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F05 reviews fellowship applications in the broad areas of molecular, cellular, and developmental biology when the research focus is to understand basic principles of cell structure, function, regulation, and differentiation. The study section encompasses the scientific disciplines covered by the Cell Biology (CB) IRG and the Biology of Development and Aging (BDA) IRG. Examples of specific areas covered are listed below.
- Gene expression and its regulation, including chromatin structure, transcription, RNA processing, translation, and RNA stability
- Nuclear organization, including chromosomal organization and nuclear import and export
- Biogenesis, organization, and functions of the plasma membrane and endomembrane organelles, including transmembrane transport, vesicular transport, macromolecular trafficking, and autophagy
- Protein stability and turnover, including chaperone function and ubiquitin-based degradation and related processes
- Signal transduction at the cellular level
- Cell cycle and cell growth regulation
- Cell senescence and cell death (apoptosis)
- Cytoskeleton and cell motility
- Cell adhesion
- Mitosis, meiosis, and cytokinesis
- Cell polarity
- Extracellular matrix, including its biogenesis, organization, and interactions with the cell surface
- Developmental cell biology, including cell fate determination, cellular basis of embryonic patterning, developmental regulation of gene expression, and cell differentiation
- Germ and stem cell biology
Shared Interests:
With F01 (Brain Disorders and Related Neuroscience) in the area of the anterior eye: Fellowship applications on diseases of the anterior eye may be assigned to F01, while those on basic biology may be assigned as appropriate, e.g., F05 may review fellowship applications on the basic cell biology of the lens.
With F02B (Sensory, Motor, and Cognitive Neuroscience), in the area of vision: Fellowship applications dealing with visual processing and related portions of the brain, eye, and extraocular muscle system may be assigned to F02B ; Fellowship applications dealing with the biology and diseases of the posterior eye may be assigned to F05.
With F03A (Biochemical and Molecular Neuroscience): Fellowship applications focusing on development, differentiation, progenitor and stem cells, and cytoskeleton in neuronal, glial, retinal and other excitable cells may be assigned to F03A; fellowship applications focusing on basic cell structure, function, and regulation may be assigned to F05 if using neural cells as model systems. F05 may also review fellowship applications on the basic cell biology of the retina.
With F04A (Chemical and Bioanalytical Sciences): Fellowship applications that are concerned with the mechanism of an enzyme or a system of enzymes may be assigned to F04A; fellowship applications concerned with the effects on cellular function may be assigned to F05.
With F04B (Biophysical and Biochemical Sciences) regarding cellular structure and function: Fellowship applications that are concerned with the molecular interactions among molecules that affect cellular structure may be assigned to F04B; fellowship applications that are concerned with structural and functional studies of cells and cell components when the emphasis is on molecular and cell biological context may be assigned to F05.
With F06 (Endocrinology, Nutritional Metabolism, and Reproductive Sciences): Fellowship applications that address hormone effects in the context of gonadal development through implantation of the embryo, as well as aspects of all stages of pregnancy, parturition, neonatal development and maternal/fetal physiology, may be assigned to F06. Fellowship applications that focus on signal transduction at the cellular and molecular level in context of cell division, cell cycle, cell senescence and death may be assigned to F05. Fellowship applications that focus on stem cell transformation and differentiation are of interest to both panels and should be assigned based on the thrust of the application with F05 more concerned with the basic process of cellular differentiation and F06 more concerned with the endocrinology of the stem cell line.
With F07 (Immunology): Fellowship applications on the role of the immune system in the host interaction with infectious agents, tumor cells, transplanted cells, self-components, the conceptus/fetus, allergens, and with substances encountered through environmental exposure may be assigned to F07; fellowship applications that utilize cells of the immune system as models to study basic cell function, regulation, and intracellular signaling may be assigned to F05.
With F08 (Genomics, Genetics, DNA Replication, and Gene Expression): Fellowship applications on molecular aspects of gene expression/ regulation and its relationship to chromatin/ chromosome structure and function, molecular mechanisms of meiosis, and mitosis and maintenance of the genome may be reviewed in F08; fellowship applications on nuclear organization and function, including chromosome architecture, meiosis and mitosis in relation to cell cycle, signaling of cell cycle and gene expression, and nuclear import and export may be reviewed in F05.
With F09 (Oncological Sciences): Fellowship applications that focus on understanding malignant processes concerning the regulation of cell growth, cell division, and gene expression may be reviewed in F09; fellowship applications that emphasize basic, normal cellular, molecular and developmental biology, including cell cycle, signal transduction, gene regulation, cell motility and differentiation may be reviewed by F05.
With F10 (Physiology and Pathobiology of Organ Systems): Fellowship applications that concern the structure and function of differentiated cells in a tissue, organ, or pathology context may be reviewed in F10; fellowship applications that utilize stem or differentiated cells to elucidate fundamental aspects of cell structure, function and regulation may be reviewed in F05.
With F13 (Infectious Diseases and Microbiology): Fellowship applications that concern cell biology studies of microbes where the results will principally apply to microbes may be assigned to F13. Fellowship applications that focus on cell biology with potentially broad applications across kingdoms (i.e., crosscutting studies) or that use model organisms in nonpathogenic settings or that use viruses or their components as tools may be assigned to F05.
F14 (Technology Development): Fellowship applications that are concerned primarily with the development of new methods, instrumentation, or technology for studies of cell structure, function, regulation, and differentiation may be assigned to F14; fellowship applications that are concerned primarily with elucidating the basic principles of cell structure, function, regulation, and differentiation may be assigned to F05. |