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Message-ID:  <[log in to unmask]>
Date:         Wed, 27 Aug 2003 15:17:19 -0400
Reply-To:     Ken Kraemer <[log in to unmask]>
Sender:       DNA Repair Interest Group <[log in to unmask]>
From:         "Kenneth H. Kraemer" <[log in to unmask]>
Subject:      DNA Repair Interest Group - UPDATE - August 27, 2003

DNA Repair Interest Group - UPDATE - August 27, 2003

1.      VIDEOCONFERENCE - SEPT 16, 2003 Dr. Satya Prakash - Translesion
synthesis DNA polymerases of yeast and humans
2.      SPECIAL SEMINARS - 1. Sept 16 - Dr. Satya Prakash -Studies of
human DNA repair diseases in yeast    2. Sept 19 - Dr. Yossi Shiloh -
Upstream and Downstream of ATM in DNA Response
3.      CONFERENCES - International workshop on ataxia-telangiectasia
2003; Molecular Signature of DNA Damage Induced Stress Responses-
September 26-30, 2003 - Cortona, Italy; Molecular cross talk among
chromosome fragility syndromes 2-4 February, 2004. Madrid (Spain); DNA
Repair and Mutagenesis: from Molecular Structure to Biological
Consequences; International Congress of Photobiology
4.      POST DOC AND EMPLOYMENT OPPORTUNITIES: Baltimore, MD; Research
Triangle Park, NC; New York, NY; Boston, MA; Portland, OR; Ontario,
Canada; Boston, MA; Saskatchewan, Canada; Washington, D.C.
5.      COMMERCIAL REAGENT SOURCES
6.      Electronic Contacts


1.0     DNA REPAIR VIDEOCONFERENCE:
Sept 16, 2003 - Tues - 12:30 PM - Dr. Satya Prakash - Translesion
synthesis DNA polymerases of yeast and humans

VIDEOCONFERENCE LOCATIONS: ; Building 45 (NATCHER) Room H, Bethesda, MD
(origin); Room 1E03 GRC Baltimore, MD Lawrence Livermore Labs, Livermore,
CA; Univ of Michigan, Ann Arbor; University of Pittsburgh; MD Anderson,
Smithville, TX (origin); Building 101 Room B200, NIEHS, Research Triangle
Park, NC; State University of New York, Stony Brook, NY (origin); Univ of
Kentucky, Lexington, KY; Building 549, Conference Room A,  FCRDC,
Frederick, MD; Brookhaven National Labs, Upton, NY; Univ of Texas,
Galveston and live on the internet at http://videocast.nih.gov


1.1     DNA REPAIR VIDEOCONFERENCE - FUTURE DATES AND VIDEO ARCHIVE
[Note: A larger and more up to date list of future and past
videoconferences can be found on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]


1.1.1 FUTURE VIDEOCONFERENCES:

Oct 14, 2003- Tues 12:30 PM - Dr. Alain Sarasin, Institut Gustave Roussy,
Villejuif France - Xeroderma pigmentosum : Role of the XP variant pol eta
gene in UV-induced mutagenesis.  Toward a gene therapy in XPC patients?

Nov 18, 2003 - Tues 12:30 PM

Dec 16, 2003 - Tues 12:30 PM

Jan 20, 2004 - Tues 12:30 PM

Feb 17, 2004 - Tues 12:30 PM

Mar 16, 2004 - Tues 12:30 PM

April 20, 2004 - Tues 12:30 PM

May 18, 2004 - Tues 12:30 PM

June 15, 2004 - Tues 12:30 PM


1.1.2 VIDEOARCHIVES: INTERNET ACCESS (WORLDWIDE):
To date 59 of these videoconferences have been archived and are available
for viewing at your leisure on the internet. You will need a web browser
(with a high speed link) and free Real Video software.  Setup details and
access are available at the NIH videocast website:
http://videocast.nih.gov. Go to Past events; DNA Repair Interest Group
Sessions.

Note: Technical improvements are made regularly on this site to increase
transmission speeds and ease of access. If you were not successful in
viewing these videos in the past it is worth trying again!

June 17, 2003 - Dr. John Bradsher, NCI, NIH, Roles of the CS proteins in
Nucleotide Excision Repair and Transcription;

June 17, 2003 - Dr. Tom Rosenquist, SUNY, NEIL proteins and base excision
repair in mice

June 17, 2003 -  Dr. Karen Vasquez, Smithville, TX - Processing of
site-specific DNA lesions by DNA repair and recombination pathways [Note:
The posting of this talk will be delayed at the request of the speaker.]

