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Neuroblastoma

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Illustrations

Neuroblastoma in the liver - CT scan
Neuroblastoma in the liver - CT scan

Definition    Return to top

Neuroblastoma is a malignant (cancerous) tumor that develops from nerve tissue. It occurs in infants and children.

Causes    Return to top

Neuroblastoma can occur in many areas of the body. It develops from the tissues that form the sympathetic nervous system (the part of the nervous system that controls body functions, such as heart rate and blood pressure, digestion, and levels of certain hormones).

Neuroblastoma most commonly begins in the abdomen in the tissues of the adrenal gland, but it may also occur in other areas. It can spread to the lymph nodes, liver, bones, and bone marrow.

The cause of theĀ tumorĀ is unknown. Neuroblastoma is most commonly diagnosed in children before age 5. The disorder occurs in approximately 1 out of 100,000 children and is slightly more common in boys.

Symptoms    Return to top

Note: Symptoms change depending on the site of the tumor.

Exams and Tests    Return to top

Signs vary depending on the location of the tumor. Examination of the abdomen with the hands (palpation) may find a mass. The liver may be enlarged, if the tumor has spread to the liver. Adrenal gland tumors can cause high blood pressure and a fast heart rate.

Testing reveals the original (primary) tumor and locations of tumor spread:

Treatment    Return to top

Treatment varies depending on the location of the tumor, the extent of tumor spread and the age of the patient. In certain cases, surgery alone is enough, but often other therapies are needed. Anticancer medications (chemotherapy) may be recommended if the tumor is widespread. Radiation therapy may also be used.

Support Groups    Return to top

The stress of illness can often be helped by joining a support group where members share common experiences and problems. See cancer - support group.

Outlook (Prognosis)    Return to top

The expected outcome varies. In very young children with neuroblastoma, the tumor may go away on its own, without any treatment, or the tissues of the tumor may mature and develop into a benign ganglioneuroma that can be surgically removed. In other cases, the tumor spreads rapidly.

Response to treatment is variable. Treatment is often successful if the cancer has not spread, but if there has been spread to other areas, neuroblastoma is much harder to cure.

Possible Complications    Return to top

When to Contact a Medical Professional    Return to top

Call your health care provider if symptoms indicate neuroblastoma may be present. Early diagnosis and treatment improves the chance of a good outcome.

Update Date: 5/22/2006

Updated by: Adam S. Levy, MD, Director, Fellowship Training Program, Section of Pediatric Hematology/Oncology, The Children's Hospital at Montefiore, Bronx, NY. Review provided by VeriMed Healthcare Network.

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