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Brief Summary

GUIDELINE TITLE

Cancer Care Ontario and American Society of Clinical Oncology adjuvant chemotherapy and adjuvant radiation therapy for stages I-IIIA resectable non-small-cell lung cancer guideline.

BIBLIOGRAPHIC SOURCE(S)

GUIDELINE STATUS

This is the current release of the guideline.

BRIEF SUMMARY CONTENT

 
RECOMMENDATIONS
 EVIDENCE SUPPORTING THE RECOMMENDATIONS
 IDENTIFYING INFORMATION AND AVAILABILITY
 DISCLAIMER

 Go to the Complete Summary

RECOMMENDATIONS

MAJOR RECOMMENDATIONS

Summary of Recommendations for Adjuvant Cisplatin-Based Chemotherapy
for Stages I-IIIA Resectable Non-Small-Cell Lung Cancer
Stage IA Adjuvant chemotherapy is not recommended.
Stage IB Adjuvant cisplatin-based chemotherapy is not recommended for routine use.
Stage IIA Adjuvant cisplatin-based chemotherapy is recommended.
Stage IIB Adjuvant cisplatin-based chemotherapy is recommended.
Stage IIIA Adjuvant cisplatin-based chemotherapy is recommended.
General The use of adjuvant chemotherapy regimens that include alkylating agents is not recommended as these agents have been found to be detrimental to survival.
Summary of Recommendations for Adjuvant Radiotherapy
for Stages I-IIIA Resectable Non-Small-Cell Lung Cancer
IA/B and IIA/B Adjuvant radiation is not recommended.
IIIA Adjuvant radiation therapy is not recommended for routine use because of the lack of prospective, randomized clinical trial data evaluating its efficacy. A clinical trial is underway to determine the advisability of its routine use.

CLINICAL ALGORITHM(S)

None provided

EVIDENCE SUPPORTING THE RECOMMENDATIONS

TYPE OF EVIDENCE SUPPORTING THE RECOMMENDATIONS

In general, the literature review supporting these recommendations centered on randomized clinical trials and meta-analyses of data from randomized clinical trials.

IDENTIFYING INFORMATION AND AVAILABILITY

BIBLIOGRAPHIC SOURCE(S)

ADAPTATION

Not applicable: The guideline was not adapted from another source.

DATE RELEASED

2007 Dec

GUIDELINE DEVELOPER(S)

American Society of Clinical Oncology - Medical Specialty Society
Cancer Care Ontario - State/Local Government Agency [Non-U.S.]

SOURCE(S) OF FUNDING

American Society of Clinical Oncology

GUIDELINE COMMITTEE

Joint Cancer Care Ontario- American Society of Clinical Oncology (CCO-ASCO) Expert Panel

COMPOSITION OF GROUP THAT AUTHORED THE GUIDELINE

Authors: Katherine M.W. Pisters; William K. Evans; Christopher G. Azzoli; Mark G. Kris; Christopher A. Smith; Christopher E. Desch; Mark R. Somerfield; Melissa C. Brouwers; Gail Darling; Peter M. Ellis; Laurie E. Gaspar; Harvey I. Pass; David R. Spigel; John R. Strawn; Yee C. Ung; Frances A. Shepherd

Panel Members: Christopher E. Desch, MD, Co-Chair National Comprehensive Cancer Network; William K. Evans, MD (Co-Chair), Juravinski Cancer Centre at Hamilton Health Sciences; Mark G. Kris, MD (Co-Chair), Memorial Sloan-Kettering Cancer Center; Katherine M.W. Pisters, MD (Co-Chair), M.D. Anderson Cancer Center; Frances A Shepherd, MD (Co-Chair), University Health Network, Princess Margaret Hospital; Christopher G. Azzoli, MD, Memorial Sloan-Kettering Cancer Center; Gail Darling, MD, University Health Network, Princess Margaret Hospital; Peter M. Ellis, MD, Juravinski Cancer Centre at Hamilton Health Sciences; Laurie E. Gaspar, MD, University of Colorado at Denver Health Sciences Centre; Harvey I. Pass, MD, NYU School of Medicine and NCI Cancer Centre; David R. Spigel, MD, The Sarah Cannon Cancer Center; John R. Strawn, MD, Patient Advocate; Yee C. Ung, MD, Toronto-Sunnybrook Regional Cancer Centre

FINANCIAL DISCLOSURES/CONFLICTS OF INTEREST

All members of the Expert Panel complied with the American Society of Clinical Oncology (ASCO) policy on conflicts of interest, which requires disclosure of any financial or other interest that might be construed as constituting an actual, potential, or apparent conflict. Members of the expert Panel completed ASCO's disclosure form and were asked to reveal ties to companies with products that might be affected by promulgation of the guidelines. Information was requested regarding employment, consultancies, stock ownership, honoraria, research funding, expert testimony, and membership on company advisory committees. The Panel made decisions on a case-by-case basis as to whether an individual's role should be limited as a result of a conflict. No limiting conflicts were identified.

Note: Although all authors completed the disclosure declaration, the following author(s) indicated a financial or other interest that is relevant to the subject matter under consideration in this article. Certain relationships marked with a "U" are those for which no compensation was received; those relationships marked with a "C" were compensated. For a detailed description of the disclosure categories, or for more information about ASCO's conflict of interest policy, please refer to the Author Disclosure Declaration and the Disclosures of Potential Conflicts of Interest section in Information for Contributors in the original journal of publication.

Employment or Leadership Position: None Consultant or Advisory Role: David R. Spigel, Genentech (C); Frances A. Shepherd, Pierre Fabre (C), GlaxoSmithKline (C)

Stock Ownership: None Honoraria: Peter M. Ellis, Bristol-Myers Squibb; Frances A. Shepherd, Pierre Fabre, GlaxoSmithKline Research Funding: Christopher G. Azzoli, Genentech Biooncology, Sanofi-aventis, Allos Therapeutics; David R. Spigel, Genentech, Sanofi-aventis Expert Testimony: None Other Remuneration: None

GUIDELINE STATUS

This is the current release of the guideline.

GUIDELINE AVAILABILITY

Electronic copies: Available from the American Society of Clinical Oncology (ASCO) Web site.

Print copies: Available from American Society of Clinical Oncology, Cancer Policy and Clinical Affairs, 1900 Duke Street, Suite 200, Alexandria, VA 22314; E-mail: guidelines@asco.org.

AVAILABILITY OF COMPANION DOCUMENTS

The following are available:

Guidelines are available for Personal Digital Assistant (PDA) download from the ASCO Web site.

PATIENT RESOURCES

The following are available:

Please note: This patient information is intended to provide health professionals with information to share with their patients to help them better understand their health and their diagnosed disorders. By providing access to this patient information, it is not the intention of NGC to provide specific medical advice for particular patients. Rather we urge patients and their representatives to review this material and then to consult with a licensed health professional for evaluation of treatment options suitable for them as well as for diagnosis and answers to their personal medical questions. This patient information has been derived and prepared from a guideline for health care professionals included on NGC by the authors or publishers of that original guideline. The patient information is not reviewed by NGC to establish whether or not it accurately reflects the original guideline's content.

NGC STATUS

This NGC summary was completed by ECRI Institute on February 19, 2008. The information was verified by the guideline developer on February 20, 2008.

COPYRIGHT STATEMENT

This summary is based on the original guideline, which is subject to the American Society of Clinical Oncology's copyright restrictions.

DISCLAIMER

NGC DISCLAIMER

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Readers with questions regarding guideline content are directed to contact the guideline developer.


 

 

   
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