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Message-ID:  <[log in to unmask]>
Date:         Thu, 3 Jan 2002 14:55:39 -0500
Reply-To:     Ken Kraemer <[log in to unmask]>
Sender:       DNA Repair Interest Group <[log in to unmask]>
From:         "Kenneth H. Kraemer" <[log in to unmask]>
Subject:      DNA Repair Interest Group -UPDATE - January 3, 2002

DNA Repair Interest Group -UPDATE - January 3, 2002

1.      VIDEOCONFERENCE - Jan 15, 2002 - Dr. Tom Kunkel- NIEHS - Recent
studies of DNA Mismatch Repair
2.      Comet assay website
3.      New DNA Repair Journal
4.      CONFERENCES - ENVIRONMENTAL MUTAGEN SOCIETY; IUPAC Symposium on
Photochemistry
5.      POST DOC AND EMPLOYMENT OPPORTUNITIES: Bethesda, MD;
Winston-Salem, NC; Worcester, MA; Boston, MA; Research Triangle Park, NC;
Livermore, CA; Baltimore, MD; Irvine, CA; Portland, OR
6.      DNA Repair antibodies
7.      Electronic Contacts


HAPPY NEW YEAR!

1.0     DNA REPAIR VIDEOCONFERENCE:

Jan 15, 2002 - Tues 12:30PM - Dr. Tom Kunkel- NIEHS - Recent studies of
DNA Mismatch Repair

VIDEOCONFERENCE LOCATIONS:  Building 45 (NATCHER) Room H, Bethesda, MD;
Building 101 Room B200, NIEHS, Research Triangle Park, NC (origin); State
University of New York, Stony Brook, NY; Room 1E03 GRC Baltimore, MD; MD
Anderson, Smithville, TX; Univ of Kentucky, Lexington, KY; Building 549,
Conference Room A,  FCRDC, Frederick, MD; Lawrence Livermore Labs,
Livermore, CA; Univ of Michigan, Ann Arbor; Brookhaven National Labs,
Upton, NY and University of Pittsburgh and live on the internet at
http://videocast.nih.gov

1.1     DNA REPAIR VIDEOCONFERENCE - FUTURE DATES AND VIDEO ARCHIVE
[Note: A larger and more up to date list of future and past
videoconferences can be found on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

1.1.1 FUTURE VIDEOCONFERENCES:

Feb 19, 2002 - Tues 12:30PM - Dr. Yves Pommier - NCI - Nucleotide excision
repair-dependent cytotoxicity of a novel anticancer agent, ecteinascidin
743.

Mar 19, 2002 - Tues 12:30PM - Smithville, TX - Speakers to be announced

Apr 16, 2002 - Tues 12:30PM - Dr. Philip Hanawalt - History of DNA Repair

May 21, 2002 - Tues 12:30PM - Talks by post doctoral fellows

June 18, 2002 - Tues 12:30PM - Dr. David Chen - Lawrence Berkeley National
Lab - Role of DNA-PK in Cellular Responses to DNA damage


1.1.2 VIDEOARCHIVES: INTERNET ACCESS (WORLDWIDE):
Now 39 of these videoconferences have been archived and are available for
viewing at your leisure on the internet. You will need a web browser (with
a high speed link) and free Real Video software.  Setup details and access
are available at the NIH videocast website:  http://videocast.nih.gov. Go
to Unicast sessions; Past events; DNA Repair Interest Group Sessions.

Note: Technical improvements are made regularly on this site to increase
transmission speeds and ease of access. If you were not successful in
viewing these videos in the past it is worth trying again!