May 20, 2003 -  Dr. Errol Friedberg, Univ of Texas Southwestern, Dallas,
Tx - Honest Jim Revealed- The Writings of James D. Watson

Apr 15, 2003 - Dr. Qingyi Wei, M.D. Anderson, Houston, Tx - DNA Repair
Function, Polymorphisms and Cancer Risk in the General Population

Mar 11, 2003 - Dr. Sankar Mitra, Univ of Texas, Galveston - Oxidative
Damage Repair and Its Co-ordination in the Mammalian Genome.[Note: The
posting of this talk will be delayed at the request of the speaker.]

March 05, 2003  - Dr. Stephen J. Elledge - Baylor College of Medicine
Houston, TX  - Sensing and Responding to DNA Damage  [Note: this talk was
part of the NIH Wed afternoon lecture series and was sponsored by: the
Mouse Club and Washington Area Yeast Club Interest Group and is now posted
on the DNA Repair Interest Group part of the videocast.nih.gov website.]

Jan 21, 2003 - Tues 12:30PM - Dr. Jack Taylor, NIEHS - Epidemiologic
studies of DNA repair gene polymorphisms and cancer risk

Dec 17, 2002 - Dr. John Tainer, UC Berkeley - Conformational Controls and
DNA Repair Coordination - [Note: The posting of this talk will be delayed
at the request of the speaker.]

Nov 12, 2002 - Dr. Rob Sobol, Univ of Pittsburgh - DNA Base Damage and
Repair Intermediates: Out of the Pan and into the Fire [Note: This talk is
now posted!]

Oct 15, 2002 - Dr. Al Fornace, NCI - Convergence of the p53 and MAP kinase
stress signaling pathways after UV radiation

Sept 17, 2002 - Dr. Dale Ramsden, UNC - DNA Double strand break repair

June 18, 2002 - Dr. David Chen - Lawrence Berkeley National Lab - Role of
DNA-PK in Cellular Responses to DNA damage

May 21, 2002 -  Dr. Mark J. Schofield - NIH, Bethesda - DNA mismatch
repair; Dr. Sunitha Yanamadala - Univ of Michigan - Role of Mismatch
Repair Proteins in Signaling p53 and Apoptosis; Dr. Federica Marini - Univ
of Pittsburgh - A human DNA helicase homologous to the DNA crosslink
sensitivity protein mus308

Apr 16, 2002 -  Dr. Philip Hanawalt - Half a century of DNA repair: An
historical perspective

Mar 19, 2002 - Dr. Alan Tomkinson - Univ of Texas, San Antonio -
Mechanisms of DNA End Joining

Feb 19, 2002 - Dr. Yves Pommier - NCI - Nucleotide excision
repair-dependent cytotoxicity of a novel anticancer agent, ecteinascidin
743

Jan 15, 2002 - Dr. Tom Kunkel- NIEHS - Recent studies of DNA Mismatch
Repair

Through the miracle of videotape we now have been able to post most of the
DNA Repair Interest Group videoconferences from 1998,1999, 2000 and 2001
on the web site.  These include talks by Drs. Anderson, Beernik,
Bogenhagen, Bohr, Brash, Brooks, Brosh, Chu, Cleaver, Copeland,
Drotschmann, Emmert, Essigman, Fornace, George, Glazer, Grossman,
Hanawalt, Jin, Kashlev, Kraemer, Kunkel, Leadon, Liu, Ljungman, Matson,
Matsumoto,  McKay,  Setlow, Sharan, Sobol, States, Stefanini, Sung,
Sutherland, Thompson, Wang, Wood, Woodgate and Yarosh.


2. SEMINARS OF NOTE

2.1  Tues Sept 16, 2003  4:00 PM Wilson Hall Building 1 NCI MERIT SEMINAR
Speaker: Dr. Satya Prakash Title: Studies of human DNA repair diseases in
yeast

2.2  Friday September 19, 2003   1:00 PM  Bldg 37 Room 1A-19 Speaker: Dr.
Yossi Shiloh, Tel Aviv University, Tel Aviv, Israel Title: Upstream and
Downstream of ATM in DNA Response [Note: This seminar will not be
videocast. Contact Dr. Michael Bustin 301-496-5234 for information]


3.    CONFERENCES - International workshop on ataxia-telangiectasia 2003;
Molecular Signature of DNA Damage Induced Stress Responses- September
26-30, 2003 - Cortona, Italy; Molecular cross talk among chromosome
fragility syndromes 2-4 February, 2004. Madrid (Spain); DNA Repair and
Mutagenesis: from Molecular Structure to Biological Consequences;
International Congress of Photobiology

