancer cells (Wynford Thomas and Poghosyan). The funding for basic research includes programme and project awards from the MRC, CRUK, BBSRC, and joint research councils. This section is exceptionally well equipped with core facilities for transcriptome analysis and mass spectrometry. Additionally, there are considerable strengths in translational research with the emphasis on leukaemia (Alan Burnett), colon cancer (Tim Maughan and Julian Sampson) and prostate cancer (Malcolm Mason and Wen Jiang). Researchers in cancer studies works closely with those in other departments at CU, such as Alan Clarke (Mouse models and colon cancer) and Trevor Dale (Wnt signalling), in Biosciences, and Chris McGuigan and Ruth Duncan in Pharmacy who both work on drug delivery. This vibrant and progressive atmosphere at CU is a superb environment for research and new appointments have little or no teaching or administrative duties. Interested parties should contact: Professor Ray Waters, Pathology Department Medical School, Cardiff University, Heath Park, Cardiff CF14 4XN, UK e-mail: [log in to unmask] tel: +44 [0]2920 744848 www.cardiff.ac.uk/medicine/research/irg/cancer/index.htm 4.9 POST DOCTORAL POSITION IN CELLULAR RESPONSES TO DNA DAMAGE AND POLY (ADP-RIBOSYL)ATION. CNRS, UNIVERSIT LOUIS PASTEUR, STRASBOURG, FRANCE. Poly(ADP-ribosyl)ation is an immediate but transient DNA-damage-dependent post-translational modification of histones and other nuclear proteins catalysed by Poly(ADP-ribose) polymerases 1 and 2 (Parp-1 and Parp-2) that contributes to the survival of injured cells. The goal of the post-doctoral project will be to generate a cellular model as well as a mouse model deficient in both Parp-1 and Parp-2 and investigate the in vivo role of poly(ADP-ribosyl)ation in genome integrity. The cellular model will be generated by down regulating Parp-2 gene using the siRNA technology in Parp-1 deficient mouse embryonic fibroblasts. This model will help to elucidate the role of poly(ADP-ribosyl)ation in centromeric and telomeric heterochromatin integrity as well as in the recruitment of DNA repair factors and enzymes involved in poly(ADP-ribose) metabolism to the site of the lesion. In collaboration with ICS (Illkirch), a mouse with a conditional targeted disruption of Parp-2 in the keratinocytes, will be generated in a Parp-1 deficient background using the Cre/lox system. This animal model will be used to study the role of Parp-1, Parp-2 and poly(ADP-ribosyl)ation activity in cellular proliferation, differentiation and carcinogenesis. Experience in standard molecular and cellular biology techniques, epifluorescence microscopy and knockout/transgenic mice is highly desirable. Start date: on or after September 1, 2006, (18 months duration). Interested candidates should send a curriculum vitae, description of relevant research experience and contact information for three references to : Dr. Gilbert de Murcia Dpartement Intgrit du Gnome de l'UMR 7175, CNRS Laboratoire Conventionn avec le Commissariat l'Energie Atomique Ecole Suprieure de Biotechnologie de Strasbourg Boulevard Sebastien Brant, BP 10413 67412 Illkirch-Cedex, France tel 33 3 90 24 47 07 fax 33 3 90 24 46 86 e-mail : [log in to unmask] http://idg.u-strasbg.fr/ http://parplink.u-strasbg.fr 5.0 COMMERCIAL REAGENT SOURCES [Note: There are more commercial reagent sources listed on the DNA Repair interest group website: http://www.nih.gov:80/sigs/dna-rep/ These sources are listed as a convenience to our readers and do not constitute an endorsement of any of these companies or their products.] 