Dec 18, 2001 -  Dr. Richard Wood - Univ of Pittsburgh- Tolerating damaged
DNA

Nov 13, 2001 - Dr. J. Christopher States - University of Louisville-
Cisplatin regulation of XPA expression in ovarian cancer cells [Note:
Posting of this videoconference will be delayed at the request of the
speaker]

Oct 16, 2001 - Dr. Daniel Yarosh - Applied Genetics - Reduction of Skin
Cancer in XP Patients Treated Topically with DNA Repair Enzymes

JUNE 19, 2001 - Dr. James Cleaver -Univ of California, San Francisco, CA -
History of DNA Repair - Mending Human Genes

MAY 15, 2001- Dr. Bill Copeland - Laboratory of Molecular Genetics NIEHS -
Family A DNA polymerases in eukaryotic DNA replication and repair

MAR 20, 2001 - Short talks at 3 sites:
Peter Beernink, LLNL - A Second Divalent Metal Ion in the Active Site of a
New Crystal Form of Human Apurinic/Apyridinimic Endonuclease, Ape1, and
its Implications for the Catalytic Mechanism

Yong Hwan Jin, NIEHS - The 3'-5' Exonuclease of DNA Polymerase d is
Redundant with 5'-flap Endonuclease Rad27/Fen1 for Processing of Okazaki
Fragments

Robert M. Brosh, NIA - Molecular Interactions of the Werner Syndrome
Protein

FEB 20, 2001 - Dr. Vilhelm Bohr - LMG, NIA, Baltimore, MD -  DNA repair
defects in premature aging disorders

JAN 16, 2001- Dr. Mats Ljungman - Univ of Michigan, Ann Arbor, MI -Stopped
in its tracks - RNA polymerase II as a sensor for DNA damage


Through the miracle of videotape we now have been able to post most of the
DNA Repair Interest Group videoconferences from 1998,1999 and 2000 on the
web site.  These include talks by Drs. Bogenhagen, Sutherland, Kunkel,
Stefanini, Hanawalt, Matson, Sharan, Kashlev , Fornace, Anderson, Leadon,
Brooks, McKay, Drotschmann, Chu, Thompson, Woodgate, George, Liu,
Grossman, Essigman, Emmert, Sobol, Glazer, Setlow, Kraemer, Matsumoto,
Wang, and Sung.


2. COMET ASSAY INFORMATION WEBSITE

Single cell gel (SCG) electrophoresis or 'Comet assay' is a rapid and very
sensitive fluorescent microscopic method to examine DNA damage and repair
at individual cell level. This international website http://cometassay.com
provides information about the assay, protocols, and a link to an NIH
listserve for discussion of the assay.


3.   New DNA REPAIR JOURNAL

Dr. Larry Thompson writes:
The DNA Repair section of Mutation Research is now changed into a new
journal, completely separate from Mutation Research. A website explains
the new journal:
http://www.elsevier.com/locate/dnarepair

4.    CONFERENCES -ENVIRONMENTAL MUTAGEN SOCIETY; IUPAC Symposium on
Photochemistry
[Note: A larger and more up-to-date list of conferences can be found on
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]
4.1 ANNUAL MEETING OF THE ENVIRONMENTAL MUTAGEN SOCIETY -
Anchorage, Alaska, 27 April - 2 May, 2002

"FRONTIERS BEYOND THE HUMAN GENOME"
Program Chair: Larry Loeb

The program for the 33rd Annual Meeting of the Environmental Mutagen
Society (EMS) is now available at http://www.ems-us.org/program02.html.

A number of symposia and sessions are devoted to DNA repair. These include
"Double-Stranded Breaks: The Ultimate End Game"
"Complex DNA Lesions: Repair and Mutagenesis"
"When Polymerases Are Arrested, Who Is at Fault, and What Are the
Options?"

Please check out the details of the conference at www.ems-us.org. Click
on"meetings."

Hope to see you there!

