Phone:
(865) 574-3138 (865) 482-5101
Fax:
(865) 574-0680
Email:
FromeEL@ornl.gov FromeStat@comcast.net
Web Site
http://www.csm.ornl.gov/~frome/ Short Bio
Education:
Ph.D.,
Emory University, Statistics & Biometry, 1972
M.S.,
University of Florida, Statistics, 1966
B.S.,
University of Florida, Physics, 1964
Postdoctoral
Fellow, Anesthesiology, Emory University, 1973
Professional Affiliations:
·
American
Statistical Association [Elected Fellow ]-
1996
·
Biometric
Society - ENAR
·
Radiation
Research Society
Professional Experience:
·
1971-
2006, Oak Ridge National Laboratory, Computer Science and Mathematics
Division, Senior Research
Staff/Statistician
·
1998- present, Adjunct Professor, University
of Tennessee, Department of Statistics
·
1986-2003,
Adjunct Professor, University of North Carolina, Biostatistics
·
1986-1996,
Adjunct Associate Professor, University of North Carolina, Biostatistics
·
1977-1981,
Medical Div. Oak Ridge Associated Universities, Biostatistics Section Leader
·
1973-1977,
University of Texas at Austin, Assistant Professor, Statistics
·
1972-1973,
Dept. of Anesthesiology, Emory University, Postdoctoral Fellow
·
1969-1972,
Dept. of Statistics and Biometry, Emory University, Research Fellow
·
1968-1969,
Marketing Research Department, Coca-Cola USA
·
1966-1968,
Medical and Health Sciences Division, Oak Ridge Associated Universities
Other Expertise:
·
Associate
Editor for The American Statistician, 1983 - 1993.
·
Statistical
Consultant for Radiation Research Society, 1991 - present.
·
Member
of the Oak Ridge Reservation Health Effects Subcommittee (ORRHES),of the Agency
for Toxic Substances and Disease Registry(ATSDR/CDC) (2000-01 )
·
Member
of the City of Oak Ridge Environmental Advisory Board (2000-03)
·
Member
of the Organizing Committee for the Conference on the Analysis and Assessment of Ionizing Radiation from Scientific and
Statistical Perspectives sponsored by the American Statistical Association
(ASA), 1983 – 1989. Chairman of 1985
ASA Conference
·
Member
of the Information Systems Working Group for the DOE Comprehensive
Epidemiologic Data Resource (CEDR): 1990 – 1993.
·
Member
of the American Statistical Association Committee on Statistics and the
Environment: 1986 – 1998.
·
Member
of the Statistics Test Panel for Data Management Systems in Genetic Toxicology,
sponsored by the US EPA through Integrated Laboratory Systems: 1987 – 1990.
Summary
of Recent and Earlier Research with links to recent work [Visit Here ].
Publications and Recent
Technical Reports:
·
E.
L. Frome and D. P. Frome 2007, "R package SAND "Statistical Analysis
Non-Detects"." (available at
www.csm.ornl.gov/esh/statoed/ )
·
E.
L. Frome and P. W. Wambach. 2006. "Statistical Methods for the Analysis of
Occupational Exposure Data with Non-Detectable Values." (Manuscript under
revision)
·
E.
L. Frome and P. F. Wambach, (June, 2005),"Statistical Methods and Software
for the Analysis of Occupational Exposure Data With Non-Detectable Values"
ORNL/TM-2005/52 (http://www.csm.ornl.gov/esh/aoed/)
·
Kerr,
G.D. , E.L. Frome, W. G. Tankersley, and J. P. Watkins, (2005)"Historical
Evaluation of the Film Badge Dosimetry Program at the Y-12 Facility in Oak
Ridge, Tennessee: Part 2 Neutron Radiation", ORAUT-OTIB-0045.