[Note: A larger and more up-to-date list of conferences can be found on
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

3.1 INTERNATIONAL WORKSHOP ON ATAXIA-TELANGIECTASIA 2003 - QUEENSLAND,
AUSTRALIA, SEPTEMBER 10-14, 2003

"Role of ATM and related proteins in DNA damage response"  September
10-14, 2003, Fraser Island, Queensland, Australia
http://www.qimr.edu.au/conf/AT2003

Organizer: Dr Nuri Gueven, Queensland Institute of Medical Research,
Radiation Biology and Oncology,Royal Brisbane Hospital Post Office,
Herston 4029, Queensland, Australia
Phone: +61 7 3362 0335, FAX: +61 7 3362 0106, Email: [log in to unmask]


3.2 MOLECULAR SIGNATURE OF DNA DAMAGE INDUCED STRESS RESPONSES- SEPTEMBER
26-30, 2003 - CORTONA, ITALY

We are organizing a workshop on "Molecular signature of DNA damage induced
stress responses", scheduled for September 26-30, 2003, in Cortona, Italy.
The workshop will be funded and organized jointly by the National Cancer
Institute (NCI, US), the National Institute of Environmental Health
Sciences (NIEHS), and the Directorate General Research (DG RTD) from the
European Commission, to bring together EU and US researchers and
representatives of health advisory bodies.

The focus of the workshop will be to characterize the molecular and
cellular responses of various organisms to different DNA-damaging agents,
in particular chemicals, ionizing radiation, and ultraviolet light.
State-of-the-art approaches in genomics, proteomics, and bioinformatics
will be included, with special emphasis on the importance of networks of
interacting DNA repair and signaling pathways as indicators of DNA damage
stress responses.

The rationale for the Workshop, as well as a preliminary program, is laid
out in the introductory part of the enclosed First Announcement (see
http://www.medgencentre.nl/molsign-workshop/CortonaSept2003.htm.) The
total number of participants is limited to 100, in the expectation that a
fruitful exchange of ideas will be most effective in a relatively small
group. Money is available for young scientists to attend and present a
poster. The deadline for abstracts and registration has been extended till
July 21.


As envisaged in the Announcement, the program will begin with a series of
keynote lectures on the experimental and computationally driven approaches
currently being used to measure and analyze global cellular responses to
genotoxic stress. This will be followed by several sessions that focus on
individual topic areas such as the use of gene profiling and
transcriptional regulation patterns to dissect the genetic control of gene
expression, new gene discovery, proteomics of DNA damage response and the
increasing need for standardization and harmonization of experimental
settings and large-scale sets that are involved in a systems biology
approach, and phylogenetic similarities and dissimilarities in DNA damage
response mechanisms.

If you have any questions please contact me.
Ben Van Houten,   Chief, Program Analysis Branch &  Investigator in the
Laboratory of Molecular Genetics, NIEHS
111 T.W. Alexander Drive
Research Triangle Park, NC 27709
PAB office: 919-541-7752;  Lab office: 919-541-2799;  FAX: 919-541-5064
[log in to unmask]



3.3  DNA REPAIR AND MUTAGENESIS: FROM MOLECULAR STRUCTURE TO BIOLOGICAL
CONSEQUENCES - BERMUDA, DECEMBER 7-13, 2003.

Dear Colleagues,
We are writing to let you know that we will be organizing an ASM
Conference entitled "DNA Repair and Mutagenesis: From Molecular Structure
to Biological Consequences" sponsored by the American Society for
Microbiology to be held at the Fairmont Southampton Princess, Bermuda,
December 7-13, 2003. The conference will bring together the various
subdisciplines that collectively comprise the field of DNA Repair and
Mutagenesis. Meetings of this type have been held at approximately four
year intervals since 1974, the preceding one in this informal series
having been at Hilton Head, South Carolina in 1999, and have played a
critical role in the development of this exciting area of research.

