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Diphenhydramine

(dye fen hye' dra meen)

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Why is this medication prescribed?   Return to top

Diphenhydramine is used to relieve red, irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. Diphenhydramine is also used to relieve cough caused by minor throat or airway irritation. Diphenhydramine is also used to prevent and treat motion sickness, and to treat insomnia (difficulty falling asleep or staying asleep). Diphenhydramine is also used to control abnormal movements in people who have early stage parkinsonian syndrome (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) or who are experiencing movement problems as a side effect of a medication. Diphenhydramine will only relieve the symptoms of these conditions but will not treat the cause of the symptoms or speed recovery. Diphenhydramine is used to treat these conditions in adults and children over age 2. Diphenhydramine should not be given to children younger than 2 years old because it may cause serious or life-threatening side effects in young children. Diphenhydramine should not be given to children older than 2 years old but younger than 6 years old unless prescribed by a doctor and should be used carefully in children who are 6-11 years old. Diphenhydramine should not be used to cause sleepiness in children younger than 12 years of age. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.

How should this medicine be used?   Return to top

Diphenhydramine comes as a tablet, a chewable tablet, a rapidly disintegrating (dissolving) tablet, a capsule, a liquid-filled capsule, a dissolving strip, and a liquid to take by mouth. When diphenhydramine is used for the relief of allergies, cold, and cough symptoms, it is usually taken very 4-6 hours. When diphenhydramine is used to treat motion sickness, it is usually taken 30 minutes before departure and, if needed, before meals and at bedtime. When diphenhydramine is used to treat insomnia it is taken at bedtime (30 minutes before planned sleep). When diphenhydramine is used to treat abnormal movements, it is usually taken three times a day at first and then taken four times a day. Follow the directions on the package or on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take diphenhydramine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor or directed on the label.

Diphenhydramine comes alone and in combination with pain relievers, fever reducers,and decongestants. Ask your doctor or pharmacist for advice on which product is best for your symptoms. Check nonprescription cough and cold product labels carefully before using two or more products at the same time. These products may contain the same active ingredient(s) and taking them together could cause you to receive an overdose. This is especially important if you will be giving cough and cold medications to a child.

If you are taking the dissolving strips, place the strips on your tongue one at a time and swallow after they melt.

If you are taking the rapidly dissolving tablets, place a tablet on your tongue and close your mouth. The tablet will quickly dissolve and can be swallowed with or without water.

If you are taking the chewable tablets, chew them thoroughly before swallowing.

If you are taking the capsules, swallow them whole. Do not try to break the capsules.

If you are taking the liquid, do not use a household spoon to measure your dose. Use the measuring spoon or cup that came with the medication or use a spoon made especially for measuring medication.

Other uses for this medicine   Return to top

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?   Return to top

Before taking diphenhydramine,

What special dietary instructions should I follow?   Return to top

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?   Return to top

Diphenhydramine is usually taken as needed. If your doctor has told you to take diphenhydramine regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?   Return to top

Diphenhydramine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

Some side effects may be serious. If you experience any of the following symptoms, call your doctor immediately:

Diphenhydramine may cause other side effects. Call your doctor if you experience any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].

What storage conditions are needed for this medicine?   Return to top

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose   Return to top

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?   Return to top

Ask your pharmacist any questions you have about diphenhydramine.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names   Return to top

  • AllerMax®
  • AllerMax® Caplets®
  • Benadryl®
  • Benadryl® Allergy
  • Benadryl® Allergy Chewables Children' s
  • Benadryl® Allergy Kapseals®
  • Benadryl® Allergy Ultratab®
  • Benadryl® Dye-Free Allergy Children' s
  • Benadryl® Dye-Free Allergy Liqui-Gels®
  • Compoz® Nighttime Sleep Aid
  • Compoz® Nighttime Sleep Aid Gelcaps®
  • Diphen® AF Elixir
  • Diphenhist®
  • Diphenhist® Captabs®
  • Diphenhydramine Hydrochloride Caplets®
  • Excedrin P.M.® Caplets®
  • Excedrin P.M.® Geltabs®
  • Excedrin P.M.® Tablets
  • Genahist®
  • Genahist® Elixir
  • Goody's® PM Powder
  • Hydramine® Cough Syrup
  • Hydramine® Elixir
  • Miles® Nervine Nighttime Sleep-Aid
  • Nytol® QuickCaps® Caplets®
  • Nytol® Quickgels® Maximum Strength
  • Simply Sleep® Nighttime Sleep Aid Caplets®
  • Sleepinal® Night-time Sleep Aid Softgels®
  • Sominex® Caplets®Maximum Strength
  • Sominex® Nighttime Sleep Aid
  • Twilite® Caplets®
  • Unisom® SleepGels® Maximum Strength

