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Message-ID:  <[log in to unmask]>
Date:         Fri, 8 Sep 2000 11:58:49 -0400
Reply-To:     Ken Kraemer <[log in to unmask]>
Sender:       DNA Repair Interest Group <[log in to unmask]>
From:         "Kenneth H. Kraemer" <[log in to unmask]>
Subject:      DNA Repair Interest Group -UPDATE -September 8, 2000

DNA Repair Interest Group -UPDATE -September 8, 2000

1.      Videoconference -Tues, Sept 19, 2000 - Dr. Kenneth Kraemer, NCI,
Bethesda, MD  -Clinical and Molecular Features of Xeroderma Pigmentosum
and Related Disorders of DNA Repair
2.      CONFERENCES -NCI SYMPOSIUM ON STRUCTURAL BIOLOGY; ANTIMUTAGENESIS; NIH
RESEARCH FESTIVAL; GRC CONFERENCE ON DNA REPAIR; EMS ANNUAL MEETING; FASEB
HELICASE MEETING
3.      POST DOC OPPORTUNITIES: Bethesda, MD; Oxford, UK; Baltimore, MD; Davis,
CA; Duarte, CA; France; New Haven, CT; Livermore, CA
4.      Electronic Contacts


1.0     DNA REPAIR VIDEOCONFERENCE:

        Tues, Sept 19, 2000, 12:30 PM - Dr. Kenneth Kraemer, NCI,
Bethesda, MD  -Clinical and Molecular Features of Xeroderma Pigmentosum
and Related Disorders of DNA Repair

VIDEOCONFERENCE LOCATIONS: Building 45 (NATCHER) Room H, Bethesda, MD
(origin); Room 1E03 GRC Baltimore, MD; Building 101 Room B200, NIEHS,
Research Triangle Park,  NC; Building 549, Conference Room A,  FCRDC,
Frederick, MD; State University of New York, Stony Brook, NY;  MD
Anderson, Smithville, TX; Lawrence Livermore Labs, Livermore, CA; Univ of
Michigan, Ann Arbor; and Univ of Kentucky, Lexington, KY. MBONE ACCESS
(NIH ONLY) and in the internet at http://videocast.nih.gov

1.1     DNA REPAIR VIDEOCONFERENCE - FUTURE DATES AND VIDEO ARCHIVE
[Note: A larger and more up to date list of future and past
videoconferences can be found on the DNA Repair Interest Group web
site: http://www.nih.gov:80/sigs/dna-rep/ ]

1.1.1 FUTURE VIDEOCONFERENCES:

Tues, Oct 17, 2000 - Dr. Yoshihiro Matsumoto - Fox Chase Cancer Center,
Philadelphia, PA -Functions of PCNA in Base Excision Repair

Tues, Nov 21, 2000 - Dr. Zhigang Wang - Univ of Kentucky -Translesion
synthesis by the UmuC family of DNA polymerases


Tues, Dec 19, 2000 - Dr. Patrick Sung - University of Texas Health Science
Center at San Antonio - Functional Interactions Among RAD52 Group Proteins
in Recombination and Repair

Tues, Jan 16, 2001 - Dr. Vilhelm Bohr - LMG, NIA, Baltimore, MD -  DNA
repair defects in premature aging disorders

Tues, Feb 20, 2001- Dr. Mats Ljungman - Univ of Michigan, Ann Arbor, MI
-Stopped in its tracks - RNA polymerase II as a sensor for DNA damage

Tues, Mar 20, 2001 - Short talks by post-doctoral fellows at 3 sites

Tues, Apr 17, 2001 - Dr. Arthur Grollman -SUNY Stony Brook, NY -
Recognition of Oxidative damage by DNA Glycosylases

Tues, May 15, 2001- Dr. Bill Copeland - Laboratory of Molecular Genetics
NIEHS - Mitochondrial DNA Replication Fidelity and Mitochondrial Diseases

Tues, June 19, 2001 - Dr. James Cleaver -Univ of California, San
Francisco, CA - History of DNA Repair - Mending Human Genes

1.1.2 VIDEOARCHIVES: INTERNET ACCESS (WORLDWIDE):

These videoconferences have been archived and are now available for
viewing at your leisure on the internet. You will need a web browser (with
a high speed link) and free Real Video software.  Setup details and access
are available at the NIH videocast website:  http://videocast.nih.gov. Go
to Unicast sessions; Past events; DNA Repair Interest Group Sessions.

