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DNAREPAIR-L archives -- June 2005, week 1 (#1)

Approved-By: [log in to unmask] Content-Type: TEXT/PLAIN; charset=US-ASCII; format=flowed Message-ID: <[log in to unmask]> Date: Mon, 6 Jun 2005 15:16:05 -0400 Reply-To: Ken Kraemer <[log in to unmask]> Sender: DNA Repair Interest Group <[log in to unmask]> From: "Kenneth H. Kraemer" <[log in to unmask]> Subject: DNA Repair Interest Group - UPDATE - June 6, 2005

DNA Repair Interest Group - UPDATE - June 6, 2005 1 - VIDEOCONFERENCE: June 14, 2005 - Tues 12:30 PM - Dr. Kurt W. Kohn, NCI - A personal history of DNA damage and repair research 1960-2005 Origin of videoconference: NIH, Bethesda 2 - NIH SEMINARS OF NOTE: June 8 - 10:00AM - 4:00 PM The Cell Cycle Interest Group annual symposium - Natcher Auditorium 3 - CONFERENCES - WORKSHOP ON ATAXIA TELANGIECTASIA, ATM AND THE DNA DAMAGE RESPONSE JUNE 8-11, 2005, LAKE MAGGIORE, ITALY; HEALTH, GENES & SOCIETY - TEL-AVIV, ISRAEL -JUNE 19-21, 2005; GORDON RESEARCH CONFERENCE ON GENETIC TOXICOLOGY - COLBY-SAWYER, NEW LONDON, NH - JULY 31ST-AUGUST 5TH 2005; INTERNATIONAL MEETING ON O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE (MGMT). AUGUST 6-9, 2005, KEELE CONFERENCE PARK, UK; STRUCTURAL BIOLOGY OF DNA REPAIR- AUG 28 - SEPT 1, 2005; CELL LINEAGES, GENETIC INSTABILITY AND HUMAN DISEASE AUGUST 31-SEPTEMBER 2, 2005, SEATTLE, WA; 9TH INTERNATIONAL CONFERENCE ON ENVIRONMENTAL MUTAGENS - SEPT 3-8, 2005 - SAN FRANCISCO; 11TH CONGRESS OF THE EUROPEAN SOCIETY FOR PHOTOBIOLOGY AIX-LES-BAINS, FRANCE, SEPTEMBER 3 - 8, 2005; RESPONSES TO DNA DAMAGE: INSIGHTS FROM CHEMICAL, BIOCHEMICAL, STRUCTURAL BIOLOGY AND CELLULAR STUDIES 19-21 SEPTEMBER 2005, BRIGHTON, UK; US-EU WORKSHOP "SYSTEMS LEVEL UNDERSTANDING OF DNA DAMAGE RESPONSES" SEPTEMBER 30-OCTOBER 4, 2005, STOWE, VERMONT, USA; 5TH INTERNATIONAL 3R SYMPOSIUM NOVEMBER 13-17, 2005, - AWAJI YUMEBUTAI INTERNATIONAL CONFERENCE CENTER, AWAJI ISLANDS, HYOGO, JAPAN 4- POST DOC AND EMPLOYMENT OPPORTUNITIES: Bethesda, MD; Indianapolis, IN; Davis, CA; Buffalo, NY; Columbia, S.C.; Worcester, MA; Burlington, VT, Rochester, MN; London, UK 5 - COMMERCIAL REAGENT SOURCES 6 - ELECTRONIC CONTACTS 1.0 DNA REPAIR VIDEOCONFERENCE: June 14, 2005 - Tues 12:30 PM - Dr. Kurt W. Kohn, NCI - A personal history of DNA damage and repair research 1960-2005 Origin of videoconference: NIH, Bethesda VIDEOCONFERENCE LOCATIONS: Building 45 (NATCHER) Room J, Bethesda, MD (origin); Room 1E03 GRC Baltimore, MD; Lawrence Livermore Labs, Livermore, CA; Univ of Michigan, Ann Arbor; University of Pittsburgh; MD Anderson, Smithville, TX; Building 101 Room B200, NIEHS, Research Triangle Park, NC State University of New York, Stony Brook, NY; Univ of Kentucky, Lexington, KY; Building 549, Conference Room A, FCRDC, Frederick, MD; Brookhaven National Labs, Upton, NY; Oregon Health & Science University, Portland, OR; Univ of North Carolina, Chapel Hill, NC and live on the internet at http://videocast.nih.gov 1.1 DNA REPAIR VIDEOCONFERENCE - FUTURE DATES AND VIDEO ARCHIVE [Note: A larger and more up to date list of future and past videoconferences can be found on the DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ ] 1.1.1 FUTURE VIDEOCONFERENCES: TBA 1.1.2 VIDEOARCHIVES: INTERNET ACCESS (WORLDWIDE): To date 84 of these videoconferences have been archived and are available for viewing at your leisure on the internet. You will need a web browser (with a high speed link) and free Real Video software. Setup details and access are available at the NIH videocast website: http://videocast.nih.gov. Go to Past events; DNA Repair Interest Group Sessions. Note: Technical improvements are made regularly on this site to increase transmission speeds and ease of access. If you were not successful in viewing these videos in the past it is worth trying again. We recently received a log of the use of these videocasts. They were downloaded nearly 10,000 times in the past two years! May 18 - Dr. Steve West - Cancer Research, UK also gave a lecture in the NIH Director.s Wed Afternoon lecture series Title: Making Ends Meet: Double-strand Break Repair in Human Cells May 17, 2005 - Dr. Steve West - Cancer Research UK, London Research Institute - Title: New insights into mechanisms of BRCA2-regulated double-strand break repair [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site. The posting of the video is delayed at the request of the speaker] April 19, 2005 - Short talks by young investigators: Dr. Miguel Garcia-Diaz - NIEHS - Structural analysis of strand misalignment during DNA synthesis; [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site. The posting of the video is delayed at the request of the speaker] Dr. Kyungjae Myung - NHGRI -Suppression and formation of gross chromosomal rearrangements through cross talk between different DNA metabolisms; [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site. The posting of the video is delayed at the request of the speaker] Dr. John Hinz - Livermore, CA -Distinct genomic instabilities associated with deficiencies in homologous recombination or the Fanconi anemia FANCD2 monoubiquitination pathway [Note: The posting of the video is delayed at the request of the speaker] March 15, 2005 - Dr. Wei Yang - NIDDK - DNA repair in 3D. [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site. The posting of the video is delayed at the request of the speaker] Feb 16, 2004 Dr. Judy Campisi also gave a lecture in the NIH Director.s Wed Afternoon lecture series on the following day. Title: Cancer