·
Frome,
E. L. and J. Watkins, (2004), Statistical Analysis of Data with Non-detectable
Values,ORNL/TM-2004/146. (http://www.csm.ornl.gov/~frome/sand/)
·
Frome,
E. L., and P. G. Groer, (2004), Individual Dose Adjustment Procedure for Y-12
Dose Reconstruction, ORAUT-TIB-0013, Revision No. 00-A, Oak Ridge Associate
Universities, Oak Ridge, Tennessee
·
Watkins,
J. P., G. D. Kerr, E. L. Frome, W. G. Tankersley, and C. M. West, (2004),
Historical Evaluation of the Film Badge Dosimetry Program at the Y-12 Facility
in Oak Ridge, Tennessee, ORAU TechnicalReport # 2004-0888. (http://www.orau.gov/cer/reports.htm
)
·
Frome,E.L.
Newman, L.S., Cragle, D.L, Colyer, S.P. and P.F. Wambach
(2003)",Identification of an Abnormal Beryllium Lymphocyte Proliferation
Test",Toxicology,183:39-56.
·
Farris,
G. M., Newman, L. S., Frome, E. L., et. al.
Detection of Beryllium Sensitivity Using a Flow Cytometric Lymphocyte
Proliferation Test: the IMMUNO-BE-LPT,” Toxicology: 143, 125-140, 2000.
·
Weresczczak,
A., Ferber, M., Kirkland, T., Barnes, A., Frome, E., Asymmetric Tensile and
Compressive Creep Deformation of Hot-isostatically-pressed Y2O3-Doped-Si3N4.
Journal European Ceramic Society. 19(1999): 227-237, 1999
·
Frome,
E. L., Cragle, D. L., Watkins, J. P., Wing, S., Shy, C. M., Tankersley, W. G.,
West, C., A mortality study of employees of the nuclear industry in Oak Ridge,
Tennessee [published erratum appears in Radiat Res 1997 Sep;148(3):297-8].
Radiation Research. 148(Jul 1997): 64-80, Jul 1997
·
Mitchell,
T. J., Ostrouchov, G., Frome, E. L., Kerr, G. D. A method for estimating occupational radiation dose to individuals,
using weekly dosimetry data. Radiation Research. 147(Feb 1997): 195-207, Feb
1997
·
Watkins,
J. P., Reagan, J. L., Cragle, D. L., Frome, E. L., West,C.M., Crawford-Brown,
D., and Tankersley, W. G., Collection, Validation, and Treatment of Data for a
Mortality Study of Nuclear Industry Workers. Applied Occupational and
Environmental Hygiene. 12(1997): 195-205, 1997
·
Frome,
E. L., Smith, M. H., Littlefield, L. G., Neubert, R.L., Colyer, S. P. Statistical methods for the blood beryllium
lymphocyte proliferation test. Environmental Health Perspectives. 104 Suppl
5(Oct 1996): 957-68, Oct 1996
·
Fry,
S. A., Cragle, D. L., Crawford-Brown, D. J., Dupree, E. A., Frome, E. L., et
al. , Health and Mortality Among Contractor Employees at US Department of
Energy Facilities. Radiation and Public Perception Benefits and Risks, Advances
in Chemistry Series.(1995): 239-258, 1995
·
Littlefield,
L. G., Joiner, E. E, Colyer, S. P., Frome, E. L., Radioprotective Chemicals as Tools for Studying Mechanisms of
Radiation-Induced Chromosome Damage in Human Lymphocytes. Chromosomal
Alterations, eds. G. Obe and A. T.(1994): 132-139, 1994
·
Wing,
S., Shy, C. M., Wood, J.L., Wolf, S., Cragle, D.L., Tankersley, W., Frome,
E.L., Job factors, radiation and cancer
mortality at Oak Ridge National Laboratory: follow-up through 1984 [published
erratum appears in Am J Ind Med 1993;23(4):673]. American Journal of Industrial
Medicine. 23(Feb 1993): 265-79, Feb 1993
·
Littlefield,
L.G., Joiner, E. E., Colyer, S. P., Sallam, F., Frome, E. L., Concentration-dependent
protection against X-ray-induced chromosome aberrations in human lymphocytes by
the aminothiol WR-1065. Radiation Research. 133(Jan 1993): 88-93, Jan 1993
·
Ostrouchov,
G. and Frome, E. (1993), "A Model Search Procedure for Hierarchical Models",
Computational Statistics and Data Analysis, 15, 285-296.