Note: Technical improvements are made regularly on this site to increase
transmission speeds and ease of access. If you were not successful in
viewing these videos in the past it is worth trying again!

JUNE 20, 2000- Dr. Richard Setlow , Brookhaven National Lab- Reflections
on how I was led into and onto DNA Repair -  Host:  SUNY

MAY 16, 2000  Dr. Veronica Maher, Michigan State Univ - Role of DNA
Replication and Repair in Carcinogen-Induced Human Cell Mutagenesis
Host: U of Michigan [Note: this talk will be posted after the data
presented is published]

APR 18, 2000 - Dr. Peter Glazer, Yale Univ - Targeted genome modification
via DNA triple helix formation

MAR 21, 2000 - Research reports by 3 Postdoctoral fellows:
Dr. Steffen Emmert, NCI - The xeroderma pigmentosum group C gene leads to
selective repair of cyclobutane pyrimidine dimers rather than 6-4
photoproducts. [See recent paper describing this
work: Proc. Natl. Acad. Sci. USA 97: 2151-2156, 2000]

Dr. Robert Sobol, NIEHS - Mutagenesis and dRP Lyase Activity in DNA
-Polymerase Dependent Base Excision Repair in Mouse Cells [See recent
paper by Dr. Sobol describing this work:  Nature 405, 807-810 (2000)]

Mr. Robert Levine, SUNY -Mutagenesis Induced by Endogenous DNA Adducts in
Human Cells

FEB 15, 2000  Dr Steve Matson, UNC - Two E. coli mismatch repair enzymes,
DNA helicase II and MutL, interact to catalyze efficient unwinding of
duplex DNA

JAN 18, 2000- Dr. John Essigman, MIT - Cellular responses to the DNA
damaging agent cisplatin

Through the miracle of vidotape we now have been able to post most of the
DNA Repair Interest Group videoconferences from 1998 and 1999 on the web
site.  These include talks by Drs. Bogenhagen, Sutherland, Kunkel,
Stefanini, Hanawalt, Matson, Sharan, Kashlev , Fornace, Anderson, Leadon,
Brooks, McKay, Drotschmann, Chu, Thompson, Woodgate,George, Liu and
Grossman


2.    CONFERENCES -NCI SYMPOSIUM ON STRUCTURAL
BIOLOGY; ANTIMUTAGENESIS; NIH RESEARCH FESTIVAL; GRC CONFERENCE ON DNA
REPAIR; EMS ANNUAL MEETING; FASEB HELICASE MEETING

[Note: A larger and more up-to-date list of conferences can be found on
the DNA Repair Interest Group web
site: http://www.nih.gov:80/sigs/dna-rep/ ]

2.1     NCI SYMPOSIUM ON STRUCTURAL BIOLOGY - FREDERICK, MD, SEPT 18, 2000

        The Program in Structural Biology of the National Cancer Institute
would like to invite you to attend the first biennial Symposium on
Structural Biology on September 18, 2000, in Frederick, Maryland. Open to
all interested members of the scientific community, the Symposium will
highlight both the current frontiers of structural biology in the new
millennium and the work of some of the new Investigators in the NCI's
Program in Structural Biology.  Please join us for an exciting day of
presentations ranging from the unique perspectives of solution dynamics
and folding by NMR, solid-state NMR investigations of enzymes,
fluorescence spectroscopy of proteins, and the latest developments and
applications in the use of crystallographic techniques in studies of
ribosomes and in drug design.  Distinguished guest speakers will include
Wim G.J. Hol, Joseph R. Lakowicz, Ann E. McDermott, Arthur G. Palmer, and
Thomas A. Steitz. Further information about the Symposium, including
on-line registration, is available at
http://web.ncifcrf.gov/home/psb/symposium.

