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Workshop on Pulmonary Immunobiology and Inflammation
August 26-27, 1999

Conference Room A, Natcher Building
National Institutes of Health, Bethesda, MD
Sponsored by
The National Heart, Lung, and Blood Institute

 
Session I - Development of the Pulmonary Immune System:  Who are the players and what do they do in the lung? Chair: Michael Sherman, M.D.
Immune system tissue in the lung   
8:30-8:55 Speaker: Michael Sherman, M.D. Pulmonary Immune Cells Go to School 
Lesson 1. Learning form Lactoferrin
8:55-9:05 Discussant: Michael Frank, M.D.
9:05-9:10 Discussant: Dallas Hyde, Ph.D.
9:15-9:45 DISCUSSION
Ontogeny of immune system in Lung   
9:45-10:10 Speaker: David Lewis, M.D. Developmental Mechanisms that May Limit or 
Alter Pulmonary T Cell Responses
10:10-10:20 Discussant: Joseph Bellanti, M.D.
10:20-10:30 Discussant: Galen Toews, M.D.
10:30-11:00 DISCUSSION
11:00-11:15 BREAK
Factors involved in maturation of T cells   
11:15-11:40 Speaker: Christopher Wilson, M.D. Regulation of Th1 Effector T Cell Development 
During Ontogeny
11:40-11:50 Discussant: Victoria Camerini, M.D.
11:50-12:00 Discussant: F. Sessions Cole, M.D.
12:00:12:30 DISCUSSION
12:30-12:40 SESSION SUMMARY
12:40-1:30 LUNCH
Session II - Pulmonary Immunity and Inflammation: 
   A double-edged sword?
Chair: Allen Harmsen, Ph.D.
Regulation of the pulmonary immune response  
1:30-1:55 Speaker: Mary Lipscomb, M.D. Antigen Handling and Processing in the Lung
1:55-2:05 Discussant: Claire Doerschuk, M.D.
2:05-2:15 Discussant: Robert North, Ph.D.
2:15-2:45 DISCUSSION
Consequences of pulmonary immune responses  
2:45-3:10 Speaker:Thomas Braciale, M.D., Ph.D. Lung Damage During Immune Responses To 
Infectious Diseases 
3:10-3:20 Discussant: Marsha Wills-Karp, Ph.D.
3:20-3:30 Discussant:Arturo Casadevall, M.D., Ph.D.
3:30-4:00 DISCUSSION
4:00-4:15 BREAK
Role of various cell types and mediators as determinants of pulmonary immune/inflammatory responses  
4:15-4:40 Speaker: Steven Kunkel, Ph.D. Mediators of Lung Immune Responses
4:40-4:50 Discussant: Susan Swain, Ph.D.
4:50-5:00 Discussant: Jeffery Curtis, M.D.
5:00-5:30 DISCUSSION
5:30-5:40 SESSION SUMMARY
August 27, 1999
Session III - Inflammation as contributor to pathogenesis in lung diseases Chair: James Crapo, M.D.
Pulmonary inflammatory response and host defense mechanisms  
8:30-8:55
Speaker: Jo Rae Wright, Ph.D. Unique Characteristics of Pulmonary Inflammation and Host Defense Mechanisms
8:55-9:05
Discussant: Galen Toews, M.D.
9:05-9:15
Discussant: William Martin, M.D.
9:15-9:45
DISCUSSION
Inflammation in pulmonary fibrosis, sarcoidosis, asthma, COPD, and ARDS  
9:45-10:10 Speaker: Bruce Freeman, Ph.D.  Oxidant/antioxidants in Mediating the Pulmonary  Immune Responses
10:10-10:20 Discussant:Caroll Cross, M.D.
10:20-10:30 Discussant: Stanley Hazen, M.D., Ph.D.
10:30-11:00 DISCUSSION
11:00-11:15 BREAK
Toward a new therapeutic approach  
11:15-11:40
Speaker: Thomas Martin, M.D.  Early Identification and Management of the  Inflammatory Component of Pulmonary Diseases
11:40-12:00
Discussant: Gary Hunninghake, M.D.
12:00-12:10
Discussant: David Schwartz, M.D.
12:10:12:20
DISCUSSION
12:20-12:40 SESSION SUMMARY
Session IV - Summary Discussion, Recommendations, and Prioritization Session Chairs and Attendees
12:40-2:00
DISCUSS AND LIST RECOMMENDATIONS IN PRIORITY ORDER
2:00
ADJOURN
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