5.1 MBL International offers many kits and reagents for research on DNA Damage and Repair. MBL is especially excited to introduce two unique monoclonal antibodies that can detect the major classes of UV-induced photolesions: Cyclobutane Pyrimidine Dimers (CPD) or pyrimidine-[6-4]-pyrimidinone photoproducts (6-4 PP). These antibodies were established by Dr. T. Mori et al. in Japan. For more information on these antibodies, please visit the following links http://www.mblintl.com/mbli/catalog/pdf/d195-1.pdf (anti-6-4PP) http://www.mblintl.com/mbli/catalog/pdf/d194-1.pdf (anti-CPD) or contact Suzan Oberle, Ph.D. Product Manager/Technical Service Manager MBL International 800-200-5459 [log in to unmask] www.mblintl.com 5.2 Biocompare - This website www.biocompare.com calls itself .The Buyer.s Guide for Life Scientists. This site includes comparisons of many reagents that are useful for DNA repair studies including a listing of antibodies. 5.3 Genetex - Antibodies for DNA repair www.genetex.com Located in Texas. 5.4 Operon Biotechnologies - Operon is asking researchers who are interesting in CPD oligos cis-syn thymine dimers or cissyn cyclobutane pyrimidine dimers (CPDs) to contact us. We are looking to make these modified oligos available and are extremely interested in speaking with you about your specific requirements. Our technology, experience, and capacity are unparalleled in the industry, resulting in unsurpassed quality and service for 20 years. Operon offers custom synthesis of affordable, high-quality oligonucleotides - including a full range of longmers and modified oligos - in a variety of scales, concentrations, formats, and purification levels. Every effort will be made to help in your research efforts. Please contact: Michael Melch Operon Biotechnologies, Inc. Southeast Business Manager Cell: (301) 814-1292 Fax: (251) 252-7753 Email: [log in to unmask] or [log in to unmask] Website: http://operon.com 5.5 Abcam Ltd ( www.abcam.com ) - At present, we have a fairly substantial range of products including those relating to DNA damage and repair (246 in total), and are actively developing this as we speak. Please find a hyperlink provided below for your review. http://www.abcam.com/index.html?pageconfig=catalog_byclass&intClassID=6 Thank you in advance for your time and kind consideration. Miss Lesa Rodgers Marketing Assistant Abcam Ltd 21 Cambridge Science Park Milton Road, Cambridge, Cambridgeshire CB4 0TP United Kingdom www.abcam.com 5.6 Bethyl Laboratories, Inc. - Antibodies for DNA Damage/Repair and related research (www.bethyl.com) New antibodies include SDS3, DMAP1, KIF14, DIS, MCM2, MCM3, MCM4, MCM6, MCM7, MCM10, Claspin, BRD2, Pumilio 1, Pescadillo, Mre11, NBS1, SERCA2, AMPK and RFC1. http://www.bethyl.com 5.7 Reliable Biopharmaceutical Corporation - As the leading U.S. manufacturer of modified nucleic acids, we wanted to introduce you to our newest product: cis-syn TpT Cyclobutane Dimer Phosporamidite. Specially developed for the DNA repair and research markets. You can see our homepage and our TpT Dimer Amidite webpage to better understand our company and products. If I or my staff can answer any of your specific questions, please call at your convenience. Sincerely, Sourena Nadji, Ph.D. Reliable Biopharmaceutical Corporation Director of Research and Development (314)429-7700 http://www.reliablebiopharm.com/ 5.8 Novus Biologicals, Inc, Littleton, CO - Antibodies for DNA Repair Research (http://www.novus-biologicals.com/research.php/8) and other research applications (www.novusbio.com). New antibodies include RNase L, ATRIP, CTR1, BRCA1, 14-3-3 gamma, DHX15, phospho-CREB [Ser121], FANCD2, BRIP 1, carbonic anhydrase IX, and p73. For more information contact: Novus Biologicals, Inc. 303-730-1950 [log in to unmask] 5.9 Santa Cruz Biotechnology, Inc, Santa Cruz, CA - Antibodies for research applications. Please find specific product information at http://www.scbt.com 5.10 Cascade Bioscience - Antibodies to various FANC proteins. Here is a link to a website we have in development featuring FANC antibodies. http://www.cascadebioscience.com Patrick Foley, President, Cascade Bioscience, Inc, 37 Pierrepont Rd, Winchester, MA 01890, Phone 781-721-4758 Fax 781-729-4731 5.11 Rockland - the leader in antibody based products is located near Philadelphia, PA. Primary antibodies include Apolipoproteins, Collagens, Cytokines and Transcription Factors. Secondary antibodies