and aging: Rival demons? Feb 15, 2005 - Dr. Judy Campisi - Univ of California Berkeley - Title: Genome maintenance systems, cancer and aging [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site. The posting of the video is delayed at the request of the speaker] Jan 18, 2005 - Dr. Michael Seidman - NIA - Repair and Mutagenesis of Triplex Targeted Interstrand Crosslinks. [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site. The posting of the video is delayed at the request of the speaker] Dec 21, 2004 - Tues 12:30 PM - Dr. Thomas Wilson - Univ of Michigan -Nonhomologous end-joining: lessons from yeast. Origin of Videoconference: Univ of Michigan [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site. The posting of the video is delayed at the request of the speaker] Nov 16, 2004 - Dr. Susan Olson - OHSU, Portland, OR - Exploring Cellular and Molecular Aspects of Fanconi Anemia from a Cytogenetic Perspective [Note: The posting of this talk is delayed at the request of the speaker] Oct 19, 2004 - Dr. Roel Schaaper - NIEHS- Novel mutators and the correction of replication errors in E. coli [Note: The posting of this talk is delayed at the request of the speaker] Sept 21, 2004 - Dr. Ken Kraemer -Clinical, Molecular and Epidemiologic Studies of Xeroderma Pigmentosum and Related Disorders of DNA Repair [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] June 15, 2004 -Young investigator showcase: Dr. Sikandar Khan - NCI - Two Essential Splice Lariat Branchpoint Sequences in One Intron in a Xeroderma Pigmentosum DNA Repair Gene [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] June 15, 2004 -Young investigator showcase: Dr. Francesca Storici - NIEHS - Addressing Mechanisms of Recombination and Double Strand Break Repair in Yeast with Targeted Oligonucleotides and the Delitto Perfetto Approach [Note: Adobe Acrobat files with slides from this talk can be downloaded at this site.] June 15, 2004 -Young investigator showcase: Dr. Diane Cabelof - Wayne State, Detroit - Induction of Spontaneous Tumors in beta-pol Haploinsufficient Mice [Note: The posting of this talk is delayed at the request of the speaker] May 18, 2004 - Dr. Larry Thompson - Lawrence Livermore National Lab, Livermore, CA - History of DNA Repair: Chinese Hamster Cells and DNA Repair - A Long-Lasting Affair [Note: An Adobe Acrobat file with slides from this talk can be downloaded at this site. The posting of the video of this talk will be delayed at the request of the speaker.] April 20, 2004 - Dr. David Wilson - NIA, NIH - Regulation of Central Steps in Human Base Excision Repair [Note: An Adobe Acrobat file with slides from this talk can also be downloaded at this site.] Mar 16, 2004 -Dr. Alan Lehmann - Brighton, UK - Translesion Synthesis and Polymerase Switching in Human Cells Feb 17, 2004 - Dr. Dmitry Gordenin - NIEHS- Inhibition of Mismatch Repair by Cadmium [Note: An Adobe Acrobat file with slides from this talk can also be downloaded at this site.] Jan 20, 2004 - Dr. Steve Kowalczykowski - Biochemistry of Recombinational DNA Repair: Common Themes [Note: An Adobe Acrobat file with slides from this talk can also be downloaded at this site.] Dec 16, 2003 - Dr. Andre Nussenzweig - Experimental Immunology Branch, CCR, NCI, NIH -The Role of DNA Breaks in Genomic Instability Nov 18, 2003 - Dr. Lei Li - Univ of Texas, M.D. Anderson Cancer Center - DNA Damage Cell Cycle Checkpoint: Beyond Buying Time for Repair Oct 14, 2003- Dr. Alain Sarasin, Institut Gustave Roussy, Villejuif France - Xeroderma pigmentosum : Role of the XP variant pol eta gene in UV-induced mutagenesis. Toward a gene therapy in XPC patients? Sept 16, 2003 - Dr. Satya Prakash - Univ of Texas, Galveston -Translesion synthesis DNA polymerases of yeast and humans Sept 16, 2003 - Dr. Satya Prakash -Studies of human DNA repair diseases in yeast Through the miracle of videotape we now have been able to post most of the DNA Repair Interest Group videoconferences from 1998,1999, 2000, 2001, 2002 and 2003 on the web site. These include talks by Drs. Anderson, Beernik, Bogenhagen, Bohr, Bradsher, Brash, Brooks, Brosh, Chu, Cleaver, Chen, Copeland, Drotschmann, Elledge, Emmert, Essigman, Fornace, Friedberg, George, Glazer, Grossman, Hanawalt, Jin, Kashlev, Kraemer, Kunkel, Leadon, Liu, Ljungman, Marini, Matson, Matsumoto, McKay, Mitra, Pommier, Ramsden, Rosenquist, Setlow, Schofield, Sharan, Sobol, States, Stefanini, Sung, Sutherland, Tainer, Taylor, Tomkinson, Thompson, Vasquez, Wang, Wei, Wood, Woodgate, Yanamadala, and Yarosh. 2. NIH SEMINARS OF NOTE: June 8 - 10:00AM - 4:00 PM The Cell Cycle Interest Group annual symposium - Natcher Auditorium Agenda: 10:00 am Keynote address: Tom Kelly, Director, Sloan-Kettering Memorial Institute Activation of the replication checkpoint 11:00 am Yves Pommier Implication of the ATM-Mre11-Chk2 axis in response to the replication double-strand breaks induced by topoisomerase I 11:20 am Munira Basrai Oxidative stress due to superoxide ions affects the MEC1 mediated checkpoint pathway response in S. cerevisiae 11:40 am Bill Bonner H2AX and genome integrity 12:00 pm Mirit Aladjem How cells regulate the timing of DNA replication 12:20 pm Mel DePamphilis and Alex Vassilev DNA replication in mammalian cells and the origin recognition complex Lunch break (12:40 - 1:40) 1:40 pm KJ Myung Mechanisms underlying the formation of gross chrosomomal rearrangements 2:00 pm Orna Cohen-Fix Yeast with nuclei bent out of shape 2:20 pm Barbara Thomas The anaphase promoting complex/cyclosome regulates Cdc25/String