Speakers will include: Genevive Almouzni, Lorena Beese, Serge Boiteux,
Jaap Brouwer, Keith Caldecott, Judith Campisi, Gilbert Chu, Priscilla
Cooper, Titia de Lange, John Diffley, Sylvie Doubli, Jean-Marc Egly,
Stephen Elledge, Tom Ellenberger, Rick Fishel, Marco Foiani, Errol
Friedberg, Robert Fuchs, James Haber, Fumio Hanaoka, Phil Hanawalt, Jan
Hoeijmakers, Peggy Hsieh, Ian Hickson, Stephen Jackson, Maria Jasin, Penny
Jeggo, Joe Jiricny, Roland Kanaar, Richard Kolodner, Stephen
Kowalczykowski, Thomas Kunkel, Tony Leadon, Alan Lehmann, Tomas Lindahl,
Bndicte Michel, Sankar Mitra, Paul Modrich, Leon Mullenders, Tanya Paull,
John Petrini, Louise Prakash, Miroslav Radman, Rodney Rothstein, Leona
Samson, Alain Sarasin, Erling Seeberg, Jesper Svejstrup, John Tainer,
Shunichi Takeda, Kiyoji Tanaka, Graham Walker, Susan Wallace, Stephen
West, Sam Wilson, Richard Wood, Roger Woodgate, and Wei Yang.

Some additional speakers on timely topics will be invited closer to the
date of the meeting, and furthermore, speakers will be chosen from among
the submitted abstracts for shorter presentations.

Careful thought has been given to the choice of the site and the design of
the program so that participants will be able to enjoy the type of
opportunities for informal discussions and interactions that are normally
found only at smaller meetings. A special feature of the meeting will be
travel grants to help support the participation of graduate students and
postdoctoral fellows. Additional information concerning the meeting and
the program is available at: http://www.asmusa.org/mtgsrc/dnarepair2.htm

We hope you will mark these dates on your calendars. We look forward to
seeing you in Bermuda in December 2003!

Best Wishes
Graham Walker, Susan Wallace, and Priscilla Cooper


3.4 MOLECULAR CROSS TALK AMONG CHROMOSOME FRAGILITY SYNDROMES
2-4 February, 2004. Madrid (Spain)

Scientific Organizers:
Hans Joenje, Department of Clinical Genetics and Human Genetics, Free
University Medical Centre, Amsterdam
Jordi Surralles, Department of Genetics and Microbiology, Universitat
Autonoma de Barcelona, Barcelona, Spain

Format:
The workshop will consist of lectures and poster sessions; there will be
extended time for formal and informal discussion. Some posters may
beselected for presentation as short talks.

Invited speakers (all confirmed):
A. Ashworth (London, UK)
M. A. Blasco (Madrid, Spain)
P. Concannon (Seattle, WA. USA)
A. D. D'Andrea (Boston, MA. USA)
S. P. Jackson (Cambridge, UK)
M. Jasin (New York, NY. USA)
P. A. Jeggo (Brighton, UK)
H. Joenje (Amsterdam, The Netherlands)
R. Kanaar (Rotterdam, The Netherlands)
M. B. Kastan (Memphis, TN. USA)
A. Nussenzweig (Bethesda, MD. USA)
K. J. Patel (Cambridge, UK)
J. H. J. Petrini (New York, NY. USA)
R. Scully (Boston, MA. USA)
Y. Shiloh (Tel Aviv, Israel)
J. Surralles (Barcelona, Spain)
S. Takeda (Kyoto, Japan)
A. M. R. Taylor (Birmingham, UK)
H. Te Riele (Amsterdam, The Netherlands)
A. Venkitaraman (Cambridge, UK)
S. C. West (Herts, UK)
M. Z. Zdzienicka (Al Leiden, The Netherlands)

Programme:
The human genome has evolved a number of cellular mechanisms in response
to chromosome breaks to counteracts the mutational load and prevent tumour
transformation. Consequently, defects in these mechanisms increase cancer
risk and lead to chromosome fragility cancer-prone syndromes such as
Fanconi anemia (FA), ataxia
telangiectasia (AT), Nijmegen breakage syndrome (NBS), and several types
of hereditary breast cancer with mutation in the BRCA1/BRCA2 genes.
Therefore, basic
research on these syndromes is particularly interesting not only to find a
cure for the patients but also to understand key biological processes
required to maintain the genome stability and prevent cancer in the
general population. The following topics will be discussed: 1) Nijmegen
breakage syndrome and the Mre11-Rad50-NBS1
complex; 2) Ataxia telangiectasia and downstream effectors; 3) Fanconi
anemia and its cross talk with DSB repair proteins; 4) BRCA proteins and
double strand break repair networking; 5) Cellular response to chromosome
breaks.

