Agricultural Research Service Date Filed: March 17, 2000 Abstract: The invention is for a method of using citrus-derived flavonoids called polymethoxylatedflavones for treating and/or reducing cardiovascular diseases and disorders. The invention can also be used for inhibiting cytokine production, particularly those associated with the production of certain kinds of tumors in mammals, including humans. Cytokines are proteins that play a role in immune function. A few diseases caused by cytokines include septic shock, cancer, cachexia, chronic rheumatism, ulcerative colitis, and Chrohn's disease. These compounds could have nutraceutical properties. Inventors:     John A. Manthey Quality Improvement in Citrus and Subtropical Products Winter Haven, FL 33883 (941) 293-4133 / Fax: (941) 299-8678 E-mail: jamwh@juno.com Najla Guthrie KGK Synergize, Inc. 100 Collip Circle, Suite 130 London, Ontario, Canada (519) 858-5044 / Fax: (519) 858-5197 Elzbieta M. Kurowska University of Western Ontario 100 Collip Circle, Suite 130 London, Ontario, Canada Robert M. Horowitz (deceased) *CIP of S.N. 09/167,634, which was filed on October 6, 1998.