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SBIR (Small Business Innovation Research) Grant Program
STTR (Small Business Technology Transfer) Grant Program

Welcome to the Home Page for information relating to the NHLBI SBIR and STTR program. On this page information can be found that will assist you in the preparation and submission of an SBIR or STTR grant application.

The NIH recently announced that it has begun to convert from the PHS 398 grant application form to the new Standard Form (SF) 424 Research and Research Related (R&R) application form. The new form requires electronic submission through .

The transition began with the December 1, 2005, submission date for the SBIR/STTR programs, with other grant mechanisms soon to follow.

For more information, please see the NIH SBIR/STTR Small Business Funding Opportunities Page.

Updated: June 2007


  • NHLBI Mission Statement
    A description of the NHLBI public health mission and areas of research emphasis for of the Institute's Divisions

    The goal of the NHLBI SBIR/STTR program is to foster research on pharmaceuticals, medical devices and implants, biologics, informatics, and biotechnologies for the causes, prevention, diagnosis, and treatment of heart, blood vessel, lung, blood diseases, and sleep disorders.

  • Staff contacts
  • SBIR/STTR Omnibus Solicitation, PHS 2007-2: includes instructions for preparation and submission of an application and application forms
  • PDF fileTopics from the Omnibus Solicitation (2.1 MB, 191 pages)

    For your convenience, the list of active SBIR/STTR Funding Opportunity Announcements with NHLBI Participation are also listed below.

    All links go to the NIH Guide, and will not open a new window.
Title: Small Business Innovation Research to Improve the Chemistry and Targeted Delivery of RNAi Molecules
Program Announcement (PA) Number: PA-06-003 (SBIR [R43/R44])
Program Announcement (PA) Number: PA-06-004 (STTR [R41/R42])

Purpose. The participating institutes of the National Institutes of Health invite the small business community to apply cutting edge-technology to develop new approaches and chemical modifications that will increase the long term stability, delivery and targeting of siRNAs in cells and tissues for laboratory and therapeutic applications.
Expiration Date: now January 8, 2008

Title: Integration of Heterogeneous Data Sources
Program Announcement (PA) Number: PA-06-010 (STTR [R41/R42])
Program Announcement (PA) Number: PA-06-011 (SBIR [R43/R44])

Purpose. This FOA invites small businesses to develop innovative software for addressing the integration of distributed cross-disciplinary data sources into coherent knowledge bases for biomedical research. Federating such data sources requires solving a large number of technical, scientific, financial, social and legal issues, and new tools are needed for aiding in almost every aspect of this problem. Applications are expected to describe at least one biomedical research problem that will benefit from the proposed tool or tool set, as well as to describe how the approach will scale when applied to additional data sources and/or to other biomedical problems. A clear description should be provided of how the impact of these tools on biomedical research will be measured. Finally, a reasonable mechanism for maintenance and expansion of the software as well as integration with existing solutions should be carefully outlined.
Expiration Date: now January 8, 2008

Title: Manufacturing Processes of Medical, Dental, and Biological Technologies
Program Announcement (PA) Number: PA-06-012 (STTR [R41/R42])
Program Announcement (PA) Number: PA-06-013 (SBIR [R43/R44])

Purpose. On February 26, 2004, Executive Order 13329 ( was signed by President George W. Bush requiring SBIR/STTR agencies, to the extent permitted by law and in a manner consistent with the mission of the Department, to give high priority within the SBIR and STTR programs to manufacturing-related research and development (R&D). In response to this Executive Order, NIH is expanding its focus by encouraging eligible United States small business concerns to submit SBIR Phase I, Phase II, and Fast-Track grant applications whose biomedical research is related to advanced processing, manufacturing processes, equipment and systems, and manufacturing workforce skills and protection.
Expiration Date: September 8, 2008

Title: Bioengineering Nanotechnology Initiative
Program Announcement (PA) Number: PA-06-008 (STTR [R41/R42])
Program Announcement (PA) Number: PA-06-009 (SBIR [R43/R44])

Purpose. This Funding Opportunity Announcement (FOA), issued as an initiative of the trans-NIH Bioengineering Consortium (BECON) on behalf of the participating Institutes and Centers, invites grant applications for projects for developing and applying nanotechnology to biomedicine. Nanotechnology is defined as the creation of functional materials, devices and systems through control of matter at the scale of 1 to 100 nanometers, and the exploitation of novel properties and phenomena at the same scale. Nanotechnology is emerging as a field critical for enabling essential breakthroughs that may have tremendous potential for affecting biomedicine. Moreover, nanotechnologies developed in the next several years may well form the foundation of significant commercial platforms that shift the paradigms of clinical applications
Expiration Date: September 8, 2008