·
Generoso,
W. M., Cain, K. T., Cornett, C. V., Frome, E. L. Comparison of two stocks of mice in spermatogonial response to
different conditions of radiation exposure. Mutation Research. 249(Aug 1991):
301-10, Aug 1991
·
Wing,
S., Shy, C. M., Wood, J. L., Wolf, S., Cragle, D. L., Frome, E. L. Mortality among workers at Oak Ridge
National Laboratory. Evidence of radiation effects in follow-up through 1984
[published errata appear in JAMA 1991 Aug 7;266(5):657 and 1992 Sep
16;268(11):1414] [see comments]. Jama. 265(Mar 1991): 1397-402, Mar 1991
·
Frome,
E. L., (1991) "Statistical Analysis of Cytogenetic Dose-Response
Curves", in Statistical Methods in Toxicological Research, eds. D. Krewski
and C. Franklin, Gordon & Breach Science Publications, Inc., 281-298.
·
Frome,
E. L., Cragle, D. L., McLain, R. W.
Poisson regression analysis of the mortality among a cohort of World War
II nuclear industry workers. Radiation Research. 123(Aug 1990): 138-52, Aug
1990
·
Littlefield,
L.G., Sayer, A.M., Frome, E.L.
Comparisons of dose-response parameters for radiation-induced acentric
fragments and micronuclei observed in cytokinesis-arrested lymphocytes.
Mutagenesis. 4(Jul 1989): 265-70, Jul 1989
·
Frome,
E. L., and Morris, M. D. Evaluating Goodness of Fit of Poisson Regression
Models in Cohort Studies. The American Statistician. 43(1989): 144-147, 1989
·
Littlefield,
L.G., Joiner, E. E., Colyer, S. P., Sayer, A. M., Frome, E. L. Modulation of radiation-induced chromosome
aberrations by DMSO, an OH radical scavenger. 1: Dose-response studies in human
lymphocytes exposed to 220 kV X-rays. International Journal of Radiation
Biology and Related Studies in Physics, Chemistry and Medicine. 53(Jun 1988):
875-90, Jun 1988
·
Carpenter,
A. V., Flanders, W. D., Frome, E. L., Tankersley, W. G., Fry, S. A. Chemical exposures and central nervous
system cancers: a case-control study among workers at two nuclear facilities.
American Journal of Industrial Medicine. 13(1988): 351-62, 1988
·
Carpenter,
A. V., Flanders, W. D., Frome, E. L., Cole, P, Fry, S. A. Brain cancer and nonoccupational risk
factors: a case-control study among workers at two nuclear facilities. American
Journal of Public Health. 77(Sep 1987): 1180-2, Sep 1987
·
Witschi,
H. P., Smith, L. H., Frome, E. L., Pequet-Goad, M. E., Griest, W. H., Ho, C.
H., Guerin, M. R. Skin tumorigenic
potential of crude and refined coal liquids and analogous petroleum products.
Fundamental and Applied Toxicology. 9(Aug 1987): 297-303, Aug 1987
·
Carpenter,
A. V., Flanders, W. D., Frome, E. L., Crawford-Brown, D. J., Fry, S. A. CNS cancers and radiation exposure: a
case-control study among workers at two nuclear facilities. Journal of
Occupational Medicine. 29(Jul 1987): 601-4, Jul 1987
·
Lindenschmidt,
R. C., Tryka, A. F., Godfrey, G. A., Frome, E. L., Witschi, H. Intratracheal versus intravenous
administration of bleomycin in mice: acute effects. Toxicology and Applied
Pharmacology. 85(Aug 1986): 69-77, Aug 1986
·
Frome,
E. L., DuFrain, R. J. Maximum
likelihood estimation for cytogenetic dose-response curves. Biometrics. 42(Mar
1986): 73-84, Mar 1986
·
Frome,
E. L., Checkoway, H. Epidemiologic
programs for computers and calculators. Use of Poisson regression models in
estimating incidence rates and ratios. American Journal of Epidemiology.