stability and G1 arrest in the developing eye of Drosophila 2:40 pm Yekaterina Boyarchuk (Dasso Lab) Bub1 is essential for the kinetochore localization of Aurora B complex 3:00 pm Kyung Lee PBIP1, a novel polo-like kinase substrate at the kinetochores 3:20 pm Eiman Aleem (Kaldis Lab) Cdc2 is regulated by p27 and cyclin E: lessons from p27-/-Cdk2-/- double knockout mice 3:40 pm Kathryn Kreimborg Stein (Golden Lab) Isolation of spindle checkpoint mutants in a C. elegans genetic screen for suppressors of meiosis-defective APC The agenda can be accessed at the following URL: http://www3.cancer.gov/intra/lmp/cellcyclesympad.html Thanks in advance and best wishes Mirit I. Aladjem, Ph.D. Laboratory of Molecular Pharmacology Bldg. 37, Rm 5056 Tel. 301-435-2848 Fax 301-402-0752 3. CONFERENCES - WORKSHOP ON ATAXIA TELANGIECTASIA, ATM AND THE DNA DAMAGE RESPONSE JUNE 8-11, 2005, LAKE MAGGIORE, ITALY; HEALTH, GENES & SOCIETY - TEL-AVIV, ISRAEL -JUNE 19-21, 2005; GORDON RESEARCH CONFERENCE ON GENETIC TOXICOLOGY - COLBY-SAWYER, NEW LONDON, NH - JULY 31ST-AUGUST 5TH 2005; INTERNATIONAL MEETING ON O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE (MGMT). AUGUST 6-9, 2005, KEELE CONFERENCE PARK, UK; STRUCTURAL BIOLOGY OF DNA REPAIR- AUG 28 - SEPT 1, 2005; CELL LINEAGES, GENETIC INSTABILITY AND HUMAN DISEASE AUGUST 31-SEPTEMBER 2, 2005, SEATTLE, WA; 9TH INTERNATIONAL CONFERENCE ON ENVIRONMENTAL MUTAGENS - SEPT 3-8, 2005 - SAN FRANCISCO; 11TH CONGRESS OF THE EUROPEAN SOCIETY FOR PHOTOBIOLOGY AIX-LES-BAINS, FRANCE, SEPTEMBER 3 - 8, 2005; RESPONSES TO DNA DAMAGE: INSIGHTS FROM CHEMICAL, BIOCHEMICAL, STRUCTURAL BIOLOGY AND CELLULAR STUDIES 19-21 SEPTEMBER 2005, BRIGHTON, UK; US-EU WORKSHOP "SYSTEMS LEVEL UNDERSTANDING OF DNA DAMAGE RESPONSES" SEPTEMBER 30-OCTOBER 4, 2005, STOWE, VERMONT, USA; 5TH INTERNATIONAL 3R SYMPOSIUM NOVEMBER 13-17, 2005, - AWAJI YUMEBUTAI INTERNATIONAL CONFERENCE CENTER, AWAJI ISLANDS, HYOGO, JAPAN [Note: A larger and more up-to-date list of conferences can be found on the DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ ] 3.1 2005 INTERNATIONAL WORKSHOP ON ATAXIA TELANGIECTASIA, ATM AND THE DNA DAMAGE RESPONSE JUNE 8-11, 2005 LAKE MAGGIORE, ITALY The Organisers are pleased to announce the 2005 International Workshop on Ataxia Telangiectasia, ATM and the DNA Damage Response to be held from 8-11 June 2005, Lake Maggiore, Italy. The topics that will be covered include: ATM, related proteins and DNA damage responses Alterations in the ATM and ATR pathways and their consequences Cellular responses to DNA single strand breaks and related phenotypes DNA damage responses in the nervous system Therapeutic strategies Full details are available at http://www.atworkshop.com The Scientific Committee, ATW2005 Luciana Chessa, Domenico Delia, Jiri Bartek, Pat Concannon, Richard Gatti, Jean Gautier, Janet Hall, Martin Lavin, Peter McKinnon, Yosef Shiloh andMalcolm Taylor Janet Hall DNA Repair Team, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08 France tel: +33 (0)472738596 fax: +33 (0)472738322 3.2 HEALTH, GENES & SOCIETY - TEL-AVIV, ISRAEL -JUNE 19-21, 2005 Personalized Medicine Europe: Health, Genes & Society Tel-Aviv University, Tel-Aviv, Israel June 19-21, 2005 http://www.functionalgenomics.org.uk/sections/activitites/2005/Livshits/info.htm Participation is free of charge, however advance registration is required. Abstract deadline: March 15, 2005 (see web site for detailed abstract submission instructions) Five prizes of Euro 300 each are offered to graduate and post-graduate students for the best abstracts chosen for oral presentation. Please register by e-mail to one of the organisers: Gregory Livshits [log in to unmask] David Gurwitz [log in to unmask] 3.3 GORDON RESEARCH CONFERENCE ON GENETIC TOXICOLOGY - COLBY-SAWYER, NEW LONDON, NH - JULY 31ST-AUGUST 5TH 2005 Session 1: Keynote talks (Bennett Van Houten/ Samuel Wilson / Peggy Jeggo/ Marc Vidal) Session 2: Genotoxicity of endogenous lesions and BER. (Larry Marnett / Sankar Mitra/ John Essignman/ Akira Yasui/ Leona Samson) Session 3: New Developments in excision repair. (Jean-Marc Egly / Caroline Kisker/ Kioji Tanaka/ Cilla Cooper) Session 4: Responses to replication blockage. (Tom Kunkel/ John Diffley/ Alan Lehmann/ Jean Wang/ TBA) Session 5: Double black diamonds of repair: DNA cross-links and protein-DNA cross-links. (Stephen Lloyd/ Peter McHugh/ Laura Neiderhofer/ Alan D. Andrea) Session 6: Damage inducible checkpoints and signaling. (Tony Carr/ Steve Elledge/ Rodney Rothstein/ Yossi Shilo/ TBA) Session 7: DNA Damage in vivo and somatic mutation in vivo. (Andrew Collins/ Bernd Eppe/Vern Walker/ Shinya Shibutani ) Session 8: Mitochondria: the other site of DNA damage. (William Copeland/ Susan Ledoux/ Ute Moll/ Takehiko Shibata/ TBA Session 9: Metals as co-carcinogens. David Wilson/ Andy Kligerman/ Anatoly Zhitkovich/ Jim Imlay As in past years this conference seeks to explore mechanisms of genotoxicty from molecules to man including systems analysis, and possible intervention strategies in disease states. The Keynote Speakers are: Drs. Sam Wilson, Penny Jeggo and Marc Vidal. Post-doctoral fellow and students are strongly encouraged to participate. Site for more information: http://www.grc.org/programs/2005/gentox.htm 3.4 INTERNATIONAL MEETING ON O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE (MGMT). AUGUST 6-9, 2005, KEELE CONFERENCE PARK, UK The meeting website is http://www.paterson.man.ac.uk/mgmt/mgmt.jsp Closing date is June 15th. For more information contact: Dr Geoff Margison Head, Cancer