David M. DeMarini
President, EMS
[log in to unmask]

4.2 IUPAC Symposium on Photochemistry - Budapest, Hungary, July 14-19,
2002

The home page of the XIXth IUPAC Symposium on Photochemistry is being
updated. You will find all necessary forms and deadlines, including the
form for the submission of abstracts. If you intend to present an oral
contribution, please note the deadline of March 1, 2002. Oral
presentations will be selectedby the International Scientific Committee
(ISC). The home page will be updated from time to time, as needed, so
please check it occasionally.
http://www.photoiupac.hu

Heinz Roth and Jozsef Nyitrai




5.      POST DOC AND EMPLOYMENT OPPORTUNITIES: Bethesda, MD;
Winston-Salem, NC; Worcester, MA; Boston, MA; Research Triangle Park, NC;
Livermore, CA; Baltimore, MD; Irvine, CA; Portland, OR [Note: Check the
list for more Job Opportunities on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

5.1 HUMAN DISEASES WITH DEFECTIVE DNA REPAIR - POST DOC POSITION

We are studying molecular, cellular and clinical abnormalities in patients
with defective DNA repair and possible links of these genes to disease in
the general population. Current emphasis is on xeroderma pigmentosum,
Cockayne syndrome and trichothiodystrophy.  A postdoctoral position is
available for a talented individual (M.D., Ph.D. or MD-PhD) with less than
5 years of postdoctoral experience who has knowledge of molecular biology
and DNA repair.

To apply, send CV and bibliography and names (with contact information) of
3 references to:

Kenneth H. Kraemer, M.D.
Basic Research Laboratory
National Cancer Institute, NIH
Building 37 Room 3E24
Bethesda,  MD 20892
TEL: 301-496-9033    FAX: 301-496-8419
e-mail: [log in to unmask]
http://rex.nci.nih.gov/RESEARCH/basic/lmc/khk.htm

NIH is an equal opportunity employer


5.2 POSTDOCTORAL OPPORTUNITY AT UNIVERSITY OF MICHIGAN, ANN ARBOR

Our laboratory's interest is to gain insight into the basis of chromosomal
rearrangement in cancer by studying the molecular mechanisms of DNA
double-strand break repair. The fellow will be able to choose from several
related project areas, including (1) use of recently developed genomic
approaches to explore the choice between recombination and nonhomologous
end joining (NHEJ), (2) biochemical and genetic characterization of the
polymerase(s), nuclease(s), and other enzymes required for end-processing
during NHEJ, and (3) the molecular basis for repair of
topoisomerase-induced breaks.

Candidates should have a strong background in applied biochemistry,
molecular biology and/or genetics. Experience with yeast would be of
benefit, but is not required. Send a cover letter, CV, and the names of
three references, to:

Thomas E. Wilson, M.D., Ph.D.
Department of Pathology
University of Michigan Medical School
Medical Science I M4214/0602
1301 Catherine Rd.
Ann Arbor, MI 48109-0602
Email: [log in to unmask]
Website: http://tewlab.path.med.umich.edu/



5.3  POSTDOC POSITION - WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE,
WINSTON-SALEM, NORTH CAROLINA

Postdoc position is available to investigate the roles of DNA
damage/repair in human cancer risk (prostate, breast, and colon).
Candidate will participate in several ongoing studies with focus on the
functional significance of DNA repair genetic polymorphisms in DNA
damage/repair and cancer susceptibility. Experience with DNA damage/repair
assays or statistics/epidemiology desirable. This position will be
supported by a NIH grant initially and the candidate is eligible to apply
for a postdoc fellowship provided by the training grant of the Department
of Cancer Biology. Candidates should have a Ph.D., M.D., or equivalent
degree in molecular biology, cell biology, biochemistry,
genetics, epidemiology, or related field. Applicant must have less than3
years of postdoctoral experience. Recent graduates are encouraged toapply.
Salary $30K-35K based on experience plus health benefits. Available
immediately.