For all requests, please go to the web site: http://www.march.es and then
link to Centre for International Meetings on Biology

Greetings and see you in Madrid
Jordi Surralles


3.5 INTERNATIONAL CONGRESS ON PHOTOBIOLOGY - JEJU ISLAND, KOREA - JUNE
10-15, 2004.

The 14th International Congress on Photobiology sponsored by the
International Union of Photobiology and hosted by the Korean Society of
Photoscience, Photobiology Association of Japan, and Asia and Oceania
Society for Photobiology will be held June 10-15, 2004, on the island of
Jeju, Korea. Both Korean Society of Photoscience, Korean Photodynamic
Association, and Asia and Oceania Society for Photobiology will also hold
their annual meetings in conjunction with the Congress at the same time.
More details can be found at:
http://photos.or.kr/ICP2004 (ICP is case-sensitive)

I would like to invite you to register to participate in the Congress by
visiting the website and filling out the registration form therein. To
make the Congress successful, your suggestions and contributions are
essential and will be greatly appreciated by the Organizing Committee. In
order to make the Congress scientifically attractive, we plan to organize
nearly 50 symposia and 10 special lectures. In addition, we are planning
to present a national photobiology-society sponsored Plenary Lecture each
day of the
Congress.

The Congress venue is the Island of Jeju. It is one of the most beautiful
islands in the world. It offers many sightseeing and leisure attractions.
Bring your family and friends. You will enjoy it.

See you all here in Jeju, Korea, in Year 2004!

Best wishes,
Pill-Soon Song
Congress President-ICP2004




4.      POST DOC AND EMPLOYMENT OPPORTUNITIES: Baltimore, MD; Research
Triangle Park, NC; Boston, MA; New York, NY; Boston, MA; Portland, OR;
Ontario, Canada; Boston, MA; Saskatchewan, Canada; Washington, D.C.
[Note: Check the list for more Job Opportunities on the DNA Repair
Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ ]


4.1 NIH POST DOCTORAL FELLOW - DNA HELICASES- NIA, BALTIMORE, MD
With nation-wide responsibility for improving the health and well being of
all Americans, the Department of Health and Human Services oversees the
biomedical research programs of the National Institutes of Health and
those of NIH's research Institutes.

The National Institute on Aging, a major research component of the
National Institutes of Health (NIH) and the Department of Health and Human
Services, is recruiting for a NIH postdoctoral fellow to conduct research
program in The Unit on DNA Helicases, Laboratory of Molecular Gerontology.
An individual is sought who will complement our current research
activities that investigate structure-function aspects of DNA helicases
defective in premature aging and cancer disorders.  The objective of this
research is to understand the molecular-cellular roles of human DNA
helicases in pathways important for the maintenance of genome stability.

The successful individual will possess an M.D. or Ph.D., have research
experience in biochemistry, and training in molecular and/or
mammalian/yeast cell culture techniques.

For additional information on this position, and for instructions on
submitting your application, please see contact:  Robert M. Brosh, Jr.,
Ph.D., Investigator NIA-NIH, Laboratory of Molecular Gerontology, 5600
Nathan Shock Drive, Baltimore, MD 21224 USA.  Phone: 410-558-8578, E-mail:
[log in to unmask]

4.2 NIH POSTDOCTORAL POSITION - GENOME STABILITY - RESEARCH TRIANGLE PARK,
NC
NIH POSTDOCTORAL POSITION to investigate highly relevant genome stability
issues using yeast and/or human cell systems.  Research projects are
available in several related directions that include i) DNA double-strand
breaks (origin, repair, recombination, replication, cell signaling, and
real time analysis); ii) replication and mutation avoidance; iii)
influence of mitochondria on genome stability; and iv) human p53 function,
role in genome stability and model for evolution of regulatory networks
(see http://dir.niehs.nih.gov/dirlmg/home.htm).  A variety of genetic,
molecular, and functional genomics approaches are used that have been
developed in this Section. Along with exceptional facilities and
resources, the Section provides a highly interactive and unique scientific
environment with several areas of expertise, so as to create an
exceptional training opportunity.
The Section is part of the Laboratory of Molecular Genetics (LMG) with
many PI's renowned for their contributions to the area of genome stability
and is located at the National Institute for Environmental Health Sciences
(NIEHS) of the NIH.  NIEHS is in a highly attractive area of North
Carolina that is central to prominent research institutions.  A unique
feature of the postdoctoral program is the opportunity to apply for
special grants for subsequent tenure-track academic appointments. Salary
and benefits are competitive.
Application.  Send CV & names of references to Dr. Michael Resnick, Head,
Chromosome Stability Section, NIEHS, P.O. Pox 12233, Research Triangle
Park, NC  27709; [log in to unmask]