121(Feb 1985): 309-23, Feb 1985
·
Frome,
E. L. The analysis of rates using
Poisson regression models. Biometrics. 39(Sep 1983): 665-74, Sep 1983
·
DuFrain,
R. J., Littlefield, L. G., Wilmer, J. L., Frome, E. L. Evaluation of chemically induced cytogenetic
lesions in rabbit oocytes. II. A comparison of streptonigrin effects on somatic
and germ cells. Mutation Research. 94(May 1982): 103-14, May 1982
·
Frome,
E. L. Fisher's Exact Variance Test for
the Poisson Distribution. Applied Statistics. 31(1982): 67-71, 1982
·
Polednak,
A. P., Frome, E. L. Mortality among men
employed between 1943 and 1947 at a uranium-processing plant. Journal of
Occupational Medicine. 23(Mar 1981): 169-78, Mar 1981
·
Frome,
E. L., Khare, M. Comments on Brodsky's
statistical methods for evaluating epidemiological results [letter]. Health
Physics. 39(Oct 1980): 695-9, Oct 1980
·
DuFrain,
R. J., Littlefield, L. G., Joiner, E. E., Frome, E. L. Human cytogenetic dosimetry: a dose-response
relationship for alpha particle radiation from 241Am. Health Physics. 37(Sep
1979): 279-89, Sep 1979
·
Yakatan,
G. J., Frome, E. L., Leonard, R. G., Shah, A. C., Doluisio, J. T. Bioavailability of acetazolamide tablets.
Journal of Pharmaceutical Sciences. 67(Feb 1978): 252-6, Feb 1978
·
Yakatan,
G. J., Smith, R. B., Frome, E. L., Doluisio, J. T. Pharmacokinetics of orally administered hydroflumethiazide in
man. Journal of Clinical Pharmacology. 17(Jan 1977): 37-47, Jan 1977
·
Armstrong,
R. D., and Frome, E. L. A Special
Pupose Linear Programming Algorithm for Obtaining Least Absolute Value
Estimators in a Linear Model with Dummy Variables. Commun. Stat. B6(4)(1977):
383-398, 1977
·
Frome,
E. L., Frederickson, E. L., Lushbaugh, C. C.
Power spectrum of the respiratory system. Biometrics. 32(Jun 1976):
423-8, Jun 1976
·
Charnes,
A., Frome, E. L. and Yu, P. L. The
Equivalence of Generalized Least Squares and Maximum Likelihood Estimation in
the Exponential Family. Journal of The American Statistical Association. 71(1976):
169-172, 1976
·
Armstrong,
R. D. and Frome, E. L. A Branch and
Bound Solution of a Restricted Least Squares Problem. Tecometrics. 18(1976):
447-450, 1976
·
Armstrong,
R. D., and Frome, E. L. A Comparison of
Two Algorithms for Absolute Deviation Curve Fitting. Journal of The American
Statistical Association. 71(1976): 328-330, 1976
·
Frome,
E. L., Frederickson, E. L. Digital
spectrum analysis of the first and second heart sounds. Computers and
Biomedical Research. 7(Oct 1974): 421-31, Oct 1974
·
Frome,
E. L. Algorithm AS 73: Cross-Spectrum
Smoothing Via the Finite Fourier Transform. Applied Statistics. 23(1974):
238-244, 1974
·
Frome,
E. L., Kutner, M. H., and Beauchamp, J. J.
Regression Analysis of Poisson-Distributed Data. Journal of The American
Statistical Association. 68(1973): 935-940, 1973
·
Lushbaugh,
C. C., Frome, E. L., Davis, H. T., Bibler, D. S. Clinical aviation and aerospace medicine. Power spectrum of the
impedance pneumograph: a data reduction system producing an analytical
parameter of potential clinical usefulness. Aerospace Medicine. 40(Apr 1969):
425-9, Apr 1969
·
Frome,
E. L., Beauchamp, J. J. Maximum
likelihood estimation of survival curve parameters. Biometrics. 24(Sep 1968):
595-605, Sep 1968