Researching the weekly update, NOPHG finds scientific literature that reports on discoveries of genetic variants, related disease outcomes, and the complex social, legal, and ethical issues surrounding genetic discoveries. A Public Health Perspective focuses on a single topic and provides you with information relevant to public health practice.

This week we are examining the public health perspective of pharmacogenomics , a burgeoning field that promises to revolutionize medicine by deciphering the genetic basis of variable drug response in individual people. (February 2001)

"For clinical medicine, pharmacogenomics holds promise of individualized drug treatment. For public health, the promise is targeted disease prevention."
The National Office of Public Health Genomics

• Pharmacogenomics and Public Health: The Promise of Targeted Disease Prevention
  Muin Khoury, MD, PhD and Jill Morris, PhD

• Pharmacogenomics: The Implementation Phase (last accessed 5/2007)
  W Sadee 
  AAPS PharmSci. 2002

• Pharmacogenetics (last accessed 5/2007)
  The American Medical Association

• Prospects for Pharmacogenetics and Ecogenetics in the new Millennium.  (last accessed 5/2007)
  Omenn GS.
  Drug Metab Dispos 2001 Apr;29(4 Pt 2):611-4.
  [MEDLINE record in process]
  PMID: 11259362

• Implications of the Human Genome Project for Medical Science (last accessed 5/2007)
  Collins FS, McKusick VM
  JAMA 2001;285:540-544.

• Pharmacogenomics: the Promise of Personalized Medicine. (last accessed 5/2007)
  Mancinelli, L. et al. 
  AAPS Pharmsci 2000;2 (1) article 4

• Assessing the Cost-Effectiveness of Pharmacogenomics. (last accessed 5/2007)
  Veenstra, David and Mitchell Higashi. 
  AAPS Pharmsci. 2000; 2(3) article 29

• Factor V Leiden: Should we Screen Oral Contraceptive Users and Pregnant Women? (last accessed 5/2007)
  Vandenbrouke J P, et al. 
  BMJ 1996; 313:1127-30

• Interaction between the G20210A Mutation of the Prothrombin Gene and Oral Contraceptive use in Deep Vein Thrombosis.  (last accessed 5/2007)
  Martinelli I, et al.
  Arterioscler Thromb Vasc Biol 1999;19:700-3.

• The Making of the Pharmacogenomic Prescription
  Hollon, T. PhD
  GeneLetter Jan 2001;1(12)

• Gene - To - Drug: a Long And Costly Path
  (Feb 11) New York Times article

• Genome Probes 'Cures that Kill' (last accessed 5/2007)
  (Feb 18) BBC News story

• Myhrvold Warns Picks and Shovels Companies to Stay Out of Drug Discovery
  (Feb 21 ) GenomeWeb story

• Pharmacogenomics, "Drugs by Design?" slide
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