This is the current release of the guideline.

The summary of recommendations is followed by evidence grades (A-C) identifying the type of supporting evidence. Definitions of the evidence grades are presented at the end of the "Major Recommendations" field.

Esophageal Cancer

Barrett's Esophagus

1. Screening esophagogastroduodenoscopy (EGD) for Barrett's esophagus should be considered in selected patients with chronic, longstanding gastroesophageal reflux disease (GERD). After a negative screening examination, further screening endoscopy is not indicated.
2. The cost effectiveness of surveillance in patients without dysplasia is controversial. Surveillance endoscopy is appropriate for patients fit to undergo therapy, should endoscopic/histologic findings dictate. For patients with established Barrett's esophagus of any length and with no dysplasia, after 2 consecutive examinations within 1 year, an acceptable interval for additional surveillance is every 3 years.
3. Patients with high-grade dysplasia are at significant risk for prevalent or incident cancer. Patients who are surgical candidates may elect to have definitive therapy. Patients who elect surveillance endoscopy should undergo follow-up every 3 months for at least 1 year, with multiple large capacity biopsy specimens obtained at 1 cm intervals. After 1 year of no cancer detection, the interval of surveillance may be lengthened if there are no dysplastic changes on 2 subsequent endoscopies performed at 3-month intervals. High-grade dysplasia should be confirmed by an expert GI pathologist.
4. Surveillance in patients with low-grade dysplasia is recommended. The significance of low-grade dysplasia as a risk factor for cancer remains poorly defined; therefore, the optimal interval and biopsy protocol has not been established. A follow-up EGD (i.e., at 6 months) should be performed with concentrated biopsies in the area of dysplasia. If low-grade dysplasia is confirmed, then one possible management scheme would be surveillance at 12 months and yearly thereafter as long as dysplasia persists.
5. If the presence or degree of dysplasia is indeterminate and there is evidence of acute inflammation due to gastroesophageal acid reflux, repeat biopsy should be performed after 8 weeks of effective acid-suppression therapy.

Achalasia

1. There are insufficient data to support routine endoscopic surveillance for patients with achalasia.
2. If surveillance were to be considered, it would be reasonable to initiate it 15 years after onset of symptoms, but the subsequent surveillance interval is not defined.

Caustic Injury

1. Begin endoscopic surveillance 15 to 20 years after caustic ingestion.
2. The time interval of endoscopic surveillance requires study. Generally, endoscopic examination should not be conducted more frequently than every 1 to 3 years. There should be a low threshold to evaluate swallowing problems with endoscopy.

Tylosis

1. Begin endoscopic surveillance at age 30 years.
2. The time interval of endoscopic surveillance requires study. Generally, endoscopic examination should not be conducted more frequently than every 1 to 3 years.

History of Upper Aerodigestive Tract Cancer

1. There are insufficient data to support routine endoscopic surveillance for patients with previous aerodigestive squamous cell cancer.
2. A single endoscopy may be indicated to identify synchronous esophageal cancer.

Gastric Cancer

Gastric Epithelial Polyps

1. Adenomatous gastric polyps are at increased risk for malignant transformation and should be resected completely. Hyperplastic polyps have a rare malignant potential. Endoscopic polyp appearance cannot differentiate histologic subtypes; therefore biopsy or polypectomy is recommended when a polyp is encountered.
2. Polypoid defects of any size detected radiographically should be evaluated endoscopically, with biopsy and/or removal of the lesions.
3. Polyps should be endoscopically excised wherever feasible and clinically appropriate. If endoscopic polypectomy is not possible, a biopsy of the polyp should be performed, and if adenomatous or dysplastic tissue is detected, referral for surgical resection should be considered. If representative biopsy samples are obtained and the polyp is nondysplastic, no further intervention is necessary. If it is felt that endoscopic biopsy cannot sufficiently exclude the presence of dysplastic elements, referral for surgical resection is reasonable in polyps that cannot be removed endoscopically.
4. When multiple gastric polyps are encountered, a biopsy of the largest polyps should be performed or they should be excised, and representative biopsy specimens should be taken from some others. Further management should be based on histologic results.
5. Surveillance endoscopy 1 year after removing adenomatous gastric polyps is reasonable to assess recurrence at the prior excision site, new or previously missed polyps, and/or supervening early carcinoma. If the results of this examination are negative, repeat surveillance endoscopy should be repeated no more frequently than at 3- to 5-year intervals. Follow-up after resection of polyps with high-grade dysplasia and early gastric cancer should be individualized.
6. No surveillance endoscopy is necessary after adequate sampling or removal of nondysplastic gastric polyps.

Gastric Intestinal Metaplasia and Dysplasia

1. Endoscopic surveillance for gastric intestinal metaplasia has not been extensively studied in the U.S. and therefore cannot be uniformly recommended.
2. Patients at increased risk for gastric cancer due to ethnic background or family history may benefit from surveillance.
3. Endoscopic surveillance should incorporate a topographic mapping of the entire stomach.
4. Patients with confirmed high-grade dysplasia are at significant risk for progressing to cancer and should be considered for gastrectomy or local (e.g., endoscopic) resection.

Pernicious Anemia and Gastric Carcinoid Tumors

1. A single endoscopy should be considered to identify prevalent lesions (gastric cancer, carcinoid tumors) in patients with pernicious anemia, but there are insufficient data to support routine subsequent endoscopic surveillance for these patients.
2. Surveillance of carcinoid tumors is controversial and should be individualized to the patient.

Postgastric Surgery

1. There are insufficient data to support routine endoscopic surveillance for patients with previous partial gastrectomy for peptic ulcer disease.
2. Because gastric surgeries are performed for peptic ulcer disease, an index endoscopy should be performed to establish the presence of Helicobacter pylori infection, chronic gastritis, and/or intestinal metaplasia.
3. If surveillance is considered, it should be initiated after an interval of 15 to 20 years. Multiple biopsies from the anastomosis and gastric remnant should be taken. The threshold should be low in order to endoscopically evaluate upper gastrointestinal symptoms.

