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Environmental Health Perspectives (EHP) is a monthly journal of peer-reviewed research and news on the impact of the environment on human health. EHP is published by the National Institute of Environmental Health Sciences and its content is free online. Print issues are available by paid subscription.DISCLAIMER
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Blueprint for Children?s Health and the Built Environment
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Environmental Health Perspectives Supplements Volume 108, Number S5, October 2000
Environmental Health Perspectives Supplements October 2000 Advances in Uterine Leiomyoma Research

Mathematical Modeling in Environmental Health Studies

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Uterine fibroid tumors (leiomyomas) are a worldwide concern occurring in a large percentage of the female population during their child-bearing years. Although the tumors are associated with a number of reproductive and gynecologic problems including infertility, there is little known about the etiology of these tumors.

Advances in Uterine Leiomyoma Research

Introduction

Women's Health and the Environment in the 21st Century
Kenneth Olden and Retha R. Newbold
p. 767

Overview, Summary, and Future Research Recommendations

Advances in Uterine Leiomyoma Research: Conference Overview, Summary, and Future Research Recommendations
Retha R. Newbold, Richard P. DiAugustine, John I. Risinger, Jeffrey I. Everitt, David K. Walmer, Estella C. Parrott, and Darlene Dixon
p. 769

Biology and Histopathology of the Uterus

Genetic Approaches to the Study of Uterine Leiomyomata
Cynthia C. Morton
p. 775

Pathology and Pathophysiology of Uterine Smooth-Muscle Tumors
Stanley J. Robboy, Rex C. Bentley, Kelly Butnor, and Malcolm C. Anderson
p. 779

Mechanisms of Tumor Development: Hormones and Growth Factors

Regulation of Vascular Endothelial Growth Factor Expression by Estrogens and Progestins
Salman M. Hyder, Jaou-Chen Huang, Zafar Nawaz, Holly Boettger-Tong, Sari Mäkelä, Connie Chiappetta, and George M. Stancel
p. 785

Advances in Uterine Leiomyoma Research: The Progesterone Hypothesis
Mitchell S. Rein
p. 791

Immunohistochemical Localization of Growth Factors and Their Receptors in Uterine Leiomyomas and Matched Myometrium
Darlene Dixon, Hong He, and Joseph K. Haseman
p. 795

Mechanisms of Tumor Development: Molecular Alterations

Structure and Function of the HMGI(Y) Family of Architectural Transcription Factors
Raymond Reeves
p. 803

Comparing Regulation of the connexin43 Gene by Estrogen in Uterine Leiomyoma and Pregnancy Myometrium
Janet Andersen
p. 811

Pregnancy, Parturition, and Prostaglandins: Defining Uterine Leiomyomas
Kimberley Cesen-Cummings, John A. Copland, J. Carl Barrett, Cheryl L. Walker, and Barbara J. Davis
p. 817

Epidemiology and Environmental Influences

Epidemiologic Contributions to Understanding the Etiology of Uterine Leiomyomata
Stephen M. Schwartz, Lynn M. Marshall, and Donna D. Baird
p. 821

Transnational Research and Experimental Model Systems

Influence of Exogenous Estrogen Receptor Ligands on Uterine Leiomyoma: Evidence from an in Vitro/in Vivo Animal Model for Uterine Fibroids
Deborah S. Hunter, Leslie C. Hodges, Patricia K. Eagon, Peter M. Vonier, Robin Fuchs-Young, Jill S. Bergerson, and Cheryl L. Walker
p. 829

Clinical Experience and Therapeutics

Clinical Decision Making Regarding Leiomyomata: What We Need in the Next Millenium
A. F. Haney
p. 835

Review of the Evidence for Treatment of Leiomyomata
David L. Olive
p. 841

Impact of Uterine Fibroids on ART Outcome
David L. Healy
p. 845

Novel Therapeutic Strategies for Leiomyomas: Targeting Growth Factors and Their Receptors
Romana A. Nowak
p. 849

Mathematical Modeling in Environmental Health Studies

Current Directions in Physiological Modeling for Environmental Health Sciences: An Overview
Michael C. Kohn
p. 857

The Multiple Indicator Dilution Method and Its Utility in Risk Assessment
Andreas J. Schwab and K. Sandy Pang
p. 861

A Model of Gonadotropin Regulation during the Menstrual Cycle in Women: Qualitative Features
Paul M. Schlosser and James F. Selgrade
p. 873

Statistical Issues in Toxicokinetic Modeling: A Bayesian Perspective
Pascale Bernillon and Frédéric Y. Bois
p. 883

Canonical Modeling: Review of Concepts with Emphasis on Environmental Health
Eberhard O. Voit
p. 895

The Privileged Access Model of 1,3-Butadiene Disposition
Michael C. Kohn and Ronald L. Melnick
p. 911

Simulation Modeling of the Tissue Disposition of Formaldehyde to Predict Nasal DNA-Protein Cross-Links in Fischer 344 Rats, Rhesus Monkeys, and Humans
Rory B. Conolly, Patrick D. Lilly, and Julia S. Kimbell
p. 919

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