Research-UK Carcinogenesis Group Paterson Institute for Cancer Research Christie Hospital Trust Manchester M20 4BX United Kingdom Phone:44 (0) 161 446 3183 Fax: 44(0) 161 446 8306 E-mail: [log in to unmask] 3.5 STRUCTURAL BIOLOGY OF DNA REPAIR- AUG 28 - SEPT 1, 2005 This one day conference will be held during the National ACS. For more information contact: Caroline Kisker Associate Professor State University of New York At Stony Brook Center for Structural Biology Department of Pharmacological Sciences Stony Brook , NY 11794-5115 Tel: (631) 632 1465 Fax: (631) 632 1555 E-Mail: [log in to unmask] 3.6 CELL LINEAGES, GENETIC INSTABILITY AND HUMAN DISEASE (AN ENVIRONMENTAL MUTAGEN SOCIETY SATELLITE MEETING) AUGUST 31-SEPTEMBER 2, 2005, SEATTLE, WA The focus of this meeting is on how the differences in DNA damage, mutagenesis, repair and cell death in specific cell types or cell lineages influences disease risk or disease pathogenesis. Organizers: Larry Loeb, Nancy Maizels and Raymond J. Monnat, Jr. For further information and regsitration, please see: http://depts.washington.edu/biowww/ems/ 3.6 9TH INTERNATIONAL CONFERENCE ON ENVIRONMENTAL MUTAGENS - SEPT 3-8, 2005 - SAN FRANCISCO This is just a reminder that June 1 is the early-bird deadline for discounted registration for the 9th International Conference on Environmental Mutagens, to be held in San Francisco this coming September 3rd through 8th. You can learn more details and register on-line at www.ICEM2005.org. The abstract deadline is also June 1, in order to have your abstract included in the published abstract book. However, we will accept abstracts after that date and place them in a booklet for distribution at the Conference. The ICEM is held every four years and co-sponsored by the Environmental Mutagen Society (EMS) and the International Association of Environmental Societies (IAEMS). The first ICEM was held in Asilomar, California in 1973 and the most recent one in the U.S. was in Cleveland, 16 years ago. This meeting is particularly important as it combines cutting-edge developments in basic science with the application of new knowledge by the organizations charged with the testing of potential genotoxins and the Governmental agencies that regulate them. There has been increasing participation from the DNA repair community in the activities of the EMS in recent years, as documented in the program for the upcoming Conference. The theme of the 9th ICEM, "Global Issues in Genetic Toxicology and Environmental Mutagenesis," transcends national boundaries and is timely for all peoples of the world. We have learned a great deal about the threats to human health from genotoxic chemicals and radiations in our environment. We also know of many inherited and acquired genetic alterations that predispose to cancer, premature aging, and other diseases. The sequencing of the entire human genome and that of many model organisms, along with the development of powerful new technologies, promise to yield even more impressive advances in the coming decade. It should certainly become possible to identify and reduce most of the principal environmental hazards that threaten our health and that of the planet. These hazards include not only genotoxins but also infectious agents and other toxic agents that adversely effect important cellular processes. You won't want to miss the outstanding science and the many opportunities for international communication in this field offered by the 9th ICEM. You should also check out the pre-conference workshops and the Satellite Meetings on specialized topics before and after the main conference. We look forward to welcoming you to the Hyatt Regency at the Embarcadero, in San Francisco, September 3rd through 8th, 2005. Philip C. Hanawalt Chair of the Organizing Committee Professor of Biology Stanford University Department of Biological Sciences 371 Serra Mall Stanford, CA 94305-5020 Tel. (650) 723-2424 Fax (650) 725 -1848 Home page: http://www.stanford.edu/~hanawalt 3.7 11TH CONGRESS OF THE EUROPEAN SOCIETY FOR PHOTOBIOLOGY AIX-LES-BAINS, FRANCE, SEPTEMBER 3 - 8, 2005 There will be no ASP meeting this year. On that occasion there will be a symposium devoted to DNA damage and repair. Obviously there will be several other symposia dealing with biological consequences of exposure to UV and solar radiation (both fundamental and more applied aspects). More information is available on the web site of the congress: http://www.esp-photobiology.it/2005congress/index.html. 3.8 RESPONSES TO DNA DAMAGE: INSIGHTS FROM CHEMICAL, BIOCHEMICAL, STRUCTURAL BIOLOGY AND CELLULAR STUDIES 19-21 SEPTEMBER 2005, BRIGHTON, UK The call for abstracts and registration are now open for the first meeting in the field of DNA Damage from the Chemical Biology Forum and Nucleic Acids Group of the RSC in conjunction with the Biochemical Society. Deadline for abstracts is 15 Jul 2005. The aim of the conference is to bring together scientists from several disciplines including nucleic acid chemistry, biochemical analysis, structural biology and cellular and whole animal studies to help promote cross-fertilisation of ideas and collaborative studies between the disciplines. The meeting will cover: " Oxidative DNA Lesions: from Chemistry to Structure to Biochemistry to Biology " Mismatch Repair " Double Strand Break Repair and Signalling " Translesion Synthesis and Lesion Bypass " Cross Link Repair/Nucleotide Excision Repair Invited speakers include Greg Verdine (Nucleic Acids Award Lecture) Harvard University, USA; Steve Jackson, Wellcome/CR-UK