are conjugated to a broad range of enzymes and fluorphors. ROCKLAND has developed new antibodies to study Signaling Pathways. We produce our own antibodies. It is for this reason researchers choose us for their custom antibody needs. Primary Antibodies AKT Signaling Antibodies; Phospho and Pan reactive antibodies involved in the PI-3 kinase pathway DNA Damage and Repair AntibodiesPhospho ATM antibodies, mTOR antibodies and many more Cancer Research Antibodies; Antibodies directed against Cell Cycle proteins, Chromatin and Apoptosis targets Neuroscience Antibodies; Beta Amyloid, Dab1, Superoxide Dismutase antibodies are just a few Ubiquitin & UBL; High quality antibodies like SUMO, ISG15 and Ubiquitin Epitope Tag Antibodies; 6X HIS, HA, GST, Myc, RFP, Biotin, GFP and their conjugates Special (United States and Canada only) Our product listing [ http://www.rockland-inc.com ] currently contains thousands of antibodies. You may also search for your favorite antibody in our ever growing database. To complete your experiment, we also have a number of other products and services that may interest you, to visit our web site click here. To obtain a Rockland catalog, please click here. Are you looking for an antibody that you just cant find? Get a quote for Custom Antibody Production. Custom Monoclonal Antibody Production Custom Polyclonal Antibody Production Regards, Tabitha A. Bauman Rockland Immunochemicals, Inc. 650 Englesville Road Boyertown, PA 19512 5.12 Trevigen is a leading supplier of DNA damage research tools, including CometAssay. Kits and Slides, FLARE Kits, PARP and PARG products, DNA repair enzymes, antibodies to DNA damage adducts, and antibodies for oxidative damage detection (8-oxo-dG antibodies). In 2006, Trevigen will be launching Comet Assay Control Cells and a UVssDNA ELISA Kit, as well as other highly anticipated products. Trevigen looks forward to serving your DNA damage research needs. For more information, please call 1-800-873-8443 or visit our website at: http://www.trevigen.com Thanks, Michael Elliott Trevigen,Inc. 6 ELECTRONIC CONTACTS: 6.1 Check out the DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ You can find the schedule for future DNA Repair Interest Group videoconferences and a listing of past videoconferences (with links to the videoarchive) as well as a current list of JOB OPPORTUNITIES in DNA repair and MEETING NOTICES. 6.2 Encourage your colleagues who are interested in DNA Repair to request that they be added to this DNA Repair Interest Group listserve e-mail list by sending a request by e-mail to: [log in to unmask] Leave the subject blank. In the message field, type in: subscribe DNARepair-L your name Alternatively, by filling out the form on the website (http://www.nih.gov:80/sigs/dna-rep/ ) you can both add your name to the e-mail list and have your name posted on the website. If you want your name to be listed you can fill out the .Join the SIG. form on the web site and add your name to the listing of members. If you are not at NIH then be sure to click the .other. box and then fill in the name of your institution. 6.3 Archives of these listserve mailings can be found at http://list.nih.gov/archives/dnarepair-l.html or via links from the DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ 6.4 I will be happy to relay information about post-doctoral positions, jobs and meetings and other information related to DNA Repair. Please send me an e-mail message ([log in to unmask]) and I will incorporate it into the next announcement list and post it on the DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ . (This list goes to nearly 1500 scientists around the world who are interested in DNA repair.) Kenneth H. Kraemer, M.D. Chief, DNA Repair Section Basic Research Laboratory National Cancer Institute Building 37 Room 3E24 Bethesda, MD 20892 301-496-9033 FAX: 301-496-8419 e-mail: [log in to unmask] DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/
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