        4.3 POSTDOCTORAL POSITION - HOMOLOGOUS RECOMBINATION - CAMBRIDGE,
MA

Postdoctoral position - Biological Engineering Division, Massachusetts
Institute of Technology, Cambridge, MA. A postdoctoral position is
available in the laboratory of Bevin P. Engelward to develop novel
transgenic mouse systems for measuring mitotic homologous recombination
via fluorescence detection within tissues, and to study interactions
between DNA excision repair and homologous recombination in eukaryotes.
Experience in genetics, molecular biology, cell biology, DNA repair, or
knockout/transgenic mouse technology is desired. Interested individuals
should send their C.V., a description of their research experience and
interests, and the names of three references to:

Bevin P. Engelward, Sc.D.
Associate Professor of Biological Engineering
MIT Biological Engineering Division, 56-631
77 Massachusetts Avenue
Cambridge, MA 02139
        http://web.mit.edu/bevin/www/

MIT is an Equal Opportunity/Affirmative Action Employer


        4.4 POST DOCTORAL POSITION - COLUMBIA UNIVERSITY, NEW YORK
A postdoctoral position is available immediately at the Department of
Radiation Oncology, Center for Radiological Research, Columbia University
to pursue studies of signal transduction pathway(s) involved in radiation
induced DNA damage and bystander response in mammalian cells. Candidate
with a recent a Ph.D. degree in Biochemistry, Molecular biology or Cell
biology is required. Experience in cell culture, protein biochemistry and
signal transduction research experience is preferred.
Interested candidates can submit their resume, areas of research interests
and three letters of recommendations to either
Prof. Charles R. Geard or Dr. A.S. Balajee
Department of Radiation Oncology
Center for Radiological Research
College of Physicians and Surgeons
Columbia University, VC-11, Room 243
168th Street, 630 West
New York, NY 10032.
Informal enquiries can be made to Dr. A.S. Balajee ([log in to unmask]).

        4.5 POSTDOCTORAL POSITION - ALKYLATION DAMAGE - BOSTON, MA
Postdoctoral position - Biological Engineering Division Massachusetts
Institute of Technology, Boston, MA.  A postdoctoral position is available
in the lab of Leona D. Samson to study the biological effects of
alkylation damage.  Research areas include: (1) exploring the molecular
basis of cellular signaling in response to DNA alkylation damage; (2)
alkylation damage-induced global transcriptional responses; (3) functional
genomic approaches (genomic phenotyping) to identifying novel recovery
pathways; (4) transgenic and knockout mice to study the influence of
alkylation damage on apoptosis, mutation, genome stability and
tumorigenesis; (5) gene therapy approaches to suppressing bone marrow
toxicity.  Experience in biochemistry, molecular biology, cell biology,
DNA repair, or knockout/transgenic mouse technology is desired.
Selected Publications:
Hickman, M. and Samson, L.D. (1999) Role of DNA mismatch repair and p53 in
signaling induction of apoptosis by alkylating agents. Proc. Natl. Acad.
Sci., 96: 10764-10769.
Roth, R.B., and Samson, L.D. (2000) Gene transfer to suppress bone marrow
alkylation toxicity.  Mutation Research, 462:107-120.
Lau, A.Y., Wyatt, M.D., Glassner, G., Samson, L.D., and Ellenberger, T.E.
(2000) Molecular basis for discriminating between normal and damaged bases
by the human alkyladenine glycosylase, AAG. Proc. Natl. Acad. Sci,
97(25):13573-13578.
Jelinsky, S., Estep, P., Church, G., and Samson, L. D. (2000) Regulatory
networks revealed by transcriptional profiling of damaged Saccharomyces
cerevisiae cells:  Rpn4 links base excision repair with proteasomes,
Molecular and Cellular Biology, 20 (21):8157-8167.
 Roth, R. and Samson, L.D. (2002) 3-methyladenine DNA
glycosylase-deficient Aag null mice display unexpected bone marrow
alkylation resistance, Cancer Research 62, 656-660.
Begley, T.J., Rosenbach, A.S., Ideker, T. and Samson, L.D. (2002) Recovery
Pathways in S. cerevisiae Revealed by Genomic Phenotyping and Interactome
Mapping, Molecular Cancer Research, in press
Begley T.J. and Samson, L.D. (2003) AlkB mystery solved:  Oxidative
demethylation of N1-methyladenine and N3-methylcytosine adducts by a
direct reversal mechanism, Trends in the Biochemical Sciences, in press

Please send CV and 3 letters of Reference to:
Leona D. Samson
Ellison American Cancer Society Research Professor
Biological Engineering Division, and
Director of the Center for Environmental Health Sciences
Massachusetts Institute of Technology
77 Massachusetts Avenue, 56-235
Cambridge, MA 02139
or via email: [log in to unmask]