To apply, send CV and list of three references(with contact information )
to:
Jennifer J. Hu, Ph.D.
Department of Cancer Biology
Wake Forest University School of Medicine
Medical Center Blvd.
Winston-Salem, NC 27157
e-mail:[log in to unmask]

5.4  POSTDOCTORAL POSITION  - WORCESTER, MA

A postdoctoral position will be available Spring-Summer 2002 to study
drug-induced recombination in Escherichia coli K-12 (see J. Bacteriol.
182,
463-468; Chemistry and Biology 7, 39-50). Working knowledge of bacterial
genetics desirable but not essential.
Applicants should send a CV and the names of three references to:
[log in to unmask]
or
Dr MG Marinus,
Biochemistry and Molecular Pharmacology,
University of Massachusetts MedicalSchool,
55 Lake Ave,
Worcester MA 01655 USA. (Worcester MA is located 50 km west of Boston).

5.5 POST DOCTORAL POSITION - BOSTON, MA
A postdoctoral position is available to study the molecular basis for DNA
damage-induced mitotic homologous recombination in mammals. Particular
emphasis is on the how the base excision repair pathway modulates cellular
susceptibility to homologous recombination. Current projects are focused
on using cell culture and whole animal models to explore the mechanisms by
which DNA lesions lead to sequence rearrangements. A system for using
fluorescence to monitor homologous recombination events in adult mice has
recently been developed in this laboratory, thus opening exciting
opportunities to study mechanisms by which genetic and environmental
factors induce homologous recombination in mammals.

For more information, please contact:
Bevin P. Engelward, Sc.D.
MIT Division of Bioengineering and Environmental [log in to unmask]


5.6 POSTDOC RESEARCH OPPORTUNITY - RESEARCH TRIANGLE PARK, NORTH CAROLINA

Molecular Epidemiology of DNA Repair Fellowship position is available to
investigate the role of human variation in DNA repair on cancer risk.
Studies will examine the correlation between repair phenotype and DNA
repair gene polymorphisms and mutation frequency in preneoplastic and
normal tissue and will also focus on applying phenotypic measures of
repair capacity in samples from case-control studies. Experience with Host
Cell Reactivation, Comet, and Chromosomal Break and other repair assays
desirable. This position is within an interdisciplinary training program
with a primary appointment to the Laboratory of Molecular Carcinogenesis
and adjunct appointment in the Epidemiology Branch.Excellent resources,
equipment, supplies, and opportunities for interdisciplinary training and
development are available.

Candidates should have a Ph.D., M.D. or equivalent degree in molecular
biology, cell biology, biochemistry, genetics, or related field. Applicant
must have less than 5 years of postdoctoral research experience. Recent
graduates are encouraged to apply. Salary $30-36.5K based on experience
plus health benefits. Available October 1, 2001.

APPLY TO:

Jack A. Taylor, MD, PhD, Head
Molecular and Genetic Epidemiology Section, MD A3-05
NIEHS, NIH, PO Box 12233
Research Triangle Park, North Carolina 27709
E-mail: [log in to unmask]
Tel: (919) 541-4631 Fax: (919) 541-2511
http://dir.niehs.nih.gov/dirlmc/lmcmges.htm



5.7  POSTDOCTORAL POSITIONS IN DNA REPAIR RESEARCH AT LAWRENCE
LIVERMORE NATIONAL LABORATORY, Livermore, California
Several positions for basic mechanistic studies exist in the Biology &
Biotechnology Research Program (BBRP) for recent PhDs (less than 5 years)
in biochemistry, molecular biology/genetics, or related fields.

To construct and characterize knockout mutants in DNA repair pathways,
including homologous recombinational repair, in CHO hamster cells; to
study the role of the Fanconi anemia group G gene in maintaining
chromosome stability by using genetic and biochemical approaches; to
obtain the structure of recombinational repair proteins. Background in DNA
repair preferred. Reply to Larry Thompson at [log in to unmask]
LLNL offers a challenging environment and competitive salary and benefits.
We are located in the scenic Livermore Valley and have interactions with
DNA repair researchers at UC Berkeley, UC San Francisco, UC Davis, and
Stanford University. LLNL is an equal opportunity employer with a
commitment to workforce diversity.