        If you have any questions, please contact the Symposium
Coordinator, Margaret Fanning, at 301-846-1995 or by e-mail at
[log in to unmask]

        Sign language interpretation will be provided if needed. If you
are an individual with a disability who needs any assistance or assistive
devices to participate in this event, please contact Ms. Fanning by
September 8 to discuss your needs.

        We look forward to your participation in the Symposium and hope
that you will join us for the scientific presentation and for the picnic
dinner following the talks.
Alexander Wlodawer, Ph.D.
Associate Director
Program in Structural Biology
Division of Basic Sciences, National Cancer Institute


2.2     7th INTERNATIONAL CONFERENCE ON MECHANISMS OF ANTIMUTAGENESIS AND
ANTICARCINOGENESIS, SEPTEMBER 23-27, 2000, GRAND RAPIDS, MI

The latest updates for the 7th ICMAA which takes place 23-27 September
2000, Grand Rapids, MI, USA are posted on the website.   Full details of
over 40 invited speakers and contributed poster presentations are
available on the conference website at
http://www.elsevier.com/locate/icmaa2000   .

 The contact location is:
 7th ICMAA Secretariat: Phillipa Orme
12 Church Street, West Hanney
Nr Wantage, Oxon, OX120LN
United Kingdom
Tel/FAX +44 (0) 1235-868811
Email: [log in to unmask]

2.3     2000 NIH RESEARCH FESTIVAL, OCTOBER 10-13, 2000

        The 14th annual NIH Research Festival, the yearly showcase for the
NIH intramural research program, will be held on October 10 through
13.  The Research Festival Organizing Committee, is co-chaired this year
by NHLBI Scientific Directors Robert Balaban and Elizabeth Nabel.  Posters
in any area of research conducted on campus will be considered for
presentation but the committee is requesting a limit of one poster
submission per first author.

        Plenary, mini-symposia, and poster sessions are scheduled on
Wednesday and
Thursday, October 11 and 12.  THERE WILL BE A DNA REPAIR WORKSHOP AND
ASSOCIATED POSTER SESSION. Plenary sessions will feature the latest
research advances in nitric oxide, angiogenesis, and genome analysis and
twelve mini-symposia will cover the wide-range of research interests of
the NIH intramural community. As in previous years, the NIH Office of
Education-sponsored NIH Job Fair for Postdoctoral Fellows will kick off
the week's events on Tuesday, October 10.  The Technical Sales
Association-sponsored Research Festival Scientific Equipment Show will cap
them off on Thursday and Friday, October 12 and 13.  For a general
schedule of events and the online poster registration form, visit the
Research Festival Web site at http://festival2000.nih.gov.

2.4      2001 GRC CONFERENCE ON DNA REPAIR - VENTURA, CA JAN 21-26, 2001
        The 2001 Gordon Research Conference on MAMMALIAN DNA REPAIR,
Chaired by Dr. Samuel Wilson of the National Institute of Environmental
Health Sciences, will be held January 21 - 26, 2001 at the Clarion Beach
Hotel in Ventura, California.

        As this conference has been oversubscribed in the past, applicants
are encouraged to apply soon; as it is possible that later applicants will
be turned away.

        The Gordon Research Conference Winter 2001 brochure will be mailed
in September.  If you wish to attend the conference you may apply on line
at our Web Site now <http://www.grc.uri.edu/>

2.5     EMS ANNUAL MEETING - SAN DIEGO, MAR 16-21, 2001

        The Environmental Mutagen Society annual meeting will be held on
March 16-21, 2001 in San Diego, CA, at the Paradise Point Resort
Hotel. The entire meeting is organized and the complete program and all
registration details are available from David M. DeMarini, Ph.D. (See
below for contact information  for obtaining a PDF file of the6 page
brochure).  We have 3 symposia on DNA repair, and we have Stephen J. Gould
as our keynote speaker.  Information is also available on the EMS
website: http://www.ems-us.org/

For more information contact:

David M. DeMarini, Ph.D.
Environmental Carcinogenesis Division (MD-68)U.S. Environmental Protection
Agency
Research Triangle Park, North Carolina 27711, USA
TEL 1-919-541-1510
FAX 1-919-541-0694
[log in to unmask]

2.6     HELICASES: STRUCTURE, FUNCTION AND ROLES IN HUMAN DISEASE  -JULY
7-12, 2001  VERMONT ACADEMY,  SAXTONS RIVER VERMONT

A FASEB helicase meeting to be held July 7-12, 2001 at the Vermont
Academy, Saxtons River Vermont.