Gurdon Institute of Cancer & Developmental Biology and Steve West, Cancer Research UK. Further information can be found on the conference web page: http://www.rsc.org/DNA Alternatively, please call +44 (0) 1223 432254 or email RSC Conferences at [log in to unmask] 3.9 US-EU WORKSHOP "SYSTEMS LEVEL UNDERSTANDING OF DNA DAMAGE RESPONSES" SEPTEMBER 30-OCTOBER 4, 2005, STOWE, VERMONT, USA Co-chairs: Anne-Claude Gavin and Marc Vidal Until now, researchers focused on specific cellular compartments and individual pathways to study the DNA-damage response, e.g. cell cycle regulation, induction of apoptosis or DNA repair. However, work during the past few years has shown that there is strong interplay between each of these major cellular defense pathways. Thus, in order to fully understand cellular responses to DNA-damage, the cell must be viewed as a large network of protein-protein and protein-DNA interactions that responds to DNA damage in a systematic way. Accordingly, it is felt that a systems biology approach is needed that studies the genetic, biochemical and molecular interactions of the DNA-damage response on a global scale rather than as individual pathways of cellular stress response. This will involve integration of technologies and scientific disciplines and increasingly for joint efforts among complementary fields. The goals of this workshop are to analyze the state of the art in the area of DNA-damage response analysis, and to stimulate collaboration between researchers in the EU and the US in this field. This meeting is a follow-up to the first EU/US workshop that was held in Cortona, Italy, Sept 26-30, 2003, and will emphasize protein~protein and protein~DNA interactions that underlie this global defense network. For more information & registration, please, go to: http://www.uvm.edu/conferences/systemsbiology05/index.html Registration deadline is set at July 1, 2005. Registration will be accepted on basis of the abstract submitted. Especially for young scientists [PhD students and postdocs] sponsored places are available. The total size of the meeting will be limited to 110 persons. 3.10 5TH INTERNATIONAL 3R SYMPOSIUM NOVEMBER 13-17, 2005, - AWAJI YUMEBUTAI INTERNATIONAL CONFERENCE CENTER, AWAJI ISLANDS, HYOGO, JAPAN The mechanism that replicates, maintains, and sometimes alters the DNA which contains the genetic information of an organism is the most fundamental and important mechanism for life. Three processes (DNA Replication, DNA Repair, and Recombination: 3R) that are involved in this mechanism are closely related each other. The scope of this Symposium is to create a forum for free exchanges of scientific information in a relaxed atmosphere and for international collaborations on DNA replication, DNA repair and recombination, furthering the analysis of 3R mechanisms. This Symposium was established in 1997 and has been held every other year until this year (the 5th symposium) in the vicinity of Osaka, Japan. We expect about 300 participants. The official language in this Symposium is English. We are looking forward to your participation. The Symposium web site is: http://www.fbs.osaka-u.ac.jp/~int3rsymp2005/ For more information, please contact: Kiyoji Tanaka, M.D., Ph. D. Human Cell Biology Group Laboratories for Organismal Biosystems Graduate School of Frontier Biosciences Osaka University 1-3 Yamadaoka, Suita, Osaka, 565-0871, Japan. Tel:+81-6-6879-7971 Fax:+81-6-6877-9136 e-mail: [log in to unmask] 4. POST DOC AND EMPLOYMENT OPPORTUNITIES: Bethesda, MD; Indianapolis, IN; Davis, CA; Buffalo, NY; Columbia, S.C.; Worcester, MA; Burlington, VT, Rochester, MN; London, UK [Note: Check the list for more Job Opportunities on the DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ ] 4.1 NIH POST DOCTORAL FELLOWSHIP - HUMAN DISEASES WITH DEFECTIVE DNA REPAIR - BETHESDA, MD We are studying molecular, cellular and clinical abnormalities in patients with defective DNA repair and possible links of these genes to disease in the general population. Current emphasis is on xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. A postdoctoral position is available for a talented individual (M.D., Ph.D. or MD-PhD) with less than 5 years of postdoctoral experience who has knowledge of molecular biology and DNA repair. To apply, send CV and bibliography and names (with contact information) of 3 references to: Kenneth H. Kraemer, M.D. Basic Research Laboratory National Cancer Institute, NIH Building 37 Room 3E24 Bethesda, MD 20892 TEL: 301-496-9033 FAX: 301-496-8419 e-mail: [log in to unmask] http://rex.nci.nih.gov/RESEARCH/basic/lmc/khk.htm NIH is an equal opportunity employer. 4.2 TWO FULL TIME FACULTY POSITIONS - PEDIATRIC HEMATOLOGY/ONCOLOGY - INDIANAPOLIS, IN The Department of Pediatrics, Section of Pediatric Hematology/Oncology at Riley Hospital for Children and Indiana University School of Medicine is recruiting two full-time academic positions at the Assistant/Associate/Full Professor level. The positions have an emphasis on basic and translational research. This senior position comes with the Earl and Betty Herr Endowed Chair in Pediatric Oncology Research. Candidates must have strong research background and either current or potential for independent funding. Successful candidates will be expected to establish a strong externally funded research program. Laboratory space is in the Herman B Wells Center for Pediatric Research, which has ongoing programs in DNA repair, cancer biology, stem cell biology, genetic blood disorders, myeloid biology, leukemogenesis