[CAMP Roster]

Specific areas covered by CAMP include:

• Oncogenes and tumor suppressor genes and their pathways in oncogenesis.
  
  
• Gene regulation including chromatin structure and remodeling, RNA stability, transcription and translation relevant to oncogenesis.
  
  
• Signaling transduction pathways related to the regulation of cell growth in cancer.
  
  

• Role of characterized stem cells in oncogenesis.
  
  

• Mechanisms of overcoming senescence in the context of oncogenesis.
  
  

• Cell death pathways (both apoptotic and non-apoptotic) in cancer.
  
  

• Mechanisms mediated through telomeres and telomerase in oncogenesis.

  
  

CAMP has the following shared interests within the ONC IRG:

• With Cancer Etiology [CE]: Studies that focus on the contribution of cell growth and apoptosis processes, oncogene and tumor suppressor functions in transformed cells could be assigned to CAMP.  If the focus is on effects of environmental or chemical carcinogens, then the application could be assigned to CE.
  
  
• With Cancer Genetics [CG]: Applications that focus on transcriptional regulation of oncogenes or tumor suppressors could be assigned to CAMP.  If the focus is on gene discovery or other genetic studies, then the application could be assigned to CG.
  
  
• With Molecular Oncogenesis [MONC]:  In general, studies on the basic signaling mechanisms contributing to oncogenic transformation could be assigned to MONC. Applications that focus on transcriptional regulation in the oncogenic transformation process could be assigned to CAMP. Studies that focus on the identification or characterization of cancer stem cells could be assigned to MONC. Studies that focus on the role of cancer stem cells could be assigned to CAMP.
  
  
• With Tumor Cell Biology [TCB]: Applications that focus on signal transduction primarily related to cell growth and/or apoptosis could be assigned to CAMP.  Other growth factor/signaling applications in tumors could be assigned to TCB.
  
  
• With Basic Mechanisms of Cancer Therapeutics [BMCT]: Basic studies of the biology/pathology of the malignant cell could be assigned to CAMP.  If the study is therapeutically oriented, then it could be assigned to BMCT.
  
  

CAMP has the following shared interests outside the ONC IRG:

• With the Cell Biology [CB] IRG: In general, studies of normal cell biology processes could be assigned to CB and processes of cell biology that are critical in tumor cells could be assigned to CAMP. Studies that combine both normal cell biological processes and processes critical for transformation would be assigned to an IRG according to the main focus of the research.
  
  
• With the Genes, Genomes and Genetics [GGG] IRG: In general, studies of normal gene regulatory processes could be assigned to GGG, whereas gene regulation processes in transformed cells could be assigned to CAMP.  Studies that combine both normal regulatory processes and processes critical for transformation and/or tumor progression would be assigned to an IRG according to the main focus of the research.
  
  
• With the Biology of Development and Aging [BDA] IRG: In general, studies that focus on oncogenes and tumor suppressors in the context of development or aging could be assigned to BDA.  Studies that focus on oncogenes and tumor suppressors in the context of cancer biology could be assigned to CAMP.
  
  
• With the Endocrinology, Metabolism, Nutrition and Reproductive Sciences [EMNR] IRG: In general, studies that focus on pre-neoplastic, dysplastic, hyperplastic disorders of the reproductive organs or that focus on cancers originating in endocrine glands could be assigned to EMNR. Studies with an emphasis on tumor suppressors or survival (apoptotic or non-apoptotic) pathways could be assigned to CAMP.
  
  
• With the Organ-system IRGs: In general, studies of normal cell biology processes unique to a specific organ system could be assigned to the appropriate organ-system IRG and studies of such mechanisms in neoplasias could be assigned to CAMP.