Session subtopics include:
Helicase Structure
Helicase Function and Mechanism
Helicases in DNA Replication
Helicases in DNA Repair and Recombination
RNA Helicases in Transcription, Splicing, RNA stability and transport
RNA Helicases in Translation and  Ribosome Biogenesis
Helicases as part of macromolecular machines
Helicases in Viral Replication
Helicases in Cancer and Aging.

This will be the first meeting held in the United States dedicated
entirely to helicases.   Further information can be obtained from meeting
organizers:  Sandy Weller, University of Connecticut HealthCenter,
[log in to unmask], 860-679-2310 and Steve Matson, Univeristy of North
Carolina [log in to unmask], 919-962-0005.  Vice-chairs will be Anna
Marie Pyle ([log in to unmask]) and Smita Patel
([log in to unmask]).  Please pass on to colleagues who may be interested.


3.      POST DOC OPPORTUNITIES: Bethesda, MD; Duarte, CA; Oxford,
UK; Baltimore, MD; Davis, CA; Duarte, CA; Livermore, CA; New Haven,
CT; France
[Note: Check the list for more Job Opportunities on the DNA Repair
Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ ]

3.1     HUMAN DISEASES WITH DEFECTIVE DNA REPAIR - POST-DOCTORAL
FELLOWSHIP - BETHESDA, MD
We are studying molecular, cellular and clinical abnormalities in patients
with defective DNA repair and possible links of these genes to disease in
the general population. Current emphasis is on xeroderma pigmentosum,
Cockayne syndrome and trichothiodystrophy.  A postdoctoral position is
available for a talented individual (M.D., Ph.D. or MD-PhD) with less than
5 years of postdoctoral experience who has knowledge of molecular biology
and DNA repair.

To apply, send CV and bibliography and names (with contact information) of
3 references to:

Kenneth H. Kraemer, M.D.
Basic Research Laboratory
National Cancer Institute, NIH
Building 37 Room 3E24
Bethesda,  MD 20892
TEL: 301-496-9033    FAX: 301-496-8419
e-mail: [log in to unmask]
http://rex.nci.nih.gov/RESEARCH/basic/lmc/khk.htm

NIH is an equal opportunity employer.

3.2 POST-DOCTORAL POSITION- Beckman Research Inst. City of Hope Med. Ctr.

       A post-doctoral position is available to study 1) study the
induction of repair enzymes (adaptation) in mammalian cells, 2) study
intracellular competition between classes of adducts for repair capacity,
or 3) Increase the sensitivity of ligation-mediated PCR by purifying DNA
fragments with rare lesions using histidine tagged repair enzymes which
bind lesions in dsDNA but do not cut.

       Applicants should send a letter of interest, C.V., and a list  of
references, including telephone numbers and e-mail addresses, to the
following address:
Gerald P. Holmquist, Ph.D.
City of Hope-Biology
City of Hope-Biology
 1450 E Duarte rd
Duarte, CA 91010
TEL: 626-301-8350:: FAX -1-626-358-7703  [log in to unmask]



3.3 POSTDOCTORAL POSITION IN DNA REPAIR (Medical Research Council,
Radiation & Genome Stability Unit, Harwell, Oxfordshire, UK,
http://www.ragsu.har.mrc.ac.uk)

A position is available in the newly formed Biochemistry Group to
investigate the biochemical, molecular and cellular processes of DNA
repair. Specific studies include defining the repair mechanism for
ionizing radiation-induced DNA damage with a particular focus on the role
of base excision repair proteins. Position is initially for 3 years with
possible extension to 5 years. Informal enquiries welcome to Grigory
Dianov ( [log in to unmask] ).