Brand names of combination products   Return to top

  • Alka-Seltzer PM® Pain Reliever and Sleep Aid (containing Diphenhydramine Citrate and Aspirin)
  • Bayer® PM Extra Strength Caplets® (containing Diphenhydramine Hydrochloride and Aspirin)
  • Benadryl® Allergy & Cold Caplets® (containing Diphenhydramine Hydrochloride, Acetaminophen, and Pseudoephedrine Hydrochloride)
  • Benadryl® Allergy & Cold Fcontaining Diphenhydramine Citrate and Pseudoephedrine Hydrochloride)
  • Benadryl® Allergy & Sinus (containing Diphenhydramine Hydrochloride and Pseudoephedrine Hydrochloride)
  • Benadryl® Allergy & Sinus Children's (containing Diphenhydramine Hydrochloride and Pseudoephedrine Hydrochloride)
  • Benadryl® Allergy & Sinus Fcontaining Diphenhydramine Citrate and Pseudoephedrine Hydrochloride)
  • Benadryl® Allergy & Sinus Headache Caplets® Maximum Strength (containing Diphenhydramine Hydrochloride, Acetaminophen, and Pseudoephedrine Hydrochloride)
  • Benadryl® Severe Allergy & Sinus Headache Caplets® Maximum Strength (containing Diphenhydramine Hydrochloride, Acetaminophen, and Pseudoephedrine Hydrochloride)
  • Doan's® P.M. Extra Strength Caplets® (containing Diphenhydramine Hydrochloride and Magnesium Salicylate)
  • Legatrin PM® Caplets® (containing Diphenhydramine Hydrochloride and Acetaminophen)
  • Percogesic® Aspirin-Free Caplets® Extra Strength (containing Diphenhydramine Hydrochloride and Acetaminophen)
  • Sine-Off® Night Time Relief Sinus Cold & Flu Medicine GelCaplets® (containing Diphenhydramine Hydrochloride, Acetaminophen, and Pseudoephedrine Hydrochloride)
  • Sominex® Pain Relief Formula (containing Diphenhydramine Hydrochloride and Acetaminophen)
  • Sudafed® Sinus Nighttime Plus Pain Relief Caplets® (containing Diphenhydramine Hydrochloride, Acetaminophen, and Pseudoephedrine Hydrochloride)
  • Tylenol® Allergy Sinus NightTime Maximum Strength Caplets® (containing Diphenhydramine Hydrochloride, Acetaminophen, and Pseudoephedrine Hydrochloride)
  • Tylenol® Allergy-D Children's containing Diphenhydramine Hydrochloride, Acetaminophen, and Pseudoephedrine Hydrochloride
  • Tylenol® Flu NightTime Maximum Strength Gelcaps® (containing Diphenhydramine Hydrochloride, Acetaminophen, and Pseudoephedrine Hydrochloride)
  • Tylenol® PM Extra Strength Caplets® (containing Diphenhydramine Hydrochloride and Acetaminophen)
  • Tylenol® PM Extra Strength Gelcaps® (containing Diphenhydramine Hydrochloride and Acetaminophen)
  • Tylenol® PM Extra Strength Geltabs® (containing Diphenhydramine Hydrochloride and Acetaminophen)
  • Tylenol® Severe Allergy Caplets® (containing Diphenhydramine Hydrochloride and Acetaminophen)

Last Revised - 03/01/2008


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