and development. The position comes with a generous start-up package, outstanding laboratory space and protected time for research-related activities. The Department of Pediatrics consistently ranks in the top 20 nationally for NIH funding to pediatric departments. This recruitment is part of a major expansion of the Herman B Wells Center for Pediatric Research, a highly interactive and multidisciplinary research center that is part of the Department of Pediatrics. The Wells Center currently occupies 65,000 sq ft of research space and will continue to expand in the forthcoming years. There are currently twenty-six principal investigators, and NIH funded areas of research include: developmental pulmonary physiology, cardiovascular developmental biology, fetal and neonatal metabolic physiology, reproductive and neuro-endocrinology, hematopoiesis, myeloid biology and gene regulation, gene therapy, cancer biology and DNA repair. Indiana University School of Medicine is also home to the nation.s only federally sponsored gene vector production and research facility, one of three molecular hematology research centers in the country, and a National Cancer Institute-designated Cancer Research Center. In addition, the IUSM hosts more than twenty NIH Centers including a Diabetes Research and Training Center, an Adolescent Sexually Transmitted Disease Center, an Alcohol Research Center, and an Alzheimer.s and Related Diseases Center. The search committee will begin evaluating applications on April 1, 2005 and applications will continue to be reviewed until the position is filled. Interested applicants should submit a curriculum vitae, summary of research accomplishments and future research plans, and the names of at least three references to Mark R. Kelly, Ph.D., 1044 West Walnut Street, Room 302C, Indianapolis, IN, 46202; email: [log in to unmask] 4.3 POSTDOCTORAL FELLOW . HOMOLOGOUS RECOMBINATION . DAVIS, CA An NIH funded postdoctoral position is available in the Center for Genetics and Development, University of California at Davis. The project involves molecular genetic, biochemical and cytological approaches to understanding the mechanism and regulation of crossing-over between homologous chromosomes during meiosis. Yeast (Saccharomyces cerevisiae) is our primary model system but mouse models are currently being established. Expertise in standard molecular biology techniques is essential. Additional expertise in one of the following areas is highly desirable: protein purification & biochemistry, yeast genetics, epifluorescence microscopy/cytology, knockout/transgenic mice. Salary will be commensurate with experience. Start date: on or after April 1, 2005. Interested candidates should forward a full CV and the contact information of two or three references to Neil Hunter, e-mail: [log in to unmask] Neil Hunter Center for Genetics and Development Section of Microbiology Division of Biological Sciences UC Davis 347 Briggs Hall One Shields Ave. Davis, CA 95616 Office: (530) 754-4401 Lab: (530) 754-4391 Fax: (530) 754-8973 4.4 POSTDOCTORAL POSITION IN PHARMACOLOGY AND CANCER THERAPEUTICS - ROSWELL PARK CANCER INSTITUTE - BUFFALO, NY Postdoctoral position in pharmacology and cancer therapeutics at Roswell Park Cancer Institute is available for studies of cellular responses to dna damaging antitumor drugs. The research will examine drug induction of pivotal DNA damage response proteins and assess changes in nuclear DNA structure as well as chromosomal abnormalities. Emphasis will be on novel drug specific DNA damage responses (e.g., ATM independent response to enediyne induced DNA double strand breaks JBC 277:20549-20554, 2002) with the ultimate goal of uncovering new chemotherapeutic strategies for cancer treatment. Candidates must have a Ph.D. degree or MD and experience in a relevant field. To apply, send a curriculum vitae an description of relevant research experience, and contact information for three references to: Dr. Terry A. Beerman Pharmacology and Therapeutics Department Carlton and Elm Streets Roswell Park Cancer Institute Buffalo, NY 14263 E-mail: [log in to unmask] 4.5 POSTDOCTORAL POSITION IN DNA REPAIR AND RESPONSES TO CHEMOTHERAPY - COLUMBIA, SC A postdoctoral position is available immediately to use molecular genetic and pharmacological approaches to study DNA repair, genomic stability, and responses to chemotherapy in mammalian cells. The NIH-funded project seeks to determine the links between base excision repair, recombination and apoptosis in response to chemotherapy that inhibits thymidylate synthase. The project is a collaboration with Dr. Alan Waldman in the Dept. of Biological Sciences at the University of South Carolina. The investigators are also part of the University's NIH/NCRR-funded Center for Colon Cancer Research. The center includes histology, pathology, statistics, and animal core facilities. We seek an enthusiastic and motivated individual holding a Ph.D., with experience in molecular biology. Experience in mammalian cell culture, DNA and RNA isolation, Southern/ Northern/Western blotting, and RNAinterference is preferred. To apply, send a curriculum vitae with bibliography, description of research experience, and contact information for three references to: Michael D. Wyatt, Ph.D. Department of Basic Pharmaceutical Sciences Coker Life Sciences Building University of South Carolina 700 Sumter Street Columbia, SC 29208 [log in to unmask] http://www.pharm.sc.edu/ http://www.cccr.sc.edu/ 4.6 POST DOCS DNA REPAIR ENZYMES, POLYMERASES, AND RECOMBINASES - BURLINGTON, VT The University of Vermont Department of Microbiology and Molecular Genetics is seeking Postdoctoral Research Associates with an interest in applying a combined genetic, biochemical, bioinformatic and crystallographic approach to study DNA repair enzymes, polymerases, and recombinases. NIH support is available for individuals with a strong quantitative background who aim to strengthen their ability to bring multiple disciplines to bear on challenging projects. We provide an intense, collaborative environment in which all participants, from students to PI's, learn and work together towards understanding these central biological processes. Students and postdocs are immersed in the theory and practice of all aspects of structural biology, from cloning and overexpression to solving and analyzing structures. The success of our collaborative approach is evidenced by recent publications (EMBO J. 2004 23:1483-1493; PNAS 2004 101:10284-10289), and by our award of an NIH Program-Project grant to further pursue these goals. State-of-the-art research facilities, coupled with established investigators eager to share their experience, provide the tools and learning opportunities to help young investigators achieve their own success. The University of Vermont is located in Burlington, Vermont, consistently ranked among the best places to live in the US by virtue of its accessible world-renowned recreation sites and respect for the environment. Positions are available immediately in any of our three research groups (Sylvie Doubli, structural biology of DNA replication and repair; Scott Morrical, homologous recombination and double-strand break repair; Susan Wallace, DNA replication and DNA repair). Interested applications should send a CV, a cover letter, and the names of 3 references to: Debra Stern 201 Stafford Hall Department of Microbiology and Molecular Genetics The University of Vermont Burlington VT 05405 Fax: (802)656-8749 Email: [log in to unmask] The University of Vermont is an affirmative action/ equal opportunity employer. 4.7 POSTDOCTORAL POSITIONS ARE AVAILABLE TO STUDY DNA DAMAGE PREVENTION AND REPAIR MECHANISMS. - UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL, WORCESTER, MASSACHUSETTS Projects include studies of the human and yeast OXR and PC4 genes, and their function. (For recent references see: PNAS, 97: 14530; MCB, 24:3180; and MCB, 24:6084) Requires strong background in biochemistry, molecular biology, and genetics. Send C. V. and names, phone numbers, and e-mail addresses of at least three references to: Michael Volkert, Ph.D., Dept. Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, or by E-mail to: [log in to unmask] Sincerely Michael Volkert, Ph.D. Professor -------------------- Department of Molecular Genetics and Microbiology University of Massachusetts Medical School Worcester, Massachusetts 01655 -------------------- Phone: (508) 856-2314 Fax: (508) 856-5920 Email: [log in to unmask] 4.8 POST DOCTORAL FELLOWS - DNA EXPANSION IN HUMAN DISEASE - ROCHESTER, MN Funding for 2 postdoctoral fellows at the Mayo Clinic in the area of DNA expansion and its role in human disease. Areas of interest: * Genetic Mechanisms of trinucleotide expansion mutations in animals * Biochemistry of DNA Repair enzymes and their defects in disease * DNA Repair * DNA breakage in neurons. * Repair and cell death mechanisms in neurodegeneration and cancer. Experimental systems are varied and include mice, cells, purified proteins, microscopy/ imaging. Therefore, qualified individuals with expertise in one of many fields are welcome to apply. Salary is commensurate with experience. I will be available at the upcoming ASM Repair Meeting in Bermuda. The Mayo Clinic offers a world-class research environment including: * Excellent salaries and benefits. * Strong Basic and Clinical research * Access to human and clinical materials * Core or collaborative service labs in transgenic mice, DNA and protein synthesis, protein analysis, NMR, mass spectrometry, stem cell, production, epidemiology and statistics, monoclonal antibody production, general clinical research, electron and confocal microscopy, stem cell laboratory, Immunological Core lab, biomedical imaging and computers, section of engineering. Cynthia T. McMurray, Ph.D. Professor and Distinguished Mayo Investigator Departments of Molecular Pharmacology and Experimental Therapeutics, and Biochemistry and Molecular Biology Mayo Clinic Rochester 200 First St. SW, Guggenheim 7 Rochester, MN 55905 e-mail: [log in to unmask] (507) 284-1597 Direct Phone (507) 284-9111 Fax (507) 284-2696 Timothy Farnham, Assistant to Dr. McMurray 5.0 COMMERCIAL REAGENT SOURCES [Note: There are more commercial reagent sources listed on the DNA Repair interest group website: http://www.nih.gov:80/sigs/dna-rep/ These sources are listed as a convenience to our readers and do not constitute an endorsement of any of these companies or their products.] 5.1 MBL International offers many kits and reagents for research on DNA Damage and Repair. MBL is especially excited to introduce two unique monoclonal antibodies that can detect the major classes of UV-induced photolesions: Cyclobutane Pyrimidine Dimers (CPD) or pyrimidine-[6-4]-pyrimidinone photoproducts (6-4 PP). These antibodies were established by Dr. T. Mori et al. in Japan. For more information on these antibodies, please visit the following linkshttp://www.mblintl.com/mbli/catalog/pdf/d195-1.pdf (anti-6-4PP) http://www.mblintl.com/mbli/catalog/pdf/d194-1.pdf (anti-CPD) or contact Suzan Oberle, Ph.D. Product Manager/Technical Service Manager MBL International 800-200-5459 [log in to unmask] www.mblintl.com 5.2 Biocompare - This website www.biocompare.com calls itself .The Buyer.s Guide for Life Scientists. This site includes comparisons of many reagents that are useful for DNA repair studies including a listing of antibodies. 