Please apply  by full CV with names of  2 referees to the
Personnel Officer ,
Medical Research Council,
Harwell, Oxfordshire, OX11 0RD, UK.
Tel. 44-1235 834393 or fax 44-1235 834776.
Closing data 18th  August. Interviews: early September 2000.

3.4 THREE POSTDOCTORAL POSITIONS - JOHNS HOPKINS ONCOLOGY CENTER,
BALTIMORE, MD

Three postdoctoral positions are available immediately to investigate the
molecular and genetic mechanisms of mitochondrial DNA damage, repair and
mutagenesis relevant to cancer (See Singh KK (Editor) Mitochondrial DNA
mutations in aging, disease and cancer, Springer, NY 1998. and Singh KK
etal
Oncogene 18:6641-6646 1999).

1.  Mammalian model system:Excellent opportunity for an individual with
experience in mammalian cell culture, DNA  transfection, Northern,
Southern, PCR, and general molecular biology techniques.

2.  Yeast model system: Excellent opportunity for an individual with
experience in yeast genetics, DNA transformation, PCR, Northern, Southern,
and general molecular biology techniques.

3. Mitochondrial Dysfunction in Breast Cancer: Excellent opportunity for
an individual with experience in mammalian cell culture, DNA
transfection, Northern, Southern, PCR, and general molecular biology
techniques. Candidate for this position should be either US citizen or
permanent resident.

Experience in mitochondrial methods desirable but not necessary.


Please forward/fax curriculum vitae and a brief description of research
experience with a list of three references to:

Keshav K. Singh, Ph.D.
Johns Hopkins Oncology Center
Bunting-Blaustein Cancer Research Building
1650 Orleans Street, Room 1-143
Baltimore, Md 21231-1000
Fax:410-502-7234
E-mail: [log in to unmask]


3.5  POST-DOCTORAL POSITION- UNIVERSITY OF CALIFORNIA, DAVIS

A post-doctoral position is available to study the pairing of  homologous
chromosomes in the budding yeast Saccharomyces cerevisiae. Projects in the
laboratory are aimed at understanding the mechanism,  regulation and roles
of homologous chromosome pairing in meiotic and nonmeiotic cells using
molecular genetic and cytological approaches.

Burgess, S.M. and Kleckner, N. (1999). Collisions between yeast
chromosomes in vivo are governed by three layers of organization. Genes &
Development. 13: 1871-1883.

Burgess, S.M., Kleckner, N. and Weiner, B . (1999). Somatic pairing of
homologs in budding yeast: Existence and modulation. Genes &
Development. 13:1627-41.

Applicants should send a letter of interest, C.V., and a list of
references (including telephone numbers and e-mail addresses) to the
following address:

Sean M. Burgess
Assistant Professor
Section of Molecular and Cellular Biology
One Shields Avenue
University of California, Davis
Davis, CA 95616

E-mail: [log in to unmask]        TEL: (530) 754-5177



3.6 POSTDOCTORAL POSITION - DUARTE, CA

Position available to work in the field of cancer biology, DNA repair and
mutagenesis in mammalian cells. A Ph.D. degree and experience in molecular
biology techniques are required.

Please send CV by email to:

Dr. Gerd P. Pfeifer
Department of Biology
Beckman Research Institute
City of Hope Cancer Center
Duarte, CA 91010. FAX: 626-358-7703.
Email: [log in to unmask]


3.7 POST-DOCTORAL SCIENTIST - LAWRENCE LIVERMORE NATIONAL LABORATORY

Post-doctoral positions available in an interactive laboratory/program
investigating the biochemical, molecular and cellular processes of
mammalian DNA repair.  Specific studies include defining the repair
mechanisms for ionizing radiation-induced DNA damage [with a particular
focus on proteins in the base excision or double-strand break
(recombinational) repair pathways], designing structure-function based
inhibitors for radiosensitization, and identifying genetic factors in
human cancer susceptibility.  Experience in protein biochemistry or signal
transduction pathways a plus.  Positions are for two years, with a
possibility for a third year extension, and begin in late 2000 or early
2001.  Salaries start in the mid 30s.  Livermore is 45 miles east of San
Francisco.