Title: Directed stem Cell Differentiation for Cell Based Therapies for Heart, Lung, Blood, and Aging Diseases
Program Announcement (PA) Number: PA-06-124 (SBIR [R43/R44])
Program Announcement (PA) Number: PA-06-125 (STTR [R41/R42])

Purpose. This funding opportunity announcement (FOA) solicits grant applications to define the factors and mechanisms controlling the differentiation of embryonic or adult stem or progenitor cells, either in vitro or in vivo. It is designed to stimulate new scientific advances in stem cell differentiation including technology research that may not be hypothesis driven. The long range goal of this program is the development of methods to direct the differentiation or development of stem cells along specific cell lineages to yield replacement cells for clinical use, whether the replacement cells are formed in vitro for delivery or formed in vivo in the tissue or organ environment.
Expiration Date: September 8, 2008

Title: Innovations in Biomedical Computational Science and Technology Initiative
Program Announcement (PA) Number: PAR-07-160 (SBIR [R43/R44])
Program Announcement (PA) Number: PAR-07-161 (STTR [R41/R42])

Purpose. This funding opportunity announcement (FOA) solicits grant applications from small business concerns (SBCs) that propose innovative research in biomedical computational science and technology to promote the progress of biomedical research. There exists an expanding need to speed the progress of biomedical research through the power of computing to manage and analyze data and to model biological processes. The NIH is interested in promoting research and developments in biomedical computational science and technology that will support rapid progress in areas of scientific opportunity in biomedical research. As defined here biomedical computing or biomedical information science and technology includes database design, graphical interfaces, querying approaches, data retrieval, data visualization and manipulation, data integration through the development of integrated analytical tools, and tools for electronic collaboration, as well as computational research including the development of structural, functional, integrative, and analytical models and simulations.
Expiration Date: May 8, 2009

Title: New Approaches to Arrhythmia Detection and Treatment
Program Announcement (PA) Number: PA-07-031 (STTR [R41/R42])
Program Announcement (PA) Number: PA-07-032 (SBIR [R43/R44])

Purpose. The funding opportunity announcement (FOA) solicits grant applications from small business concerns (SBCs) that propose innovative research to improve our ability to detect, treat and prevent cardiac arrhythmias using new or improved methods, tools, and technologies. Applications are invited for the development and significant improvements of innovative monitoring tools, diagnostic methods, and therapeutic approaches for arrhythmia detection, treatment and prevention.
Expiration Date: December 6, 2009

Title: New Technology for Proteomics and Glycomics
Program Announcement (PA) Number: PA-07-451 (SBIR [R43/R44])
Program Announcement (PA) Number: PA-07-452 (STTR [R41/R42])

Purpose. Proteomics technologies and methods remain largely inadequate, particularly with respect to quantitative and real time measurements. This funding opportunity announcement (FOA) solicits grant applications from small business concerns (SBCs) that propose the development of broadly applicable research tools that address the core technical challenges in proteomics and glycomics. This includes but is not restricted to robotics, sample preparation and pre-fractionation, analytical separations, gel and array imaging, quantitation, mass spectrometry, intelligent automated data acquisition, and improved informatics technologies.
Expiration Date: August 6, 2010

Title: Bioengineering Approaches to Energy Balance and Obesity
Program Announcement (PA) Number: PA-07-435 (SBIR [R43/R44])
Program Announcement (PA) Number: PA-07-436 (STTR [R41/R42])

Purpose: This funding opportunity will develop and validate new and innovative bioengineering technology to address clinical problems related to energy balance, intake, and expenditure. Novel sensors, devices, imaging, and other approaches are expected to be developed and evaluated by collaborating engineers, physical scientists, and scientists from other relevant disciplines with expertise in obesity and nutrition. The goal is to increase the number of useful technologies and tools available to scientists to facilitate their research in energy balance and health. Eventually these research tools should facilitate therapeutic advances and behavioral changes to address such problems as weight control and obesity.
Expiration Date: August 6, 2010

For more information please contact:
Susan Pucie, NHLBI SBIR/STTR Program Coordinator
Tel: 301-435-0079, Email:

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