5.3 Genetex - Antibodies for DNA repair www.genetex.com Located in Texas. 5.4 Phoenix BioTechnologies Inc. - cis-syn thymine dimers now available at 0.2 and 1 umol scale synthesis. As a top provider of specialty DNA, RNA and LNA synthesis services to labs with unique requirements, Phoenix BioTechnologies also announces synthesis services for oligonucleotides containing thymine glycol. Working with Glen Research, we have optimized synthesis with these amidites to attain excellent coupling efficiencies and high product yields. For additional information, please contact us at your convenience through the information listed below. Donna Brown Company Scientist Phoenix BioTechnologies, Inc. 1000 Meridian Street Huntsville, AL 35801 Toll-free 866-319-0900 FAX 256-319-0902 [log in to unmask] http://www.phxbio.com 5.5 Abcam Ltd ( www.abcam.com ) - At present, we have a fairly substantial range of products including those relating to DNA damage and repair (246 in total), and are actively developing this as we speak. Please find a hyperlink provided below for your review. http://www.abcam.com/index.html?pageconfig=catalog_byclass&intClassID=6 Thank you in advance for your time and kind consideration. Miss Lesa Rodgers Marketing Assistant Abcam Ltd 21 Cambridge Science Park Milton Road, Cambridge, Cambridgeshire CB4 0TP United Kingdom www.abcam.com 5.6 Bethyl Laboratories, Inc. - Antibodies for DNA Damage/Repair and related research (www.bethyl.com) New antibodies include SDS3, DMAP1, KIF14, DIS, MCM2, MCM3, MCM4, MCM6, MCM7, MCM10, Claspin, BRD2, Pumilio 1, Pescadillo, Mre11, NBS1, SERCA2, AMPK and RFC1. http://www.bethyl.com 5.7 Reliable Biopharmaceutical Corporation - As the leading U.S. manufacturer of modified nucleic acids, we wanted to introduce you to our newest product: cis-syn TpT Cyclobutane Dimer Phosporamidite. Specially developed for the DNA repair and research markets. You can see our homepage and our TpT Dimer Amidite webpage to better understand our company and products. If I or my staff can answer any of your specific questions, please call at your convenience. Sincerely, Sourena Nadji, Ph.D. Reliable Biopharmaceutical Corporation Director of Research and Development (314)429-7700 http://www.reliablebiopharm.com/ 5.8 Novus Biologicals, Inc, Littleton, CO - Antibodies for DNA Repair Research (http://www.novus-biologicals.com/research.php/8) and other research applications (www.novusbio.com). New antibodies include RNase L, ATRIP, CTR1, BRCA1, 14-3-3 gamma, DHX15, phospho-CREB [Ser121], FANCD2, BRIP 1, carbonic anhydrase IX, and p73. For more information contact: Novus Biologicals, Inc. 303-730-1950 [log in to unmask] 5.9 Santa Cruz Biotechnology, Inc, Santa Cruz, CA - Antibodies for research applications. Please find specific product information at http://www.scbt.com 5.10 Austral Biologicals, Inc, San Ramon, CA. - Antibodies for research applications. Please visit our web site: http://www.australbio.com 5.11 Cascade Bioscience - Antibodies to various FANC proteins. Here is a link to a website we have in development featuring FANC antibodies. http://www.cascadebioscience.com/test/ Patrick Foley, President, Cascade Bioscience, Inc, 37 Pierrepont Rd, Winchester, MA 01890, Phone 781-721-4758 Fax 781-729-4731 6 ELECTRONIC CONTACTS: 6.1 Check out the DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ You can find the schedule for future DNA Repair Interest Group videoconferences and a listing of past videoconferences (with links to the videoarchive) as well as a current list of JOB OPPORTUNITIES in DNA repair and MEETING NOTICES. 6.2 Encourage your colleagues who are interested in DNA Repair to request that they be added to this DNA Repair Interest Group listserve e-mail list by sending a request by e-mail to: [log in to unmask] Leave the subject blank. In the message field, type in: subscribe DNARepair-L your name Alternatively, by filling out the form on the website (http://www.nih.gov:80/sigs/dna-rep/ ) you can both add your name to the e-mail list and have your name posted on the website. If you want your name to be listed you can fill out the .Join the SIG. form on the web site and add your name to the listing of members. If you are not at NIH then be sure to click the .other. box and then fill in the name of your institution. 6.3 Archives of these listserve mailings can be found at http://list.nih.gov/archives/dnarepair-l.html or via links from the DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ 6.4 I will be happy to relay information about post-doctoral positions, jobs and meetings and other information related to DNA Repair. Please send me an e-mail message ([log in to unmask]) and I will incorporate it into the next announcement list and post it on the DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ . (This list goes to nearly 1300 scientists around the world who are interested in DNA repair.) Kenneth H. Kraemer, M.D. Chief, DNA Repair Section Basic Research Laboratory National Cancer Institute Building 37 Room 3E24 Bethesda, MD 20892 301-496-9033 FAX: 301-496-8419 e-mail: [log in to unmask] DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/

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