Please send current CV and letters of recommendation to:

David M.Wilson III,
Lawrence Livermore National Laboratory,
Biology & Biotechnology Research Program, L-441,
7000 East Avenue,
Livermore, CA 94526
e-mail: [log in to unmask]

3.8 POSTDOCTORAL FELLOW AT YALE UNIVERSITY:

Position available immediately to study the role of mutagenesis in
cancer.  See Proc. Natl. Acad. Sci. USA, 96: 9580-9585.  Experience in
tissue cell culture, mutagenesis, and molecular biology is a plus.

Send curriculum vitae, reprints, and the names of three references to :

Dr. Joann B. Sweasy
Department of Therapeutic Radiology
Yale University School of Medicine
333 Cedar Street
PO Box 208040
New Haven, CT 06520
e-mail: [log in to unmask]


3.9     POST-DOC POSITIONS IN TRANSCRIPTION/DNA REPAIR -GENOTYPE/PHENOTYPE
RELATIONSHIP IN XERODERMA PIGMENTOSUM PATIENTS - FRANCE

Two postdocs position are available to conduct research on:

1) Transcription coupled repair. Studies will use reconstituted
transcription and NER systems and chromatine template. Components will be
isolated from HeLa and XP patients cell lines

2) Regulation of cdk7, a kinase associated with a basal transcription
factor. Four hybrid systems has already identified a battery of proteins
associated with postranscriptional processses as well as with apoptose.

The studies involve techniques in molecular biology, protein expression
and purification, cell culture and enzymatic assays.

Please forward your CV  and names and telephone numbers of two references
to:
Jean-Marc Egly
Institut de Biologie Moleculaire et Cellulaire
1 rue Laurent Fries, BP 163,
67400 ILLKIRCH Cedex,
FRANCE
Tel : 33 3 88 65 34 47    Fax : 33 3 88 65 32 01
e-mail:[log in to unmask]

4.      ELECTRONIC CONTACTS:

4.1     Check out the DNA Repair Interest Group web
site: http://www.nih.gov:80/sigs/dna-rep/

You can find the schedule for future DNA Repair Interest Group
videoconferences and a listing of past videoconferences (with links to the
videoarchive) as well as a current list of JOB OPPORTUNITIES in DNA repair
and MEETING NOTICES.

4.2.    Encourage your colleagues who are interested in DNA Repair to request
that they be added to this DNA Repair Interest Group listserve  e-mail
list by sending a request by e-mail to: [log in to unmask]     Leave
the subject  blank. In the message field, type in: subscribe DNARepair-L
your name

        Alternatively, by filling out the form on the website you can both
add your name to the e-mail list and have your name posted on the
website.  If you want your name to be listed you can fill out the "Join
the SIG" form on the web site and add your name to the listing of
members.  If you are not at NIH then be sure to click the "other" box and
then fill in the name of your institution.

4.3     Archives of these listserve mailings can be found at
        http://list.nih.gov/archives/dnarepair-l.html
                or via links from the DNA Repair Interest Group web
site: http://www.nih.gov:80/sigs/dna-rep/

4.4     I will be happy to relay information about post-doctoral
positions, jobs and meetings and other information related to DNA
Repair.  Please send me an e-mail message ([log in to unmask]) and I will
incorporate it into the next announcement list and post it on the DNA
Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ .
(This list goes to more than 625 scientists around the world who are
interested in DNA repair.)


Kenneth H. Kraemer, M.D.
Basic Research Laboratory
National Cancer Institute
Building 37 Room 3E24
Bethesda,  MD 20892
301-496-9033    FAX: 301-496-8419
e-mail: [log in to unmask]
DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/

Center for Information Technology National Institutes of Health Bethesda, Maryland 20892 301 594 6248 (v) 301 496 8294 (TDD) Comments and Assistance Accessibility