Guidelines for

Investigator-Initiated Resource-Related Research Projects Applications (R24)

National Heart, Lung, and Blood Institute
National Institutes of Health

Posted: August 2008

These guidelines are in effect for the January 25, 2009 and future submission deadlines.

The R24 is an investigator-initiated mechanism used by the NIH to support projects that will enhance the capability of resources to serve biomedical research. Within the NHLBI, the R24 is used to support projects that enhance the conduct of basic, translational, and clinical research through the development of resources or infrastructure. As noted below, the scope of the R24 must address a national need that fulfills the NHLBI's strategic vision and provides resources to the broader scientific community.

Advance permission from the NHLBI is required prior to submitting an R24 resource application that is related to the Institute's mission. New and renewal (formerly “competing continuation”) applications are subject to the policy.

All prospective R24 grant applicants should send a letter to the Institute requesting permission to submit an R24 grant application. Beginning October 1, 2008, the NHLBI will accept requests for advance permission to submit an R24 resource application to the NHLBI twice a year, on May 15 and on November 15. The NHLBI will respond to all such requests by letter.

If the decision is positive, the letter must be included as a cover letter with the application upon its submission to the Center for Scientific Review. Without the letter, the application will be returned to the applicant. If approved, the applicant can submit a new (Type 1) or a renewal (Type 2) application on any of the following three dates:

The request should be sent to the Director of the Division most relevant to the proposed research and should generally be no longer than 5 pages. In order to enable the Institute to make an informed decision, the request must provide:

• Specific aims of the proposed resource-related research
• Details of any resource or infrastructure that will be created or enhanced
• Description of the need or gap that will be addressed
• An explanation of the benefit, value, significance, and potential impact on NHLBI-supported research, with a clear description of how the broader scientific or clinical community will benefit
• Direct costs and total costs for each year and direct and total costs for the entire program period
• Names of key investigators
• Plans to distribute and share the resources
• Sunset or transition plans

Applications for NHLBI R24 grants with direct costs of $500,000 or more in any year must also comply with the NHLBI Guidelines for Applications with Direct Costs of $500,000 or More in Any One Year .   Applicants should contact the appropriate NHLBI Program Staff as early as possible when contemplating submission of an application. One letter can be used to address the $500,000 direct cost policy and the R24 request to submit an application.

NHLBI Extramural Program Division Directors

All written requests for NHLBI agreement to accept applications subject to this policy are to be submitted to one of the following Division Directors:

Division of Cardiovascular Diseases

Dr. Sonia Skarlatos
Deputy Director
NHLBI/DCVD
Two Rockledge Center, Room 8124
6701 Rockledge Drive, MSC 7940
Bethesda, MD 20892-7940
Phone: 301-435-0466
Fax: 301-480-7971
Email: skarlats@nhlbi.nih.gov

Division of Lung Diseases

Division of Blood Diseases and Resources

Division of Prevention and Population Sciences

Dr. Michael Lauer
Director
NHLBI/DPPS
Two Rockledge Center, Room 10122
6701 Rockledge Drive, MSC 7936
Bethesda, MD 20892-7936
Phone: 301-435-0422
Fax: 301-480-1864
Email: lauerm@nhlbi.nih.gov