        4.6 POSTDOCTORAL POSITION-NERVOUS SYSTEM DNA REPAIR, PORTLAND, OR
A postdoctoral position is available immediately to study the role of DNA
damage and DNA repair in the nervous system. Particular emphasis is on
understanding the role of BER and NER in maintaining the integrity of
neurons and other cell types of the central nervous system. Currently
funded projects involve the use of whole animal and cell culture models
from transgenic/knockout DNA repair mutant mice to explore the
relationship between neuronal cell death and DNA damage during development
and in age-related neurodegenerative disease (e.g., Parkinson's,
Alzheimer's, and Lou Gehrig's disease). PhD candidates (less than 5 yrs
experience) with a strong background in molecular or cell biology and DNA
repair and experience in mammalian cell culture, protein biochemistry,
gene expression, protein-protein interaction, DNA microarrays are
encouraged to apply.

For more information, send an email to the address below. To apply, please
send your C.V., a description of your research experience, and the names,
addresses, telephone numbers and email addresses of three references to:


Glen Kisby, PhD
Associate Professor
Ctr for Res on Occup
& Environ Toxicol (CROET)
Oregon Health & Science University (OHSU)
3181 SW Sam Jackson Park Rd
Portland, OR 97201-3098
E-mail: [log in to unmask]

Portland is an affordable centrally located city in the beautiful state of
Oregon. The University is only 1 h away from year round skiing at Mt Hood,
the Pacific Ocean, and the scenic deserts of eastern Oregon. The campus
contains a large group of distinguished faculty with special emphasis on
the nervous system. CROET is a unique research institute with faculty that
conduct applied research in the workplace (i.e., epidemiology) and basic
research at the cellular and molecular level.


        4.7 POSTDOCTORAL POSITION IN MAMMALIAN DNA REPAIR DEPARTMENT OF
BIOLOGY, McMASTER UNIVERSITY, ONTARIO, CANADA

A postdoctoral position is available immediately to study the DNA repair
pathways in mammalian cells. Our laboratory is particularly interested in
the mechanisms of inducible DNA repair pathways following exposure to UVA,
UVB and UVC and how deficiencies in DNA repair play a role in human
disease. Research areas include the role of several human ERCC genes in
inducible DNA repair as well as several aspects of the DNA repair
deficiency in cells from patients with xeroderma pigmentosum, Cockayne
syndrome, Li-Fraumeni syndrome and ataxia telangiectasia. Our laboratory
has developed a number of techniques to study DNA repair using
adenoviruses as probes and expression vectors and the application of these
techniques to other areas of mammalian DNA repair are also possible
research areas in my laboratory.

The position is initially for one year (minimum starting salary of
$30,000) with the possibility of extension for two further years.
Candidates with a recent Ph.D., a background in cell biology, molecular
biology and genetics, some experience in mammalian cell culture and a good
knowledge of both written and spoken English are encouraged to apply.
Please send a CV and the names and addresses (including email address and
telephone number) of three references to:

Andrew J. Rainbow, Ph.D.
Department of Biology
McMaster University
Hamilton, Ontario L8S 4K1
Canada.

Telephone: (905)-525-9140, ext. 23544
Fax: (905)-522-6066
Email: [log in to unmask]
Website:
http://www.science.mcmaster.ca/biology/faculty/rainbow/rainbow.htm

        4.8 POSTDOCTORAL/RESEARCH ASSOCIATE POSITIONS - BOSTON
Two openings available immediately to study the role of AP endonuclease in
the cell physiology and biochemistry of DNA base excision repair.  We are
a dynamic group in a young department with lots of opportunity.  The
successful candidate will be smart, enterprising and hard working.  We
need you!
Contact:  Phyllis Strauss, Northeastern University, Boston MA 02115,
e-mail: [log in to unmask]

        4.9 POSTDOCTORAL POSITIONS - UNIVERSITY OF SASKATCHEWAN, CANADA

Two postdoctoral positions are available immediately. One is to study DNA
postreplication repair and mutagenesis in mammalian cells and in a
transgenic mouse model. The second position is to study molecular
mechanisms of gene regulation in response to DNA damage, using budding
yeast as a model eukaryote.