5.8  POST DOCTORAL POSITION -NIA, BALTIMORE, MD
A postdoctoral position for a recent Ph.D. (less than 5 yr of experience)
is available to study DNA helicases defective in premature aging and
cancer syndromes. The goal is to understand the roles of human helicases
in pathways of genome stability. The focus of the work is to understand
how protein and DNA interactions of DNA helicases are important to the
biological roles of these enzymes in DNA metabolism. The postdoctoral
fellow will work in a collaborative group of scientists who have interests
in DNA replication/repair and the emerging field of molecular gerontology.

For more information, please contact:
Robert M. Brosh, Jr., Ph.D.
Laboratory of Molecular Gerontology
National Institute on Aging, NIH
email:  [log in to unmask]

5.9 POSTDOCTORAL OPPORTUNITY AT UNIVERSITY OF CALIFORNIA, IRVINE

My laboratory has recently knocked out mlh3, a novel DNA mismatch repair
gene with both scientific and medical significance, and has already
generated compound
knockout mouse lines as well.

I seek a highly motivated postdoctoral fellow interested in genomic
characterization of infertility and cancer susceptibility phenotypes in
these mice at my new laboratory at UC Irvine, available September 2001.
Candidates who have recently finished their PhD studies
are particularly encouraged to apply.

Please email cv and contact info for two references to:
Steven M Lipkin M.D., Ph.D. (email: [log in to unmask])

For background information, please read: Lipkin, SM, Wang, V., Jacoby, R.,
Basu, S., Baxevanis, A., Lynch, H., Elliott, R.,and Collins, F. MLH3: A
novel DNA mismatch repair gene associated with mammalian microsatellite
instability and a colon
cancer susceptibility locus in the mouse. Nature Genetics (Article) 2000
Jan 24(1):27-35.



6. DNA Repair Antibodies

Novus Biologicals, Inc introduces their latest service on obtaining
information on NEW antibodies in the DNA Repair and related fields. To
sign up for this e-mail notification, please visit our web site,
www.novus-biologicals.com.

For more information contact:
Bryan Tinsley
Novus Biologicals, Inc
Telephone: 303-730-1950
Toll-Free: 888-506-6887
Fax: 303-730-1966


7.      ELECTRONIC CONTACTS:

7.1     Check out the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
You can find the schedule for future DNA Repair Interest Group
videoconferences and a listing of past videoconferences (with links to the
videoarchive) as well as a current list of JOB OPPORTUNITIES in DNA repair
and MEETING NOTICES.

7.2     Encourage your colleagues who are interested in DNA Repair to
request that they be added to this DNA Repair Interest Group listserve
e-mail list by sending a request by e-mail to: [log in to unmask]
Leave the subject  blank. In the message field, type in: subscribe
DNARepair-L your name
        Alternatively, by filling out the form on the website you can both
add your name to the e-mail list and have your name posted on the website.
If you want your name to be listed you can fill out the "Join the SIG"
form on the web site and add your name to the listing of members.  If you
are not at NIH then be sure to click the "other" box and then fill in the
name of your institution.

7.3     Archives of these listserve mailings can be found at
        http://list.nih.gov/archives/dnarepair-l.html
                or via links from the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/

7.4     I will be happy to relay information about post-doctoral
positions, jobs and meetings and other information related to DNA Repair.
Please send me an e-mail message ([log in to unmask]) and I will incorporate
it into the next announcement list and post it on the DNA Repair Interest
Group web site: http://www.nih.gov:80/sigs/dna-rep/ .
(This list goes to more than 800 scientists around the world who are
interested in DNA repair.)


Kenneth H. Kraemer, M.D.
Chief, Basic Research Laboratory
National Cancer Institute
Building 37 Room 3E24
Bethesda,  MD 20892
301-496-9033    FAX: 301-496-8419
e-mail: [log in to unmask]
DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/

Center for Information Technology National Institutes of Health Bethesda, Maryland 20892 301 594 6248 (v) 301 496 8294 (TDD) Comments and Assistance Accessibility