Stage 0 (Carcinoma in Situ)
Stage I Vaginal Cancer
Stage II Vaginal Cancer
Stage III Vaginal Cancer
Stage IVA Vaginal Cancer
Stage IVB Vaginal Cancer

A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.

Treatment of stage 0 may include the following:

• Wide local excision, with or without a skin graft.
• Partial or total vaginectomy, with or without a skin graft.
• Topical chemotherapy.
• Laser surgery.
• Internal radiation therapy.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage 0 vaginal cancer.

Treatment of stage I squamous cell vaginal cancer may include the following:

• Internal radiation therapy, with or without external radiation therapy to lymph nodes or large tumors.
• Wide local excision or vaginectomy with vaginal reconstruction. Radiation therapy may be given after the surgery.
• Vaginectomy and lymphadenectomy, with or without vaginal reconstruction. Radiation therapy may be given after the surgery.

Treatment of stage I vaginal adenocarcinoma may include the following:

• Vaginectomy, hysterectomy, and lymphadenectomy. This may be followed by vaginal reconstruction and/or radiation therapy.
• Internal radiation therapy, with or without external radiation therapy to lymph nodes.
• A combination of therapies that may include wide local excision with or without lymphadenectomy and internal radiation therapy.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage I vaginal cancer.

Treatment of stage II vaginal cancer is the same for squamous cell cancer and adenocarcinoma. Treatment may include the following:

• Both internal and external radiation therapy to the vagina, with or without external radiation therapy to lymph nodes.
• Vaginectomy or pelvic exenteration, with or without radiation therapy.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage II vaginal cancer.

Treatment of stage III vaginal cancer is the same for squamous cell cancer and adenocarcinoma. Treatment may include both internal and external radiation therapy, with or without surgery.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage III vaginal cancer.

Treatment of stage IVA vaginal cancer is the same for squamous cell cancer and adenocarcinoma. Treatment may include both internal and external radiation therapy, with or without surgery.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage IVA vaginal cancer.

Treatment of stage IVB vaginal cancer is the same for squamous cell cancer and adenocarcinoma. Treatment may include the following:

• Radiation therapy as palliative therapy, to relieve symptoms and improve the quality of life. Chemotherapy may also be given.
• A clinical trial of chemotherapy and/or radiosensitizers.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage IVB vaginal cancer.

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