Candidates with recent Ph.D. and background in biochemistry, cell biology,
molecular biology and genetics are encouraged to apply. Annual salary
begins with $32,000 - $35,000, based on experience. Please send CV and
names of three references with contact information to:

Wei Xiao, Ph.D.,
Professor, Department of Microbiology and Immunology
University of Saskatchewan
107 Wiggins Road
Saskatoon, SK, S7N 5E5 Canada
Tel: 306-966-4308
Fax: 306-966-4311
E-mail: [log in to unmask]
Web site:http://www.usask.ca/medicine/microbio/xiaow/


        5.0  COMMERCIAL REAGENT SOURCES
[Note: There are more commercial reagent sources listed on the DNA Repair
interest group website: http://www.nih.gov:80/sigs/dna-rep/    These
sources are listed as a convenience to our readers and do not constitute
an endorsement of any of these companies or their products.]


5.1 Bethyl Laboratories, Inc.
Antibodies for DNA Damage/Repair and related research (www.bethyl.com)
New antibodies include SDS3, DMAP1, KIF14, DIS, MCM2, MCM3, MCM4, MCM6,
MCM7, MCM10, Claspin, BRD2, Pumilio 1, Pescadillo, Mre11, NBS1, SERCA2,
AMPK and RFC1. http://www.bethyl.com

        5.2  Reliable Biopharmaceutical Corporation
As the leading U.S. manufacturer of modified nucleic acids, we wanted to
introduce you to our newest product: cis-syn TpT Cyclobutane Dimer
Phosporamidite. Specially developed for the DNA repair and research
markets. You can see our homepage and our TpT Dimer Amidite webpage to
better understand our company and products.

If I or my staff can answer any of your specific questions, please call at
your convenience.

Sincerely,
Sourena Nadji, Ph.D.
Reliable Biopharmaceutical Corporation
Director of Research and Development
(314)429-7700
http://www.reliablebiopharm.com/

        5.3 Novus Biologicals, Inc., Littleton, CO - Antibodies for DNA
Repair Research (http://www.novus-biologicals.com/research.php/8) and
other research applications (www.novusbio.com). New antibodies include
Rad9, HLTF, Aurora A and B, XAGE, chk1, and phosphorylated proteins
(mNBS1, hNBS1, SMC-1 and 3, BRCA1, Rad17, and chk1).  For more information
contact:


Bryan Tinsley
Novus Biologicals, Inc.
5951 S. Middlefield Rd. Suite 103
Littleton, CO 80123
303-730-1950
fax: 303-730-1966
[log in to unmask]
Visit our website for the most up to date product listings
www.novusbio.com


5.4 Santa Cruz Biotechnology, Inc, Santa Cruz, CA - Antibodies for
research applications.  Please find specific product information at
http://www.scbt.com

        5.5 Austral Biologicals, Inc, San Ramon, CA. - Antibodies for
research applications.
Please visit our web site: http://www.australbio.com


        6       ELECTRONIC CONTACTS:
6.1     Check out the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
You can find the schedule for future DNA Repair Interest Group
videoconferences and a listing of past videoconferences (with links to the
videoarchive) as well as a current list of JOB OPPORTUNITIES in DNA repair
and MEETING NOTICES.

6.2     Encourage your colleagues who are interested in DNA Repair to
request that they be added to this DNA Repair Interest Group listserve
e-mail list by sending a request by e-mail to: [log in to unmask]
Leave the subject  blank. In the message field, type in: subscribe
DNARepair-L your name
        Alternatively, by filling out the form on the website
(http://www.nih.gov:80/sigs/dna-rep/ ) you can both add your name to the
e-mail list and have your name posted on the website.  If you want your
name to be listed you can fill out the "Join the SIG" form on the web site
and add your name to the listing of members.  If you are not at NIH then
be sure to click the "other" box and then fill in the name of your
institution.

6.3     Archives of these listserve mailings can be found at
        http://list.nih.gov/archives/dnarepair-l.html  or via links from
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/

6.4     I will be happy to relay information about post-doctoral
positions, jobs and meetings and other information related to DNA Repair.
Please send me an e-mail message ([log in to unmask]) and I will incorporate
it into the next announcement list and post it on the DNA Repair Interest
Group web site: http://www.nih.gov:80/sigs/dna-rep/ .
(This list goes to more than 1000 scientists around the world who are
interested in DNA repair.)


Kenneth H. Kraemer, M.D.
Chief, DNA Repair Section
Basic Research Laboratory
National Cancer Institute
Building 37 Room 3E24
Bethesda,  MD 20892
301-496-9033    FAX: 301-496-8419
e-mail: [log in to unmask]
DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/

Center for Information Technology National Institutes of Health Bethesda, Maryland 20892 301 594 6248 (v) 301 496 8294 (TDD) Comments and Assistance Accessibility