The Digestive Sciences IRG will review applications on basic and clinical aspects of gastrointestinal, hepatobiliary and pancreatic physiology and pathobiology, and on the disposition and action of nutrients and xenobiotics. Specific areas include mucosal immunity and immune-mediated disorders, microbial pathogenesis, inflammation, and molecular and cell biology of pre-cancer, differentiation, growth and development. Applications involving integrative physiology including brain-gut interactions, hormones, secretion and absorption, motility, and genetic determinants of GI diseases will be reviewed here, as well as studies related to the disposition of nutrients, drugs, biopharmaceutical agents, alcohol and other toxicants, and their mechanisms of action. Investigators may employ a broad range of basic and clinical research methods including pharmacologic, chemical and biochemical approaches, genetics, genomics and proteomics, molecular and cell biology techniques and animal models. Patient-oriented studies including pediatric gastroenterology are included in this IRG, but large population studies and randomized clinical trials involving digestive disorders will be reviewed elsewhere.
The following Study Sections are included in the DIG IRG:
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