Familial Adenomatous Polyposis and Hereditary Nonpolyposis Colorectal Cancer

1. Patients with familial adenomatous polyposis (FAP) should undergo upper endoscopy with both end-viewing and side-viewing instruments. The optimal timing of initial upper endoscopy is unknown, but could be performed around the time the patient is considered for colectomy, or early in the third decade of life. If no adenomas are detected, another exam should be performed in 5 years because adenomatous change may occur later in the course of the disease.
2. For patients with duodenal and periampullary adenomas, surveillance endoscopy and biopsy should be performed at intervals based on stage of disease. Endoscopic treatment of papillary adenomas may be appropriate in selected patients. If excision is complete, one approach is for follow-up endoscopy and multiple biopsies every 6 months for a minimum of 2 years, with endoscopy thereafter at 3-year intervals.
3. A biopsy of the duodenal polyps should be performed or sampled at the time of initial discovery and on each subsequent examination to determine the stage of duodenal polyposis. The frequency of exams and referral for prophylactic surgery are determined on the basis of duodenal polyp stage.
4. Biopsies of gastric polyps in patients with FAP may be performed to confirm that they are fundic gland polyps and to assess for dysplasia. Antral polyps are usually adenomas and should be resected.
5. Surgical consultation should be obtained for those patients with advanced (stage IV) duodenal polyposis in an effort to prevent periampullary/duodenal carcinoma. Management of high-grade dysplasia in the periampullary region (surgery/ablative therapy versus more frequent surveillance) is controversial and must be individualized.
6. Patients with hereditary nonpolyposis colorectal cancer (HNPCC) are at increased risk for the development of gastric and small-bowel cancer. Although there is insufficient data to show a benefit for upper endoscopic surveillance in patients with HNPCC, endoscopic surveillance should be considered.

Summary

• Patients with chronic GERD at risk for Barrett's esophagus should be considered for endoscopic screening (B).
• In patients with Barrett's esophagus without dysplasia, the cost effectiveness of surveillance endoscopy is controversial. If surveillance is performed, an interval of 3 years is acceptable (C).
• Although an increased cancer risk has not been established in patients with Barrett's esophagus and low-grade dysplasia, endoscopy at 6 months and yearly thereafter should be considered (C).
• Patients with Barrett's esophagus with confirmed high-grade dysplasia should be considered for surgery or aggressive endoscopic therapy (B). Patients with high-grade dysplasia who elect endoscopic surveillance should be followed up closely (i.e., every 3 months) for at least 1 year. If no further high-grade dysplasia is confirmed, then the interval between follow-ups may be lengthened (B).
• There are insufficient data to recommend routine surveillance for patients with achalasia (C).
• Patients with a severe caustic esophageal injury should undergo surveillance every 1 to 3 years beginning 15 to 20 years after the injury (C).
• Patients with tylosis should undergo surveillance endoscopy every 1 to 3 years beginning at age 30 years (C).
• There are insufficient data to support routine endoscopic surveillance for patients with previous aerodigestive squamous cell cancer (C).
• Adenomatous gastric polyps should be resected because of the risk for malignant transformation (B). Adenomatous polyps may recur in synchronous and metachronous sites, and surveillance endoscopies should be performed at 3- to 5-year intervals (C).
• Endoscopic surveillance for gastric intestinal metaplasia has not been extensively studied in the U.S. and therefore cannot be routinely recommended (C). However, there may be a subgroup of high-risk patients who will benefit from endoscopic surveillance (B).
• Patients with confirmed gastric high-grade dysplasia should be considered for gastrectomy or local resection because of the high incidence of prevalent carcinoma (B).
• Patients with pernicious anemia may be considered for a single screening endoscopy, particularly if symptomatic, but there are insufficient data to recommend ongoing surveillance (C).
• There are insufficient data to support routine endoscopic surveillance in patients with previous partial gastrectomy for peptic ulcer disease (C).
• Patients with FAP should undergo regular surveillance endoscopy using both end-viewing and side-viewing endoscopes, starting around the time of colectomy or after age 30 years (B).
• Patients with HNPCC have an increased risk of gastric and small-bowel cancer (B). Surveillance should be strongly considered (C).

Definitions:

1. Prospective controlled trials
2. Observational studies
3. Expert opinion

None provided

The type of supporting evidence is identified and classified for the recommendations using the following scheme:

1. Prospective controlled trials
2. Observational studies
3. Expert opinion

When little or no data exist from well-designed prospective trials, emphasis is given to results from large series and reports from recognized experts. Guidelines for appropriate utilization of endoscopy are based on a critical review of the available data and expert consensus.

Not applicable: The guideline was not adapted from another source.

2006 Apr

American Society for Gastrointestinal Endoscopy - Medical Specialty Society

American Society for Gastrointestinal Endoscopy

Standards of Practice Committee

Committee Members: William K. Hirota, MD; Marc J. Zuckerman, MD; Douglas G. Adler, MD; Raquel E. Davila, MD; James Egan, MD; Jonathan A. Leighton, MD; Waqar A. Qureshi, MD; Elizabeth Rajan, MD; Robert Fanelli, MD (SAGES Representative); Jo Wheeler-Harbaugh, RN (SGNA Representative); Todd H. Baron, MD (Vice Chair); Douglas O. Faigel, MD (Chair)

Not stated

This is the current release of the guideline.

None available

None available

This NGC summary was completed by ECRI on June 9, 2006.

This NGC summary is based on the original guideline, which is subject to the guideline developer's copyright restrictions.