Polychlorinated Biphenyls (PCBs) and Female Fecundity, New York State Angler Prospective Pregnancy Study
Principal investigator: Germaine M. Buck Louis, Ph.D., M.S.
The New York State Angler Cohort Study (NYSACS) Prospective Pregnancy Study enrolled women who, at recruitment into the larger NYSACS cohort study, indicated that they had not yet completed childbearing. The intent of the study was to empirically demonstrate that women could be recruited for intensive follow-up, including the collection of daily information for up to 12 menstrual cycles determined to be at risk of pregnancy. Much of the early work focused on laboratory procedures that may impact study findings, including how best to model congeners, handling concentrations below the limits of detection, and lipid adjustment. Investigators are now beginning to look at the association between exposure to PCBs and various reproductive endpoints, such as time to pregnancy and birth size.
DESPR Collaborators
· Enrique F. Schisterman, Ph.D.
· Rajeshwari Sundaram, Ph.D.
Selected Publications Taylor KC, Jackson LW, Lynch CD, Kostyniak PJ, & Buck Louis GM. (2007). Preconception maternal polychlorinated biphenyl concentrations and the secondary sex ratio. Environ Res, 103(1):99-105. [Abstract]
Louis GMB, Lynch CD, & Cooney MA. (2006). Environmental influences on female fecundity and fertility. Seminars in Reproductive Medicine, 24(3):178-190. [Abstract]
Senn KM, McGuinness BM, Buck GM, Vena JE, Anderson S, & Rogers BT. (2005). Longitudinal study of babies born to mothers enrolled in a preconception prospective pregnancy study: Study design and methodology, New York State Angler Cohort Study. Environ Res, 97(2):163-169. [Abstract]
Buck GM, Vena JE, Greizerstein HB, Weiner JM, McGuiness B, Mendola P, Kostyniak PJ, Swanson M, Bloom MS, & Olson JR. (2002). PCB congeners and female fecundity, New York State Angler Cohort Study. Environmental Toxicology and Pharmacology, 12(2):83-92.